Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares
El cemento óseo fue descubierto en 1902 por el químico Otto Röhm. como “plexiglás”, un material endurecido similar al cristal, en 1936 la compañía Kulzer (1936; patente drp 737058) descubrió que se podía componer una pasta mezclando Polimetilmetacrilato (PMMA) en polvo y un monómero líquido, que end...
- Autores:
-
Mejía Rodríguez, Manuel Alejandro
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2018
- Institución:
- Universidad ECCI
- Repositorio:
- Repositorio Institucional ECCI
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.ecci.edu.co:001/1347
- Acceso en línea:
- https://repositorio.ecci.edu.co/handle/001/1347
- Palabra clave:
- Iniciador redox
Cemento óseo
Polimerización exótermica
Redox initiator
Exothermic polymerization
Bone cement
- Rights
- openAccess
- License
- Derechos Reservados - Universidad ECCI 2018
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| dc.title.spa.fl_str_mv |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares |
| title |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares |
| spellingShingle |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares Iniciador redox Cemento óseo Polimerización exótermica Redox initiator Exothermic polymerization Bone cement |
| title_short |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares |
| title_full |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares |
| title_fullStr |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares |
| title_full_unstemmed |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares |
| title_sort |
Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articulares |
| dc.creator.fl_str_mv |
Mejía Rodríguez, Manuel Alejandro |
| dc.contributor.advisor.none.fl_str_mv |
Torres Medina, Jorge Humberto |
| dc.contributor.author.none.fl_str_mv |
Mejía Rodríguez, Manuel Alejandro |
| dc.subject.proposal.spa.fl_str_mv |
Iniciador redox Cemento óseo Polimerización exótermica |
| topic |
Iniciador redox Cemento óseo Polimerización exótermica Redox initiator Exothermic polymerization Bone cement |
| dc.subject.proposal.eng.fl_str_mv |
Redox initiator Exothermic polymerization Bone cement |
| description |
El cemento óseo fue descubierto en 1902 por el químico Otto Röhm. como “plexiglás”, un material endurecido similar al cristal, en 1936 la compañía Kulzer (1936; patente drp 737058) descubrió que se podía componer una pasta mezclando Polimetilmetacrilato (PMMA) en polvo y un monómero líquido, que endureciera cuando se añade Peróxido de Benzoilo (BPO) y siempre cuando se calentara a (100ºC) en un molde de piedra. El primer uso clínico de esta mezcla de PMMA fue introducido para cerrar defectos craneales en monos en 1938. Ha sido utilizado para múltiples propósitos desde entonces; Con la evolución de la tecnología se ha intentado estudiar sus características físico-químico-mecánicas, y optimizarlas para un mejor rendimiento quirúrgico. |
| publishDate |
2018 |
| dc.date.issued.none.fl_str_mv |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2021-08-21T02:07:39Z |
| dc.date.available.none.fl_str_mv |
2021-08-21T02:07:39Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
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http://purl.org/coar/version/c_dc82b40f9837b551 |
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Text |
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info:eu-repo/semantics/bachelorThesis |
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https://purl.org/redcol/resource_type/TP |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_7a1f |
