Hyperprolactinaemia in primary Sjogren's syndrome [1]

Prolactin (PRL) is a neuroendocrine hormone that has important immunoregulatory properties. It is a potent mitogen in Nb2 T lymphoma cell line and stimulates both T-cell mediated and humoral immunity.' Recently an association between hyperprolactinaemia and certain rheumatic diseases has been described suggesting that PRL may play a role in the pathogenesis of some autoimmune diseases.94 In addition, PRL seems to be an autocrine factor required for viability and proliferation of B lymphoma cells.5 Furthermore, it was recently proposed that hyperprolactinaemia observed in oestrogentreated mice may predispose to development of lymphoma in these animals.6 Primary Sj6gren's syndrome (P-SS) is a chronic autoimmune disease characterised by exocrine glandular insufficiency secondary to lymphocytic and plasma cell infiltration. The spectrum of the disease extends from an organ specific autoimmune disease to a systemic involvement.7 Characteristically, patients with Sjogren's syndrome (SS) have an increased risk of developing lymphoma.'

• Fecha de publicación: 1994
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/28453
• Acceso en línea: http://dx.doi.org/10.1136/ard.53.6.425-a; https://repository.urosario.edu.co/handle/10336/28453
• Palabra clave: Hyperprolactinaemia; Primary Sjogren's syndrome
• License: Abierto (Texto Completo)