Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures
Este artículo analiza la solubilidad de la sulfamerazina (SMR) en cosolventes de Acetonitrilo (MeCN) + Metanol (MeOH) a nueve temperaturas (278,15-318,15 K). Aquí, se alcanzó la solubilidad máxima de SMR en una mezcla de cosolvente a la temperatura más alta estudiada, y se alcanzó la solubilidad mín...
- Autores:
-
Cárdenas-Torres, Rossember E.
Ortiz, Claudia P.
Acree Jr, William E.
Jouyban, Abolghasem
Martínez, Fleming
Delgado, Daniel Ricardo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/46631
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/46631
- Palabra clave:
- Sulfamerazina
Acetonitrilo
Termodinámica de soluciones
Solvatación Preferencial
Modelos Matemáticos
Q1
Sulfamerazine
Acetonitrile
Dissolution thermodynamics
Preferential solvation
Mathematical model
- Rights
- closedAccess
- License
- Atribución – No comercial
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Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures |
| title |
Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures |
| spellingShingle |
Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures Sulfamerazina Acetonitrilo Termodinámica de soluciones Solvatación Preferencial Modelos Matemáticos Q1 Sulfamerazine Acetonitrile Dissolution thermodynamics Preferential solvation Mathematical model |
| title_short |
Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures |
| title_full |
Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures |
| title_fullStr |
Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures |
| title_full_unstemmed |
Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures |
| title_sort |
Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures |
| dc.creator.fl_str_mv |
Cárdenas-Torres, Rossember E. Ortiz, Claudia P. Acree Jr, William E. Jouyban, Abolghasem Martínez, Fleming Delgado, Daniel Ricardo |
| dc.contributor.advisor.none.fl_str_mv |
Delgado, Daniel Ricardo |
| dc.contributor.author.none.fl_str_mv |
Cárdenas-Torres, Rossember E. Ortiz, Claudia P. Acree Jr, William E. Jouyban, Abolghasem Martínez, Fleming Delgado, Daniel Ricardo |
| dc.subject.spa.fl_str_mv |
Sulfamerazina Acetonitrilo Termodinámica de soluciones Solvatación Preferencial Modelos Matemáticos |
| topic |
Sulfamerazina Acetonitrilo Termodinámica de soluciones Solvatación Preferencial Modelos Matemáticos Q1 Sulfamerazine Acetonitrile Dissolution thermodynamics Preferential solvation Mathematical model |
| dc.subject.classification.spa.fl_str_mv |
Q1 |
| dc.subject.other.spa.fl_str_mv |
Sulfamerazine Acetonitrile Dissolution thermodynamics Preferential solvation Mathematical model |
| description |
Este artículo analiza la solubilidad de la sulfamerazina (SMR) en cosolventes de Acetonitrilo (MeCN) + Metanol (MeOH) a nueve temperaturas (278,15-318,15 K). Aquí, se alcanzó la solubilidad máxima de SMR en una mezcla de cosolvente a la temperatura más alta estudiada, y se alcanzó la solubilidad mínima de SMR en metanol limpio a la temperatura más baja estudiada. Utilizando datos experimentales, se calcularon las funciones termodinámicas tanto para la solución como para la mezcla utilizando las ecuaciones de Gibbs y van't Hoff, determinando así que el proceso de solución es endotérmico con favores entrópicos. Además, se informan los parámetros de solvación preferencial (δx3,1), calculados utilizando el método inverso de los integrales Kirkwood-Buff (IKBI); SMR se solvaciona preferentemente por MeOH en mezclas ricas en MeOH, y en mezclas intermedias y ricas en MeCN, los valores de δx3,1 indican que Finalmente, se evaluaron ocho modelos (Apelblat, van't Hoff, Yaws, λh, Weibull, NRTL, Wilson y Wilson modificados), con todos presentando porcentajes medios de desviación relativa (MRD%) por debajo del 6%, lo que indica una buena correlación con los datos experimentales. |