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https://repositorio.ecci.edu.co/handle/001/1347 |
| url |
https://repositorio.ecci.edu.co/handle/001/1347 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
Burke dw, gates ei, harris wh. centrifugation as a method of improving tensile and fatigue properties of acrylic bone cement. j bone joint surg am. 1984 oct; 66(8):1265-73.) Lidgren l, bodelind b, moller j. bone cement improved by vacuum mixing and chilling. acta orthop scand. 1987 feb; 58(1):27-32. Effect of vacuum-treatment on deformation properties of pmma bone cement fatima zivica,∗, miroslav babica, nenad grujovica, slobodan mitrovica, gregory favarob,mihaela cauniiba faculty of mechanical engineering, kragujevac, serbiab csm instruments, Switzerland. The genesis and evolution of acrylic bone cement Dennis C. Smith, PhD, DSc, FRSCan* Orthop Clin N Am 36 (2005) 1 – 10 Properties of Bone Cement: The Mechanical Properties of PMMA Bone Cement. Clive Lee. Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg 1960; 42B:28– 30. Charnley J. Arthroplasty of the hip by the low friction technique. J Bone Joint Surg 1961; 43B:601. Effect of vacuum-treatment on deformation properties of PMMA bone cement Fatima Ziuica'*, Miroslau Bábica, Nenad Grujovica, Slobodan Mitrouica, Gregory Favaroh, Mihaela Cauniih JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 5 (20 I 2) I 29-I 38. Outcomes of Charnley total hip arthroplasty using improved cementing with so-called second- and third-generation techniques Shiro Hirose • Hiromi Otsuka • Takkan Morishima Keiji Sato J Orthop Sci (2012) 17:118-123. Comparison of the mechanical properties of Simplex P, Zimmer Regular, and LVC bone cements Jeff P. Davies, Daniel O. O'Connor, James A. Greer, and William H. HarrisOrthopedic Biomcchanics Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 Estudio del patrón de penetración del cemento óseo en la artroplastia de rodilla sobre modelo sintético, rubén pérez mañanes, universidad complutense de madrid facultad de medicina. The role of polymethylmethacrylate bone cement in modern orthopaedic surgery J. C. J. Webb, R. F. Spencer The journal of bone and j. surgery Kulzer Co. DRP- Patent 973 590 1943 Spence WT. Form-fitting plastic cranioplasty. J Neurosurg 1954; 11:219–25. Robinson RG, Macalister AD. Acrylic cranioplasty. A simple one-stage method using a cold curing material. Br J Surg 1954; 42:312–5. Robinson RG, Macalister AD. Acrylic cranioplasty. A simple one-stage method using a cold curing material. Br J Surg 1954; 42:312–5. Robinson RG, Macalister AD. Acrylic cranioplasty. A simple one-stage method using a cold curing material. Br J Surg 1954; 42:312–5. Smith DC. Studies in denture base materials with special reference to polymethyl methacrylate. PhD Thesis. Manchester, England7 University of Manchester; 1957 Bot G M, Ismail N J, Usman B, Shilong D J, Obande J O, Aliu S, Sale D, Shehu B B. Using the head as a mould for cranioplasty with methylmethacrylate. J Neurosci Rural Pract 2013;4:471-4 Sanan A, Haines SJ. Repairing holes in the head: A history of cranioplasty. Neurosurgery 1997; 40:588-603. International Programme on Chemical Safety-World Health Organization; 1998. Robinson RG, Macalister AD. Acrylic cranioplasty a simple one-stage method using a cold curing material. Br J Surg 1954; 42:312-5 Oliver LC, Blaine G. A new one-stage method of cranioplasty with acrylic plastic. Med Press 1948; 220:167-8. Woringer E, Schweig B, Brogly G, Schneider J. New ultramodern