Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE
El objetivo de este estudio fue identificar las posibles relaciones entre el nivel terapéutico de la titulación inicial de presión positiva en las vías respiratorias y los niveles de colapso en la endoscopia del sueño inducida por fármacos (DISE). Un objetivo secundario fue establecer la relación en...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- spa
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/38186
- Acceso en línea:
- https://doi.org/10.48713/10336_38186
https://repository.urosario.edu.co/handle/10336/38186
- Palabra clave:
- Apnea obstructiva del sueño
Colapso epiglótico
Presión positiva continua en la vía aérea
Presión positiva en las vías respiratorias
Endoscopia del sueño inducida por fármacos
Titulación automática
Obstructive sleep apnea
Epiglottic collapse
Continuous positive airway pressure
Positive airway pressure
Drug-induced sleep endoscopy
Automatic titration
- Rights
- License
- Attribution-NonCommercial-ShareAlike 4.0 International
id |
EDOCUR2_0b2629d88498a286fcd5ca4786309b05 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/38186 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
dc.title.none.fl_str_mv |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE |
dc.title.TranslatedTitle.none.fl_str_mv |
Relación entre el nivel de titulación inicial CPAP, variables antropométricas, y endoscopia inducida del sueño |
title |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE |
spellingShingle |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE Apnea obstructiva del sueño Colapso epiglótico Presión positiva continua en la vía aérea Presión positiva en las vías respiratorias Endoscopia del sueño inducida por fármacos Titulación automática Obstructive sleep apnea Epiglottic collapse Continuous positive airway pressure Positive airway pressure Drug-induced sleep endoscopy Automatic titration |
title_short |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE |
title_full |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE |
title_fullStr |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE |
title_full_unstemmed |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE |
title_sort |
Relationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISE |
dc.contributor.advisor.none.fl_str_mv |
Buitrago Medina, Daniel Alejandro Delgado Salazar, Nelsón Alexis |
dc.subject.none.fl_str_mv |
Apnea obstructiva del sueño Colapso epiglótico Presión positiva continua en la vía aérea Presión positiva en las vías respiratorias Endoscopia del sueño inducida por fármacos Titulación automática |
topic |
Apnea obstructiva del sueño Colapso epiglótico Presión positiva continua en la vía aérea Presión positiva en las vías respiratorias Endoscopia del sueño inducida por fármacos Titulación automática Obstructive sleep apnea Epiglottic collapse Continuous positive airway pressure Positive airway pressure Drug-induced sleep endoscopy Automatic titration |
dc.subject.keyword.none.fl_str_mv |
Obstructive sleep apnea Epiglottic collapse Continuous positive airway pressure Positive airway pressure Drug-induced sleep endoscopy Automatic titration |
description |
El objetivo de este estudio fue identificar las posibles relaciones entre el nivel terapéutico de la titulación inicial de presión positiva en las vías respiratorias y los niveles de colapso en la endoscopia del sueño inducida por fármacos (DISE). Un objetivo secundario fue establecer la relación entre las demás variables y la DISE. |
publishDate |
2023 |
dc.date.accessioned.none.fl_str_mv |
2023-03-06T17:21:55Z |
dc.date.available.none.fl_str_mv |
2023-03-06T17:21:55Z |
dc.date.created.none.fl_str_mv |
2023-01-13 |
dc.type.none.fl_str_mv |
bachelorThesis |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.document.none.fl_str_mv |
Artículo |
dc.type.spa.none.fl_str_mv |
Trabajo de grado |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.48713/10336_38186 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/38186 |
url |
https://doi.org/10.48713/10336_38186 https://repository.urosario.edu.co/handle/10336/38186 |
dc.language.iso.none.fl_str_mv |
spa |
language |
spa |
dc.relation.uri.none.fl_str_mv |
https://rdcu.be/c3o43 |
dc.rights.*.fl_str_mv |
