Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review

Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23295
Acceso en línea:
https://doi.org/10.1016/j.semarthrit.2014.09.006
https://repository.urosario.edu.co/handle/10336/23295
Palabra clave:
Antinuclear antibody
C reactive protein
Rheumatoid factor
Autoantibody
Adult
Age distribution
Article
Asia
Clinical evaluation
Colombia
Computer assisted tomography
Cross-sectional study
Disease duration
Echography
Europe
Female
Human
Major clinical study
Male
Mexico
Non erosive rheumatoid arthritis
Onset age
Population research
Prevalence
Priority journal
Rheumatoid arthritis
South and central america
Systematic review (topic)
Visual analog scale
X ray
Bone
Immunology
Middle aged
Radiography
Rheumatoid arthritis
Adult
Autoantibodies
Bone and bones
Female
Humans
Male
Middle aged
Computed tomography
Erosions
Rheumatoid arthritis
Ultrasonography
X-ray
rheumatoid
Arthritis
Rights
License
Abierto (Texto Completo)
id EDOCUR2_12b1ce13caeac98d8f76c1b6c72d8bea
oai_identifier_str oai:repository.urosario.edu.co:10336/23295
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
spellingShingle Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
Antinuclear antibody
C reactive protein
Rheumatoid factor
Autoantibody
Adult
Age distribution
Article
Asia
Clinical evaluation
Colombia
Computer assisted tomography
Cross-sectional study
Disease duration
Echography
Europe
Female
Human
Major clinical study
Male
Mexico
Non erosive rheumatoid arthritis
Onset age
Population research
Prevalence
Priority journal
Rheumatoid arthritis
South and central america
Systematic review (topic)
Visual analog scale
X ray
Bone
Immunology
Middle aged
Radiography
Rheumatoid arthritis
Adult
Autoantibodies
Bone and bones
Female
Humans
Male
Middle aged
Computed tomography
Erosions
Rheumatoid arthritis
Ultrasonography
X-ray
rheumatoid
Arthritis
title_short Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_full Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_fullStr Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_full_unstemmed Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
title_sort Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
dc.subject.keyword.spa.fl_str_mv Antinuclear antibody
C reactive protein
Rheumatoid factor
Autoantibody
Adult
Age distribution
Article
Asia
Clinical evaluation
Colombia
Computer assisted tomography
Cross-sectional study
Disease duration
Echography
Europe
Female
Human
Major clinical study
Male
Mexico
Non erosive rheumatoid arthritis
Onset age
Population research
Prevalence
Priority journal
Rheumatoid arthritis
South and central america
Systematic review (topic)
Visual analog scale
X ray
Bone
Immunology
Middle aged
Radiography
Rheumatoid arthritis
Adult
Autoantibodies
Bone and bones
Female
Humans
Male
Middle aged
Computed tomography
Erosions
Rheumatoid arthritis
Ultrasonography
X-ray
topic Antinuclear antibody
C reactive protein
Rheumatoid factor
Autoantibody
Adult
Age distribution
Article
Asia
Clinical evaluation
Colombia
Computer assisted tomography
Cross-sectional study
Disease duration
Echography
Europe
Female
Human
Major clinical study
Male
Mexico
Non erosive rheumatoid arthritis
Onset age
Population research
Prevalence
Priority journal
Rheumatoid arthritis
South and central america
Systematic review (topic)
Visual analog scale
X ray
Bone
Immunology
Middle aged
Radiography
Rheumatoid arthritis
Adult
Autoantibodies
Bone and bones
Female
Humans
Male
Middle aged
Computed tomography
Erosions
Rheumatoid arthritis
Ultrasonography
X-ray
rheumatoid
Arthritis
dc.subject.keyword.eng.fl_str_mv rheumatoid
Arthritis
description Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc.