technique of repair of cranial damages with acrylic resins; advantage of acrylic resins over tantalum. Rev Neurol 1951; 85:527-35. Neurosurg Focus 36 (4):E19, 2014 ©AANS, 2014 Materials used in cranioplasty: a history and analysis AATMAN m. SHAH, B.S.,1 HENRY JUNG, m.D.,1 AND STEPHEN SKIRBOLL, m.D.1,2 Blum KS, Schneider SJ, Rosenthal AD: Methyl methacrylate cranioplasty in children: long term results. Pediatr Neuro-surg 26:33-35, 1997 Matsuno A, Tanaka H, Iwamuro H, Takanashi S, Miyawaki S, Nakashima M, et al: Analyses of the factors influencing bone graft infection after delayed cranioplasty. Acta Neurochir (Wien) 148:535-540, 2006. Galicich JH, Hovind KH: Stainless steel mesh-acrylic cranioplasty.Technical note. J Neurosurg 27:376–378, 1967. cranioplastias e correção de rinoliquorréias com metilmetacrilato consideracoes a propósito de 35 casos walter c. pekbira rolando a. tenuto darcy f. vellutini trotot, r. p. & cor-beil, r. — Réparation des brèches craniennes ã ]'aide de plaques de résine acry-lique. Présentatíon de malades. Rev. neurol. 79:426-427, 1947en 1947. oppenheimer, b. s.; oppenheimer, e. t. & stout, a. p. — Sarcomas induced in rats by implanting cellophane. Proc. Soc. exp. Biol. 67:33-34, 1948. Chiarini L, Figurelli S, Pollastri G, Torcia E, Ferrari F, Albanese M, et al: Cranioplasty using acrylic material: a new technical procedure. J Craniomaxillofac Surg 32:5–9, 2004 Properties of Bone Cement: Antibiotic-Loaded Cement Lars Frommelt, Klaus-Dieter Kühn, Iniciación térmica. iniciación química, un intento por describir la polimerización capítulo 4 1-60 Materials used in cranioplasty: a history and analysis Aatman M. Shah, B.S.,1 Henry Jung, M.D.,1 and Stephen Skirboll, M.D.1,2 sabokbar a, fujikawa y, murray DW, Athanasou NA. Radio-opaque agents in bone cement increase bone resorption. J Bone Joint Surg Br. 1997 Jan; 79(1):129-34 Buchholz HW, Engelbrecht H (1970) Über die Depotwirkung einiger Antibiotika bei Vermischung mit dem Kunstharz Palacos. Chirurg 41:511–515. Mader JT, Adams KR (1988) Experimental Osteomyelitis. In: Schlossberg D (ed) Orthopedic Infection. Springer, New York, pp 39–48 Properties of Bone Cement: Antibiotic-Loaded Cement Lars Frommelt, Klaus-Dieter Kühn Pfefferle HJ, Nies B (2004) Charakterisierung arzneimittelhaltiger Biomaterialien als kundenspezifische Sonderanfertigung. Orthopäde 33:817–821 International Organization for Standardization. Implants for surgery- acrylic resin cements, 2010(ISO 5833:2002). http://www.iso.org/iso/ iso_catalogue/catalogue_tc/catalogue_detail.htm?csnumber=30980 (date last accessed 12 July 2011). McNie CM, Barton DC, Fisher J, Stone MH. Modeling of damage to articulating surfaces by third body particles in total joint replacements. J Mater Sci Mater Med 2000; 11:569–578 Graves RM, Sands KC. Making a cost-effective contrast bone cement with or without antibiotics, using aqueous methylene blue for easy cement removal in revision and primary total joint arthroplasty. Orthopedics 2007; 30:825–827 Bargar WL, Martin RB, de Jesus R, Madison MT. The addition of tobramycin to contrast bone cement: effect on flexural strength. J Arthroplasty 1986;1:165–168 Bargar WL, Heiple KG, Weber S, et al. Contrast bone cement. J Orthop Res 1983; 1:92– 100. Davies JP, Harris WH. The effect of the addition of methylene blue on the fatigue strength of Simplex P bone-cement. J Appl Biomater 1992;3:81–85, Lewis G. Effect of methylene blue on the fracture toughness of acrylic bone cement. Biomaterials 1994; 15:1024–1028 Bargar WL, Heiple KG, Weber S, et al. Contrast bone