Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC)
La Traqueobronquitis infecciosa canina (TIC) es una enfermedad contagiosa que afecta a caninos de diferentes edades, siendo más susceptible en perros menores de 6 meses y perros de edad avanzada; esta enfermedad se caracteriza por afectar a perros con un estado nutricional o de salud deficiente o qu...
- Autores:
-
Zamora Males, Harlly Arney
Rojas Tafur, Yuli Alexandra
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/52071
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/52071
- Palabra clave:
- Bordetella bronchiseptica
Traqueobronquitis infecciosa canina
Complejo respiratorio canino
TG 2023 MVZ 52071
Bordetella bronchiseptica
Canine infectious tracheobronchitis
Canine respiratory complex
- Rights
- openAccess
- License
- Atribución – No comercial – Compartir igual
id |
COOPER2_f9da067fe45ddce65291f88922f10361 |
---|---|
oai_identifier_str |
oai:repository.ucc.edu.co:20.500.12494/52071 |
network_acronym_str |
COOPER2 |
network_name_str |
Repositorio UCC |
repository_id_str |
|
dc.title.none.fl_str_mv |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) |
title |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) |
spellingShingle |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) Bordetella bronchiseptica Traqueobronquitis infecciosa canina Complejo respiratorio canino TG 2023 MVZ 52071 Bordetella bronchiseptica Canine infectious tracheobronchitis Canine respiratory complex |
title_short |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) |
title_full |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) |
title_fullStr |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) |
title_full_unstemmed |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) |
title_sort |
Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC) |
dc.creator.fl_str_mv |
Zamora Males, Harlly Arney Rojas Tafur, Yuli Alexandra |
dc.contributor.advisor.none.fl_str_mv |
Plazas Hernández, Fernely Augusto |
dc.contributor.author.none.fl_str_mv |
Zamora Males, Harlly Arney Rojas Tafur, Yuli Alexandra |
dc.subject.none.fl_str_mv |
Bordetella bronchiseptica Traqueobronquitis infecciosa canina Complejo respiratorio canino |
topic |
Bordetella bronchiseptica Traqueobronquitis infecciosa canina Complejo respiratorio canino TG 2023 MVZ 52071 Bordetella bronchiseptica Canine infectious tracheobronchitis Canine respiratory complex |
dc.subject.classification.none.fl_str_mv |
TG 2023 MVZ 52071 |
dc.subject.other.none.fl_str_mv |
Bordetella bronchiseptica Canine infectious tracheobronchitis Canine respiratory complex |
description |
La Traqueobronquitis infecciosa canina (TIC) es una enfermedad contagiosa que afecta a caninos de diferentes edades, siendo más susceptible en perros menores de 6 meses y perros de edad avanzada; esta enfermedad se caracteriza por afectar a perros con un estado nutricional o de salud deficiente o que no han completado su esquema de vacunación, produciendo signos respiratorios agudos que pueden llegar a convertirse en crónicos si no se tratan a tiempo. |
publishDate |
2023 |
dc.date.accessioned.none.fl_str_mv |
2023-07-18T17:41:49Z |
dc.date.available.none.fl_str_mv |
2023-07-18T17:41:49Z |
dc.date.issued.none.fl_str_mv |
2023-07-17 |
dc.type.none.fl_str_mv |
Trabajo de grado - Pregrado |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
format |
http://purl.org/coar/resource_type/c_7a1f |
status_str |
acceptedVersion |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/52071 |
