Exercise and postprandial lipemia : Effects on vascular health in inactive adults

Background: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity...

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Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/20361
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/20361
Palabra clave:
Glucose
High-Fat
Vascular
High Density Lipoprotein Cholesterol
Triacylglycerol
Cholesterol
Arterial Stiffness
Augmentation Index
Cholesterol Blood Level
Comparative Effectiveness
Controlled Study
Diet Restriction
Endothelial Dysfunction
Exercise
Glucose Blood Level
High Intensity Training
Human
Human Experiment
Hyperlipidemia
Lipid Diet
Male
Moderate Continuous Training
Normal Human
Physical Inactivity
Postprandial State
Prospective Study
Pulse Wave
Randomized Controlled Trial
Blood
Exercise
Hyperlipidemia
Pathophysiology
Physiology
Postprandial State
Vascular Endothelium
Vasodilatation
Cholesterol
Diet
Endothelium
Exercise
Hyperlipidemias
Male
Postprandial Period
Vascular Stiffness
Vasodilation
Enfermedades
Postprandial lipemia
Endothelial function
Exercise intensity
High-intensity exercise
Moderate continuous training
Adult
Article
Female
Adult
Female
Humans
Glucosa
Azucar en el organismo
Colesterol
Rights
License
Abierto (Texto Completo)
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network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Exercise and postprandial lipemia : Effects on vascular health in inactive adults
title Exercise and postprandial lipemia : Effects on vascular health in inactive adults
spellingShingle Exercise and postprandial lipemia : Effects on vascular health in inactive adults
Glucose
High-Fat
Vascular
High Density Lipoprotein Cholesterol
Triacylglycerol
Cholesterol
Arterial Stiffness
Augmentation Index
Cholesterol Blood Level
Comparative Effectiveness
Controlled Study
Diet Restriction
Endothelial Dysfunction
Exercise
Glucose Blood Level
High Intensity Training
Human
Human Experiment
Hyperlipidemia
Lipid Diet
Male
Moderate Continuous Training
Normal Human
Physical Inactivity
Postprandial State
Prospective Study
Pulse Wave
Randomized Controlled Trial
Blood
Exercise
Hyperlipidemia
Pathophysiology
Physiology
Postprandial State
Vascular Endothelium
Vasodilatation
Cholesterol
Diet
Endothelium
Exercise
Hyperlipidemias
Male
Postprandial Period
Vascular Stiffness
Vasodilation
Enfermedades
Postprandial lipemia
Endothelial function
Exercise intensity
High-intensity exercise
Moderate continuous training
Adult
Article
Female
Adult
Female
Humans
Glucosa
Azucar en el organismo
Colesterol
title_short Exercise and postprandial lipemia : Effects on vascular health in inactive adults
title_full Exercise and postprandial lipemia : Effects on vascular health in inactive adults
title_fullStr Exercise and postprandial lipemia : Effects on vascular health in inactive adults
title_full_unstemmed Exercise and postprandial lipemia : Effects on vascular health in inactive adults
title_sort Exercise and postprandial lipemia : Effects on vascular health in inactive adults
dc.contributor.gruplac.spa.fl_str_mv Centro de Estudios en Medición de la Actividad Física (CEMA)
dc.subject.spa.fl_str_mv Glucose
High-Fat
Vascular
High Density Lipoprotein Cholesterol
Triacylglycerol
Cholesterol
Arterial Stiffness
Augmentation Index
Cholesterol Blood Level
Comparative Effectiveness
Controlled Study
Diet Restriction
Endothelial Dysfunction
Exercise
Glucose Blood Level
High Intensity Training
Human
Human Experiment
Hyperlipidemia
Lipid Diet
Male
Moderate Continuous Training
Normal Human
Physical Inactivity
Postprandial State
Prospective Study
Pulse Wave
Randomized Controlled Trial
Blood
Exercise
Hyperlipidemia
Pathophysiology
Physiology
Postprandial State
Vascular Endothelium
Vasodilatation
Cholesterol
Diet
Endothelium
Exercise
Hyperlipidemias
Male
Postprandial Period
Vascular Stiffness
Vasodilation
topic Glucose
High-Fat
Vascular
High Density Lipoprotein Cholesterol
Triacylglycerol
Cholesterol
Arterial Stiffness
Augmentation Index
Cholesterol Blood Level
Comparative Effectiveness
Controlled Study
Diet Restriction
Endothelial Dysfunction
Exercise
Glucose Blood Level
High Intensity Training
Human
Human Experiment
Hyperlipidemia
Lipid Diet
Male
Moderate Continuous Training
