Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate
1 documento
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2001
- Institución:
- Ministerio de Ciencia Tecnología e Innovación
- Repositorio:
- Repositorio Institucional de Minciencias
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.minciencias.gov.co:20.500.14143/50766
- Acceso en línea:
- https://repositorio.minciencias.gov.co/handle/20.500.14143/50766
- Palabra clave:
- Proyectos de investigación
Biología molecular
Inmunología
Parásitos
Experimentos clínicos
Péptido
- Rights
- License
- https://creativecommons.org/licenses/by/4.0/
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Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidateProyectos de investigaciónBiología molecularInmunologíaParásitosExperimentos clínicosPéptido1 documentoThis project was aimed at conducting a Phase 1 clinical trial to assess the safety, immunogenicity and protective efficacy of synthetic peptides derived from different regions of the P. vívax es protein in human volunteers. The trial was proposed on the bases of previous studies that had allowed us to partially characterize immunologically the protein . We had study the P . vívax CS antigenicity in humans and monkeys and had defined B, Th and eTL epitopes (refs) . Additionally we had conducted studies on the immunogenicity of peptides derived from this protein both in rodents and in non-human primates using bench quality synthetic peptides . Because of the minimal requirement of the vaccine quality for human use , we proposed to produce 3 long synthetic peptides under GLP conditions and to test them in young human naive volunteers . Although this objective was approved , Colciencias recommended that a further pre-clinical trial in monkeys must be performed with the new GLP quality vaccines . This recommendation was accepted by the group and is reported here.Universidad del ValleColcienciasCali2024-02-15T20:43:39Z2024-02-15T20:43:39Z2001Informe de investigaciónhttp://purl.org/coar/resource_type/c_18wsTextinfo:eu-repo/semantics/reporthttp://purl.org/redcol/resource_type/INFhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_18ghhttp://purl.org/coar/resource_type/c_93fc79 p.application/pdfapplication/pdfhttps://repositorio.minciencias.gov.co/handle/20.500.14143/50766spahttps://creativecommons.org/licenses/by/4.0/Atribución 4.0 Internacional (CC BY 4.0)http://purl.org/coar/access_right/c_abf2Herrera, Sócratesoai:repositorio.minciencias.gov.co:20.500.14143/507662024-09-02T19:23:09Z |
| dc.title.none.fl_str_mv |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate |
| title |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate |
| spellingShingle |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate Proyectos de investigación Biología molecular Inmunología Parásitos Experimentos clínicos Péptido |
| title_short |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate |
| title_full |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate |
| title_fullStr |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate |
| title_full_unstemmed |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate |
| title_sort |
Phase I trial of a Plasmodium vivax CS derived synthetic peptide vaccine candidate |
| dc.subject.none.fl_str_mv |
Proyectos de investigación Biología molecular Inmunología Parásitos Experimentos clínicos Péptido |
| topic |
Proyectos de investigación Biología molecular Inmunología Parásitos Experimentos clínicos Péptido |
| description |
1 documento |
| publishDate |
2001 |
| dc.date.none.fl_str_mv |
2001 2024-02-15T20:43:39Z 2024-02-15T20:43:39Z |
| dc.type.none.fl_str_mv |
Informe de investigación http://purl.org/coar/resource_type/c_18ws Text info:eu-repo/semantics/report http://purl.org/redcol/resource_type/INF |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_18gh http://purl.org/coar/resource_type/c_93fc |
| dc.identifier.none.fl_str_mv |
https://repositorio.minciencias.gov.co/handle/20.500.14143/50766 |
| url |
https://repositorio.minciencias.gov.co/handle/20.500.14143/50766 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.rights.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional (CC BY 4.0) |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional (CC BY 4.0) http://purl.org/coar/access_right/c_abf2 |
| dc.format.none.fl_str_mv |
79 p. application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad del Valle Colciencias Cali |
| publisher.none.fl_str_mv |
Universidad del Valle Colciencias Cali |
| institution |
Ministerio de Ciencia Tecnología e Innovación |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1860676508585033728 |