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2022 |
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2022-10-06T16:50:54Z |
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2022-10-06T16:50:54Z 2024-01-01 |
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2022-03-01 |
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Artículo |
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10.1016/j.molliq.2021.118172 |
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https://hdl.handle.net/20.500.12494/46631 |
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Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile+ methanol cosolvent mixtures at different temperatures RE Cárdenas-Torres, CP Ortiz, WE Acree Jr, A Jouyban, F Martínez, Daniel Delgado, Journal of Molecular Liquids 349, 118172 |
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0167-7322 10.1016/j.molliq.2021.118172 Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile+ methanol cosolvent mixtures at different temperatures RE Cárdenas-Torres, CP Ortiz, WE Acree Jr, A Jouyban, F Martínez, Daniel Delgado, Journal of Molecular Liquids 349, 118172 |
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Journal of Molecular Liquids |
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S. Padberg, Anti-infective Agents, in: Drugs Dur. Pregnancy Lact. Treat. Options Risk Assess, third ed., Elsevier Inc., 2015, pp. 115–176. https://doi-org.bbibliograficas.ucc.edu.co/10.1016/B978-0-12-408078-2.00007-X. B.T. Lunestad, O. Samuelsen, Veterinary drug use in aquaculture, in: Improv. Farmed Fish Qual. Saf., Elsevier Inc., 2008, pp. 97–127. https://doi-org.bbibliograficas.ucc.edu.co/10.1533/9781845694920.1.97. Daniel R. Delgado, Fleming Martínez Solution thermodynamics and preferential solvation of sulfamerazine in methanol + water mixtures J. Solution Chem., 44 (2) (2015), pp. 360-377, 10.1007/s10953-015-0317-1 D.R. Delgado, F. Martínez Solubility and solution thermodynamics of sulfamerazine and sulfamethazine in some ethanol+water mixtures Fluid Phase Equilib., 360 (2013), pp. 88-96, 10.1016/j.fluid.2013.09.018 D.R. Delgado, F. Martínez Solubility and solution thermodynamics of some sulfonamides in 1-propanol + water mixtures J. Solut. Chem., 43 (2014), pp. 836-852, 10.1007/s10953-014-0169-0 Joaquín H. Blanco-Márquez, Claudia P. Ortiz, Nestor Enrique Cerquera, Fleming Martínez, Abolghasem Jouyban, Daniel Ricardo Delgado Thermodynamic analysis of the solubility and preferential solvation of sulfamerazine in (acetonitrile + water) cosolvent mixtures at different temperatures J. Mol. Liq., 293 (2019), p. 111507, 10.1016/j.molliq.2019.111507 María del Mar Muñoz, Daniel R. Delgado, María Ángeles Peña, Abolghasem Jouyban, Fleming Martínez Solubility and preferential solvation of sulfadiazine, sulfamerazine and sulfamethazine in propylene glycol + water mixtures at 298.15 K J. Mol. Liq., 204 (2015), pp. 132-136, 10.1016/j.molliq.2015.01.047 Daniel Ricardo Delgado, Otto Bahamón-Hernandez, Nestor Enrique Cerquera, Claudia Patricia Ortiz, Fleming Martínez, Elaheh Rahimpour, Abolghasem Jouyban, William E. Acree Solubility of sulfadiazine in (acetonitrile + methanol) mixtures: determination, correlation, dissolution thermodynamics and preferential solvation J. Mol. Liq., 322 (2021), p. 114979, 10.1016/j.molliq.2020.114979 Daniel Ricardo Delgado, Diego Iván Caviedes-Rubio, Claudia Patricia Ortiz, Yarly Lizeth Parra-Pava, María Ángeles Peña, Abolghasem Jouyban, Seyyedeh Narjes Mirheydari, Fleming Martínez, William E. Acree Solubility of sulphadiazine in (acetonitrile + water) mixtures: measurement, correlation, thermodynamics and