Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review
Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2015
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23295
- Acceso en línea:
- https://doi.org/10.1016/j.semarthrit.2014.09.006
https://repository.urosario.edu.co/handle/10336/23295
- Palabra clave:
- Antinuclear antibody
C reactive protein
Rheumatoid factor
Autoantibody
Adult
Age distribution
Article
Asia
Clinical evaluation
Colombia
Computer assisted tomography
Cross-sectional study
Disease duration
Echography
Europe
Female
Human
Major clinical study
Male
Mexico
Non erosive rheumatoid arthritis
Onset age
Population research
Prevalence
Priority journal
Rheumatoid arthritis
South and central america
Systematic review (topic)
Visual analog scale
X ray
Bone
Immunology
Middle aged
Radiography
Rheumatoid arthritis
Adult
Autoantibodies
Bone and bones
Female
Humans
Male
Middle aged
Computed tomography
Erosions
Rheumatoid arthritis
Ultrasonography
X-ray
rheumatoid
Arthritis
- Rights
- License
- Abierto (Texto Completo)
Summary: | Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease. © 2014 Elsevier Inc. |
---|