Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines

Novel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines were synthesized from three different approaches. The first one, involved a one-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and O,S-diethyl hetaroylimidothiocarbonates or S,S-diethyl hetaroylimidodithiocarbonates under solvent-free conditio...

Full description

Autores:

Tipo de recurso:

Fecha de publicación:: 2012

Institución:: Ministerio de Ciencia Tecnología e Innovación

Repositorio:: Repositorio Institucional de Minciencias

Idioma:: eng

id	E-ANAQUEL2_3c52f10fa4b60beefe9fa313ec894a2f
oai_identifier_str	oai:repositorio.minciencias.gov.co:20.500.14143/21974
network_acronym_str	E-ANAQUEL2
network_name_str	Repositorio Institucional de Minciencias
repository_id_str
spelling	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazinesRadicales (química)Síntesis (química orgánica)Pyrazolo[1,5-a][1,3,5]triazinesO,S-Diethyl hetaroylimidothiocarbonatesS,S-Diethyl hetaroylimidodithiocarbonatesAmino H-pyrazolesPyrazolylthioureasReacciones químicasTecnología químicaCompuestos orgánicosProductos químicos orgánicosQuímica orgánicaResiduos orgánicosNovel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines were synthesized from three different approaches. The first one, involved a one-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and O,S-diethyl hetaroylimidothiocarbonates or S,S-diethyl hetaroylimidodithiocarbonates under solvent-free conditions employing microwave irradiation as the energy source. In the second approach, conventional heating under reflux in DMF as solvent was used instead of the microwave irradiation; and the third one was achieved from a two-step sequence through the treatment of 5-amino-3-hetaryl-1H-pyrazoles with hetaroyl isothiocyanates and the subsequent S-alkylation and cyclization process in DMF as solvent. Some intermediates were isolated and characterized to support the regiochemistry of the studied reactions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques.Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias1104-489-25175Síntesis de nuevas pirazolo[1,5-a]-1,3,5-triazinas sustituidas con fragmentos amino y anillos heterocíclicos de reconocida bioactividad, en condiciones libre de disolvente, empleando irradiación con microondasno2018-09-26T20:16:06Z2018-09-26T20:16:06Z2012info:eu-repo/date/embargoEnd/2024-01-31Artículo científicoinfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1pdf7 páginasapplication/pdfhttps://repositorio.minciencias.gov.co/handle/20.500.14143/2197410.1016/j.tet.2012.09.029Tetrahedron 68 (2012) 9384e9390Contiene 11 referencias bibliográficas. Véase el documento adjuntoengSíntesis de nuevas pirazolo [1,5-a] -1,3,5- triazinas sustituidas con fragmentos amino y anillos heterocíclicos de reconocida bioactividad, en condiciones libre de disolvente, empleando irradiación con microondas. La publicación completa está disponible en : <a href="http://repositorio.colciencias.gov.co:80/handle/11146/21973" target="blank">http://repositorio.colciencias.gov.co:80/handle/11146/21973</a>Pasto, Nariñohttp://purl.org/coar/access_right/c_f1cfInsuasty Insuasty, Henry EdgardoInsuasty Obando, Braulio ArgiroCastro, EdisonQuiroga Pueyo, JairoAbonia González, RodrigoNogueras, ManuelCobo, Justooai:repositorio.minciencias.gov.co:20.500.14143/219742023-11-29T17:41:14Z
dc.title.none.fl_str_mv	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines
title	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines
spellingShingle	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines Radicales (química) Síntesis (química orgánica) Pyrazolo[1,5-a][1,3,5]triazines O,S-Diethyl hetaroylimidothiocarbonates S,S-Diethyl hetaroylimidodithiocarbonates Amino H-pyrazoles Pyrazolylthioureas Reacciones químicas Tecnología química Compuestos orgánicos Productos químicos orgánicos Química orgánica Residuos orgánicos
title_short	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines
title_full	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines
title_fullStr	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines
title_full_unstemmed	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines
title_sort	Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines
dc.subject.none.fl_str_mv	Radicales (química) Síntesis (química orgánica) Pyrazolo[1,5-a][1,3,5]triazines O,S-Diethyl hetaroylimidothiocarbonates S,S-Diethyl hetaroylimidodithiocarbonates Amino H-pyrazoles Pyrazolylthioureas Reacciones químicas Tecnología química Compuestos orgánicos Productos químicos orgánicos Química orgánica Residuos orgánicos
topic	Radicales (química) Síntesis (química orgánica) Pyrazolo[1,5-a][1,3,5]triazines O,S-Diethyl hetaroylimidothiocarbonates S,S-Diethyl hetaroylimidodithiocarbonates Amino H-pyrazoles Pyrazolylthioureas Reacciones químicas Tecnología química Compuestos orgánicos Productos químicos orgánicos Química orgánica Residuos orgánicos
description	Novel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines were synthesized from three different approaches. The first one, involved a one-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and O,S-diethyl hetaroylimidothiocarbonates or S,S-diethyl hetaroylimidodithiocarbonates under solvent-free conditions employing microwave irradiation as the energy source. In the second approach, conventional heating under reflux in DMF as solvent was used instead of the microwave irradiation; and the third one was achieved from a two-step sequence through the treatment of 5-amino-3-hetaryl-1H-pyrazoles with hetaroyl isothiocyanates and the subsequent S-alkylation and cyclization process in DMF as solvent. Some intermediates were isolated and characterized to support the regiochemistry of the studied reactions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques.
publishDate	2012
dc.date.none.fl_str_mv	2012 2018-09-26T20:16:06Z 2018-09-26T20:16:06Z info:eu-repo/date/embargoEnd/2024-01-31
dc.type.none.fl_str_mv	Artículo científico info:eu-repo/semantics/article
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.none.fl_str_mv	https://repositorio.minciencias.gov.co/handle/20.500.14143/21974 10.1016/j.tet.2012.09.029
url	https://repositorio.minciencias.gov.co/handle/20.500.14143/21974
identifier_str_mv	10.1016/j.tet.2012.09.029
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Síntesis de nuevas pirazolo [1,5-a] -1,3,5- triazinas sustituidas con fragmentos amino y anillos heterocíclicos de reconocida bioactividad, en condiciones libre de disolvente, empleando irradiación con microondas. La publicación completa está disponible en : <a href="http://repositorio.colciencias.gov.co:80/handle/11146/21973" target="blank">http://repositorio.colciencias.gov.co:80/handle/11146/21973</a>
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_f1cf
rights_invalid_str_mv	http://purl.org/coar/access_right/c_f1cf
dc.format.none.fl_str_mv	pdf 7 páginas application/pdf
dc.coverage.none.fl_str_mv	Pasto, Nariño
dc.source.none.fl_str_mv	Tetrahedron 68 (2012) 9384e9390 Contiene 11 referencias bibliográficas. Véase el documento adjunto
institution	Ministerio de Ciencia Tecnología e Innovación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1860676507057258496

Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a] [1,3,5] triazines

Publicaciones similares