Impact and effectiveness of the quadrivalent human papillomavirus vaccine: A systematic review of 10 years of real-world experience

Prophylactic human papillomavirus (HPV) vaccination programs constitute major public health initiatives worldwide. We assessed the global effect of quadrivalent HPV (4vHPV) vaccination on HPV infection and disease. PubMed and Embase were systematically searched for peer-reviewed articles from January 2007 through February 2016 to identify observational studies reporting the impact or effectiveness of 4vHPV vaccination on infection, anogenital warts, and cervical cancer or precancerous lesions. Over the last decade, the impact of HPV vaccination in real-world settings has become increasingly evident, especially among girls vaccinated before HPV exposure in countries with high vaccine uptake. Maximal reductions of approximately 90% for HPV 6/11/16/18 infection, approximately 90% for genital warts, approximately 45% for low-grade cytological cervical abnormalities, and approximately 85% for high-grade histologically proven cervical abnormalities have been reported. The full public health potential of HPV vaccination is not yet realized. HPV-related disease remains a significant source of morbidity and mortality in developing and developed nations, underscoring the need for HPV vaccination programs with high population coverage. © 2016 The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

• Fecha de publicación: 2016
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23687
• Acceso en línea: https://doi.org/10.1093/cid/ciw354; https://repository.urosario.edu.co/handle/10336/23687
• Palabra clave: Wart virus vaccine; Wart virus vaccine; Clinical effectiveness; Condyloma acuminatum; Drug exposure; Embase; Histopathology; Human; Human papillomavirus type 11; Human papillomavirus type 18; Human papillomavirus type 6; Medline; Observational study; Papillomavirus infection; Precancer; Priority journal; Review; Systematic review; Uterine cervix cancer; Uterine cervix cytology; Vaccination; Condyloma acuminatum; Female; Immunology; Male; Papillomaviridae; Papillomavirus infection; Uterine cervix tumor; Vaccination; Virology; Condylomata Acuminata; Female; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Male; Papillomaviridae; Papillomavirus Infections; Uterine Cervical Neoplasms; Vaccination; Cervical cancer; CIN; Gardasil/Silgard; Genital warts; HPV vaccination
• License: Abierto (Texto Completo)