Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both access...

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Autores:
Tipo de recurso:
Fecha de publicación:
2011
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24294
Acceso en línea:
https://doi.org/10.1016/j.meegid.2010.12.002
https://repository.urosario.edu.co/handle/10336/24294
Palabra clave:
Membrane protein
Merozoite surface protein 10
Merozoite surface protein 7a
Merozoite surface protein 7k
Unclassified drug
Article
Colombia
Controlled study
Genetic conservation
Genetic polymorphism
Genetic variability
Geography
Haplotype
Nonhuman
Nucleotide sequence
Plasmodium vivax
Priority journal
Colombia
Genetic variation
Genotype
Host-parasite interactions
Humans
Malaria vaccines
Membrane proteins
Molecular sequence data
Plasmodium vivax
Polymerase chain reaction
Protozoan proteins
Plasmodium vivax
Genetic polymorphism
Merozoite surface protein
P
Vivax
Vaccine candidate
protozoan
genetic
vivax
Antigens
Malaria
Polymorphism
Rights
License
Abierto (Texto Completo)
id EDOCUR2_0bcfef19e4cd00f1c64518f2cb3fae2b
oai_identifier_str oai:repository.urosario.edu.co:10336/24294
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 35f69913-269a-4264-bd0b-63f725ce293d-138cffb6d-7660-499f-a14c-08c750773c4f-12734b359-484f-4396-b7ca-262fe0d6851a-19fc64f6d-a903-48f1-ac2e-4e55fd2ed9af-12020-05-26T00:11:18Z2020-05-26T00:11:18Z2011The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.application/pdfhttps://doi.org/10.1016/j.meegid.2010.12.00215671348https://repository.urosario.edu.co/handle/10336/24294eng531No. 2528Infection, Genetics and EvolutionVol. 11Infection, Genetics and Evolution, ISSN:15671348, Vol.11, No.2 (2011); pp. 528-531https://www.scopus.com/inward/record.uri?eid=2-s2.0-79951953688&doi=10.1016%2fj.meegid.2010.12.002&partnerID=40&md5=c39402701ec8261bbec40aa60e4eef6bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMembrane proteinMerozoite surface protein 10Merozoite surface protein 7aMerozoite surface protein 7kUnclassified drugArticleColombiaControlled studyGenetic conservationGenetic polymorphismGenetic variabilityGeographyHaplotypeNonhumanNucleotide sequencePlasmodium vivaxPriority journalColombiaGenetic variationGenotypeHost-parasite interactionsHumansMalaria vaccinesMembrane proteinsMolecular sequence dataPlasmodium vivaxPolymerase chain reactionProtozoan proteinsPlasmodium vivaxGenetic polymorphismMerozoite surface proteinPVivaxVaccine candidateprotozoangeneticvivaxAntigensMalariaPolymorphismLow genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolatesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Garzón-Ospina D.Romero-Murillo L.Tobón L.F.Patarroyo M.A.10336/24294oai:repository.urosario.edu.co:10336/242942022-05-02 07:37:21.576198https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
spellingShingle Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
Membrane protein
Merozoite surface protein 10
Merozoite surface protein 7a
Merozoite surface protein 7k
Unclassified drug
Article
Colombia
Controlled study
Genetic conservation
Genetic polymorphism
Genetic variability
Geography
Haplotype
Nonhuman
Nucleotide sequence
Plasmodium vivax
Priority journal
Colombia
Genetic variation
Genotype
Host-parasite interactions
Humans
Malaria vaccines
Membrane proteins
Molecular sequence data
Plasmodium vivax
Polymerase chain reaction
Protozoan proteins
Plasmodium vivax
Genetic polymorphism
Merozoite surface protein
P
Vivax
Vaccine candidate
protozoan
genetic
vivax
Antigens
Malaria
Polymorphism
title_short Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_full Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_fullStr Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_full_unstemmed Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
title_sort Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates
dc.subject.keyword.spa.fl_str_mv Membrane protein
Merozoite surface protein 10
Merozoite surface protein 7a
Merozoite surface protein 7k
Unclassified drug
Article
Colombia
Controlled study
Genetic conservation
Genetic polymorphism
Genetic variability
Geography
Haplotype
Nonhuman
Nucleotide sequence
Plasmodium vivax
Priority journal
Colombia
Genetic variation
Genotype
Host-parasite interactions
Humans
Malaria vaccines
Membrane proteins
Molecular sequence data
Plasmodium vivax
Polymerase chain reaction
Protozoan proteins
Plasmodium vivax
Genetic polymorphism
Merozoite surface protein
P
Vivax
Vaccine candidate
topic Membrane protein
Merozoite surface protein 10
Merozoite surface protein 7a
Merozoite surface protein 7k
Unclassified drug
Article
Colombia
Controlled study
Genetic conservation
Genetic polymorphism
Genetic variability
Geography
Haplotype
Nonhuman
Nucleotide sequence
Plasmodium vivax
Priority journal
Colombia
Genetic variation
Genotype
Host-parasite interactions
Humans
Malaria vaccines
Membrane proteins
Molecular sequence data
Plasmodium vivax
Polymerase chain reaction
Protozoan proteins
Plasmodium vivax
Genetic polymorphism
Merozoite surface protein
P
Vivax
Vaccine candidate
protozoan
genetic
vivax
Antigens
Malaria
Polymorphism
dc.subject.keyword.eng.fl_str_mv protozoan
genetic
vivax
Antigens
Malaria
Polymorphism
description The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.
publishDate 2011
dc.date.created.spa.fl_str_mv 2011
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:11:18Z
dc.date.available.none.fl_str_mv 2020-05-26T00:11:18Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.meegid.2010.12.002
dc.identifier.issn.none.fl_str_mv 15671348
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24294
url https://doi.org/10.1016/j.meegid.2010.12.002
https://repository.urosario.edu.co/handle/10336/24294
identifier_str_mv 15671348
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 531
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationStartPage.none.fl_str_mv 528
dc.relation.citationTitle.none.fl_str_mv Infection, Genetics and Evolution
dc.relation.citationVolume.none.fl_str_mv Vol. 11
dc.relation.ispartof.spa.fl_str_mv Infection, Genetics and Evolution, ISSN:15671348, Vol.11, No.2 (2011); pp. 528-531
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-79951953688&doi=10.1016%2fj.meegid.2010.12.002&partnerID=40&md5=c39402701ec8261bbec40aa60e4eef6b
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167572816330752

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