Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed. Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. Due to the importance of astrocytes in brain homeost...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/24095
- Acceso en línea:
- https://doi.org/10.3389/fnmol.2017.00427
https://repository.urosario.edu.co/handle/10336/24095
- Palabra clave:
- 4 aminobutyric acid
Amyloid beta protein
Apolipoprotein
Chemokine
Cytokine
Estrogen receptor
Phytochemical
Reactive nitrogen species
Alzheimer disease
Astrocyte
Calcium cell level
Calcium signaling
Cell damage
Degenerative disease
Excitotoxicity
Homeostasis
Human
Induced pluripotent stem cell
Macroglia
Nerve degeneration
Nervous system inflammation
Neuroprotection
Neurotransmission
Neurotransmitter uptake
Oxidative stress
Rage
Review
Signal transduction
Alzheimer’s disease
Astrocytes
Neurodegeneration
Neuroinflammation
Nf-?b pathway
Oxidative stress
- Rights
- License
- Abierto (Texto Completo)
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dc.title.spa.fl_str_mv |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective |
title |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective |
spellingShingle |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective 4 aminobutyric acid Amyloid beta protein Apolipoprotein Chemokine Cytokine Estrogen receptor Phytochemical Reactive nitrogen species Alzheimer disease Astrocyte Calcium cell level Calcium signaling Cell damage Degenerative disease Excitotoxicity Homeostasis Human Induced pluripotent stem cell Macroglia Nerve degeneration Nervous system inflammation Neuroprotection Neurotransmission Neurotransmitter uptake Oxidative stress Rage Review Signal transduction Alzheimer’s disease Astrocytes Neurodegeneration Neuroinflammation Nf-?b pathway Oxidative stress |
title_short |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective |
title_full |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective |
title_fullStr |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective |
title_full_unstemmed |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective |
title_sort |
Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective |
dc.subject.keyword.spa.fl_str_mv |
4 aminobutyric acid Amyloid beta protein Apolipoprotein Chemokine Cytokine Estrogen receptor Phytochemical Reactive nitrogen species Alzheimer disease Astrocyte Calcium cell level Calcium signaling Cell damage Degenerative disease Excitotoxicity Homeostasis Human Induced pluripotent stem cell Macroglia Nerve degeneration Nervous system inflammation Neuroprotection Neurotransmission Neurotransmitter uptake Oxidative stress Rage Review Signal transduction Alzheimer’s disease Astrocytes Neurodegeneration Neuroinflammation Nf-?b pathway Oxidative stress |
topic |
4 aminobutyric acid Amyloid beta protein Apolipoprotein Chemokine Cytokine Estrogen receptor Phytochemical Reactive nitrogen species Alzheimer disease Astrocyte Calcium cell level Calcium signaling Cell damage Degenerative disease Excitotoxicity Homeostasis Human Induced pluripotent stem cell Macroglia Nerve degeneration Nervous system inflammation Neuroprotection Neurotransmission Neurotransmitter uptake Oxidative stress Rage Review Signal transduction Alzheimer’s disease Astrocytes Neurodegeneration Neuroinflammation Nf-?b pathway Oxidative stress |
description |
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed. Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. Due to the importance of astrocytes in brain homeostasis they have become interesting targets for the study of AD. Changes in astrocyte function have been observed in brains from individuals with AD, as well as in AD in vitro and in vivo animal models. The presence of amyloid beta (A?) has been shown to disrupt gliotransmission, neurotransmitter uptake, and alter calcium signaling in astrocytes. Furthermore, astrocytes express apolipoprotein E and are involved in the production, degradation and removal of A?. As well, changes in astrocytes that precede other pathological characteristics observed in AD, point to an early contribution of astroglia in this disease. Astrocytes participate in the inflammatory/immune responses of the central nervous system. The presence of A? activates different cell receptors and intracellular signaling pathways, mainly the advanced glycation end products receptor/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) pathway, responsible for the transcription of pro-inflammatory cytokines and chemokines in astrocytes. The release of these pro-inflammatory agents may induce cellular damage or even stimulate the production of A? in astrocytes. Additionally, A? induces the appearance of oxidative stress (OS) and production of reactive oxygen species and reactive nitrogen species in astrocytes, affecting among others, intracellular calcium levels, NADPH oxidase (NOX), NF-?B signaling, glutamate uptake (increasing the risk of excitotoxicity) and mitochondrial function. Excessive neuroinflammation and OS are observed in AD, and astrocytes seem to be involved in both. The A?/NF-?B interaction in astrocytes may play a central role in these inflammatory and OS changes present in AD. In this paper, we also discuss therapeutic measures highlighting the importance of astrocytes in AD pathology. Several new therapeutic approaches involving phenols (curcumin), phytoestrogens (genistein), neuroesteroids and other natural phytochemicals have been explored in astrocytes, obtaining some promising results regarding cognitive improvements and attenuation of neuroinflammation. Novel strategies comprising astrocytes and aimed to reduce OS in AD have also been proposed. These include estrogen receptor agonists (pelargonidin), Bambusae concretio Salicea, Monascin, and various antioxidatives such as resveratrol, tocotrienol, anthocyanins, and epicatechin, showing beneficial effects in AD models. © 2017 González-Reyes, Nava-Mesa, Vargas-Sánchez, Ariza-Salamanca and Mora-Muñoz. |