dc.identifier.bibliographicCitation.none.fl_str_mv |
Zamora Males, H. A. y Rojas Tafur, H. A. (2023). Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC). [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/52071 |
url |
https://hdl.handle.net/20.500.12494/52071 |
identifier_str_mv |
Zamora Males, H. A. y Rojas Tafur, H. A. (2023). Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC). [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/52071 |
dc.relation.references.none.fl_str_mv |
BINNS SH, SPEAKMAN AJ, DAWSON S, BENNETT M, GASKELL RM, HART CA. The use of pulsed-field gel electrophoresis to examine the epidemiology of Bordetella bronchiseptica isolated from cats and other species. Epidemiol Infect. 1998 Mar 1;120(2):201–8. Foley JE, Rand C, Bannasch MJ, Norris CR, Milan J. Molecular epidemiology of feline bordetellosis in two animal shelters in California, USA. Prev Vet Med. 2002 Jun;54(2):141–56. Chalker VJ, Toomey C, Opperman S, Brooks HW, Ibuoye MA, Brownlie J, et al. Respiratory Disease in Kennelled Dogs: Serological Responses to Bordetella bronchiseptica Lipopolysaccharide Do Not Correlate with Bacterial Isolation or Clinical Respiratory Symptoms. Clinical and Vaccine Immunology. 2003 May;10(3):352–6. Lavan R, Knesl O. Prevalence of canine infectious respiratory pathogens in asymptomatic dogs presented at US animal shelters. Journal of Small Animal Practice. 2015 Sep;56(9):572–6. Sykes J, Greene C. Infectious Diseases of the Dog and Cat. In: Saunders E, editor. 4 th edition. 2013. p. 55–65. Inatsuka CS, Xu Q, Vujkovic-Cvijin I, Wong S, Stibitz S, Miller JF, et al. Pertactin Is Required for Bordetella Species To Resist Neutrophil-Mediated Clearance. Infect Immun. 2010 Jul;78(7):2901–9. Pilione MR, Harvill ET. The Bordetella bronchiseptica Type III Secretion System Inhibits Gamma Interferon Production That Is Required for Efficient Antibody-Mediated Bacterial Clearance. Infect Immun. 2006 Feb;74(2):1043–9. Weyrich LS, Rolin OY, Muse SJ, Park J, Spidale N, Kennett MJ, et al. A Type VI Secretion System Encoding Locus Is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo. PLoS One. 2012 Oct 12;7(10):e45892. Vojtova J, Kamanova J, Sebo P. Bordetella adenylate cyclase toxin: a swift saboteur of host defense. Curr Opin Microbiol. 2006 Feb;9(1):69–75. Shrivastava R, Miller JF. Virulence factor secretion and translocation by Bordetella species. Curr Opin Microbiol. 2009 Feb;12(1):88–93. Mattoo S. Mechanisms of bordetella pathogenesis. Frontiers in Bioscience. 2001;6(1):e168. Bemis DA, Greisen HA, Appel MJG. Pathogenesis of Canine Bordetellosis. Journal of Infectious Diseases. 1977 May 1;135(5):753–62. Ellis JA. How well do vaccines for Bordetella bronchiseptica work in dogs? A critical review of the literature 1977–2014. The Veterinary Journal. 2015 Apr;204(1):5–16. Ford RB. Canine Infectious Tracheobronchitis. En C. Greene, Infectious Diseases of the Dog and Cat. 3rd Edition. Missouri: Elsevier; 2008. 1–15 p. Mauro LD. Manejo de la traqueobronquitis infecciosa canina (TIC) "Tos de las Perreras. REDVET Revista Electrónica de Veterinaria. 2006 Feb 2;7:1–9. Damián M, Morales E, Salas G, Trigo FJ. Immunohistochemical Detection of Antigens of Distemper, Adenovirus and Parainfluenza Viruses in Domestic Dogs with Pneumonia. J Comp Pathol. 2005 Nov;133(4):289–93. Chvala S, Benetka V, Möstl K, Zeugswetter F, Spergser J, Weissenböck H. Simultaneous Canine Distemper Virus, Canine Adenovirus Type 2, and Mycoplasma Cynos Infection in a Dog with Pneumonia. Vet Pathol. 