Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020

El presente estudio describe las principales características clínicas, paraclínicas y desenlaces de los pacientes que son llevados a trasplante hepático en una institución de cuarto nivel de la ciudad de Bogotá entre los años 2015-2020 y que presentaban Trombosis Portal previo al mismo.

Autores:
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/41966
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/41966
Palabra clave:
Trasplante hepático
Trombosis portal
Trombosis eje porto-espleno-mesentérico
Desenlaces postrasplante hepático
Liver transplant
Portal Thrombosis
Porto-spleno-mesenteric axis thrombosis
Post-liver transplant outcomes
Rights
License
Attribution-NonCommercial-ShareAlike 4.0 International
id EDOCUR2_02f8fd90d33c25c0e533445f6474ede5
oai_identifier_str oai:repository.urosario.edu.co:10336/41966
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.none.fl_str_mv Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
dc.title.TranslatedTitle.none.fl_str_mv Portal thrombosis, splenomesenteric axis, course and outcomes in post-liver transplant patients La Cardio 2015-2020
title Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
spellingShingle Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
Trasplante hepático
Trombosis portal
Trombosis eje porto-espleno-mesentérico
Desenlaces postrasplante hepático
Liver transplant
Portal Thrombosis
Porto-spleno-mesenteric axis thrombosis
Post-liver transplant outcomes
title_short Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
title_full Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
title_fullStr Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
title_full_unstemmed Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
title_sort Trombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020
dc.contributor.advisor.none.fl_str_mv Varón Puerta, Adriana
Cruz Reyes, Danna Lesley
dc.subject.none.fl_str_mv Trasplante hepático
Trombosis portal
Trombosis eje porto-espleno-mesentérico
Desenlaces postrasplante hepático
topic Trasplante hepático
Trombosis portal
Trombosis eje porto-espleno-mesentérico
Desenlaces postrasplante hepático
Liver transplant
Portal Thrombosis
Porto-spleno-mesenteric axis thrombosis
Post-liver transplant outcomes
dc.subject.keyword.none.fl_str_mv Liver transplant
Portal Thrombosis
Porto-spleno-mesenteric axis thrombosis
Post-liver transplant outcomes
description El presente estudio describe las principales características clínicas, paraclínicas y desenlaces de los pacientes que son llevados a trasplante hepático en una institución de cuarto nivel de la ciudad de Bogotá entre los años 2015-2020 y que presentaban Trombosis Portal previo al mismo.
publishDate 2023
dc.date.created.none.fl_str_mv 2023-12-15
dc.date.accessioned.none.fl_str_mv 2024-01-11T19:07:57Z
dc.date.available.none.fl_str_mv 2024-01-11T19:07:57Z
dc.type.none.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.none.fl_str_mv Trabajo de grado
dc.type.spa.none.fl_str_mv Trabajo de grado
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/41966
url https://repository.urosario.edu.co/handle/10336/41966
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.*.fl_str_mv Attribution-NonCommercial-ShareAlike 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.none.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
rights_invalid_str_mv Attribution-NonCommercial-ShareAlike 4.0 International
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-sa/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.extent.none.fl_str_mv 42 pp
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad del Rosario
dc.publisher.department.none.fl_str_mv Escuela de Medicina y Ciencias de la Salud
dc.publisher.program.none.fl_str_mv Especialización en Medicina Interna
publisher.none.fl_str_mv Universidad del Rosario
institution Universidad del Rosario
dc.source.bibliographicCitation.none.fl_str_mv Senzolo M, Garcia-Tsao G, García-Pagán JC. Current knowledge and management of portal vein thrombosis in cirrhosis. J Hepatol [Internet]. 2021;75(2):442–53. Available from: https://doi.org/10.1016/j.jhep.2021.04.029
Francoz C, Valla D, Durand F. Portal vein thrombosis, cirrhosis, and liver transplantation. J Hepatol [Internet]. 2012;57(1):203–12. Available from: http://dx.doi.org/10.1016/j.jhep.2011.12.034
Manzanet G, Sanjuán F, Orbis P, López R, Moya Á, Juan M, et al. Liver transplantation in patients with portal vein thrombosis. Vol. 7, Liver Transplantation. 2001. p. 125–31.