Normal Human
Physical Inactivity
Postprandial State
Prospective Study
Pulse Wave
Randomized Controlled Trial
Blood
Exercise
Hyperlipidemia
Pathophysiology
Physiology
Postprandial State
Vascular Endothelium
Vasodilatation
Cholesterol
Diet
Endothelium
Exercise
Hyperlipidemias
Male
Postprandial Period
Vascular Stiffness
Vasodilation
Enfermedades
Postprandial lipemia
Endothelial function
Exercise intensity
High-intensity exercise
Moderate continuous training
Adult
Article
Female
Adult
Female
Humans
Glucosa
Azucar en el organismo
Colesterol
dc.subject.ddc.spa.fl_str_mv Enfermedades
dc.subject.keyword.spa.fl_str_mv Postprandial lipemia
Endothelial function
Exercise intensity
High-intensity exercise
Moderate continuous training
Adult
Article
Female
Adult
Female
Humans
dc.subject.lemb.spa.fl_str_mv Glucosa
Azucar en el organismo
Colesterol
description Background: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. Methods: A randomized clinical trial was conducted in 20 healthy, inactive adults (31.6 ± 7.1 years). Participants followed the two exercise protocols for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received a HFM. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, high-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. Results: The effects of a HFM were evaluated in a fasted state and 60, 120, 180, and 240 min postprandially. A significant decrease in serum glucose between 0 min (fasted state) and 120 min postprandially was found in the HIT group (P = 0.035). Likewise, FMD (%) was significantly different between the fasted state and 60 min after a HFM in the HIT group (P = 0.042). The total cholesterol response expressed as area under curve (AUC)(0-240) was lower following HIT than following MCT, but no significant differences were observed (8%, P > 0.05). Similarly, triglycerides AUC(0-240) was also lower after HIT compared with MCT, which trended towards significance (24%, P = 0.076). The AUC(0-240) for the glucose response was significantly lower following HIT than MCT (10%, P = 0.008). FMD and nFMD AUC(0-240) were significantly higher following HIT than following MCT (46.9%, P = 0.021 and 67.3%, P = 0.009, respectively). PWV AUC(0-240) did not differ following between the two exercise groups (2.3%, P > 0.05). Conclusions: Supervised exercise training mitigates endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, and medium-term HIT may be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairment. Trial registration: ClinicalTrials.gov ID: NCT02738385 Date of registration: April 14, 2016. © 2018 The Author(s).
publishDate 2018
dc.date.created.none.fl_str_mv 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2019-09-30T13:40:35Z
dc.date.available.none.fl_str_mv 2019-09-30T13:40:35Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv 10.1186/s12944-018-0719-3
dc.identifier.issn.none.fl_str_mv 1476-511X
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/20361
identifier_str_mv 10.1186/s12944-018-0719-3
1476-511X
url https://repository.urosario.edu.co/handle/10336/20361
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationTitle.none.fl_str_mv Lipids in Health and Disease
dc.relation.citationVolume.none.fl_str_mv Vol. 17
dc.relation.ispartof.spa.fl_str_mv Lipids in Health and Disease, ISSN:1476-511X, Vol. 17 (2018)
dc.relation.uri.spa.fl_str_mv https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-018-0719-3
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dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
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institution Universidad del Rosario
dc.source.bibliographicCitation.spa.fl_str_mv Endemann, D.H., Schiffrin, E.L., Endothelial dysfunction (2004) J Am Soc Nephrol, 15 (8), pp. 1983-1992. , 1:CAS:528:DC%2BD2cXlvVKmurY%3D 15284284
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