2007 Jul 26;44(4):508–12. Carter G, Chengappa M. Bacteriología y Micología Veterinaria Aspectos Esenciales. Manual Moderno S.A. 1991. 341–345 p. Mendoza C. Bordetella bronchiseptica EN CANINOS. [torreon, coahuila]: UNIVERSIDAD AUTÓNOMA AGRARIA ANTONIO NARRO UNIDAD LAGUNA DIVISIÓN REGIONAL DE CIENCIA ANIMAL; 2008. Vadillo S, Piriz S, Mateos E. Manual de Microbiología Veterinaria. McGraw-Hill. Vol. 1. 2002. 293–295 p. Mattoo S, Cherry JD. Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies. Clin Microbiol Rev. 2005 Apr;18(2):326–82. FERNANDES S.C, COUTINHO S.D.A. Traqueobronquite infecciosa canina . Revista do Institito de Ciência da Saúde. 2004;279–85. Buonavoglia C, Martella V. Canine respiratory viruses. Vet Res. 2007 Mar 9;38(2):355–73. SUZUKI EY, PENHA G de A, SALVARANI R de S, BOCARDO M, BISSOLI EDG. TRAQUEOBRONQUITE INFECCIOSA CANINA - RELATO DE CASO . REVISTA CIENTÍFICA ELETÔNICA DE MEDICINA VETERINÁRIA – ISSN: 1679-7353 . 2008 Jul 11;1–5. Krüger RM. UNIVERSIDADE FEDERAL DE SANTA MARIA CENTRO DE CIÊNCIAS RURAIS PROGRAMA DE PÓS-GRADUAÇÃO EM MEDICINA VETERINÁRIA TOSSE EM CÃES: FISIOPATOLOGIA, DOENÇAS ASSOCIADAS E MÉTODOS DIAGNÓSTICOS MONOGRAFIA DE ESPECIALIZAÇÃO. 2010. MENDONÇA C. AVALIAÇÃO DOS FACTORES DE RISCO DA TRAQUEOBRONQUITE INFECIOSA CANINA. 2014. CARMEN S. Enfermedades Infeciosas del Perro y del Gato . - Temis Network,SL. 2001; Appel M, Binn LN. “Canine infectious tracheobronchitis short review: kennel cough.” Elsevier Science. 1987;201–11. Ford R, Vaden S. Canine infectious tracheobronchitis. In: Greene, CE. Infectious diseases of the dogs and the cats. Saunders. 1998;33–8. Thayer GW. Canine infectious tracheobronchitis. In: Greene CE. Clinical microbiology and infectious diseases of the dog and the cat. Saunders. 1984;430–6. Appel M, Binn LN. Canine Parainfluenzavirus. In: Appel M. Virus infections of carnivores. Elsevier. 1987;125–32. Ford RB, Vaden SL. Ford RB. Canine Infectious Tracheobronchitis. En C. Greene, Infectious Diseases of the Dog and Cat. 3rd Edition. Missouri: Elsevier; 2008. 1–15 p. Saunders. 1998;33–8. Wagener JS, Sobonya R, Minnich L, Taussig LM. Role of canine parainfluenza virus and Bordetella bronchiseptica in kennel cough. Am J Vet Res. 1984;45(9):1862–6. Appel M. Canine Adenovirus type 2 (Infectious laryngotracheitis virus). In: Appel M. Virus infections of carnivores. Elsevier. 1987;45–51. Ford RB. Infectious tracheobronchitis. In: Bonagura JD. Kirk’s current veterinary therapy XII – small animal practice. Saunders. 1995;905–8. Edwards JA, Groathouse NA, Boitano S. Bordetella bronchiseptica Adherence to Cilia Is Mediated by Multiple Adhesin Factors and Blocked by Surfactant Protein A. Infect Immun. 2005 Jun;73(6):3618–26. Lugo S, Peña J. Bordetella bronchiséptica en animales de laboratorio. CENPALAB; 2007. JERICÓ MM. Tratado de Medicina Interna de Cães e Gatos. GUANABARA KOOGAN. Rio de Janeiro; 2014. 748–750 p. M.R L, J B, D B, E.B. Breitschwerdt, L. Guardabassi, D.H. Lloyd, et al. Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases. journal of veterinary internal medicine . 2017;1–16. Brito C, Cortezi A, Gomes D. TRAQUEOBRONQUITE INFECCIOSA CANINA – REVISÃO DE LITERATURA. Revista Cientifica Unilagos. 2019 Sep 14;1(1). Milanov, D., Đilas, M., Velhner, M., & Aleksić, N. (2018). Laboratory diagnosis of Bordetella bronchiseptica tracheobronchitis in dog. . Robbins SN, Goggs R, Lhermie G, et al. Prácticas de prescripción de antimicrobianos en emergencias y cuidados críticos de pequeños animales. Ciencia veterinaria frontal . 