The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator pr...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22895
Acceso en línea:
https://doi.org/10.1002/pro.3727
https://repository.urosario.edu.co/handle/10336/22895
Palabra clave:
Regulator protein
Single stranded dna binding protein
Transcription factor
Article
Candida auris
Drug resistance
Fungal virulence
Nonhuman
Priority journal
Protein domain
Protein structure
Structure analysis
Transcription initiation
Transcription regulation
Activation and repression domains
Amphotericin b
Antifungal resistance mechanisms
Candida
Filamentation in fungi
Flocculence
Lufs domain
Single nucleotide polymorphisms
Transcription factors
Whole-genome sequence comparisons
Rights
License
Abierto (Texto Completo)
Description
Summary:The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society