The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society

• Fecha de publicación: 2019
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22895
• Acceso en línea: https://doi.org/10.1002/pro.3727; https://repository.urosario.edu.co/handle/10336/22895
• Palabra clave: Regulator protein; Single stranded dna binding protein; Transcription factor; Article; Candida auris; Drug resistance; Fungal virulence; Nonhuman; Priority journal; Protein domain; Protein structure; Structure analysis; Transcription initiation; Transcription regulation; Activation and repression domains; Amphotericin b; Antifungal resistance mechanisms; Candida; Filamentation in fungi; Flocculence; Lufs domain; Single nucleotide polymorphisms; Transcription factors; Whole-genome sequence comparisons
• License: Abierto (Texto Completo)