Model-based identifiable parameter determination applied to a simultaneous saccharification and fermentation process model for bio-ethanol production
In this work, a methodology for the model-based identifiable parameter determination (MBIPD) is presented. This systematic approach is proposed to be used for structure and parameter identification of nonlinear models of biological reaction networks. Usually, this kind of problems are over-parameter...
- Autores:
-
Diana C. Lopez C
Tilman Barz
Mariana Peñuela
Villegas Quiceno, Adriana Patricia
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/41369
- Palabra clave:
- Bio-ethanols
Identifiability analysis
Ill posed problem
Non-linear least squares
Parameter subsets
Sugar-cane bagasse
Algorithms
Bioethanol
Fermentation
Inverse problems
Parameter estimation
Iterative methods
alcohol
algorithm
article
bio-ethanol
biological model
biotechnology
fermentation
identifiability analysis
ill-posed problem
metabolism
nonlinear least squares parameter estimation
nonlinear system
parameter subset selection
SSF process
sugarcane bagasse
bio-ethanol
identifiability analysis
ill-posed problem
nonlinear least squares parameter estimation
parameter subset selection
SSF process
sugarcane bagasse
Algorithms
Biotechnology
Ethanol
Fermentation
Models
Biological
Nonlinear Dynamics
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb
| Summary: | In this work, a methodology for the model-based identifiable parameter determination (MBIPD) is presented. This systematic approach is proposed to be used for structure and parameter identification of nonlinear models of biological reaction networks. Usually, this kind of problems are over-parameterized with large correlations between parameters. Hence, the related inverse problems for parameter determination and analysis are mathematically ill-posed and numerically difficult to solve. The proposed MBIPD methodology comprises several tasks: (i) model selection, (ii) tracking of an adequate initial guess, and (iii) an iterative parameter estimation step which includes an identifiable parameter subset selection (SsS) algorithm and accuracy analysis of the estimated parameters. The SsS algorithm is based on the analysis of the sensitivity matrix by rank revealing factorization methods. Using this, a reduction of the parameter search space to a reasonable subset, which can be reliably and efficiently estimated from available measurements, is achieved. The simultaneous saccharification and fermentation (SSF) process for bio-ethanol production from cellulosic material is used as case study for testing the methodology. The successful application of MBIPD to the SSF process demonstrates a relatively large reduction in the identified parameter space. It is shown by a cross-validation that using the identified parameters (even though the reduction of the search space), the model is still able to predict the experimental data properly. Moreover, it is shown that the model is easily and efficiently adapted to new process conditions by solving reduced and well conditioned problems. © 2013 American Institute of Chemical Engineers. |
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