cement. J Orthop Res 1983; 1:92– 100 Physical, mechanical, and pharmacological properties of coloured bone cement with and without antibiotics O. Galasso, M. Mariconda,G. Calonego, G. Gaspar in From University Magna Graecia, Catanzaro, Italy j.bone.j surgery Katti, K.S., Verma, D., Katti, D.R., 2008. Materials for joint replacement. In: Revell, P.A. (Ed.), Joint Replacement Technology. Woodhead Publishing Limited, p. 90. (Chapter 4). http://www.elespectador.com/noticias/salud/articulo114216-colombia-se-realizan-10000- reemplazos-de-cadera-o-rodilla-al-ano. Fecha de ingreso: 03 de abril del 2014. hora 4:15 pm Dunne NJ, Orr JF. Curing characteristics of acrylic bone cement. J Mater Sci Mater Med. 2002 Jan; 13(1):17-22. Berman AT, Reid JS, Yanicko DR, Jr., Sih GC, Zimmerman MR. Thermally induced bone necrosis in rabbits. Relation to implant failure in humans. Clin Orthop Relat Res. 1984 Jun(186):284-92 Eriksson AR, Albrektsson T. Temperature threshold levels for heat-induced bone tissue injury: a vital-microscopic study in the rabbit. J Prosthet Dent. 1983 Jul;50(1):101-7 Sullivan SJ, Topoleski LD. Influence of initial component temperature on the apparent viscosity and handling characteristics of acrylic (PMMA) bone cement. J Biomed Mater Res B Appl Biomater. 2007 Apr; 81(1):224-30. Iniciación térmica, iniciación química capítulo 4 pag 120, pag web// htt: polimerización en cemento quirúrgicos// efgr.-hh// hora de búsqueda: 4:00pm fecha de búsqueda: 23 de mayo del 2014 Bamford, 1988; Eastmond 1976a, 1976b y 1976c, Concentraciones de monómero e iniciadores experimentales. Schultz y Blaschke, 1942; Modelamientos matemáticos en sistemas redox y Biopolímeros Kamachi et al, 1978 Constantes experimentales en sistemas redox. Imoto y Choe, 1955 Producción de radicales libres y modelamientos experimentales. Odian, 1991, Mecanismos químicos generados entre el peróxido de benzoilo y el N,N - dimetil- p- toluidina Kühn K-D. Bone Cements. New York Tokyo: Springer; 2000. Lee AJ, Ling RS, Gheduzzi S, Simon JP, Renfro RJ. Factors affecting the mechanical and viscoelastic properties of acrylic bone cement. J Mater Sci Mater Med. 2002 Aug; 13(8):723-33 Dunne NJ, Orr JF. Flow characteristics of curing polymethyl methacrylate bone cement. Proc Inst Mech Eng H. 1998; 212(3):199-207 Lidgren L, Bodelind B, Moller J. Bone cement improved by vacuum mixing and chilling. Acta Orthop Scand. 1987 Feb; 58(1):27-32 Klein RW, Scott CP, Higham PA. The strength of acrylic bone cement cured under thumb pressure. Biomaterials. 2004 Feb; 25(5):943-7 Evans, S.L., 2006. Fatigue of PMMA bone cement, fracture of nano and engineering materials and structures. In: Gdoutos, E.E. (Ed.), Fracture of Nano and Engineering Materials and Structures. In: Proceedings of the 16th European Conference of Fracture, Springer, pp. 271– 272 Müller, R.T., Heger, I., Oldenburg, M., 1997. The mechanism of loosening in cemented hip prostheses determined from long term results. Arch. Orthop. Trauma Surg. 116, 41–45. Buckley, P.J., Orr, J.F., Revie, I.C., Breusch, S.J., Dunne, N.J., 2003. Fracture characteristics of acrylic bone cement–bone composites. Proc. Inst. Mech. Eng. Part H J. Eng. Med. 217, 419–427 Lewis, G., 2003. Fatigue testing and performance of acrylic bone–cement materials: state of-the-art review. J. Biomed. Mater. Res. Part B 66B, 457–486. Ries, M.D., Young, E., Al-Marashi, L., Goldstein, P., Hetherington, A., Petrie, T., Pruitt, L., 2006. In vivo behavior of acrylic bone cement in total hip arthroplasty. Biomaterials 27, 256– 261. Sinnett-Jones, P.E., Browne, M., Ludwig, W., Buffiére, J.