preferential solvation Phys. Chem. Liq., 58 (3) (2020), pp. 381-396, 10.1080/00319104.2019.1594227 Martha Sofía Vargas-Santana, Ana María Cruz-González, Claudia Patricia Ortiz, Daniel Ricardo Delgado, Fleming Martínez, María Ángeles Peña, William E. Acree, Abolghasem Jouyban Solubility of sulfamerazine in (ethylene glycol + water) mixtures: measurement, correlation, dissolution thermodynamics and preferential solvation J. Mol. Liq., 337 (2021), p. 116330, 10.1016/j.molliq.2021.116330 Fleming Martínez, M. Ángeles Peña, Pilar Bustamante Thermodynamic analysis and enthalpy-entropy compensation for the solubility of indomethacin in aqueous and non-aqueous mixtures Fluid Ph. Equilibria., 308 (1-2) (2011), pp. 98-106, 10.1016/j.fluid.2011.06.016 D.R. Delgado, F. Martínez Preferential solvation of sulfadiazine, sulfamerazine and sulfamethazine in ethanol + water solvent mixtures according to the IKBI method J. Mol. Liq., 193 (2014), pp. 152-159, 10.1016/j.molliq.2013.12.021 Daniel R. Delgado, Abolghasem Jouyban, Fleming Martínez Solubility and preferential solvation of meloxicam in methanol + water mixtures at 298.15 K J. Mol. Liq., 197 (2014), pp. 368-373, 10.1016/j.molliq.2014.06.006 María Ángeles Peña, Daniel Ricardo Delgado, Fleming Martínez Preferential solvation of some n-alkyl p-substituted benzoates in propylene glycol + water cosolvent mixtures Phys. Chem. Liq., 53 (4) (2015), pp. 455-466, 10.1080/00319104.2015.1006221 R.E. Cardenas, L.E. Tinoco, D.M. Galindres, A. Beltrán, C.D. Oviedo, J. Osorio Prediction of sulfadiazine solubility in some cosolvent mixtures using non-ideal solution models Rev. Colomb. Cienc. Quím. Farm., 49 (2020), pp. 822-842 Edgar A. Ahumada, Daniel R. Delgado, Fleming Martínez Solution thermodynamics of acetaminophen in some PEG 400+water mixtures Fluid Phase Equilib., 332 (2012), pp. 120-127, 10.1016/j.fluid.2012.07.004 |
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Delgado, Daniel RicardoCárdenas-Torres, Rossember E.Ortiz, Claudia P.Acree Jr, William E.Jouyban, AbolghasemMartínez, FlemingDelgado, Daniel Ricardo3492022-10-06T16:50:54Z2022-10-06T16:50:54Z2024-01-012022-03-010167-732210.1016/j.molliq.2021.118172https://hdl.handle.net/20.500.12494/46631Thermodynamic study and preferential solvation of sulfamerazine in acetonitrile+ methanol cosolvent mixtures at different temperatures RE Cárdenas-Torres, CP Ortiz, WE Acree Jr, A Jouyban, F Martínez, Daniel Delgado, Journal of Molecular Liquids 349, 118172Este artículo analiza la solubilidad de la sulfamerazina (SMR) en cosolventes de Acetonitrilo (MeCN) + Metanol (MeOH) a nueve temperaturas (278,15-318,15 K). Aquí, se alcanzó la solubilidad máxima de SMR en una mezcla de cosolvente a la temperatura más alta estudiada, y se alcanzó la solubilidad mínima de SMR en metanol limpio a la temperatura más baja estudiada. Utilizando datos experimentales, se calcularon las funciones termodinámicas tanto para la solución como para la mezcla utilizando las ecuaciones de Gibbs y van't Hoff, determinando así que el proceso de solución es endotérmico con favores entrópicos. Además, se informan los parámetros de solvación preferencial (δx3,1), calculados utilizando el método inverso de los integrales Kirkwood-Buff (IKBI); SMR se solvaciona preferentemente por MeOH en mezclas ricas en MeOH, y en mezclas intermedias y ricas en MeCN, los valores de δx3,1 indican que Finalmente, se evaluaron ocho modelos (Apelblat, van't Hoff, Yaws, λh, Weibull, NRTL, Wilson y Wilson modificados), con todos presentando porcentajes medios de desviación relativa (MRD%) por debajo del 6%, lo que indica una buena correlación con los datos experimentales.This paper discusses sulfamerazine (SMR) solubility in Acetonitrile (MeCN) + Methanol (MeOH) cosolvents at nine