Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

In order to characterize immunoglobulin heavy?chain variable (IGHV ) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non?human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study rep...

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Autores:
Tipo de recurso:
Fecha de publicación:
2005
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27837
Acceso en línea:
https://doi.org/10.1111/j.1399-0039.2005.00491.x
https://repository.urosario.edu.co/handle/10336/27837
Palabra clave:
Animal model
Aotus
IGHV
Molecular evolution
New World monkey
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_14cc29262bca7269b7c80753220abf3c
oai_identifier_str oai:repository.urosario.edu.co:10336/27837
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 9cd4f14b-6f9f-492b-b6ab-1ea2d614a01c-120b87ac9-637e-491a-88a8-542cfcd798d2-103c4b902-8a61-4978-b28f-b74f3eebcfe1-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-176e03223-040d-4e46-864f-3bdecc8d2790-12020-08-19T14:44:09Z2020-08-19T14:44:09Z2005-09-29In order to characterize immunoglobulin heavy?chain variable (IGHV ) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non?human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae . Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae . Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response.application/pdfhttps://doi.org/10.1111/j.1399-0039.2005.00491.xISSN: 2059-2302EISSN: 2059-2310https://repository.urosario.edu.co/handle/10336/27837engJohn Wiley & Sons649No. 6640HLA, Tissue AntigensVol. 66HLA, Tissue Antigens, ISSN: 2059-2302;EISSN: 2059-2310, Vol.66, No.6 (December 2005); pp. 640-649https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1399-0039.2005.00491.xRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecHLA, Tissue Antigensinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAnimal modelAotusIGHVMolecular evolutionNew World monkeyIdentification of five different IGHV gene families in owl monkeys (Aotus nancymaae)Identificación de cinco familias de genes IGHV diferentes en monos búho (Aotus nancymaae)articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Hernández, E. C.Suárez, C. F.Parra, C. A.Patarroyo, M. A.Patarroyo, M. E.10336/27837oai:repository.urosario.edu.co:10336/278372021-06-03 00:51:01.169https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
dc.title.TranslatedTitle.spa.fl_str_mv Identificación de cinco familias de genes IGHV diferentes en monos búho (Aotus nancymaae)
title Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
spellingShingle Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
Animal model
Aotus
IGHV
Molecular evolution
New World monkey
title_short Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
title_full Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
title_fullStr Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
title_full_unstemmed Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
title_sort Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)
dc.subject.keyword.spa.fl_str_mv Animal model
Aotus
IGHV
Molecular evolution
New World monkey
topic Animal model
Aotus
IGHV
Molecular evolution
New World monkey
description In order to characterize immunoglobulin heavy?chain variable (IGHV ) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non?human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae . Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae . Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response.
publishDate 2005
dc.date.created.spa.fl_str_mv 2005-09-29
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:44:09Z
dc.date.available.none.fl_str_mv 2020-08-19T14:44:09Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1111/j.1399-0039.2005.00491.x
dc.identifier.issn.none.fl_str_mv ISSN: 2059-2302
EISSN: 2059-2310
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27837
url https://doi.org/10.1111/j.1399-0039.2005.00491.x
https://repository.urosario.edu.co/handle/10336/27837
identifier_str_mv ISSN: 2059-2302
EISSN: 2059-2310
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 649
dc.relation.citationIssue.none.fl_str_mv No. 6
dc.relation.citationStartPage.none.fl_str_mv 640
dc.relation.citationTitle.none.fl_str_mv HLA, Tissue Antigens
dc.relation.citationVolume.none.fl_str_mv Vol. 66
dc.relation.ispartof.spa.fl_str_mv HLA, Tissue Antigens, ISSN: 2059-2302;EISSN: 2059-2310, Vol.66, No.6 (December 2005); pp. 640-649
dc.relation.uri.spa.fl_str_mv https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1399-0039.2005.00491.x
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv John Wiley & Sons
dc.source.spa.fl_str_mv HLA, Tissue Antigens
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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