2020;7:110. Feyes EE, Díaz-Campos D, Mollenkopf DF, et al. Implementación de un programa de administración de antimicrobianos en una institución de enseñanza médica veterinaria. JAVMA . 2021;258(2):170-178. Wolfson W. Tracheobronchitis, infectious (dog). In: Cohn LA, Côté E, eds. Côté’s Clinical Veterinary Advisor: Dogs and Cats. 4th ed. Philadelphia: Mosby; 2019:987-989. Fletcher J. Upper respiratory infection (cat). In: Cohn LA, Côté E. Côté’s Clinical Veterinary Advisor: Dogs and Cats. 4th ed. Philadelphia: Mosby; 2019:1006-1007. Canonne AM, Roels E, Menard M, et al. Clinical response to 2 protocols of aerosolized gentamicin in 46 dogs with Bordetella bronchiseptica infection (2012-2018). J Vet Intern Med. 2020;34(5):2078 Grobman M, Reinero C. Investigation of neurokinin-1 receptor antagonism as a novel treatment for chronic bronchitis in dogs. J Vet Intern Med. 2016;30(3):847-852. Kadlec K, Schwarz S. Antimicrobial Resistance in Bordetella bronchiseptica. Microbiol Spectr. 2018 Jul;6(4). Laura A. Nafe, Diagnostic and Therapeutic Approach: Dogs Infected with Bordetella bronchiseptica and Canine Influenza Virus (H3N8), 2014 Mitchell, J. A., & Brownlie, J. (2015). The challenges in developing effective canine infectious respiratory disease vaccines. The Journal of pharmacy and pharmacology, 67(3), 372–381. https://doi.org/10.1111/jphp.12380 |
dc.rights.license.none.fl_str_mv |
Atribución – No comercial – Compartir igual |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución – No comercial – Compartir igual http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.none.fl_str_mv |
31 p. |
dc.publisher.none.fl_str_mv |
Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Ibagué |
dc.publisher.program.none.fl_str_mv |
Medicina veterinaria y zootecnia |
dc.publisher.place.none.fl_str_mv |
Ibagué |
publisher.none.fl_str_mv |
Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Ibagué |
institution |
Universidad Cooperativa de Colombia |
bitstream.url.fl_str_mv |
https://repository.ucc.edu.co/bitstreams/2a2c9b05-605c-4588-a1db-b022793cc84b/download https://repository.ucc.edu.co/bitstreams/e61b3d40-80bd-4cb4-97aa-0d6696506096/download https://repository.ucc.edu.co/bitstreams/5de9dc4f-aa93-4d51-959f-65694361d9de/download https://repository.ucc.edu.co/bitstreams/f8867ed7-e172-42b6-8424-558d1ce595c0/download https://repository.ucc.edu.co/bitstreams/cf2ed38a-9e3a-462a-9388-298bcb701c9a/download https://repository.ucc.edu.co/bitstreams/9b6ec770-34bc-4a45-b94e-c30a131763c9/download https://repository.ucc.edu.co/bitstreams/1ec632d1-e52c-4b6b-9603-eb3a504d5f20/download https://repository.ucc.edu.co/bitstreams/801649bf-786b-4b93-a2e2-ae16d565a5bb/download https://repository.ucc.edu.co/bitstreams/7fd33bce-cf0f-4c03-b6cf-be14675a1f38/download https://repository.ucc.edu.co/bitstreams/fa520fd3-4e77-49e6-871a-677d138cab92/download https://repository.ucc.edu.co/bitstreams/63c61312-3cdb-41fa-bab8-155aa184a232/download https://repository.ucc.edu.co/bitstreams/d698986f-fceb-4717-ba9b-9c28c0895711/download https://repository.ucc.edu.co/bitstreams/78342745-58bd-4173-82aa-9e281879f947/download |
bitstream.checksum.fl_str_mv |
3bce4f7ab09dfc588f126e1e36e98a45 689baccfb6c2bd14eb6492549e9dd842 885d272bb6f2c2e9f7da283e11c2e00d 68ec99aeb575efff7bb9171d7cf8e3f7 3aa1b5dd9c4e48634419b52e0cad7f55 d791c4ac6cf6302d1c6c1bbddc11570a 0638fe47d6f29fdb70fb5a86ac70e089 453ee0220da3161b96fc007ee3dec9c9 b4f4b1a97671d3442c2e9fcb185f0e07 def09e4c869b737da3effa7901dfd04f 280bfa48710b6599d32483fbc4c68f8c edffbd955d472a5427fca3fca68dc68a a9ea350867bbc07e83b167d903a86b5a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1814247163789574144 |