temperatures (278.15–318.15 K). Herein, the maximum SMR solubility was reached in a cosolvent mixture at the highest studied temperature, and the minimum SMR solubility was reached in neat methanol at the lowest studied temperature. Using experimental data, thermodynamic functions were calculated for both the solution and mixture using the Gibbs and van’t Hoff equations, thus determining that the solution process is endothermic with entropic favoring. In addition, the preferential solvation parameters (δx3,1), calculated using the inverse Kirkwood-Buff integrals (IKBI) method, are reported; SMR is preferentially solvated by MeOH in MeOH-rich mixtures, and in intermediate and MeCN-rich mixtures, the δx3,1 values indicate that SMR is not preferentially solvated by any of the two solvents in the mixture (MeCN + MeOH). Finally, eight models were assessed (Apelblat, van’t Hoff, Yaws, λh, Weibull, NRTL, Wilson, and Wilson modified), with all presenting mean relative deviation percentages (MRD%) under 6%, which indicates a good correlation with the experimental data.Introducción, Metodos, Resultados, Conclusiones, Bibliografía.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116https://orcid.org/0000-0002-4835-9739https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000004151danielr.delgado@campusucc.edu.cohttps://scholar.google.com/citations?hl=es&user=OW0mejcAAAAJ&view_op=list_works&sortby=pubdate13Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, NeivaElsevierIngeniería CivilNeivahttps://www.sciencedirect.com/science/article/abs/pii/S016773222102897X#!Journal of Molecular LiquidsS. Padberg, Anti-infective Agents, in: Drugs Dur. Pregnancy Lact. Treat. Options Risk Assess, third ed., Elsevier Inc., 2015, pp. 115–176. https://doi-org.bbibliograficas.ucc.edu.co/10.1016/B978-0-12-408078-2.00007-X.B.T. Lunestad, O. Samuelsen, Veterinary drug use in aquaculture, in: Improv. Farmed Fish Qual. Saf., Elsevier Inc., 2008, pp. 97–127. https://doi-org.bbibliograficas.ucc.edu.co/10.1533/9781845694920.1.97.Daniel R. Delgado, Fleming Martínez Solution thermodynamics and preferential solvation of sulfamerazine in methanol + water mixtures J. Solution Chem., 44 (2) (2015), pp. 360-377, 10.1007/s10953-015-0317-1D.R. Delgado, F. Martínez Solubility and solution thermodynamics of sulfamerazine and sulfamethazine in some ethanol+water mixtures Fluid Phase Equilib., 360 (2013), pp. 88-96, 10.1016/j.fluid.2013.09.018D.R. Delgado, F. Martínez Solubility and solution thermodynamics of some sulfonamides in 1-propanol + water mixtures J. Solut. Chem., 43 (2014), pp. 836-852, 10.1007/s10953-014-0169-0Joaquín H. Blanco-Márquez, Claudia P. Ortiz, Nestor Enrique Cerquera, Fleming Martínez, Abolghasem Jouyban, Daniel Ricardo Delgado Thermodynamic analysis of the solubility and preferential solvation of sulfamerazine in (acetonitrile + water) cosolvent mixtures at different temperatures J. Mol. Liq., 293 (2019), p. 111507, 10.1016/j.molliq.2019.111507María del Mar Muñoz, Daniel R. Delgado, María Ángeles Peña, Abolghasem Jouyban, Fleming Martínez Solubility and preferential solvation of sulfadiazine, sulfamerazine and sulfamethazine in propylene glycol + water mixtures at 298.15 K J. Mol. Liq., 204 (2015), pp. 132-136, 10.1016/j.molliq.2015.01.047Daniel Ricardo Delgado, Otto Bahamón-Hernandez, Nestor Enrique Cerquera, Claudia Patricia Ortiz, Fleming Martínez, Elaheh Rahimpour, Abolghasem Jouyban, William E. Acree Solubility of sulfadiazine in (acetonitrile + methanol) mixtures: determination, correlation, dissolution thermodynamics and preferential solvation J. Mol. Liq., 322 (2021), p. 114979, 10.1016/j.molliq.2020.114979Daniel Ricardo Delgado, Diego Iván Caviedes-Rubio, Claudia Patricia Ortiz, Yarly Lizeth Parra-Pava, María