Loudin M, Ahn J. Portal Vein Thrombosis in Cirrhosis. Vol. 51, Journal of Clinical Gastroenterology. 2015. p. 579–85
Shukla A, Giri S. Portal Vein Thrombosis in Cirrhosis. J Clin Exp Hepatol [Internet]. 2022;12(3):965–79. Available from: https://doi.org/10.1016/j.jceh.2021.11.003
Stine JG, Wang J, Shah PM, Argo CK, Intagliata N, Uflacker A, et al. of Portal Vein Thrombosis : a Matched Case-Control Study. 2023;38(1):94–101.
Maruyama H, Okugawa H, Takahashi M, Yokosuka O. De novo portal vein thrombosis in virus-related cirrhosis: Predictive factors and long-term outcomes. Am J Gastroenterol [Internet]. 2013;108(4):568–74. Available from: http://dx.doi.org/10.1038/ajg.2012.452
Xu X, Guo X, De Stefano V, Silva-Junior G, Goyal H, Bai Z, et al. Nonselective beta-blockers and development of portal vein thrombosis in liver cirrhosis: a systematic review and meta-analysis. Hepatol Int [Internet]. 2019;13(4):468–81. Available from: https://doi.org/10.1007/s12072-019-09951-6
Ayala R, Grande S, Bustelos R, Ribera C, García-Sesma A, Jimenez C, et al. Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients. BMC Gastroenterol. 2012;12.
Bhangui P, Lim C, Levesque E, Salloum C, Lahat E, Feray C, et al. Novel classification of non-malignant portal vein thrombosis: A guide to surgical decision-making during liver transplantation. J Hepatol [Internet]. 2019;71(5):1038–50. Available from: https://doi.org/10.1016/j.jhep.2019.08.012
Mantaka A, Augoustaki A, Kouroumalis EA, Samonakis DN. Portal vein thrombosis in cirrhosis: Diagnosis, natural history, and therapeutic challenges. Ann Gastroenterol. 2018;31(3):315–29.
Anton A, Campreciós G, Pérez-Campuzano V, Orts L, García-Pagán JC, Hernández-Gea V. The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad. J Clin Med. 2022;11(3).
Dong G, Huang X-Q, Zhu Y-L, Ding H, Li F, Chen S-Y. Increased portal vein diameter is predictive of portal vein thrombosis development in patients with liver cirrhosis. Ann Transl Med. 2021;9(4):289–289.
Zocco MA, Di Stasio E, De Cristofaro R, Novi M, Ainora ME, Ponziani F, et al. Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development. J Hepatol [Internet]. 2009;51(4):682–9. Available from: http://dx.doi.org/10.1016/j.jhep.2009.03.013
Lisman T, Porte RJ. Rebalanced hemostasis in patients with liver disease: Evidence and clinical consequences. Blood. 2010;116(6):878–85.
Lisman T, Porte RJ. The role of platelets in liver inflammation and regeneration. Semin Thromb Hemost. 2010;36(2):170–4.
Tripodi A, Primignani M, Chantarangkul V, Dell’Era A, Clerici M, de Franchis R, et al. An Imbalance of Pro- vs Anti-Coagulation Factors in Plasma From Patients With Cirrhosis. Gastroenterology [Internet]. 2009;137(6):2105–11. Available from: http://dx.doi.org/10.1053/j.gastro.2009.08.045
Condat B, Valla D. Nonmalignant portal vein thrombosis in adults. Nat Clin Pract Gastroenterol Hepatol. 2006;3(9):505–15.
Trifan A, Stanciu C, Girleanu I. Portal Vein Thrombosis in Patients with Liver Cirrhosis. Liver Cirrhosis - Updat Curr Challenges. 2017;
Shukla A, Jain A. Association of acute-on-chronic liver failure with vascular liver diseases. Hepatol Int [Internet]. 2019;13(4):399–402. Available from: https://doi.org/10.1007/s12072-019-09958-z
Ghabril M, Agarwal S, Lacerda M, Chalasani N, Kwo P, Joseph Tector A. Portal vein thrombosis is a risk factor for poor early outcomes after liver transplantation: Analysis of risk factors and outcomes for portal vein thrombosis in waitlisted patients. Transplantation. 2016;100(1):126–33.
Northup PG, Garcia-Pagan JC, Garcia-Tsao G, Intagliata NM, Superina RA, Roberts LN, et al. Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases. Vol. 73, Hepatology. 2021. 366–413 p.
Sharshar M, Yagi S, Iida T, Yao S, Miyachi Y, Macshut M, et al. Liver transplantation in patients with portal vein thrombosis: A strategic road map throughout management. Surg (United States) [Internet]. 2020;168(6):1160–8. Available from: https://doi.org/10.1016/j.surg.2020.07.023
Choi HJ, Kim DG, Kim Y, Kwak BJ, Han JH, Hong TH, et al. Clinical Course of Hepatic Artery Thrombosis After Living Donor Liver Transplantation Using the Right Lobe. Liver Transplant. 2018 Nov 1;24(11):1554–60.
Szklo, M., & Nieto, F. J. (2014). Epidemiology: beyond the basics. Jones & Bartlett Publishers.
Barrera Lozano, L. M.; Ramírez Arbelaez, J. A.; Muñoz, C. L.; et al. (2023) Portal vein thrombosis in liver transplantation: A retrospective cohort study, J.Clin. Med.
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
bitstream.url.fl_str_mv https://repository.urosario.edu.co/bitstreams/beac5237-fa82-481b-b8fb-7ac3561b0db3/download
https://repository.urosario.edu.co/bitstreams/8d2e8b54-d92f-48ad-adf4-62d260de179e/download
https://repository.urosario.edu.co/bitstreams/6dab1f55-3eab-4863-8b1e-ef2b7af69142/download
https://repository.urosario.edu.co/bitstreams/ffeef1a2-c7d6-4021-b627-56b8cd46a5dd/download
https://repository.urosario.edu.co/bitstreams/77d9bd6e-bcb1-4427-9c13-8fa467b01025/download
bitstream.checksum.fl_str_mv 36312e89be78c335998ac1c10ea28805
b2825df9f458e9d5d96ee8b7cd74fde6
5643bfd9bcf29d560eeec56d584edaa9
dd320bada0768ec1f9dfcca9ffc1878d
382bb77054d64904fc55bfeece347b8e
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167557566889984
spelling Varón Puerta, Adriana30e6fa1a-fc12-4d60-81a3-7efc0e347023-1Cruz Reyes, Danna Lesley1032415315600Bedoya Peña, Sergio AlejandroCalderón Vásquez, Angie TatianaEspecialista en Medicina InternaMaestríaFull time72975dc9-4db7-4e23-b712-7521dd85b33b593ff8ea-ce83-44fa-9206-8282cdb5fb732024-01-11T19:07:57Z2024-01-11T19:07:57Z2023-12-15El presente estudio describe las principales características clínicas, paraclínicas y desenlaces de los pacientes que son llevados a trasplante hepático en una institución de cuarto nivel de la ciudad de Bogotá entre los años 2015-2020 y que presentaban Trombosis Portal previo al mismo.The present study describes the main clinical, paraclinical characteristics and outcomes of patients who underwent liver transplantation in a fourth-level institution in the city of Bogotá between the years 2015-2020 and who presented Portal Thrombosis prior to transplantation.42 ppapplication/pdfhttps://repository.urosario.edu.co/handle/10336/41966spaUniversidad del RosarioEscuela de Medicina y Ciencias de la SaludEspecialización en Medicina InternaAttribution-NonCommercial-ShareAlike 4.0 InternationalAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2Senzolo M, Garcia-Tsao G, García-Pagán JC. Current knowledge and management of portal vein thrombosis in cirrhosis. J Hepatol [Internet]. 2021;75(2):442–53. Available from: https://doi.org/10.1016/j.jhep.2021.04.029Francoz C, Valla D, Durand F. Portal vein thrombosis, cirrhosis, and liver transplantation. J Hepatol [Internet]. 2012;57(1):203–12. Available from: http://dx.doi.org/10.1016/j.jhep.2011.12.034Manzanet G, Sanjuán F, Orbis P, López R, Moya Á, Juan M, et al. Liver transplantation in patients with portal vein thrombosis. Vol. 7, Liver Transplantation. 2001. p. 125–31.Loudin M, Ahn J. Portal Vein Thrombosis in Cirrhosis. Vol. 51, Journal of Clinical Gastroenterology. 2015. p. 579–85Shukla A, Giri S. Portal Vein Thrombosis in Cirrhosis. J Clin Exp Hepatol [Internet]. 2022;12(3):965–79. Available from: https://doi.org/10.1016/j.jceh.2021.11.003Stine JG, Wang J, Shah PM, Argo CK, Intagliata N, Uflacker A, et al. of Portal Vein Thrombosis : a Matched Case-Control Study. 2023;38(1):94–101.Maruyama H, Okugawa H, Takahashi M, Yokosuka O. De novo portal vein thrombosis in virus-related cirrhosis: Predictive factors and long-term outcomes. Am J Gastroenterol [Internet]. 2013;108(4):568–74. Available from: http://dx.doi.org/10.1038/ajg.2012.452Xu X, Guo X, De Stefano V, Silva-Junior G, Goyal H, Bai Z, et al. Nonselective beta-blockers and development of portal vein thrombosis in liver cirrhosis: a systematic review and meta-analysis. Hepatol Int [Internet]. 2019;13(4):468–81. Available from: https://doi.org/10.1007/s12072-019-09951-6Ayala R, Grande S, Bustelos R, Ribera C, García-Sesma A, Jimenez C, et al. Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients. BMC Gastroenterol. 2012;12.Bhangui P, Lim C, Levesque E, Salloum C, Lahat E, Feray C, et al. Novel classification of non-malignant portal vein thrombosis: A guide to surgical decision-making during liver transplantation. J Hepatol [Internet]. 2019;71(5):1038–50. Available from: https://doi.org/10.1016/j.jhep.2019.08.012Mantaka A, Augoustaki A, Kouroumalis EA, Samonakis DN. Portal vein thrombosis in cirrhosis: Diagnosis, natural history, and therapeutic challenges. Ann Gastroenterol. 2018;31(3):315–29.Anton A, Campreciós G, Pérez-Campuzano V, Orts L, García-Pagán JC, Hernández-Gea V. The Pathophysiology of Portal Vein Thrombosis in Cirrhosis: Getting Deeper into Virchow’s Triad. J Clin Med. 2022;11(3).Dong G, Huang X-Q, Zhu Y-L, Ding H, Li F, Chen S-Y. Increased portal vein diameter is predictive of portal vein thrombosis development in patients with liver cirrhosis. Ann Transl Med. 2021;9(4):289–289.Zocco MA, Di Stasio E, De Cristofaro R, Novi M, Ainora ME, Ponziani F, et al. Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development. J Hepatol [Internet]. 2009;51(4):682–9. Available from: http://dx.doi.org/10.1016/j.jhep.2009.03.013Lisman T, Porte RJ. Rebalanced hemostasis in patients with liver disease: Evidence and clinical consequences. Blood. 2010;116(6):878–85.Lisman T, Porte RJ. The role of platelets in liver inflammation and regeneration. Semin Thromb Hemost. 2010;36(2):170–4.Tripodi A, Primignani M, Chantarangkul V, Dell’Era A, Clerici M, de Franchis R, et al. An Imbalance of Pro- vs Anti-Coagulation Factors in Plasma From Patients With Cirrhosis. Gastroenterology [Internet]. 2009;137(6):2105–11. Available from: http://dx.doi.org/10.1053/j.gastro.2009.08.045Condat B, Valla D. Nonmalignant portal vein thrombosis in adults. Nat Clin Pract Gastroenterol Hepatol. 2006;3(9):505–15.Trifan A, Stanciu C, Girleanu I. Portal Vein Thrombosis in Patients with Liver Cirrhosis. Liver Cirrhosis - Updat Curr Challenges. 2017;Shukla A, Jain A. Association of acute-on-chronic liver failure with vascular liver diseases. Hepatol Int [Internet]. 