HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine

The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day 1 and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers. © 2008 Elsevier Ltd. All rights reserved.

• Fecha de publicación: 2008
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23448
• Acceso en línea: https://doi.org/10.1016/j.vaccine.2008.09.073; https://repository.urosario.edu.co/handle/10336/23448
• Palabra clave: Placebo; Silgard; Unclassified drug; Virus antibody; Wart virus vaccine; Adolescent; Adult; Antibody production; Antibody response; Article; Cancer immunization; Cancer prevention; Clinical trial; Controlled clinical trial; Controlled study; Double blind procedure; Drug efficacy; Female; Human; Infection prevention; Major clinical study; Phase 3 clinical trial; Priority journal; Randomized controlled trial; Uterine cervix carcinoma in situ; Wart virus; Adolescent; Condylomata acuminata; Female; Follow-up studies; Human papillomavirus 11; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus 6; Humans; Immunization schedule; Papillomavirus infections; Papillomavirus vaccines; Reverse transcriptase polymerase chain reaction; Vagina; Vaginal smears; Vulva; Young adult; Human papillomavirus; Humoral immunity; Immune memory; viral; Antibodies
• License: Abierto (Texto Completo)