spelling |
Plazas Hernández, Fernely AugustoZamora Males, Harlly ArneyRojas Tafur, Yuli Alexandra2023-07-18T17:41:49Z2023-07-18T17:41:49Z2023-07-17https://hdl.handle.net/20.500.12494/52071Zamora Males, H. A. y Rojas Tafur, H. A. (2023). Actualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC). [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/52071La Traqueobronquitis infecciosa canina (TIC) es una enfermedad contagiosa que afecta a caninos de diferentes edades, siendo más susceptible en perros menores de 6 meses y perros de edad avanzada; esta enfermedad se caracteriza por afectar a perros con un estado nutricional o de salud deficiente o que no han completado su esquema de vacunación, produciendo signos respiratorios agudos que pueden llegar a convertirse en crónicos si no se tratan a tiempo.Canine infectious tracheobronchitis (TIC) is a contagious disease that affects canines of different ages, being more susceptible in dogs younger than 6 months and older dogs; This disease is characterized by affecting dogs with a poor nutritional or health status or that have not completed their vaccination schedule, producing acute respiratory signs that can become chronic if not treated in time.harlly.zamora@campusucc.edu.coyuli.rojast.@campusucc.edu.co31 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéBordetella bronchisepticaTraqueobronquitis infecciosa caninaComplejo respiratorio caninoTG 2023 MVZ 52071Bordetella bronchisepticaCanine infectious tracheobronchitisCanine respiratory complexActualización de las alternativas de tratamiento para la traqueobronquitis infecciosa canina (TIC)Trabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2BINNS SH, SPEAKMAN AJ, DAWSON S, BENNETT M, GASKELL RM, HART CA. The use of pulsed-field gel electrophoresis to examine the epidemiology of Bordetella bronchiseptica isolated from cats and other species. Epidemiol Infect. 1998 Mar 1;120(2):201–8.Foley JE, Rand C, Bannasch MJ, Norris CR, Milan J. Molecular epidemiology of feline bordetellosis in two animal shelters in California, USA. Prev Vet Med. 2002 Jun;54(2):141–56.Chalker VJ, Toomey C, Opperman S, Brooks HW, Ibuoye MA, Brownlie J, et al. Respiratory Disease in Kennelled Dogs: Serological Responses to Bordetella bronchiseptica Lipopolysaccharide Do Not Correlate with Bacterial Isolation or Clinical Respiratory Symptoms. Clinical and Vaccine Immunology. 2003 May;10(3):352–6.Lavan R, Knesl O. Prevalence of canine infectious respiratory pathogens in asymptomatic dogs presented at US animal shelters. Journal of Small Animal Practice. 2015 Sep;56(9):572–6.Sykes J, Greene C. Infectious Diseases of the Dog and Cat. In: Saunders E, editor. 4 th edition. 2013. p. 55–65.Inatsuka CS, Xu Q, Vujkovic-Cvijin I, Wong S, Stibitz S, Miller JF, et al. Pertactin Is Required for Bordetella Species To Resist Neutrophil-Mediated Clearance. Infect Immun. 2010 Jul;78(7):2901–9.Pilione MR, Harvill ET. The Bordetella bronchiseptica Type III Secretion System Inhibits Gamma Interferon Production That Is Required for Efficient Antibody-Mediated Bacterial Clearance. Infect Immun. 