Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides

Erythrocyte binding ligand 1 (EBL-1) is a member of the ebl multigene family involved in Plasmodiumfalciparum invasion of erythrocytes. We found that five EBL-1 high-activity binding peptides (HABPs)bound specifically to erythrocytes: 29895 (41HKKKSGELNNNKSGILRSTY60), 29903 (201LYECGK-KIKEMKWICTDNQF...

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Autores:
Tipo de recurso:
Fecha de publicación:
2005
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26987
Acceso en línea:
https://doi.org/10.1110/ps.041084305
https://repository.urosario.edu.co/handle/10336/26987
Palabra clave:
Malaria protein
Erythrocyte binding ligand-1
Peptides
Plasmodium falciparum
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License
Abierto (Texto Completo)
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network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 91225589-1ef6547b6-3130-435a-8a09-7ca050cd7b64-151848826-15e82e691-ba88-4d28-b934-b924d1350834-1a650efd0-af5f-4ce9-9620-e1cad93a9173-14255e3fa-2b0d-47ce-ab18-c66a1b12d04d-134b82e95-53e0-4ba5-a5c5-d4191164afa1-1eba5265c-2b9f-49a4-8c8c-4e3459a41e19-151721018-15e48b055-035f-44d8-9867-a21686777f9d-12020-08-19T14:40:41Z2020-08-19T14:40:41Z2005-02Erythrocyte binding ligand 1 (EBL-1) is a member of the ebl multigene family involved in Plasmodiumfalciparum invasion of erythrocytes. We found that five EBL-1 high-activity binding peptides (HABPs)bound specifically to erythrocytes: 29895 (41HKKKSGELNNNKSGILRSTY60), 29903 (201LYECGK-KIKEMKWICTDNQF220), 29923 (601CNAILGSYADIGDIVRGLDV620), 29924(621WRDINTNKLSEK-FQKIFMGGY640), and 30018 (2481LEDIINLSKKKKKSINDTSFY2500). We also show that binding wassaturable, not sialic acid-dependent, and that all peptides specifically bound to a 36-kDa protein on theerythrocyte membrane. The five HABPs inhibited in vitro merozoite invasion depending on the peptideconcentration used, suggesting their possible role in the invasion process.application/pdfhttps://doi.org/10.1110/ps.041084305ISSN: 0961-8368EISSN: 1469-896Xhttps://repository.urosario.edu.co/handle/10336/26987engThe Protein SocietyJohn Wiley & Son473No. 2464Protein ScienceVol. 14Protein Science, ISSN: 0961-8368;EISSN: 1469-896X, Vol.14, No.2 (February 2005); pp. 464-473https://onlinelibrary.wiley.com/doi/epdf/10.1110/ps.041084305Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Protein Scienceinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMalaria proteinErythrocyte binding ligand-1PeptidesPlasmodium falciparumSpecific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptidesCapacidad de unión a eritrocitos específica y actividad biológica de péptidos derivados del ligando 1 de unión a eritrocitos de Plasmodium falciparum (EBL-1)articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Curtidor, HernandoRodríguez, Luis EOcampo, MarisolLópez, RamsesGarcía, Javier EValbuena, JohnVera, RicardoPuentes, AlvaroVanegas, MagnoliaPatarroyo, Manuel E10336/26987oai:repository.urosario.edu.co:10336/269872021-06-03 00:50:03.576https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
dc.title.TranslatedTitle.spa.fl_str_mv Capacidad de unión a eritrocitos específica y actividad biológica de péptidos derivados del ligando 1 de unión a eritrocitos de Plasmodium falciparum (EBL-1)
title Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
spellingShingle Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
Malaria protein
Erythrocyte binding ligand-1
Peptides
Plasmodium falciparum
title_short Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
title_full Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
title_fullStr Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
title_full_unstemmed Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
title_sort Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides
dc.subject.keyword.spa.fl_str_mv Malaria protein
Erythrocyte binding ligand-1
Peptides
Plasmodium falciparum
topic Malaria protein
Erythrocyte binding ligand-1
Peptides
Plasmodium falciparum
description Erythrocyte binding ligand 1 (EBL-1) is a member of the ebl multigene family involved in Plasmodiumfalciparum invasion of erythrocytes. We found that five EBL-1 high-activity binding peptides (HABPs)bound specifically to erythrocytes: 29895 (41HKKKSGELNNNKSGILRSTY60), 29903 (201LYECGK-KIKEMKWICTDNQF220), 29923 (601CNAILGSYADIGDIVRGLDV620), 29924(621WRDINTNKLSEK-FQKIFMGGY640), and 30018 (2481LEDIINLSKKKKKSINDTSFY2500). We also show that binding wassaturable, not sialic acid-dependent, and that all peptides specifically bound to a 36-kDa protein on theerythrocyte membrane. The five HABPs inhibited in vitro merozoite invasion depending on the peptideconcentration used, suggesting their possible role in the invasion process.
publishDate 2005
dc.date.created.spa.fl_str_mv 2005-02
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:41Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:41Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1110/ps.041084305
dc.identifier.issn.none.fl_str_mv ISSN: 0961-8368
EISSN: 1469-896X
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26987
url https://doi.org/10.1110/ps.041084305
https://repository.urosario.edu.co/handle/10336/26987
identifier_str_mv ISSN: 0961-8368
EISSN: 1469-896X
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 473
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationStartPage.none.fl_str_mv 464
dc.relation.citationTitle.none.fl_str_mv Protein Science
dc.relation.citationVolume.none.fl_str_mv Vol. 14
dc.relation.ispartof.spa.fl_str_mv Protein Science, ISSN: 0961-8368;EISSN: 1469-896X, Vol.14, No.2 (February 2005); pp. 464-473
dc.relation.uri.spa.fl_str_mv https://onlinelibrary.wiley.com/doi/epdf/10.1110/ps.041084305
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv The Protein Society
John Wiley & Son
dc.source.spa.fl_str_mv Protein Science
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167654202605568

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