publishDate |
2017 |
dc.date.created.spa.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:08:34Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:08:34Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3389/fnmol.2017.00427 |
dc.identifier.issn.none.fl_str_mv |
16625099 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/24095 |
url |
https://doi.org/10.3389/fnmol.2017.00427 https://repository.urosario.edu.co/handle/10336/24095 |
identifier_str_mv |
16625099 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationTitle.none.fl_str_mv |
Frontiers in Molecular Neuroscience |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 10 |
dc.relation.ispartof.spa.fl_str_mv |
Frontiers in Molecular Neuroscience, ISSN:16625099, Vol.10,(2017) |
dc.relation.uri.spa.fl_str_mv |
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http://purl.org/coar/access_right/c_abf2 |
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Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Frontiers Media S.A. |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
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reponame:Repositorio Institucional EdocUR |
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7994277260080216571600a05467d0-43f3-40a0-afc2-bb4f5a9b5fb9dfb4faf9-7955-428b-b150-08e402da8cb5bc7aac27-9b1f-48fc-8881-864a868dc9e32020-05-26T00:08:34Z2020-05-26T00:08:34Z2017Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed. Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. Due to the importance of astrocytes in brain homeostasis they have become interesting targets for the study of AD. Changes in astrocyte function have been observed in brains from individuals with AD, as well as in AD in vitro and in vivo animal models. The presence of amyloid beta (A?) has been shown to disrupt gliotransmission, neurotransmitter uptake, and alter calcium signaling in astrocytes. Furthermore, astrocytes express apolipoprotein E and are involved in the production, degradation and removal of A?. As well, changes in astrocytes that precede other pathological characteristics observed in AD, point to an early contribution of astroglia in this disease. Astrocytes participate in the inflammatory/immune responses of the central nervous system. The presence of A? activates different cell receptors and intracellular signaling pathways, mainly the advanced glycation end products receptor/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) pathway, responsible for the transcription of pro-inflammatory cytokines and chemokines in astrocytes. The release of these pro-inflammatory agents may induce cellular damage or even stimulate the production of A? in astrocytes. Additionally, A? induces the appearance of oxidative stress (OS) and production of reactive oxygen species and reactive nitrogen species in astrocytes, affecting among others, intracellular calcium levels, NADPH oxidase (NOX), NF-?B signaling, glutamate uptake (increasing the risk of excitotoxicity) and mitochondrial function. Excessive neuroinflammation and OS are observed in AD, and astrocytes seem to be involved in both. The A?/NF-?B interaction in astrocytes may play a central role in these inflammatory and OS changes present in AD. In this paper, we also discuss therapeutic measures highlighting the importance of astrocytes in AD pathology. Several new therapeutic approaches involving phenols (curcumin), phytoestrogens (genistein), neuroesteroids and other natural phytochemicals have been explored in astrocytes, obtaining some promising results regarding cognitive improvements and attenuation of neuroinflammation. Novel strategies comprising astrocytes and aimed to reduce OS in AD have also been proposed. These include estrogen receptor agonists (pelargonidin), Bambusae concretio Salicea, Monascin, and various antioxidatives such as resveratrol, tocotrienol, anthocyanins, and epicatechin, showing beneficial effects in AD models. © 2017 González-Reyes, Nava-Mesa, Vargas-Sánchez, Ariza-Salamanca and Mora-Muñoz.application/pdfhttps://doi.org/10.3389/fnmol.2017.0042716625099https://repository.urosario.edu.co/handle/10336/24095engFrontiers Media S.A.Frontiers in Molecular NeuroscienceVol. 10Frontiers in Molecular Neuroscience, ISSN:16625099, Vol.10,(2017)https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041820350&doi=10.3389%2ffnmol.2017.00427&partnerID=40&md5=d08cbacdafb6ec7347261628ed550beaAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUR4 aminobutyric acidAmyloid beta proteinApolipoproteinChemokineCytokineEstrogen receptorPhytochemicalReactive nitrogen speciesAlzheimer diseaseAstrocyteCalcium cell levelCalcium signalingCell damageDegenerative diseaseExcitotoxicityHomeostasisHumanInduced pluripotent stem cellMacrogliaNerve degenerationNervous system inflammationNeuroprotectionNeurotransmissionNeurotransmitter uptakeOxidative stressRageReviewSignal transductionAlzheimer’s diseaseAstrocytesNeurodegenerationNeuroinflammationNf-?b pathwayOxidative stressInvolvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspectivearticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501González Reyes, Rodrigo EstebanNava Mesa, Mauricio OrlandoVargas-Sánchez, KarinaAriza-Salamanca, DanielMora-Muñoz, LauraORIGINALfnmol-10-00427.pdfapplication/pdf1034430https://repository.urosario.edu.co/bitstreams/70929c69-ca4e-4268-bd10-6e1ad70f9871/download9ce21568ed9b05b775f937f2b5bc1956MD51TEXTfnmol-10-00427.pdf.txtfnmol-10-00427.pdf.txtExtracted texttext/plain139365https://repository.urosario.edu.co/bitstreams/267e0d36-3b5e-43a7-bc56-511c7174baf4/downloade5ec0322cee1b39523dec448d02002e4MD52THUMBNAILfnmol-10-00427.pdf.jpgfnmol-10-00427.pdf.jpgGenerated Thumbnailimage/jpeg4382https://repository.urosario.edu.co/bitstreams/31ad78ea-306b-436b-93bb-4a5250651d90/download540845e2f76583be7d103c5f029c9ee5MD5310336/24095oai:repository.urosario.edu.co:10336/240952022-05-02 07:37:16.831692https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |