Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico
Objetivos: Evaluar los cambios en la microcirculación asociados al uso del milrinona en niños con sepsis. Se utilizó videomicroscopía sublingual para medir flujo y densidad capilar (DC) y región limite perfundida (PBR, parámetro inverso del grosor del glicocálix). El desenlace primario fue los cambi...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- spa
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/40754
- Acceso en línea:
- https://doi.org/10.48713/10336_40754
https://repository.urosario.edu.co/handle/10336/40754
- Palabra clave:
- Choque séptico
Sepsis
Microcirculacion
Milrinone
Endotelio
Shock
Sepsis
Microcirculation
Endothelium
Milrinone
- Rights
- License
- Attribution-NonCommercial-ShareAlike 4.0 International
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| dc.title.none.fl_str_mv |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico |
| dc.title.TranslatedTitle.none.fl_str_mv |
Changes in microcirculation associated with using milrinone in children with sepsis shock |
| title |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico |
| spellingShingle |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico Choque séptico Sepsis Microcirculacion Milrinone Endotelio Shock Sepsis Microcirculation Endothelium Milrinone |
| title_short |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico |
| title_full |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico |
| title_fullStr |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico |
| title_full_unstemmed |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico |
| title_sort |
Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico |
| dc.contributor.advisor.none.fl_str_mv |
Fernandez-Sarmiento, Jaime |
| dc.contributor.none.fl_str_mv |
Nieto, Andrés Lucena, Natalia |
| dc.subject.none.fl_str_mv |
Choque séptico Sepsis Microcirculacion Milrinone Endotelio |
| topic |
Choque séptico Sepsis Microcirculacion Milrinone Endotelio Shock Sepsis Microcirculation Endothelium Milrinone |
| dc.subject.keyword.none.fl_str_mv |
Shock Sepsis Microcirculation Endothelium Milrinone |
| description |
Objetivos: Evaluar los cambios en la microcirculación asociados al uso del milrinona en niños con sepsis. Se utilizó videomicroscopía sublingual para medir flujo y densidad capilar (DC) y región limite perfundida (PBR, parámetro inverso del grosor del glicocálix). El desenlace primario fue los cambios en la microcirculación asociados al uso de milrinona al ingreso y a las 24 horas. Diseño: Cohorte prospectiva realizado de Febrero 2021 – Enero 2022 Lugar: Unidad de cuidados intensivos pediátricos (UCIP) en hospital universitario. Pacientes: Niños con sepsis/choque séptico con y sin infusión de milrinona. Intervención: Ninguna Métodos y resultados principales: Se incluyeron 140 niños (mediana edad 2 años RIQ 0.58-12.1). El 58% de los pacientes recibieron infusión de milrinona. La DC se mantuvo en el grupo que recibió milrinona comparado con el grupo que no recibió (p<0.01). Los menores de dos años con milrinona, tenían mejor DC comparado con los niños mayores (50% vs 25%; OR 0.33; CI 95% 0.12-0.89;p=0.02). En el análisis multivariado controlando variables confusoras los niños que recibieron milrinona tenían menos degradación del glicocálix endotelial comparado con los que no lo recibieron ( aOR 0.34 CI 95% 0.11-0.99; p=0.04). Estos cambios se mantenían a pesar de ferritina y proteína C reactiva elevadas (aOR 0.41; CI 95% 0.18-0.93;p=0.03). Conclusiones: En niños con sepsis, el uso de milrinona se asoció a cambios en la microcirculación. Se encontró persistencia de reclutamiento de capilares luego de 24 horas de su administración, menos heterogeneidad del flujo sanguíneo capilar y menos degradación del glicocálix. |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-25T12:29:10Z |
| dc.date.available.none.fl_str_mv |
2023-08-25T12:29:10Z |
| dc.date.created.none.fl_str_mv |
2023-08-22 |
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info:eu-repo/date/embargoEnd/2024-08-26 |
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bachelorThesis |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
| dc.type.document.none.fl_str_mv |
Trabajo de grado |
| dc.type.spa.none.fl_str_mv |
Trabajo de grado |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.48713/10336_40754 |
| dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/40754 |
| url |
https://doi.org/10.48713/10336_40754 https://repository.urosario.edu.co/handle/10336/40754 |
| dc.language.iso.none.fl_str_mv |
spa |
| language |
spa |
| dc.rights.*.fl_str_mv |
Attribution-NonCommercial-ShareAlike 4.0 International |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_f1cf |
| dc.rights.acceso.none.fl_str_mv |
Restringido (Temporalmente bloqueado) |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
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Attribution-NonCommercial-ShareAlike 4.0 International Restringido (Temporalmente bloqueado) http://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_f1cf |
| dc.format.extent.none.fl_str_mv |
75 pp |
| dc.format.mimetype.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad del Rosario |
| dc.publisher.department.none.fl_str_mv |
Escuela de Medicina y Ciencias de la Salud |
| dc.publisher.program.none.fl_str_mv |
Especialización en Cuidado Intensivo Pediátrico |
| publisher.none.fl_str_mv |
Universidad del Rosario |
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Universidad del Rosario |
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Weiss SL, Balamuth F, Hensley J, Fitzgerald JC, Bush J, Nadkarni VM, Thomas NJ, Hall M, Muszynski J. The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die. Pediatr Crit Care Med. 2017 Sep;18(9):823-830 Weiss SL, Peters MJ, Agus MSD, Alhazzani W, Choong K, Flori HR, Inwald DP, Nadel S, Nunnally ME, Schlapbach LJ, Tasker RC, Tissieres P, Kissoon N; Children’s Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Taskforce. Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019. Pediatr Crit Care Med. 2020 Nov;21(11):e1031-e1037. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018 Mar;6(3):223-230. De Backer D, Ricottilli F, Ospina-Tascón GA. Septic shock: a microcirculation disease. Curr Opin Anaesthesiol. 2021 Apr 1;34(2):85-91. Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019 Jan 17;23(1):16. Tarbell JM, Cancel LM. The glycocalyx and its significance in human medicine. J Intern Med. 2016 Jul;280(1):97-113. Yajnik V, Maarouf R. Sepsis and the microcirculation: the impact on outcomes. Curr Opin Anaesthesiol. 2022 Apr 1;35(2):230-235. Iba T, Levy JH. Derangement of the endothelial glycocalyx in sepsis. J Thromb Haemost. 2019 Feb;17(2):283-294 Walley KR. Sepsis-induced myocardial dysfunction. Curr Opin Crit Care. 2018 Aug;24(4):292-299 Gelinas JP, Russell JA. Vasopressors During Sepsis: Selection and Targets. Clin Chest Med. 2016 Jun;37(2):251-62 Liet JM, Jacqueline C, Orsonneau JL, et al. The effects of milrinone on hemodynamics in an experimental septic shock model. Pediatr Crit Care Med 2005;6:195-9 Jain S. Sepsis: An Update on Current Practices in Diagnosis and Management. Am J Med Sci. 2018 Sep;356(3):277-286. doi: 10.1016/j.amjms.2018.06.012. Weiss SL, Fitzgerald JC, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A, Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ; Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57. Joffre J, Hellman J, Ince C, Ait-Oufella H. Endothelial Responses in Sepsis. Am J Respir Crit Care Med. 2020 Aug 1;202(3):361-370 Fernández-Sarmiento J, Carcillo JA, Salinas CM, Galvis EF, López PA, Jagua-Gualdrón A. Effect of a Sepsis Educational Intervention on Hospital Stay. Pediatr Crit Care Med. 2018 Jun;19(6):e321-e328. Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016 Jun;37(2):263-75. doi: 10.1016/j.ccm.2016.01.009. Chanani NK, Cowan DB, Takeuchi K, et al. Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation 2002;106:I284-9 Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL; Sepsis Prevalence, Outcomes, and Therapy Study Investigators. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017 Jan;18(1):8-16. Beurskens DM, Bol ME, Delhaas T, van de Poll MC, Reutelingsperger CP, Nicolaes GA, Sels JE. Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis. Anaesth Intensive Care. 2020 May;48(3):221-228. Rohlenova K, Veys K, Miranda-Santos I, De Bock K, Carmeliet P. Endothelial Cell Metabolism in Health and Disease. Trends Cell Biol. 2018 Mar;28(3):224-236. Shi Y, Vanhoutte PM. Macro- and microvascular endothelial dysfunction in diabetes. J Diabetes. 2017 May;9(5):434-449. Büchele GL, Ospina-Tascon GA, De Backer D. How microcirculation data have changed my clinical practice. Curr Opin Crit Care. 2007 Jun;13(3):324-31. Jourde-Chiche N, Fakhouri F, Dou L, Bellien J, Burtey S, Frimat M, Jarrot PA, Kaplanski G, Le Quintrec M, Pernin V, Rigothier C, Sallée M, Fremeaux-Bacchi V, Guerrot D, Roumenina LT. Endothelium structure and function in kidney health and disease. Nat Rev Nephrol. 2019 Feb;15(2):87-108. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev. 2004 Jul;84(3):869-901. Petzelbauer P, Halama T, Gröger M. Endothelial adherens junctions. J Investig Dermatol Symp Proc. 2000 Dec;5(1):10-3. Foote CA, Soares RN, Ramirez-Perez FI, Ghiarone T, Aroor A, Manrique-Acevedo C, Padilla J, Martinez-Lemus L. Endothelial Glycocalyx. Compr Physiol. 2022 Aug 23;12(4):3781-3811. Luft JH. Fine structures of capillary and endocapillary layer as revealed by ruthenium red. Fed Proc. Alphonsus CS, Rodseth RN. The endothelial glycocalyx: a review of the vascular barrier. Anaesthesia. 2014 Jul;69(7):777-84. Jacob M, Chappell D. Reappraising Starling: the physiology of the microcirculation. Curr Opin Crit Care. 2013 Aug;19(4):282-9. Pillinger NL, Kam P. Endothelial glycocalyx: basic science and clinical implications. Anaesth Intensive Care. 2017 May;45(3):295-307 Vink H., Duling B.R. Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries. Circ Res 1996; 79: 581–589 Nieuwdorp M., Meuwese M.C., Mooij H.L., Ince C., Broekhuizen L.N., Kastelein J.J. et al. Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability. J Appl Physiol 2008; 104: 845–852 Reitsma S., Slaaf D.W., Vink H., van Zandvoort M.A., oude Egbrink M.G. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch 2007; 454: 345–359 Weinbaum S., Tarbell J.M., Damiano E.R. The structure and function of the endothelial glycocalyx layer. Annu Rev Biomed Eng 2007; 9: 121–167. Curry F.E., Adamson R.H. Endothelial glycocalyx: permeability barrier and mechanosensor. Ann Biomed Eng 2012; 40: 828–839. van Haaren PM, VanBavel E, Vink H, Spaan JA. Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2848-56. Han S, Lee S-J, Kim KE, Lee HS, Oh N, Park I, Ko E, Oh SJ, Lee Y-S, Kim D, Lee S, Lee DH, Lee K-H, Chae SY, Lee J-H, Kim S-J, Kim H-C, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin HG, Hu J, Song PH, Kim Y-I, Kim P, Kim I, Koh GY. Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 2016;8:335ra55 King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc Res. 2004 Mar;67(2):139-51. Mochizuki S, Takayama A, Sasaki T, Yada T, Endo K, Horike H, Kashihara N, Ogasawara Y, Kajiya F. Clear correlation of tetrahydrobiopterin with nitric oxide bioavailability in continuous ambulatory peritoneal dialysis. Blood Purif. 2010;30(2):96-7. Lupu F, Kinasewitz G, Dormer K. The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis. J Cell Mol Med. 2020 Nov;24(21):12258-12271. Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010 Jul 15;87(2):198-210. Kudo S, Morigaki R, Saito J, Ikeda M, Oka K, Tanishita K. Shear-stress effect on mitochondrial membrane potential and albumin uptake in cultured endothelial cells. Biochem Biophys Res Commun. 2000 Apr 13;270(2):616-21 Hellenthal KEM, Brabenec L, Wagner NM. Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation. Cells. 2022 Jun 15;11(12):1935. Suzuki A, Tomita H, Okada H. Form follows function: The endothelial glycocalyx. Transl Res. 2022 Sep;247:158-167. doi: 10.1016/j.trsl.2022.03.014. Zhao F, Wang R, Huang Y, Li L, Zhong L, Hu Y, Han Z, Fan J, Liu P, Zheng Y, Luo Y. Elevated plasma syndecan-1 as glycocalyx injury marker predicts unfavorable outcomes after rt-PA intravenous thrombolysis in acute ischemic stroke. Front Pharmacol. 2022 Jul 15;13:949290 Richter RP, Payne GA, Ambalavanan N, Gaggar A, Richter JR. The endothelial glycocalyx in critical illness: A pediatric perspective. Matrix Biol Plus. 2022 Mar 9;14:100106. Goligorsky MS, Sun D. Glycocalyx in Endotoxemia and Sepsis. Am J Pathol. 2020 Apr;190(4):791-798 Annecke T, Fischer J, Hartmann H, Tschoep J, Rehm M, Conzen P, Sommerhoff CP, Becker BF. Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion. Br J Anaesth. 2011 Nov;107(5):679-86 Suzuki K, Okada H, Sumi K, Tomita H, Kobayashi R, Ishihara T, Mizuno Y, Yamaji F, Kamidani R, Miura T, Yasuda R, Kitagawa Y, Fukuta T, Suzuki K, Miyake T, Kanda N, Doi T, Yoshida T, Yoshida S, Tetsuka N, Ogura S, Suzuki A. Syndecan-1 as a severity biomarker for patients with trauma. Front Med (Lausanne). 2022 Sep 27;9:985955 Woods A, Couchman JR. Syndecan-4 and focal adhesion function. Curr Opin Cell Biol. 2001 Oct;13(5):578-83. Couchman JR, Woods A. Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J Cell Sci. 1999 Oct;112 ( Pt 20):3415-20. Li JP, Kusche-Gullberg M. Heparan Sulfate: Biosynthesis, Structure, and Function. Int Rev Cell Mol Biol. 2016;325:215-73. Nelson A, Berkestedt I, Bodelsson M. Circulating glycosaminoglycan species in septic shock. Acta Anaesthesiol Scand. 2014 Jan;58(1):36-43. Fernández-Sarmiento J, Schlapbach LJ, Acevedo L, Santana CR, Acosta Y, Diana A, Monsalve M, Carcillo JA. Endothelial Damage in Sepsis: The Importance of Systems Biology. Front Pediatr. 2022 Mar 9;10:828968. Eickhoff MK, Winther SA, Hansen TW, Diaz LJ, Persson F, Rossing P, Frimodt-Møller M. Assessment of the sublingual microcirculation with the GlycoCheck system: Reproducibility and examination conditions. PLoS One. 2020 Dec 23;15(12):e0243737 Dubin A, Kanoore Edul VS, Caminos Eguillor JF, Ferrara G. Monitoring Microcirculation: Utility and Barriers - A Point-of-View Review. Vasc Health Risk Manag. 2020 Dec 31;16:577-589. Fernández-Sarmiento J, Salazar-Peláez LM, Acevedo L, Niño-Serna LF, Flórez S, Alarcón-Forero L, Mulett H, Gómez L, Villar JC. Endothelial and Glycocalyx Biomarkers in Children With Sepsis After One Bolus of Unbalanced or Balanced Crystalloids. Pediatr Crit Care Med. 2023 Mar 1;24(3):213-221 Rovas A, Seidel LM, Vink H, Pohlkötter T, Pavenstädt H, Ertmer C, Hessler M, Kümpers P. Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Crit Care. 2019 Jul 24;23(1):260. Scholz A, Plate KH, Reiss Y. Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation. Ann N Y Acad Sci. 2015 Jul;1347:45-51. Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med. 2006 Feb;12(2):235-9. Crowley LC, Marfell BJ, Scott AP, Waterhouse NJ. Quantitation of Apoptosis and Necrosis by Annexin V Binding, Propidium Iodide Uptake, and Flow Cytometry. Cold Spring Harb Protoc. 2016 Nov 1;2016(11). Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 Jun;101(6):1644-55 Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005 Jan;6(1):2-8. Fernández-Sarmiento J, De Souza DC, Martinez A, Nieto V, López-Herce J, Soares Lanziotti V, Arias López MDP, De Carvalho WB, Oliveira CF, Jaramillo-Bustamante JC, Díaz F, Yock-Corrales A, Ruvinsky S, Munaico M, Pavlicich V, Iramain R, Márquez MP, González G, Yunge M, Tonial C, Cruces P, Palacio G, Grela C, Slöcker-Barrio M, Campos-Miño S, González-Dambrauskas S, Sánchez-Pinto NL, Celiny García P, Jabornisky R. Latin American Consensus on the Management of Sepsis in Children: Sociedad Latinoamericana de Cuidados Intensivos Pediátricos [Latin American Pediatric Intensive Care Society] (SLACIP) Task Force: Executive Summary. J Intensive Care Med. 2022 Jun;37(6):753-763 Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 Feb;21(2):e52-e106. Hilarius KWE, Skippen PW, Kissoon N. Early Recognition and Emergency Treatment of Sepsis and Septic Shock in Children. Pediatr Emerg Care. 2020 Feb;36(2):101-106 Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016 May 23;353:i1585. Carcillo JA, Halstead ES, Hall MW, Nguyen TC, Reeder R, Aneja R, Shakoory B, Simon D; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigators. Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. Pediatr Crit Care Med. 2017 Jun;18(6):513-523. Font MD, Thyagarajan B, Khanna AK. Sepsis and Septic Shock - Basics of diagnosis, pathophysiology and clinical decision making. Med Clin North Am. 2020 Jul;104(4):573-585 van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017 Jul;17(7):407-420. Kudo D, Goto T, Uchimido R, Hayakawa M, Yamakawa K, Abe T, Shiraishi A, Kushimoto S. Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies. Crit Care. 2021 Mar 19;25(1):114 Diehl JL, Borgel D. Sepsis and coagulation. Curr Opin Crit Care. 2005 Oct;11(5):454-60. Carcillo JA, Davis AL, Zaritsky A. Role of early fluid resuscitation in pediatric septic shock. JAMA. 1991 Sep 4;266(9):1242-5. PMID: 1870250 Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM; FEAST Trial Group. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011 Jun 30;364(26):2483-95 Maitland K, Gibb DM, Babiker A; FEAST trial team. Secondary re-analysis of the FEAST trial. Lancet Respir Med. 2019 Oct;7(10):e29. Martin GS, Bassett P. Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis. J Crit Care. 2019 Apr;50:144-154. Sankar J, Ismail J, Sankar MJ, C P S, Meena RS. Fluid Bolus Over 15-20 Versus 5-10 Minutes Each in the First Hour of Resuscitation in Children With Septic Shock: A Randomized Controlled Trial. Pediatr Crit Care Med. 2017 Oct;18(10):e435-e445. Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Hervé F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P; SEPSISPAM Investigators. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014 Apr 24;370(17):1583-93 De Backer D, Donadello K, Cortes DO. Monitoring the microcirculation. J Clin Monit Comput. 2012 Oct;26(5):361-6. Kara A, Akin S, Ince C. Monitoring microcirculation in critical illness. Curr Opin Crit Care. 2016 Oct;22(5):444-52. Koster G, Bekema HJ, Wetterslev J, Gluud C, Keus F, van der Horst IC. Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med. 2016 Sep;42(9):1322-35 Kakihana Y, Ito T, Nakahara M, Yamaguchi K, Yasuda T. Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care. 2016 Mar 23;4:22. Tomicic V; Zouein L; Iribarren G; Arenas A; Rol de la milrinona en el tratamiento del shock séptico; Rev Chil Med Intensiv 2021; 36(2): 61-71. Rich N, West N, McMaster P, Alexander J. Milrinone in meningococcal sepsis. Pediatr Crit Care Med. 2003 Jul;4(3):394-5. Meyer S, Gortner L, Brown K, Abdul-Khaliq H. The role of milrinone in children with cardiovascular compromise: review of the literature. Wien Med Wochenschr. 2011 Apr;161(7-8):184-91. Ospina-Tascón GA, Calderón-Tapia LE. Inodilators in septic shock: should these be used? Ann Transl Med. 2020 Jun;8(12):796. de Miranda ML, Pereira SJ, Santos AO, Villela NR, Kraemer-Aguiar LG, Bouskela E. Milrinone attenuates arteriolar vasoconstriction and capillary perfusion deficits on endotoxemic hamsters. PLoS One. 2015 Feb 3;10(2):e0117004 |
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Nieto, AndrésLucena, NataliaFernandez-Sarmiento, Jaimee59328d2-ccbe-4f16-90b5-8a74ca5ece63-1Sarta Mantilla, Carlos MauricioFernández-Sarmiento, JaimeAcevedo Sedano, LorenaMulett Hoyos, HernandoEspecialista en Cuidado Intensivo PediátricoMaestríaFull time4b232cb1-a3b8-49ce-9650-82482ba21a9e-1f35f374e-babe-4ebf-9eec-69597328fb0f-1b367243d-b036-4046-959a-88b455f4bff5-19bdde45d-55b0-49b9-be28-cda7e5bb70be-12023-08-25T12:29:10Z2023-08-25T12:29:10Z2023-08-22info:eu-repo/date/embargoEnd/2024-08-26Objetivos: Evaluar los cambios en la microcirculación asociados al uso del milrinona en niños con sepsis. Se utilizó videomicroscopía sublingual para medir flujo y densidad capilar (DC) y región limite perfundida (PBR, parámetro inverso del grosor del glicocálix). El desenlace primario fue los cambios en la microcirculación asociados al uso de milrinona al ingreso y a las 24 horas. Diseño: Cohorte prospectiva realizado de Febrero 2021 – Enero 2022 Lugar: Unidad de cuidados intensivos pediátricos (UCIP) en hospital universitario. Pacientes: Niños con sepsis/choque séptico con y sin infusión de milrinona. Intervención: Ninguna Métodos y resultados principales: Se incluyeron 140 niños (mediana edad 2 años RIQ 0.58-12.1). El 58% de los pacientes recibieron infusión de milrinona. La DC se mantuvo en el grupo que recibió milrinona comparado con el grupo que no recibió (p<0.01). Los menores de dos años con milrinona, tenían mejor DC comparado con los niños mayores (50% vs 25%; OR 0.33; CI 95% 0.12-0.89;p=0.02). En el análisis multivariado controlando variables confusoras los niños que recibieron milrinona tenían menos degradación del glicocálix endotelial comparado con los que no lo recibieron ( aOR 0.34 CI 95% 0.11-0.99; p=0.04). Estos cambios se mantenían a pesar de ferritina y proteína C reactiva elevadas (aOR 0.41; CI 95% 0.18-0.93;p=0.03). Conclusiones: En niños con sepsis, el uso de milrinona se asoció a cambios en la microcirculación. Se encontró persistencia de reclutamiento de capilares luego de 24 horas de su administración, menos heterogeneidad del flujo sanguíneo capilar y menos degradación del glicocálix.Objectives: To evaluate changes in microcirculation (capillary density - blood flow) and the endothelial glycocalyx associated with using milrinone in children with sepsis. Sublingual videomicroscopy was used to assess capillary density (DC4-6 microns and DC7-25 microns), microvascular flow index, and perfused blood region (perfusion boundary region (PBR), inverse parameter of glycocalyx thickness - abnormal > 2.0 microns). The primary outcome was the association between changes in microcirculation and the endothelial glycocalyx related to milrinone use. Design: Prospective cohort study from February 2021 - January 2022. Place: 12-bed pediatric intensive care unit (PICU) in a university hospital. Patients: Children with sepsis/septic shock with and without milrinone infusion. Intervention: None Methods and Main Results: 140 children with a mean age of 2 years (IQR 0.58-12.1) were included. Fifty-eight percent (81/140) of patients received milrinone infusion. The main focus of infection was respiratory (43/140;30.7%). After 24 hours of administering milrinone, it was observed that capillary density (4-6 microns) was maintained only in this group (p<0.01). Children younger than two years who received milrinone had better DC4-6 than older ones (OR 0.33; CI 95% 0.12-0.89;p=0.02). In milrinone patients, capillary blood flow was more homogeneous and capillary recruitment capacity was maintained (p<0.05). Additionally, these children had less endothelial glycocalyx degradation (aOR 0.34 CI 95% 0.11-0.99; p=0.04), which was maintained despite elevated ferritin and C-reactive protein (aOR 0.41; CI 95% 0.18-0.93;p=0.03). The group without milrinone had more organ failure associated with microcirculation dysfunction, glycocalyx degradation (p<0.01) and a lower number of functional recruited capillaries (p<0.01). Elevated PBR was associated with mortality in both groups (p=0.04). Conclusions: in this investigation of children with sepsis, we found that milrinone was associated with changes in microcirculation. We found persistence of capillary recruitment of 4-6 microns after 24 hours of its administration, and maintenance and less heterogeneity of capillary blood flow as well as less degradation of the glycocalyx, particularly in children under two years of age.75 ppapplication/pdfhttps://doi.org/10.48713/10336_40754 https://repository.urosario.edu.co/handle/10336/40754spaUniversidad del RosarioEscuela de Medicina y Ciencias de la SaludEspecialización en Cuidado Intensivo PediátricoAttribution-NonCommercial-ShareAlike 4.0 InternationalRestringido (Temporalmente bloqueado)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_f1cfWeiss SL, Balamuth F, Hensley J, Fitzgerald JC, Bush J, Nadkarni VM, Thomas NJ, Hall M, Muszynski J. The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die. Pediatr Crit Care Med. 2017 Sep;18(9):823-830Weiss SL, Peters MJ, Agus MSD, Alhazzani W, Choong K, Flori HR, Inwald DP, Nadel S, Nunnally ME, Schlapbach LJ, Tasker RC, Tissieres P, Kissoon N; Children’s Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Taskforce. Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019. Pediatr Crit Care Med. 2020 Nov;21(11):e1031-e1037.Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018 Mar;6(3):223-230.De Backer D, Ricottilli F, Ospina-Tascón GA. Septic shock: a microcirculation disease. Curr Opin Anaesthesiol. 2021 Apr 1;34(2):85-91.Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019 Jan 17;23(1):16.Tarbell JM, Cancel LM. The glycocalyx and its significance in human medicine. J Intern Med. 2016 Jul;280(1):97-113.Yajnik V, Maarouf R. Sepsis and the microcirculation: the impact on outcomes. Curr Opin Anaesthesiol. 2022 Apr 1;35(2):230-235.Iba T, Levy JH. Derangement of the endothelial glycocalyx in sepsis. J Thromb Haemost. 2019 Feb;17(2):283-294Walley KR. Sepsis-induced myocardial dysfunction. Curr Opin Crit Care. 2018 Aug;24(4):292-299Gelinas JP, Russell JA. Vasopressors During Sepsis: Selection and Targets. Clin Chest Med. 2016 Jun;37(2):251-62Liet JM, Jacqueline C, Orsonneau JL, et al. The effects of milrinone on hemodynamics in an experimental septic shock model. Pediatr Crit Care Med 2005;6:195-9Jain S. Sepsis: An Update on Current Practices in Diagnosis and Management. Am J Med Sci. 2018 Sep;356(3):277-286. doi: 10.1016/j.amjms.2018.06.012.Weiss SL, Fitzgerald JC, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A, Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ; Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57.Joffre J, Hellman J, Ince C, Ait-Oufella H. Endothelial Responses in Sepsis. Am J Respir Crit Care Med. 2020 Aug 1;202(3):361-370Fernández-Sarmiento J, Carcillo JA, Salinas CM, Galvis EF, López PA, Jagua-Gualdrón A. Effect of a Sepsis Educational Intervention on Hospital Stay. Pediatr Crit Care Med. 2018 Jun;19(6):e321-e328.Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016 Jun;37(2):263-75. doi: 10.1016/j.ccm.2016.01.009.Chanani NK, Cowan DB, Takeuchi K, et al. Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation 2002;106:I284-9Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL; Sepsis Prevalence, Outcomes, and Therapy Study Investigators. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017 Jan;18(1):8-16.Beurskens DM, Bol ME, Delhaas T, van de Poll MC, Reutelingsperger CP, Nicolaes GA, Sels JE. Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis. Anaesth Intensive Care. 2020 May;48(3):221-228.Rohlenova K, Veys K, Miranda-Santos I, De Bock K, Carmeliet P. Endothelial Cell Metabolism in Health and Disease. Trends Cell Biol. 2018 Mar;28(3):224-236.Shi Y, Vanhoutte PM. Macro- and microvascular endothelial dysfunction in diabetes. J Diabetes. 2017 May;9(5):434-449.Büchele GL, Ospina-Tascon GA, De Backer D. How microcirculation data have changed my clinical practice. Curr Opin Crit Care. 2007 Jun;13(3):324-31.Jourde-Chiche N, Fakhouri F, Dou L, Bellien J, Burtey S, Frimat M, Jarrot PA, Kaplanski G, Le Quintrec M, Pernin V, Rigothier C, Sallée M, Fremeaux-Bacchi V, Guerrot D, Roumenina LT. Endothelium structure and function in kidney health and disease. Nat Rev Nephrol. 2019 Feb;15(2):87-108.Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev. 2004 Jul;84(3):869-901.Petzelbauer P, Halama T, Gröger M. Endothelial adherens junctions. J Investig Dermatol Symp Proc. 2000 Dec;5(1):10-3.Foote CA, Soares RN, Ramirez-Perez FI, Ghiarone T, Aroor A, Manrique-Acevedo C, Padilla J, Martinez-Lemus L. Endothelial Glycocalyx. Compr Physiol. 2022 Aug 23;12(4):3781-3811.Luft JH. Fine structures of capillary and endocapillary layer as revealed by ruthenium red. Fed Proc.Alphonsus CS, Rodseth RN. The endothelial glycocalyx: a review of the vascular barrier. Anaesthesia. 2014 Jul;69(7):777-84.Jacob M, Chappell D. Reappraising Starling: the physiology of the microcirculation. Curr Opin Crit Care. 2013 Aug;19(4):282-9.Pillinger NL, Kam P. Endothelial glycocalyx: basic science and clinical implications. Anaesth Intensive Care. 2017 May;45(3):295-307Vink H., Duling B.R. Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries. Circ Res 1996; 79: 581–589Nieuwdorp M., Meuwese M.C., Mooij H.L., Ince C., Broekhuizen L.N., Kastelein J.J. et al. Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability. J Appl Physiol 2008; 104: 845–852Reitsma S., Slaaf D.W., Vink H., van Zandvoort M.A., oude Egbrink M.G. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch 2007; 454: 345–359Weinbaum S., Tarbell J.M., Damiano E.R. The structure and function of the endothelial glycocalyx layer. Annu Rev Biomed Eng 2007; 9: 121–167.Curry F.E., Adamson R.H. Endothelial glycocalyx: permeability barrier and mechanosensor. Ann Biomed Eng 2012; 40: 828–839.van Haaren PM, VanBavel E, Vink H, Spaan JA. Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2848-56.Han S, Lee S-J, Kim KE, Lee HS, Oh N, Park I, Ko E, Oh SJ, Lee Y-S, Kim D, Lee S, Lee DH, Lee K-H, Chae SY, Lee J-H, Kim S-J, Kim H-C, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin HG, Hu J, Song PH, Kim Y-I, Kim P, Kim I, Koh GY. Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 2016;8:335ra55King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc Res. 2004 Mar;67(2):139-51.Mochizuki S, Takayama A, Sasaki T, Yada T, Endo K, Horike H, Kashihara N, Ogasawara Y, Kajiya F. Clear correlation of tetrahydrobiopterin with nitric oxide bioavailability in continuous ambulatory peritoneal dialysis. Blood Purif. 2010;30(2):96-7.Lupu F, Kinasewitz G, Dormer K. The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis. J Cell Mol Med. 2020 Nov;24(21):12258-12271.Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010 Jul 15;87(2):198-210.Kudo S, Morigaki R, Saito J, Ikeda M, Oka K, Tanishita K. Shear-stress effect on mitochondrial membrane potential and albumin uptake in cultured endothelial cells. Biochem Biophys Res Commun. 2000 Apr 13;270(2):616-21Hellenthal KEM, Brabenec L, Wagner NM. Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation. Cells. 2022 Jun 15;11(12):1935.Suzuki A, Tomita H, Okada H. Form follows function: The endothelial glycocalyx. Transl Res. 2022 Sep;247:158-167. doi: 10.1016/j.trsl.2022.03.014.Zhao F, Wang R, Huang Y, Li L, Zhong L, Hu Y, Han Z, Fan J, Liu P, Zheng Y, Luo Y. Elevated plasma syndecan-1 as glycocalyx injury marker predicts unfavorable outcomes after rt-PA intravenous thrombolysis in acute ischemic stroke. Front Pharmacol. 2022 Jul 15;13:949290Richter RP, Payne GA, Ambalavanan N, Gaggar A, Richter JR. The endothelial glycocalyx in critical illness: A pediatric perspective. Matrix Biol Plus. 2022 Mar 9;14:100106.Goligorsky MS, Sun D. Glycocalyx in Endotoxemia and Sepsis. Am J Pathol. 2020 Apr;190(4):791-798Annecke T, Fischer J, Hartmann H, Tschoep J, Rehm M, Conzen P, Sommerhoff CP, Becker BF. Shedding of the coronary endothelial glycocalyx: effects of hypoxia/reoxygenation vs ischaemia/reperfusion. Br J Anaesth. 2011 Nov;107(5):679-86Suzuki K, Okada H, Sumi K, Tomita H, Kobayashi R, Ishihara T, Mizuno Y, Yamaji F, Kamidani R, Miura T, Yasuda R, Kitagawa Y, Fukuta T, Suzuki K, Miyake T, Kanda N, Doi T, Yoshida T, Yoshida S, Tetsuka N, Ogura S, Suzuki A. Syndecan-1 as a severity biomarker for patients with trauma. Front Med (Lausanne). 2022 Sep 27;9:985955Woods A, Couchman JR. Syndecan-4 and focal adhesion function. Curr Opin Cell Biol. 2001 Oct;13(5):578-83.Couchman JR, Woods A. Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J Cell Sci. 1999 Oct;112 ( Pt 20):3415-20.Li JP, Kusche-Gullberg M. Heparan Sulfate: Biosynthesis, Structure, and Function. Int Rev Cell Mol Biol. 2016;325:215-73.Nelson A, Berkestedt I, Bodelsson M. Circulating glycosaminoglycan species in septic shock. Acta Anaesthesiol Scand. 2014 Jan;58(1):36-43.Fernández-Sarmiento J, Schlapbach LJ, Acevedo L, Santana CR, Acosta Y, Diana A, Monsalve M, Carcillo JA. Endothelial Damage in Sepsis: The Importance of Systems Biology. Front Pediatr. 2022 Mar 9;10:828968.Eickhoff MK, Winther SA, Hansen TW, Diaz LJ, Persson F, Rossing P, Frimodt-Møller M. Assessment of the sublingual microcirculation with the GlycoCheck system: Reproducibility and examination conditions. PLoS One. 2020 Dec 23;15(12):e0243737Dubin A, Kanoore Edul VS, Caminos Eguillor JF, Ferrara G. Monitoring Microcirculation: Utility and Barriers - A Point-of-View Review. Vasc Health Risk Manag. 2020 Dec 31;16:577-589.Fernández-Sarmiento J, Salazar-Peláez LM, Acevedo L, Niño-Serna LF, Flórez S, Alarcón-Forero L, Mulett H, Gómez L, Villar JC. Endothelial and Glycocalyx Biomarkers in Children With Sepsis After One Bolus of Unbalanced or Balanced Crystalloids. Pediatr Crit Care Med. 2023 Mar 1;24(3):213-221Rovas A, Seidel LM, Vink H, Pohlkötter T, Pavenstädt H, Ertmer C, Hessler M, Kümpers P. Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Crit Care. 2019 Jul 24;23(1):260.Scholz A, Plate KH, Reiss Y. Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation. Ann N Y Acad Sci. 2015 Jul;1347:45-51.Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med. 2006 Feb;12(2):235-9.Crowley LC, Marfell BJ, Scott AP, Waterhouse NJ. Quantitation of Apoptosis and Necrosis by Annexin V Binding, Propidium Iodide Uptake, and Flow Cytometry. Cold Spring Harb Protoc. 2016 Nov 1;2016(11).Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 Jun;101(6):1644-55Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005 Jan;6(1):2-8.Fernández-Sarmiento J, De Souza DC, Martinez A, Nieto V, López-Herce J, Soares Lanziotti V, Arias López MDP, De Carvalho WB, Oliveira CF, Jaramillo-Bustamante JC, Díaz F, Yock-Corrales A, Ruvinsky S, Munaico M, Pavlicich V, Iramain R, Márquez MP, González G, Yunge M, Tonial C, Cruces P, Palacio G, Grela C, Slöcker-Barrio M, Campos-Miño S, González-Dambrauskas S, Sánchez-Pinto NL, Celiny García P, Jabornisky R. Latin American Consensus on the Management of Sepsis in Children: Sociedad Latinoamericana de Cuidados Intensivos Pediátricos [Latin American Pediatric Intensive Care Society] (SLACIP) Task Force: Executive Summary. J Intensive Care Med. 2022 Jun;37(6):753-763Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 Feb;21(2):e52-e106.Hilarius KWE, Skippen PW, Kissoon N. Early Recognition and Emergency Treatment of Sepsis and Septic Shock in Children. Pediatr Emerg Care. 2020 Feb;36(2):101-106Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016 May 23;353:i1585.Carcillo JA, Halstead ES, Hall MW, Nguyen TC, Reeder R, Aneja R, Shakoory B, Simon D; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigators. Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome. Pediatr Crit Care Med. 2017 Jun;18(6):513-523.Font MD, Thyagarajan B, Khanna AK. Sepsis and Septic Shock - Basics of diagnosis, pathophysiology and clinical decision making. Med Clin North Am. 2020 Jul;104(4):573-585van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017 Jul;17(7):407-420.Kudo D, Goto T, Uchimido R, Hayakawa M, Yamakawa K, Abe T, Shiraishi A, Kushimoto S. Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies. Crit Care. 2021 Mar 19;25(1):114Diehl JL, Borgel D. Sepsis and coagulation. Curr Opin Crit Care. 2005 Oct;11(5):454-60.Carcillo JA, Davis AL, Zaritsky A. Role of early fluid resuscitation in pediatric septic shock. JAMA. 1991 Sep 4;266(9):1242-5. PMID: 1870250Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM; FEAST Trial Group. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011 Jun 30;364(26):2483-95Maitland K, Gibb DM, Babiker A; FEAST trial team. Secondary re-analysis of the FEAST trial. Lancet Respir Med. 2019 Oct;7(10):e29.Martin GS, Bassett P. Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis. J Crit Care. 2019 Apr;50:144-154.Sankar J, Ismail J, Sankar MJ, C P S, Meena RS. Fluid Bolus Over 15-20 Versus 5-10 Minutes Each in the First Hour of Resuscitation in Children With Septic Shock: A Randomized Controlled Trial. Pediatr Crit Care Med. 2017 Oct;18(10):e435-e445.Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Hervé F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P; SEPSISPAM Investigators. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014 Apr 24;370(17):1583-93De Backer D, Donadello K, Cortes DO. Monitoring the microcirculation. J Clin Monit Comput. 2012 Oct;26(5):361-6.Kara A, Akin S, Ince C. Monitoring microcirculation in critical illness. Curr Opin Crit Care. 2016 Oct;22(5):444-52.Koster G, Bekema HJ, Wetterslev J, Gluud C, Keus F, van der Horst IC. Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med. 2016 Sep;42(9):1322-35Kakihana Y, Ito T, Nakahara M, Yamaguchi K, Yasuda T. Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care. 2016 Mar 23;4:22.Tomicic V; Zouein L; Iribarren G; Arenas A; Rol de la milrinona en el tratamiento del shock séptico; Rev Chil Med Intensiv 2021; 36(2): 61-71.Rich N, West N, McMaster P, Alexander J. Milrinone in meningococcal sepsis. Pediatr Crit Care Med. 2003 Jul;4(3):394-5.Meyer S, Gortner L, Brown K, Abdul-Khaliq H. The role of milrinone in children with cardiovascular compromise: review of the literature. Wien Med Wochenschr. 2011 Apr;161(7-8):184-91.Ospina-Tascón GA, Calderón-Tapia LE. Inodilators in septic shock: should these be used? Ann Transl Med. 2020 Jun;8(12):796.de Miranda ML, Pereira SJ, Santos AO, Villela NR, Kraemer-Aguiar LG, Bouskela E. Milrinone attenuates arteriolar vasoconstriction and capillary perfusion deficits on endotoxemic hamsters. PLoS One. 2015 Feb 3;10(2):e0117004instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURChoque sépticoSepsisMicrocirculacionMilrinoneEndotelioShockSepsisMicrocirculationEndotheliumMilrinoneCambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque sépticoChanges in microcirculation associated with using milrinone in children with sepsis shockbachelorThesisTrabajo de gradoTrabajo de gradohttp://purl.org/coar/resource_type/c_7a1fEscuela de Medicina y Ciencias de la SaludORIGINALCambios-en-la-microcirculacion-asociados-al-uso-de-infusiones-de-Milrinona-en-ninos-con-choque-septico.pdfCambios-en-la-microcirculacion-asociados-al-uso-de-infusiones-de-Milrinona-en-ninos-con-choque-septico.pdfCorreo recibido 24ago2023: Mi nombre es Carlos Mauricio Sarta Mantilla. Soy residente de cuidado intensivo pediátrico. Mi trabajo de grado (" Cambios en la microcirculación asociados al uso de infusiones de Milrinona en niños con choque séptico") en este momento, lo sometí a la Revista Pediatric Critical Care. Es una revista Q1 con un alto nivel de impacto y esta en sometimiento. Mi intensión es publicarla por eso solicito se bloquee por un periodo de un año mientras es sometido y corregido para publicación. Agradezco su colaboracion Atentamente: Carlos Mauricio Sarta Mantillaapplication/pdf2054847https://repository.urosario.edu.co/bitstreams/70a919c2-6341-48c1-ba41-7565ef432ab3/download211fbeea16bba6651273d257e10d46c5MD51LICENSElicense.txtlicense.txttext/plain1483https://repository.urosario.edu.co/bitstreams/47fcbe04-277a-416e-91fe-9e8e1041a052/downloadb2825df9f458e9d5d96ee8b7cd74fde6MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81160https://repository.urosario.edu.co/bitstreams/32d4c95f-1445-4f86-8570-7e7b59b4d4ac/download5643bfd9bcf29d560eeec56d584edaa9MD53TEXTCambios-en-la-microcirculacion-asociados-al-uso-de-infusiones-de-Milrinona-en-ninos-con-choque-septico.pdf.txtCambios-en-la-microcirculacion-asociados-al-uso-de-infusiones-de-Milrinona-en-ninos-con-choque-septico.pdf.txtExtracted texttext/plain101975https://repository.urosario.edu.co/bitstreams/f73da496-04f3-425a-ba40-8422170e4cbd/download784d71ad9de0d9199b9ac5b6c843b55cMD54THUMBNAILCambios-en-la-microcirculacion-asociados-al-uso-de-infusiones-de-Milrinona-en-ninos-con-choque-septico.pdf.jpgCambios-en-la-microcirculacion-asociados-al-uso-de-infusiones-de-Milrinona-en-ninos-con-choque-septico.pdf.jpgGenerated Thumbnailimage/jpeg2376https://repository.urosario.edu.co/bitstreams/c6d8936c-96d9-4662-a132-ceed99cb92dd/downloada417bda8aaa867a8003a70f8db1fd76dMD5510336/40754oai:repository.urosario.edu.co:10336/407542023-08-26 03:02:38.66http://creativecommons.org/licenses/by-nc-sa/4.0/Attribution-NonCommercial-ShareAlike 4.0 Internationalhttps://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.coRUwoTE9TKSBBVVRPUihFUyksIG1hbmlmaWVzdGEobWFuaWZlc3RhbW9zKSBxdWUgbGEgb2JyYSBvYmpldG8gZGUgbGEgcHJlc2VudGUgYXV0b3JpemFjacOzbiBlcyBvcmlnaW5hbCB5IGxhIHJlYWxpesOzIHNpbiB2aW9sYXIgbyB1c3VycGFyIGRlcmVjaG9zIGRlIGF1dG9yIGRlIHRlcmNlcm9zLCBwb3IgbG8gdGFudG8gbGEgb2JyYSBlcyBkZSBleGNsdXNpdmEgYXV0b3LDrWEgeSB0aWVuZSBsYSB0aXR1bGFyaWRhZCBzb2JyZSBsYSBtaXNtYS4KPGJyLz4KUEFSQUdSQUZPOiBFbiBjYXNvIGRlIHByZXNlbnRhcnNlIGN1YWxxdWllciByZWNsYW1hY2nDs24gbyBhY2Npw7NuIHBvciBwYXJ0ZSBkZSB1biB0ZXJjZXJvIGVuIGN1YW50byBhIGxvcyBkZXJlY2hvcyBkZSBhdXRvciBzb2JyZSBsYSBvYnJhIGVuIGN1ZXN0acOzbiwgRUwgQVVUT1IsIGFzdW1pcsOhIHRvZGEgbGEgcmVzcG9uc2FiaWxpZGFkLCB5IHNhbGRyw6EgZW4gZGVmZW5zYSBkZSBsb3MgZGVyZWNob3MgYXF1w60gYXV0b3JpemFkb3M7IHBhcmEgdG9kb3MgbG9zIGVmZWN0b3MgbGEgdW5pdmVyc2lkYWQgYWN0w7phIGNvbW8gdW4gdGVyY2VybyBkZSBidWVuYSBmZS4KPGhyLz4KRUwgQVVUT1IsIGF1dG9yaXphIGEgTEEgVU5JVkVSU0lEQUQgREVMIFJPU0FSSU8sICBwYXJhIHF1ZSBlbiBsb3MgdMOpcm1pbm9zIGVzdGFibGVjaWRvcyBlbiBsYSBMZXkgMjMgZGUgMTk4MiwgTGV5IDQ0IGRlIDE5OTMsIERlY2lzacOzbiBhbmRpbmEgMzUxIGRlIDE5OTMsIERlY3JldG8gNDYwIGRlIDE5OTUgeSBkZW3DoXMgbm9ybWFzIGdlbmVyYWxlcyBzb2JyZSBsYSBtYXRlcmlhLCAgdXRpbGljZSB5IHVzZSBsYSBvYnJhIG9iamV0byBkZSBsYSBwcmVzZW50ZSBhdXRvcml6YWNpw7NuLgoKLS0tLS0tLS0tLS0tLS0tLS0tLS0tLS0tLS0tLS0tLS0tLS0tLS0KClBPTElUSUNBIERFIFRSQVRBTUlFTlRPIERFIERBVE9TIFBFUlNPTkFMRVMuIERlY2xhcm8gcXVlIGF1dG9yaXpvIHByZXZpYSB5IGRlIGZvcm1hIGluZm9ybWFkYSBlbCB0cmF0YW1pZW50byBkZSBtaXMgZGF0b3MgcGVyc29uYWxlcyBwb3IgcGFydGUgZGUgTEEgVU5JVkVSU0lEQUQgREVMIFJPU0FSSU8gIHBhcmEgZmluZXMgYWNhZMOpbWljb3MgeSBlbiBhcGxpY2FjacOzbiBkZSBjb252ZW5pb3MgY29uIHRlcmNlcm9zIG8gc2VydmljaW9zIGNvbmV4b3MgY29uIGFjdGl2aWRhZGVzIHByb3BpYXMgZGUgbGEgYWNhZGVtaWEsIGNvbiBlc3RyaWN0byBjdW1wbGltaWVudG8gZGUgbG9zIHByaW5jaXBpb3MgZGUgbGV5LiBQYXJhIGVsIGNvcnJlY3RvIGVqZXJjaWNpbyBkZSBtaSBkZXJlY2hvIGRlIGhhYmVhcyBkYXRhICBjdWVudG8gY29uIGxhIGN1ZW50YSBkZSBjb3JyZW8gaGFiZWFzZGF0YUB1cm9zYXJpby5lZHUuY28sIGRvbmRlIHByZXZpYSBpZGVudGlmaWNhY2nDs24gIHBvZHLDqSBzb2xpY2l0YXIgbGEgY29uc3VsdGEsIGNvcnJlY2Npw7NuIHkgc3VwcmVzacOzbiBkZSBtaXMgZGF0b3MuCg== |