The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries
There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained fr...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2009
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23470
- Acceso en línea:
- https://doi.org/10.1016/j.vph.2008.11.002
https://repository.urosario.edu.co/handle/10336/23470
- Palabra clave:
- 4 aminopyridine
Caffeine
Glibenclamide
Noradrenalin
Potassium channel
Potassium channel blocking agent
Tetrylammonium
Article
Bath
Clinical article
Concentration (parameters)
Coronary artery bypass surgery
Endothelium
Human
Human tissue
Incubation time
Internal mammary artery
Mental concentration
Priority journal
Vasodilatation
Caffeine
Glyburide
Humans
Mammary arteries
Potassium channel blockers
Potassium channels
Vasodilation
Caffeine
Internal mammary artery
Potassium channel
Vasodilation
drug
Dose-response relationship
- Rights
- License
- Abierto (Texto Completo)
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5ee38339-ca7a-4ab8-8451-99d76f728a7a-1bc54061b-7ea1-45b8-b02f-a9c8e72476b1-1e6341c24-1ff3-4b44-9865-924cc5e9e94d-1f915930c-6cd7-4e6e-b876-868dddf68360-12d345211-adbe-4771-b6ac-a07098a3157c-12020-05-26T00:02:18Z2020-05-26T00:02:18Z2009There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained from 29 patients who underwent coronary artery bypass graft surgery. They were cut into rings, suspended between two wire hooks in organ bath chambers and constricted submaximally with norepinephrine. Caffeine (3.16 × 10- 9 to 10- 4 mol/L) was added in a cumulative fashion to rings with or without functional endothelium and concentration response curves were constructed. The response to caffeine was also evaluated after incubation with adenosine 3?,5?-triphosphate (ATP)-dependent potassium channel blocker glibenclamide, voltage-dependent potassium channel blocker 4-aminopyridine and large-conductance calcium-activated potassium channel inhibitor tetraethylammonium. Caffeine produced a potent, concentration-dependent relaxation of IMA. The relaxant responses did not differ significantly between endothelium-intact and endothelium-denuded preparations. Incubation with different potassium channel inhibitors (glibenclamide, 4-aminopyridine and tetraethylammonium) did not cause significant alterations in the relaxant responses to caffeine. These results suggest that the vasodilatory response to caffeine in human IMA is independent of endothelial function and is not mediated by potassium channels. © 2008 Elsevier Inc. All rights reserved.application/pdfhttps://doi.org/10.1016/j.vph.2008.11.00215371891https://repository.urosario.edu.co/handle/10336/23470eng136No. 43924132Vascular PharmacologyVol. 50Vascular Pharmacology, ISSN:15371891, Vol.50, No.43924 (2009); pp. 132-136https://www.scopus.com/inward/record.uri?eid=2-s2.0-58549102308&doi=10.1016%2fj.vph.2008.11.002&partnerID=40&md5=64ba0d0bea4da031b615f07b7da23ff6Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUR4 aminopyridineCaffeineGlibenclamideNoradrenalinPotassium channelPotassium channel blocking agentTetrylammoniumArticleBathClinical articleConcentration (parameters)Coronary artery bypass surgeryEndotheliumHumanHuman tissueIncubation timeInternal mammary arteryMental concentrationPriority journalVasodilatationCaffeineGlyburideHumansMammary arteriesPotassium channel blockersPotassium channelsVasodilationCaffeineInternal mammary arteryPotassium channelVasodilationdrugDose-response relationshipThe role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteriesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Montes, Felix R.Cabrera, MarianaDelgadillo, AlexandraSalgar, CarlosEcheverri, Dario10336/23470oai:repository.urosario.edu.co:10336/234702022-05-02 07:37:20.994807https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries |
title |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries |
spellingShingle |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries 4 aminopyridine Caffeine Glibenclamide Noradrenalin Potassium channel Potassium channel blocking agent Tetrylammonium Article Bath Clinical article Concentration (parameters) Coronary artery bypass surgery Endothelium Human Human tissue Incubation time Internal mammary artery Mental concentration Priority journal Vasodilatation Caffeine Glyburide Humans Mammary arteries Potassium channel blockers Potassium channels Vasodilation Caffeine Internal mammary artery Potassium channel Vasodilation drug Dose-response relationship |
title_short |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries |
title_full |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries |
title_fullStr |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries |
title_full_unstemmed |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries |
title_sort |
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries |
dc.subject.keyword.spa.fl_str_mv |
4 aminopyridine Caffeine Glibenclamide Noradrenalin Potassium channel Potassium channel blocking agent Tetrylammonium Article Bath Clinical article Concentration (parameters) Coronary artery bypass surgery Endothelium Human Human tissue Incubation time Internal mammary artery Mental concentration Priority journal Vasodilatation Caffeine Glyburide Humans Mammary arteries Potassium channel blockers Potassium channels Vasodilation Caffeine Internal mammary artery Potassium channel Vasodilation |
topic |
4 aminopyridine Caffeine Glibenclamide Noradrenalin Potassium channel Potassium channel blocking agent Tetrylammonium Article Bath Clinical article Concentration (parameters) Coronary artery bypass surgery Endothelium Human Human tissue Incubation time Internal mammary artery Mental concentration Priority journal Vasodilatation Caffeine Glyburide Humans Mammary arteries Potassium channel blockers Potassium channels Vasodilation Caffeine Internal mammary artery Potassium channel Vasodilation drug Dose-response relationship |
dc.subject.keyword.eng.fl_str_mv |
drug Dose-response relationship |
description |
There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained from 29 patients who underwent coronary artery bypass graft surgery. They were cut into rings, suspended between two wire hooks in organ bath chambers and constricted submaximally with norepinephrine. Caffeine (3.16 × 10- 9 to 10- 4 mol/L) was added in a cumulative fashion to rings with or without functional endothelium and concentration response curves were constructed. The response to caffeine was also evaluated after incubation with adenosine 3?,5?-triphosphate (ATP)-dependent potassium channel blocker glibenclamide, voltage-dependent potassium channel blocker 4-aminopyridine and large-conductance calcium-activated potassium channel inhibitor tetraethylammonium. Caffeine produced a potent, concentration-dependent relaxation of IMA. The relaxant responses did not differ significantly between endothelium-intact and endothelium-denuded preparations. Incubation with different potassium channel inhibitors (glibenclamide, 4-aminopyridine and tetraethylammonium) did not cause significant alterations in the relaxant responses to caffeine. These results suggest that the vasodilatory response to caffeine in human IMA is independent of endothelial function and is not mediated by potassium channels. © 2008 Elsevier Inc. All rights reserved. |
publishDate |
2009 |
dc.date.created.spa.fl_str_mv |
2009 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:02:18Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:02:18Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.vph.2008.11.002 |
dc.identifier.issn.none.fl_str_mv |
15371891 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23470 |
url |
https://doi.org/10.1016/j.vph.2008.11.002 https://repository.urosario.edu.co/handle/10336/23470 |
identifier_str_mv |
15371891 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
136 |
dc.relation.citationIssue.none.fl_str_mv |
No. 43924 |
dc.relation.citationStartPage.none.fl_str_mv |
132 |
dc.relation.citationTitle.none.fl_str_mv |
Vascular Pharmacology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 50 |
dc.relation.ispartof.spa.fl_str_mv |
Vascular Pharmacology, ISSN:15371891, Vol.50, No.43924 (2009); pp. 132-136 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-58549102308&doi=10.1016%2fj.vph.2008.11.002&partnerID=40&md5=64ba0d0bea4da031b615f07b7da23ff6 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167520711540736 |