Attribution-NonCommercial-ShareAlike 4.0 International |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.none.fl_str_mv |
Abierto (Texto Completo) |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
rights_invalid_str_mv |
Attribution-NonCommercial-ShareAlike 4.0 International Abierto (Texto Completo) http://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.none.fl_str_mv |
11 pp |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidad del Rosario |
dc.publisher.department.none.fl_str_mv |
Escuela de Medicina y Ciencias de la Salud |
dc.publisher.program.none.fl_str_mv |
Especialización en Otorrinolaringología |
publisher.none.fl_str_mv |
Universidad del Rosario |
institution |
Universidad del Rosario |
dc.source.bibliographicCitation.none.fl_str_mv |
Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90(1):47–112. https://doi.org/10.1152/physrev.00043.2008 Senaratna CV, Perret JL, Lodge CJ et al (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81. https://doi.org/10.1016/j.smrv. 2016.07.002 Verbraecken JA, De Backer WA (2009) Upper airway mechanics. Respiration 78(2):121–133. https://doi.org/10.1159/000222508 Kushida CA, Littner MR, Morgenthaler T, Alessi CA et al (2005) Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 28(4):499–521. https://doi.org/10.1093/sleep/28.4.499 Randerath WJ, Verbraecken J, Andreas S et al (2011) Non-CPAP therapies in obstructive sleep apnoea. Eur Respir J 37(5):1000– 1028. https://doi.org/10.1183/09031936.00099710 De Vito A, Carrasco Llatas M, Ravesloot MJ et al (2018) Euro- pean position paper on drug-induced sleep endoscopy: 2017 update. Clin Otolaryngol 43(6):1541–1552. https://doi.org/10. 1111/coa.13213 Croft CB, Pringle M (1991) Sleep nasendoscopy: a technique of assessment in snoring and obstructive sleep apnoea. Clin Otolar- yngol Allied Sci 16(5):504–509. https://doi.org/10.1111/j.1365- 2273.1991.tb02103.x Chong K, Vito A, Vicini C (2019) Drug-induced sleep endos- copy in treatment options selection. Sleep Med Clin 14(1):33–40. https://doi.org/10.1016/j.jsmc.2018.11.001 Vanderveken OM (2018) Drug-induced sleep endoscopy (DISE) as a guide towards upper airway behavior and treatment outcome: the quest for a vigorous standardization of DISE. Sleep Breath 22(4):897–899. https://doi.org/10.1007/s11325-018-1743-2 Barends CR, Absalom A, van Minnen B et al (2017) Dexmedeto- midine versus midazolam in procedural sedation. A systematic review of efficacy and safety. PLoS One 12(1):e0169525. https:// doi.org/10.1371/journal.pone.0169525 Hessel NS, Vries N (2004) Increase of the apnoea-hypopnoea index after uvulopalatopharyngoplasty: analysis of failure. Clin Otolaryngol Allied Sci 29:682–685. https://doi.org/10.1111/j. 1365-2273.2004.00864.x Johal A, Battagel JM, Kotecha BT (2005) Sleep nasendoscopy: a diagnostic tool for predicting treatment success with mandibular advancement splints in obstructive sleep apnoea. Eur J Orthod 27:607–614. https://doi.org/10.1093/ejo/cji063 Op de Beeck S, Dieltjens M, Verbruggen AE et al (2019) Phe- notypic labelling using drug-induced sleep endoscopy improves patient selection for mandibular advancement device outcome: a prospective study. J Clin Sleep Med 15(8):1089–1099. https://doi. org/10.5664/jcsm.7796 Torre C, Camacho M, Liu SY et al (2016) Epiglottis collapse in adult obstructive sleep apnea: a systematic review. Laryngoscope 126(2):515–523. https://doi.org/10.1002/lary.25589 Woodson BT (2015) A method to describe the pharyngeal airway. Laryngoscope 125:1233–1238. https://doi.org/10.1002/lary.24972 |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
bitstream.url.fl_str_mv |
https://repository.urosario.edu.co/bitstreams/b749edac-973c-4c91-996d-d020be02ec08/download https://repository.urosario.edu.co/bitstreams/cdcc46c6-2fe1-4362-bf62-9b3de571422f/download https://repository.urosario.edu.co/bitstreams/dfd6db25-1492-4ca3-a7c3-b0d229e221ce/download https://repository.urosario.edu.co/bitstreams/d6c1536d-0431-4448-8fed-264ab984c00b/download https://repository.urosario.edu.co/bitstreams/989a805c-59b8-4415-b857-5b21e7095dcd/download https://repository.urosario.edu.co/bitstreams/1e5112d7-91fa-48e5-9317-044e809ccf45/download https://repository.urosario.edu.co/bitstreams/80cc8251-8935-4268-a95f-04b733631841/download https://repository.urosario.edu.co/bitstreams/7e9aba45-15f8-42ca-bdaa-89ce8a2bb772/download |