Ángeles Peña, Abolghasem Jouyban, Seyyedeh Narjes Mirheydari, Fleming Martínez, William E. Acree Solubility of sulphadiazine in (acetonitrile + water) mixtures: measurement, correlation, thermodynamics and preferential solvation Phys. Chem. Liq., 58 (3) (2020), pp. 381-396, 10.1080/00319104.2019.1594227Martha Sofía Vargas-Santana, Ana María Cruz-González, Claudia Patricia Ortiz, Daniel Ricardo Delgado, Fleming Martínez, María Ángeles Peña, William E. Acree, Abolghasem Jouyban Solubility of sulfamerazine in (ethylene glycol + water) mixtures: measurement, correlation, dissolution thermodynamics and preferential solvation J. Mol. Liq., 337 (2021), p. 116330, 10.1016/j.molliq.2021.116330Fleming Martínez, M. Ángeles Peña, Pilar Bustamante Thermodynamic analysis and enthalpy-entropy compensation for the solubility of indomethacin in aqueous and non-aqueous mixtures Fluid Ph. Equilibria., 308 (1-2) (2011), pp. 98-106, 10.1016/j.fluid.2011.06.016D.R. Delgado, F. Martínez Preferential solvation of sulfadiazine, sulfamerazine and sulfamethazine in ethanol + water solvent mixtures according to the IKBI method J. Mol. Liq., 193 (2014), pp. 152-159, 10.1016/j.molliq.2013.12.021Daniel R. Delgado, Abolghasem Jouyban, Fleming Martínez Solubility and preferential solvation of meloxicam in methanol + water mixtures at 298.15 K J. Mol. Liq., 197 (2014), pp. 368-373, 10.1016/j.molliq.2014.06.006María Ángeles Peña, Daniel Ricardo Delgado, Fleming Martínez Preferential solvation of some n-alkyl p-substituted benzoates in propylene glycol + water cosolvent mixtures Phys. Chem. Liq., 53 (4) (2015), pp. 455-466, 10.1080/00319104.2015.1006221R.E. Cardenas, L.E. Tinoco, D.M. Galindres, A. Beltrán, C.D. Oviedo, J. Osorio Prediction of sulfadiazine solubility in some cosolvent mixtures using non-ideal solution models Rev. Colomb. Cienc. Quím. Farm., 49 (2020), pp. 822-842Edgar A. Ahumada, Daniel R. Delgado, Fleming Martínez Solution thermodynamics of acetaminophen in some PEG 400+water mixtures Fluid Phase Equilib., 332 (2012), pp. 120-127, 10.1016/j.fluid.2012.07.004SulfamerazinaAcetonitriloTermodinámica de solucionesSolvatación PreferencialModelos MatemáticosQ1SulfamerazineAcetonitrileDissolution thermodynamicsPreferential solvationMathematical modelThermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperaturesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAtribución – No comercialinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublicationORIGINALThermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures.pdfThermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures.pdfArticuloapplication/pdf1018472https://repository.ucc.edu.co/bitstreams/7a4c8026-4c7d-421d-913b-f231d7e4d197/downloadfe15b6afe04ecde5e14f3a3ff3fda4bdMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/4bfb6bdf-94be-4e7e-a051-df4b80639b0d/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILThermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures.pdf.jpgThermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures.pdf.jpgGenerated Thumbnailimage/jpeg5980https://repository.ucc.edu.co/bitstreams/cc719fce-f960-43fa-9cd2-4ecd4a63f7a9/download6de11c6e5837399892b61f594ab9086eMD53TEXTThermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures.pdf.txtThermodynamic study and preferential solvation of sulfamerazine in acetonitrile + methanol cosolvent mixtures at different temperatures.pdf.txtExtracted texttext/plain67872https://repository.ucc.edu.co/bitstreams/d8d6040b-1498-40b0-bc31-0fc9472a1a55/downloadf10ac8a427ed47638397573e74bb1d60MD5420.500.12494/46631oai:repository.ucc.edu.co:20.500.12494/466312024-08-20 16:17:20.251open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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 |