publishDate 2015
dc.date.created.spa.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:00:59Z
dc.date.available.none.fl_str_mv 2020-05-26T00:00:59Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.semarthrit.2014.09.006
dc.identifier.issn.none.fl_str_mv 490172
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23295
url https://doi.org/10.1016/j.semarthrit.2014.09.006
https://repository.urosario.edu.co/handle/10336/23295
identifier_str_mv 490172
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 498
dc.relation.citationIssue.none.fl_str_mv No. 5
dc.relation.citationStartPage.none.fl_str_mv 489
dc.relation.citationTitle.none.fl_str_mv Seminars in Arthritis and Rheumatism
dc.relation.citationVolume.none.fl_str_mv Vol. 44
dc.relation.ispartof.spa.fl_str_mv Seminars in Arthritis and Rheumatism, ISSN:490172, Vol.44, No.5 (2015); pp. 489-498
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926337355&doi=10.1016%2fj.semarthrit.2014.09.006&partnerID=40&md5=22637736616e6b1725766f9fbe03ae9b
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv W.B. Saunders
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
bitstream.url.fl_str_mv https://repository.urosario.edu.co/bitstreams/5505870d-a861-4f11-a851-944ebcc70a88/download
https://repository.urosario.edu.co/bitstreams/954fbdbb-9730-4e3e-a667-de70ae779ec6/download
https://repository.urosario.edu.co/bitstreams/71f2ed2f-8d1c-4f3b-be03-e0ca816b162d/download
bitstream.checksum.fl_str_mv dc542804cfd0e513f947ade928608e76
2d8a8e594d624109c7612387a1433666
b4bf66998502b885770317f68dd74f0d
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167504443932672
spelling 06d01a9c-7112-4ad7-b82e-5dedc26c7a1f2af7274f-4228-4a32-9948-87516d4fe5394409e34d-4b63-48cf-9790-4dea785652e585ffdb9c-f583-4a63-8008-cb407b0d22f180ad7a9c-42eb-4d68-b578-b9670635e93252249701194747786002020-05-26T00:00:59Z2020-05-26T00:00:59Z2015Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc.application/pdfhttps://doi.org/10.1016/j.semarthrit.2014.09.006490172https://repository.urosario.edu.co/handle/10336/23295engW.B. Saunders498No. 5489Seminars in Arthritis and RheumatismVol. 44Seminars in Arthritis and Rheumatism, ISSN:490172, Vol.44, No.5 (2015); pp. 489-498https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926337355&doi=10.1016%2fj.semarthrit.2014.09.006&partnerID=40&md5=22637736616e6b1725766f9fbe03ae9bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAntinuclear antibodyC reactive proteinRheumatoid factorAutoantibodyAdultAge distributionArticleAsiaClinical evaluationColombiaComputer assisted tomographyCross-sectional studyDisease durationEchographyEuropeFemaleHumanMajor clinical studyMaleMexicoNon erosive rheumatoid arthritisOnset agePopulation researchPrevalencePriority journalRheumatoid arthritisSouth and central americaSystematic review (topic)Visual analog scaleX rayBoneImmunologyMiddle agedRadiographyRheumatoid arthritisAdultAutoantibodiesBone and bonesFemaleHumansMaleMiddle agedComputed tomographyErosionsRheumatoid arthritisUltrasonographyX-rayrheumatoidArthritisDoes non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature reviewarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Amaya-Amaya, JennyCalixto, Omar-JavierSaade-Lemus, SandraCalvo-Paramo, EnriqueMantilla, Ruben-DarioRojas-Villarraga, AdrianaAnaya, Juan-ManuelORIGINAL1-s2-0-S0049017214002224-main.pdfapplication/pdf2155036https://repository.urosario.edu.co/bitstreams/5505870d-a861-4f11-a851-944ebcc70a88/downloaddc542804cfd0e513f947ade928608e76MD51TEXT1-s2-0-S0049017214002224-main.pdf.txt1-s2-0-S0049017214002224-main.pdf.txtExtracted texttext/plain54176https://repository.urosario.edu.co/bitstreams/954fbdbb-9730-4e3e-a667-de70ae779ec6/download2d8a8e594d624109c7612387a1433666MD52THUMBNAIL1-s2-0-S0049017214002224-main.pdf.jpg1-s2-0-S0049017214002224-main.pdf.jpgGenerated Thumbnailimage/jpeg4454https://repository.urosario.edu.co/bitstreams/71f2ed2f-8d1c-4f3b-be03-e0ca816b162d/downloadb4bf66998502b885770317f68dd74f0dMD5310336/23295oai:repository.urosario.edu.co:10336/232952022-05-02 07:37:13.574592https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co