2019;13(4):399–402. Available from: https://doi.org/10.1007/s12072-019-09958-zGhabril M, Agarwal S, Lacerda M, Chalasani N, Kwo P, Joseph Tector A. Portal vein thrombosis is a risk factor for poor early outcomes after liver transplantation: Analysis of risk factors and outcomes for portal vein thrombosis in waitlisted patients. Transplantation. 2016;100(1):126–33.Northup PG, Garcia-Pagan JC, Garcia-Tsao G, Intagliata NM, Superina RA, Roberts LN, et al. Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases. Vol. 73, Hepatology. 2021. 366–413 p.Sharshar M, Yagi S, Iida T, Yao S, Miyachi Y, Macshut M, et al. Liver transplantation in patients with portal vein thrombosis: A strategic road map throughout management. Surg (United States) [Internet]. 2020;168(6):1160–8. Available from: https://doi.org/10.1016/j.surg.2020.07.023Choi HJ, Kim DG, Kim Y, Kwak BJ, Han JH, Hong TH, et al. Clinical Course of Hepatic Artery Thrombosis After Living Donor Liver Transplantation Using the Right Lobe. Liver Transplant. 2018 Nov 1;24(11):1554–60.Szklo, M., & Nieto, F. J. (2014). Epidemiology: beyond the basics. Jones & Bartlett Publishers.Barrera Lozano, L. M.; Ramírez Arbelaez, J. A.; Muñoz, C. L.; et al. (2023) Portal vein thrombosis in liver transplantation: A retrospective cohort study, J.Clin. Med.instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURTrasplante hepáticoTrombosis portalTrombosis eje porto-espleno-mesentéricoDesenlaces postrasplante hepáticoLiver transplantPortal ThrombosisPorto-spleno-mesenteric axis thrombosisPost-liver transplant outcomesTrombosis portal, eje esplenomesentérico, curso y desenlaces en pacientes post trasplante hepático La Cardio 2015-2020Portal thrombosis, splenomesenteric axis, course and outcomes in post-liver transplant patients La Cardio 2015-2020bachelorThesisTrabajo de gradoTrabajo de gradohttp://purl.org/coar/resource_type/c_7a1fEscuela de Medicina y Ciencias de la SaludORIGINALTrombosis_portal_esplenomesentérico_Sergio_Alejandro_Bedoya_Peña.pdfTrombosis_portal_esplenomesentérico_Sergio_Alejandro_Bedoya_Peña.pdfapplication/pdf840255https://repository.urosario.edu.co/bitstreams/beac5237-fa82-481b-b8fb-7ac3561b0db3/download36312e89be78c335998ac1c10ea28805MD51LICENSElicense.txtlicense.txttext/plain1483https://repository.urosario.edu.co/bitstreams/8d2e8b54-d92f-48ad-adf4-62d260de179e/downloadb2825df9f458e9d5d96ee8b7cd74fde6MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81160https://repository.urosario.edu.co/bitstreams/6dab1f55-3eab-4863-8b1e-ef2b7af69142/download5643bfd9bcf29d560eeec56d584edaa9MD53TEXTTrombosis_portal_esplenomesentérico_Sergio_Alejandro_Bedoya_Peña.pdf.txtTrombosis_portal_esplenomesentérico_Sergio_Alejandro_Bedoya_Peña.pdf.txtExtracted texttext/plain65299https://repository.urosario.edu.co/bitstreams/ffeef1a2-c7d6-4021-b627-56b8cd46a5dd/downloaddd320bada0768ec1f9dfcca9ffc1878dMD54THUMBNAILTrombosis_portal_esplenomesentérico_Sergio_Alejandro_Bedoya_Peña.pdf.jpgTrombosis_portal_esplenomesentérico_Sergio_Alejandro_Bedoya_Peña.pdf.jpgGenerated Thumbnailimage/jpeg2677https://repository.urosario.edu.co/bitstreams/77d9bd6e-bcb1-4427-9c13-8fa467b01025/download382bb77054d64904fc55bfeece347b8eMD5510336/41966oai:repository.urosario.edu.co:10336/419662024-02-05 08:39:03.725http://creativecommons.org/licenses/by-nc-sa/4.0/Attribution-NonCommercial-ShareAlike 4.0 Internationalhttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.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