bitstream.checksum.fl_str_mv |
87c0e67defc08b704f6ca6b5b4e04e9d 10b9cf27db1b921c957653200b485b4a b2825df9f458e9d5d96ee8b7cd74fde6 5643bfd9bcf29d560eeec56d584edaa9 4ef2c98cf7502e35dccefde9037120c7 2221f56d950a1807eb65b955c8023a8a 3665143573a0a39a3bd3dc000c95757b 323fb4d97c07da472b9cceaca62f7378 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167542249291776 |
spelling |
Buitrago Medina, Daniel Alejandro79750632600Delgado Salazar, Nelsón Alexise2d22b5d-ef76-477e-a795-68dee5f8a453-1Ramirez Merlano, Shirley AndreaEspecialista en OtorrinolaringologíaMaestríaFull timeb113e43e-4541-48d8-ae7f-892cc0657f3e-12023-03-06T17:21:55Z2023-03-06T17:21:55Z2023-01-13El objetivo de este estudio fue identificar las posibles relaciones entre el nivel terapéutico de la titulación inicial de presión positiva en las vías respiratorias y los niveles de colapso en la endoscopia del sueño inducida por fármacos (DISE). Un objetivo secundario fue establecer la relación entre las demás variables y la DISE.Introduction Subjects with palatal obstruction alone vs. multilevel obstruction on DISE had better outcomes after palate surgery. We asked ourselves if the therapeutic level positive airway pressure (PAP) titration could predict the level of airway obstruction and its complexity. Purpose The aim of this study was to identify possible relationships between therapeutic level of positive airway pressure initial titration and levels of collapse in drug-induced sleep endoscopy (DISE). A secondary objective was to establish the relationship the other variables and DISE. Methods We analyzed retrospective clinical histories between March 2020 to March 2022 of 37 patients with polysomnog- raphy or cardiorespiratory polygraphy studies and PAP initial titration who were taken to drug-induced sleep endoscopy. Sleep study data, anthropometric variables, and patterns of airway collapse during DISE were analyzed with PAP initial titration levels. Results Most of the patients with complex collapse had concentric velum collapse (p < 0.006). A significant association was found between the apnea–hypopnea index (AHI) and oropharyngeal collapse; (p < 0.0030) and finally we demonstrated relationship between neck circumference and gender with epiglottis collapse (p < 0.046), (p < 0.037), respectively. Conclusions Our findings show a strong relationship between that complex collapses and concentric velum collapse; patients with greater oropharyngeal collapse have a higher mean AHI. Patients without epiglottic collapse have a higher mean neck circumference. An association between mean pressure initial titration and complex collapse could not be established.11 ppapplication/pdfhttps://doi.org/10.48713/10336_38186https://repository.urosario.edu.co/handle/10336/38186spaUniversidad del RosarioEscuela de Medicina y Ciencias de la SaludEspecialización en Otorrinolaringologíahttps://rdcu.be/c3o43Attribution-NonCommercial-ShareAlike 4.0 InternationalAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90(1):47–112. https://doi.org/10.1152/physrev.00043.2008Senaratna CV, Perret JL, Lodge CJ et al (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81. https://doi.org/10.1016/j.smrv. 2016.07.002Verbraecken JA, De Backer WA (2009) Upper airway mechanics. Respiration 78(2):121–133. https://doi.org/10.1159/000222508Kushida CA, Littner MR, Morgenthaler T, Alessi CA et al (2005) Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 28(4):499–521. https://doi.org/10.1093/sleep/28.4.499Randerath WJ, Verbraecken J, Andreas S et al (2011) Non-CPAP therapies in obstructive sleep apnoea. Eur Respir J 37(5):1000– 1028. https://doi.org/10.1183/09031936.00099710De Vito A, Carrasco Llatas M, Ravesloot MJ et al (2018) Euro- pean position paper on drug-induced sleep endoscopy: 2017 update. Clin Otolaryngol 43(6):1541–1552. https://doi.org/10. 