-Y., Sinclair, I., 2005. Microtomography assessment of failure in acrylic bone cement. Biomaterials 26, 6460–6466. Hoey, D., Taylor, D., 2008. Fatigue in porous PMMA: the effect of stress concentrations. Int. J. Fatigue 30, 989–995. Lelovics, H., Liptakova, T., 2010. Time and mixing techniquedependent changes in bone cement smartset§HV. Acta Bioeng. Biomech. 12, 63–67. Lewis, G., 2011. Viscoelastic properties of injectable bone cements for orthopaedic applications: state-of-the-art review. J. Biomed. Mater. Res. Part B Appl. Biomater. 98, 171–191. Lewis, G., Xu, J., Dunne, N., Daly, C., Orr, J., 2007. Evaluation of an accelerated ageing medium for acrylic bone cement based on analysis of nanoindentation measurements on laboratoryprepared and retrieved specimens. J. Biomed. Mater. Res. Part B 81, 544–550 Provenzano, M., Murphy, K.P.J., Riley III, L.H., 2004. Bone cements: review of their physiochemical and biochemical properties in percutaneous vertebroplasty. AJNR Am. J. Neuroradiol. 25, 1286–1290. Nottrott, M., Mølster, A.O., Gjerdet, N.R., 2007. Time dependent mechanical properties of bone cement. An in vitro study over one year. J. Biomed. Mater. Res. Part B Appl. Biomater. 83, 416–421 Joschek S, Nies B, Krotz R, Göpferich A. Chemical and physicochemical characterization of porous hydroxyapatite ceramics made of natural bone. Biomaterials 2000; 21:1645-1658. Mehta KA, Serpil M, Phuapradit W, Waseem A, Shah NH. Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. J Control Release 2000; 63:201-211. Lewis G, Mladsi S. Effect of sterilization method on properties of Palacos R acrylic bone cement. Biomaterials 1998; 19:117-24 Kühn K-D. Bone cement: up-to-date comparison of physical and chemical properties of commercial interests. Berlin: Springer, 2000 Lewis G. Properties of acrylic bone cement: state of the art review. J Biomed Mater Res 1997; 38: 155–182. Saha S, Pal S. The mechanical properties of bone cement: a review. J Biomed Mater Res 1984, 18: 435–462 Kühn K-D. Bone cements. Springer, Berlin Heidelberg New York Tokyo, 2000 Meyer PR Jr, Lautenschlager EP, Moore BK. On the setting properties of acrylic bone cement. J Bone Joint Surg [Am] 1973;55-A:149-56 Lee AJ, Ling RS, Vangala SS. Some clinically relevant variables affecting the mechanical behaviour of bone cement. Arch Orthop Trauma Surg 1978; 92:1-18. Reckling FW, Dillon WL. The bone-cement interface temperature during total joint replacement. J Bone Joint Surg [Am] 1977; 59-A:80-2 Linder L. Reaction of bone to the acute chemical trauma of bone cement. J Bone Joint Surg [Am] 1977; 59:82-7 Lee AJC. The time-dependent properties of polymethylmethacrylate bone cement: the interaction of shape of femoral stems, surface finish and bone cement. In: Learmonth ID, ed. Interfaces in total hip arthroplasty. London: Springer-Verlag Ltd, 2000:11-19. Armstrong M, Spencer RF, Lovering AM, et al. Antibiotic elution from bone cement: a study of common cement-antibiotic combinations. Hip International 2002; 12:23-7 Lee A J C, Ling RSM, Vangala SS. Some clinically relevant variables affecting the mechanical behaviour of bone cement. Arch Orthop Traumat Surg 1978; 92: 1–18 Lee AJC, Ling RSM, Gheduzzi S, Simon J-P, Renfro RJ. Factors affecting the mechanical and viscoelastic properties of acrylic bone cement. J Mater Sci – Mater in Med, 2002, 13: 723– 733 Furnes O, Lie SA, Havelin LI, Vollset SE, Engesaeter LB: Exeter and Charnley arthroplasties with Boneloc or high viscosity cement. Comparison of 1,127 arthroplasties followed for 5 years in