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spelling Centro de Estudios en Medición de la Actividad Física (CEMA)Ramírez-Vélez, RobinsonCorrea-Rodríguez, MaríaTordecilla Sanders, María AlejandraAya-Aldana, VivianaIzquierdo, MikelCorrea Bautista, Jorge EnriqueÁlvarez, CristianGarcia-Hermoso, AntonioRamírez-Vélez, RobinsonCorrea-Rodríguez, MaríaTordecilla-Sanders, AlejandraAya-Aldana, VivianaIzquierdo, MikelCorrea-Bautista, Jorge EnriqueÁlvarez, CristianGarcia-Hermoso, Antonio945181836002229d50b-949b-47e1-82e9-e748bdeb6e486001022382805600d933ffd7-72d9-46f0-8b0e-d2684af3d4ad60075b6b2fa-230d-4c46-b327-97ca28a5215a60079139103600c4e04fc6-3635-4412-9a28-4c09ebc7658b6006782a93c-e7a5-44f4-bcf2-0f9cfda0ee3e6002019-09-30T13:40:35Z2019-09-30T13:40:35Z20182018Background: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. Methods: A randomized clinical trial was conducted in 20 healthy, inactive adults (31.6 ± 7.1 years). Participants followed the two exercise protocols for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received a HFM. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, high-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. Results: The effects of a HFM were evaluated in a fasted state and 60, 120, 180, and 240 min postprandially. A significant decrease in serum glucose between 0 min (fasted state) and 120 min postprandially was found in the HIT group (P = 0.035). Likewise, FMD (%) was significantly different between the fasted state and 60 min after a HFM in the HIT group (P = 0.042). The total cholesterol response expressed as area under curve (AUC)(0-240) was lower following HIT than following MCT, but no significant differences were observed (8%, P > 0.05). Similarly, triglycerides AUC(0-240) was also lower after HIT compared with MCT, which trended towards significance (24%, P = 0.076). The AUC(0-240) for the glucose response was significantly lower following HIT than MCT (10%, P = 0.008). FMD and nFMD AUC(0-240) were significantly higher following HIT than following MCT (46.9%, P = 0.021 and 67.3%, P = 0.009, respectively). PWV AUC(0-240) did not differ following between the two exercise groups (2.3%, P > 0.05). Conclusions: Supervised exercise training mitigates endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, and medium-term HIT may be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairment. Trial registration: ClinicalTrials.gov ID: NCT02738385 Date of registration: April 14, 2016. © 2018 The Author(s).application/pdf10.1186/s12944-018-0719-31476-511Xhttps://repository.urosario.edu.co/handle/10336/20361engLipids in Health and DiseaseVol. 17Lipids in Health and Disease, ISSN:1476-511X, Vol. 17 (2018)https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-018-0719-3Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Endemann, D.H., Schiffrin, E.L., Endothelial dysfunction (2004) J Am Soc Nephrol, 15 (8), pp. 1983-1992. , 1:CAS:528:DC%2BD2cXlvVKmurY%3D 15284284instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURGlucoseHigh-FatVascularHigh Density Lipoprotein CholesterolTriacylglycerolCholesterolArterial StiffnessAugmentation IndexCholesterol Blood LevelComparative EffectivenessControlled StudyDiet RestrictionEndothelial DysfunctionExerciseGlucose Blood LevelHigh Intensity TrainingHumanHuman ExperimentHyperlipidemiaLipid DietMaleModerate Continuous TrainingNormal HumanPhysical InactivityPostprandial StateProspective StudyPulse WaveRandomized Controlled TrialBloodExerciseHyperlipidemiaPathophysiologyPhysiologyPostprandial StateVascular EndotheliumVasodilatationCholesterolDietEndotheliumExerciseHyperlipidemiasMalePostprandial PeriodVascular StiffnessVasodilationEnfermedades616600Postprandial lipemiaEndothelial functionExercise intensityHigh-intensity exerciseModerate continuous trainingAdultArticleFemaleAdultFemaleHumansGlucosaAzucar en el organismoColesterolExercise and postprandial lipemia : Effects on vascular health in inactive adultsarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501ORIGINAL70.pdfapplication/pdf661604https://repository.urosario.edu.co/bitstreams/a37e2147-a899-4f7d-bcdf-3bfd824163dc/download823e8d974e505c4bcac1568307ce42a6MD51TEXT70.pdf.txt70.pdf.txtExtracted texttext/plain49409https://repository.urosario.edu.co/bitstreams/1024b6f3-964a-4f3a-931e-58c35b6cdd11/download376e9c6c8540120c13ab21ff49a6dd7eMD52THUMBNAIL70.pdf.jpg70.pdf.jpgGenerated Thumbnailimage/jpeg4028https://repository.urosario.edu.co/bitstreams/fde63113-a4f1-4c22-9af7-f112e413b362/download4fc9048b0b80effcb46e5f98a76cb004MD5310336/20361oai:repository.urosario.edu.co:10336/203612020-02-12 16:21:05.223https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co