1111/coa.13213Croft CB, Pringle M (1991) Sleep nasendoscopy: a technique of assessment in snoring and obstructive sleep apnoea. Clin Otolar- yngol Allied Sci 16(5):504–509. https://doi.org/10.1111/j.1365- 2273.1991.tb02103.xChong K, Vito A, Vicini C (2019) Drug-induced sleep endos- copy in treatment options selection. Sleep Med Clin 14(1):33–40. https://doi.org/10.1016/j.jsmc.2018.11.001Vanderveken OM (2018) Drug-induced sleep endoscopy (DISE) as a guide towards upper airway behavior and treatment outcome: the quest for a vigorous standardization of DISE. Sleep Breath 22(4):897–899. https://doi.org/10.1007/s11325-018-1743-2Barends CR, Absalom A, van Minnen B et al (2017) Dexmedeto- midine versus midazolam in procedural sedation. A systematic review of efficacy and safety. PLoS One 12(1):e0169525. https:// doi.org/10.1371/journal.pone.0169525Hessel NS, Vries N (2004) Increase of the apnoea-hypopnoea index after uvulopalatopharyngoplasty: analysis of failure. Clin Otolaryngol Allied Sci 29:682–685. https://doi.org/10.1111/j. 1365-2273.2004.00864.xJohal A, Battagel JM, Kotecha BT (2005) Sleep nasendoscopy: a diagnostic tool for predicting treatment success with mandibular advancement splints in obstructive sleep apnoea. Eur J Orthod 27:607–614. https://doi.org/10.1093/ejo/cji063Op de Beeck S, Dieltjens M, Verbruggen AE et al (2019) Phe- notypic labelling using drug-induced sleep endoscopy improves patient selection for mandibular advancement device outcome: a prospective study. J Clin Sleep Med 15(8):1089–1099. https://doi. org/10.5664/jcsm.7796Torre C, Camacho M, Liu SY et al (2016) Epiglottis collapse in adult obstructive sleep apnea: a systematic review. Laryngoscope 126(2):515–523. https://doi.org/10.1002/lary.25589Woodson BT (2015) A method to describe the pharyngeal airway. Laryngoscope 125:1233–1238. https://doi.org/10.1002/lary.24972instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURApnea obstructiva del sueñoColapso epiglóticoPresión positiva continua en la vía aéreaPresión positiva en las vías respiratoriasEndoscopia del sueño inducida por fármacosTitulación automáticaObstructive sleep apneaEpiglottic collapseContinuous positive airway pressurePositive airway pressureDrug-induced sleep endoscopyAutomatic titrationRelationship between level CPAP titration, anthropometric variables, and drug‐induced sleep endoscopy DISERelación entre el nivel de titulación inicial CPAP, variables antropométricas, y endoscopia inducida del sueñobachelorThesisArtículoTrabajo de gradohttp://purl.org/coar/resource_type/c_7a1fORIGINALRelationship-between-level-CPAPs00405-022-07771-3 (1).pdfRelationship-between-level-CPAPs00405-022-07771-3 (1).pdfapplication/pdf567720https://repository.urosario.edu.co/bitstreams/b749edac-973c-4c91-996d-d020be02ec08/download87c0e67defc08b704f6ca6b5b4e04e9dMD51Relationship-between-level-CPAP-titration.pdfRelationship-between-level-CPAP-titration.pdfapplication/pdf491195https://repository.urosario.edu.co/bitstreams/cdcc46c6-2fe1-4362-bf62-9b3de571422f/download10b9cf27db1b921c957653200b485b4aMD52LICENSElicense.txtlicense.txttext/plain1483https://repository.urosario.edu.co/bitstreams/dfd6db25-1492-4ca3-a7c3-b0d229e221ce/downloadb2825df9f458e9d5d96ee8b7cd74fde6MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81160https://repository.urosario.edu.co/bitstreams/d6c1536d-0431-4448-8fed-264ab984c00b/download5643bfd9bcf29d560eeec56d584edaa9MD54TEXTRelationship-between-level-CPAPs00405-022-07771-3 (1).pdf.txtRelationship-between-level-CPAPs00405-022-07771-3 (1).pdf.txtExtracted texttext/plain32547https://repository.urosario.edu.co/bitstreams/989a805c-59b8-4415-b857-5b21e7095dcd/download4ef2c98cf7502e35dccefde9037120c7MD55Relationship-between-level-CPAP-titration.pdf.txtRelationship-between-level-CPAP-titration.pdf.txtExtracted texttext/plain29657https://repository.urosario.edu.co/bitstreams/1e5112d7-91fa-48e5-9317-044e809ccf45/download2221f56d950a1807eb65b955c8023a8aMD57THUMBNAILRelationship-between-level-CPAPs00405-022-07771-3 (1).pdf.jpgRelationship-between-level-CPAPs00405-022-07771-3 (1).pdf.jpgGenerated Thumbnailimage/jpeg4504https://repository.urosario.edu.co/bitstreams/80cc8251-8935-4268-a95f-04b733631841/download3665143573a0a39a3bd3dc000c95757bMD56Relationship-between-level-CPAP-titration.pdf.jpgRelationship-between-level-CPAP-titration.pdf.jpgGenerated Thumbnailimage/jpeg2758https://repository.urosario.edu.co/bitstreams/7e9aba45-15f8-42ca-bdaa-89ce8a2bb772/download323fb4d97c07da472b9cceaca62f7378MD5810336/38186oai:repository.urosario.edu.co:10336/381862023-03-07 03:01:16.434http://creativecommons.org/licenses/by-nc-sa/4.0/Attribution-NonCommercial-ShareAlike 4.0 Internationalhttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.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 |