the Norwegian Arthroplasty Register. Acta Orthop Scand 1997; 68: 515- 20. Guzmán A. Estudio técnico económico en la recuperación de monómero de metacrilato de metilo a partir de polímero. México. Facultad de Química 1974: 150. www.state.nj.us/health/eoh/odisweb. (new jersey department of health and seniorservice. Fecha de ingreso: 03 de abril del 2014. hora 4:15 pm Vástagos cementados en la artroplastía de cadera: Historia y evolución Simesen-de Bielke H, González-Della Valle A, Salvati EA Hospital Weill Medical College of Cornell University, New York, USA. Pag.324 optimización mediante modificaciones farmacotécnicas de matrices poliméricas: desarrollo de formulaciones alternativas, María Rosa Virto García Madrid, 2005. Vacuum-mixing cement does not decrease overall porosity in cemented femoral stems AN IN VITRO LABORATORY INVESTIGATION K. J. Messick, M. A. Miller, L. A. Damron, A. Race, M. T. Clarke, K. A. Mann, J Bone Joint Surg [Br] 2007;89-B:1115-21 Determinación de monómero residual de metacrilato de metilo en 3 diferentes marcas comerciales para base de dentaduras por cromatografía de gases Fernando Solórzano Lemus, Rogelio Danovan Venegas Lancón, Víctor Moreno Maldonado, Salvador López Morales. Revista Odontológica Mexicana. vol. 14 núm. 2 junio 2010. Termodinamica de Wark,k, Sexta edición,Kenneth Wark, Jr, Donald E. Richards pag33 The effect of centrifuging bone cement j. p. davies, m. jasty, d. o. oconnor, d. w. burke, t. p. harrigan, w. h. harris J Bone Joint Surg [Br] 1989;71-B :39-42. Pre-heating of components in cemented total hip arthroplasty A. A. Jafri, S. M. Green, P. F. Partington, A. W. McCaskie, S. D. Muller J Bone Joint Surg [Br] 2004;86-B:1214-19 http://www.medicalexpo.es/prod/zimmer/product-74894-630953.html Fecha de ingreso: 13 de agosto del 2015. hora 9:15 am. http://www.debramedix.com/descargas/mezclado_vacio.pdf Fecha de ingreso: 13 de agosto del 2015. hora 9:38 am. http://www.medicalexpo.es/prod/stryker/product-70192-447780.html Fecha de ingreso: 13 de agosto del 2015. hora 2:05 Pm. |
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Torres Medina, Jorge Humberto28f53fdaf341d8dfb9a4e7afd4f15420Mejía Rodríguez, Manuel Alejandro695a553d4cd7edb1af44a3fb5820da6f2021-08-21T02:07:39Z2021-08-21T02:07:39Z2018https://repositorio.ecci.edu.co/handle/001/1347El cemento óseo fue descubierto en 1902 por el químico Otto Röhm. como “plexiglás”, un material endurecido similar al cristal, en 1936 la compañía Kulzer (1936; patente drp 737058) descubrió que se podía componer una pasta mezclando Polimetilmetacrilato (PMMA) en polvo y un monómero líquido, que endureciera cuando se añade Peróxido de Benzoilo (BPO) y siempre cuando se calentara a (100ºC) en un molde de piedra. El primer uso clínico de esta mezcla de PMMA fue introducido para cerrar defectos craneales en monos en 1938. Ha sido utilizado para múltiples propósitos desde entonces; Con la evolución de la tecnología se ha intentado estudiar sus características físico-químico-mecánicas, y optimizarlas para un mejor rendimiento quirúrgico.Glosario 1 Título de Investigación 2 Problema de Investigación 3 Formulación de Problema 4 Descripción del Problema 5 Objetivo general 51 Objetivos específicos 52 Objetivos secundarios 6 Justificación 7 Marco teórico 71 Cemento óseo: Historia y desarrollo 8 Marco conceptual 81 Composición 82 Polimerización exotérmica 83 Descomposición térmica del iniciador 84 Descomposición química del iniciador (iniciador redox) 85 Viscosidad del Pmma 86 Requisitos de la norma iso 5833:2002 para cementos óseos 87 Toxicidad del monómero de metilo 88 Límites de exposición laboral 9 Metodología 91 Etapa 1: Diseño de hardware y selección de tecnología 911 Código de programación en lenguaje C 912 Características del lenguaje de programación 913 Elección de la placa integrada de Arduino 914 Lenguaje de programación en Arduino 915 Selección de tecnología 916 Diseño de carcasa 917 Selección de los materiales para la construcción de la carcasa 918 Programación en sistema Arduino uno 919 Simulación de la programación en software Proteus 9110 Síntesis de la sección Etapa 1 9111 Recurso Financiero 92 Etapa 2: Diseño de modelo CAD/ Diseño de código de programación 921 Objetivo del modelo CAD 922 Modelo CAD del prototipo 923 Diseño base del prototipo 924 Diseño CAD de la tapa o carcasa del prototipo 925 Diseño de vaso de mezclado 926 Programa para la detección de poros en cemento, usando Matlab 927 Ingeniería Biomédica 928 Uso del software Matlab para este proyecto 929 Algoritmo General Para La Detección De Bordes 9210 Filtro lineal mediana repaso espacial y matemático 9211 Binarización de la imagen de prueba 9212 Etiquetado de porosidad y características geométricas de los poros 9213 Sintesis de la etapa 2 93 Etapa 3: Acople de software y hardware 931 Fabricación del prototipo 932 Síntesis de la etapa 3 94 Etapa 4: Verificación de la reducción de poros, por medio de código de programación en Matlab 941 Proceso de mezclado 942 Proceso de mezclado a vacío en el prototipo 943 Proceso De Mezclado A Cielo Abierto (Técnica Actual) 944 Diseño Metodológico Para Tratamiento De Muestras 945 Etiquetado de las muestras de mezclado a cielo abierto CA en Matlab 946 Etiquetado De Muestras Mezcladas A Vacío En Matlab 947 Algoritmo para la detección de poros, bajo muestras procesadas a cielo abierto CA 948 Algoritmo para la detección de poros, bajo muestras procesadas a vacío VAC 949 Prueba de t-student 10 Resultados 101 Tabulación De Resultados 102 Análisis de resultados muestras a cielo abierto CA 103 Análisis de resultados muestras a vacío VAC en prototipo 11 Discusión 12 Conclusión 13 BibliografíaPregradoTecnólogo en Mantenimiento de Equipos BiomédicosIngeniería Biomédica182 p.application/pdfspaUniversidad ECCIColombiaFacultad de IngenieríasDerechos Reservados - Universidad ECCI 2018info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Prototipo automatizado para mezclado a vacío de polimetilmetacrilato para reducción de porosidad en cemento quirúrgico en prótesis articularesTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fTextinfo:eu-repo/semantics/bachelorThesishttps://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/version/c_dc82b40f9837b551Burke dw, gates ei, harris wh. centrifugation as a method of improving tensile and fatigue properties of acrylic bone cement. j bone joint surg am. 1984 oct; 66(8):1265-73.) Lidgren l, bodelind b, moller j. bone cement improved by vacuum mixing and chilling. acta orthop scand. 1987 feb; 58(1):27-32.Effect of vacuum-treatment on deformation properties of pmma bone cement fatima zivica,∗, miroslav babica, nenad grujovica, slobodan mitrovica, gregory favarob,mihaela cauniiba faculty of mechanical engineering, kragujevac, serbiab csm instruments, Switzerland.The genesis and evolution of acrylic bone cement Dennis C. Smith, PhD, DSc, FRSCan* Orthop Clin N Am 36 (2005) 1 – 10Properties of Bone Cement: The Mechanical Properties of PMMA Bone Cement. Clive Lee.Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg 1960; 42B:28– 30.Charnley J. Arthroplasty of the hip by the low friction technique. J Bone Joint Surg 1961; 43B:601.Effect of vacuum-treatment on deformation properties of PMMA bone cement Fatima Ziuica'*, Miroslau Bábica, Nenad Grujovica, Slobodan Mitrouica, Gregory Favaroh, Mihaela Cauniih JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 5 (20 I 2) I 29-I 38.Outcomes of Charnley total hip arthroplasty using improved cementing with so-called second- and third-generation techniques Shiro Hirose • Hiromi Otsuka • Takkan Morishima Keiji Sato J Orthop Sci (2012) 17:118-123.Comparison of the mechanical properties of Simplex P, Zimmer Regular, and LVC bone cements Jeff P. Davies, Daniel O. O'Connor, James A. Greer, and William H. HarrisOrthopedic Biomcchanics Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114Estudio del patrón de penetración del cemento óseo en la artroplastia de rodilla sobre modelo sintético, rubén pérez mañanes, universidad complutense de madrid facultad de medicina.The role of polymethylmethacrylate bone cement in modern orthopaedic surgery J. C. J. Webb, R. F. Spencer The journal of bone and j. surgeryKulzer Co. DRP- Patent 973 590 1943Spence WT. Form-fitting plastic cranioplasty. J Neurosurg 1954; 11:219–25.Robinson RG, Macalister AD. Acrylic cranioplasty. A simple one-stage method using a cold curing material. Br J Surg 1954; 42:312–5.Robinson RG, Macalister AD. Acrylic cranioplasty. A simple one-stage method using a cold curing material. Br J Surg 1954; 42:312–5.Robinson RG, Macalister AD. Acrylic cranioplasty. A simple one-stage method using a cold curing material. Br J Surg 1954; 42:312–5.Smith DC. Studies in denture base materials with special reference to polymethyl methacrylate. PhD Thesis. Manchester, England7 University of Manchester; 1957Bot G M, Ismail N J, Usman B, Shilong D J, Obande J O, Aliu S, Sale D, Shehu B B. Using the head as a mould for cranioplasty with methylmethacrylate. J Neurosci Rural Pract 2013;4:471-4Sanan A, Haines SJ. Repairing holes in the head: A history of cranioplasty. Neurosurgery 1997; 40:588-603. International Programme on Chemical Safety-World Health Organization; 1998.Robinson RG, Macalister AD. Acrylic cranioplasty a simple one-stage method using a cold curing material. Br J Surg 1954; 42:312-5Oliver LC, Blaine G. A new one-stage method of cranioplasty with acrylic plastic. Med Press 1948; 220:167-8.Woringer E, Schweig B, Brogly G, Schneider J. New ultramodern technique of repair of cranial damages with acrylic resins; advantage of acrylic resins over tantalum. 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Muller J Bone Joint Surg [Br] 2004;86-B:1214-19 http://www.medicalexpo.es/prod/zimmer/product-74894-630953.html Fecha de ingreso: 13 de agosto del 2015. hora 9:15 am.http://www.debramedix.com/descargas/mezclado_vacio.pdf Fecha de ingreso: 13 de agosto del 2015. hora 9:38 am.http://www.medicalexpo.es/prod/stryker/product-70192-447780.html Fecha de ingreso: 13 de agosto del 2015. hora 2:05 Pm.Iniciador redoxCemento óseoPolimerización exótermicaRedox initiatorExothermic polymerizationBone cementORIGINALTrabajo de grado.pdfTrabajo de grado.pdfapplication/pdf7256507https://repositorio.ecci.edu.co/bitstream/001/1347/1/Trabajo%20de%20grado.pdff40bfdd2d60351a0b4e4cba57135b81fMD51Cesión de derechos.pdfCesión de derechos.pdfapplication/pdf93047https://repositorio.ecci.edu.co/bitstream/001/1347/2/Cesi%c3%b3n%20de%20derechos.pdf40d460cc743d31954200def6a813b9d7MD52Acta de sustentación.pdfActa de 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ECCIrepositorio.institucional@ecci.edu.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