2006 Feb;74(2):1043–9.Weyrich LS, Rolin OY, Muse SJ, Park J, Spidale N, Kennett MJ, et al. A Type VI Secretion System Encoding Locus Is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo. PLoS One. 2012 Oct 12;7(10):e45892.Vojtova J, Kamanova J, Sebo P. Bordetella adenylate cyclase toxin: a swift saboteur of host defense. Curr Opin Microbiol. 2006 Feb;9(1):69–75.Shrivastava R, Miller JF. Virulence factor secretion and translocation by Bordetella species. Curr Opin Microbiol. 2009 Feb;12(1):88–93.Mattoo S. Mechanisms of bordetella pathogenesis. Frontiers in Bioscience. 2001;6(1):e168.Bemis DA, Greisen HA, Appel MJG. Pathogenesis of Canine Bordetellosis. Journal of Infectious Diseases. 1977 May 1;135(5):753–62.Ellis JA. How well do vaccines for Bordetella bronchiseptica work in dogs? A critical review of the literature 1977–2014. The Veterinary Journal. 2015 Apr;204(1):5–16.Ford RB. Canine Infectious Tracheobronchitis. En C. Greene, Infectious Diseases of the Dog and Cat. 3rd Edition. Missouri: Elsevier; 2008. 1–15 p.Mauro LD. Manejo de la traqueobronquitis infecciosa canina (TIC) "Tos de las Perreras. REDVET Revista Electrónica de Veterinaria. 2006 Feb 2;7:1–9.Damián M, Morales E, Salas G, Trigo FJ. Immunohistochemical Detection of Antigens of Distemper, Adenovirus and Parainfluenza Viruses in Domestic Dogs with Pneumonia. J Comp Pathol. 2005 Nov;133(4):289–93.Chvala S, Benetka V, Möstl K, Zeugswetter F, Spergser J, Weissenböck H. Simultaneous Canine Distemper Virus, Canine Adenovirus Type 2, and Mycoplasma Cynos Infection in a Dog with Pneumonia. Vet Pathol. 2007 Jul 26;44(4):508–12.Carter G, Chengappa M. Bacteriología y Micología Veterinaria Aspectos Esenciales. Manual Moderno S.A. 1991. 341–345 p.Mendoza C. Bordetella bronchiseptica EN CANINOS. [torreon, coahuila]: UNIVERSIDAD AUTÓNOMA AGRARIA ANTONIO NARRO UNIDAD LAGUNA DIVISIÓN REGIONAL DE CIENCIA ANIMAL; 2008.Vadillo S, Piriz S, Mateos E. Manual de Microbiología Veterinaria. McGraw-Hill. Vol. 1. 2002. 293–295 p.Mattoo S, Cherry JD. Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies. Clin Microbiol Rev. 2005 Apr;18(2):326–82.FERNANDES S.C, COUTINHO S.D.A. Traqueobronquite infecciosa canina . Revista do Institito de Ciência da Saúde. 2004;279–85.Buonavoglia C, Martella V. Canine respiratory viruses. Vet Res. 2007 Mar 9;38(2):355–73.SUZUKI EY, PENHA G de A, SALVARANI R de S, BOCARDO M, BISSOLI EDG. TRAQUEOBRONQUITE INFECCIOSA CANINA - RELATO DE CASO . REVISTA CIENTÍFICA ELETÔNICA DE MEDICINA VETERINÁRIA – ISSN: 1679-7353 . 2008 Jul 11;1–5.Krüger RM. UNIVERSIDADE FEDERAL DE SANTA MARIA CENTRO DE CIÊNCIAS RURAIS PROGRAMA DE PÓS-GRADUAÇÃO EM MEDICINA VETERINÁRIA TOSSE EM CÃES: FISIOPATOLOGIA, DOENÇAS ASSOCIADAS E MÉTODOS DIAGNÓSTICOS MONOGRAFIA DE ESPECIALIZAÇÃO. 2010.MENDONÇA C. AVALIAÇÃO DOS FACTORES DE RISCO DA TRAQUEOBRONQUITE INFECIOSA CANINA. 2014.CARMEN S. Enfermedades Infeciosas del Perro y del Gato . - Temis Network,SL. 2001;Appel M, Binn LN. “Canine infectious tracheobronchitis short review: kennel cough.” Elsevier Science. 1987;201–11.Ford R, Vaden S. Canine infectious tracheobronchitis. In: Greene, CE. Infectious diseases of the dogs and the cats. Saunders. 1998;33–8.Thayer GW. Canine infectious tracheobronchitis. In: Greene CE. Clinical microbiology and infectious diseases of the dog and the cat. Saunders. 1984;430–6.Appel M, Binn LN. Canine Parainfluenzavirus. In: Appel M. Virus infections of carnivores. Elsevier. 1987;125–32.Ford RB, Vaden SL. Ford RB. Canine Infectious Tracheobronchitis. En C. Greene, Infectious Diseases of the Dog and Cat. 3rd Edition. Missouri: Elsevier; 2008. 1–15 p. Saunders. 1998;33–8.Wagener JS, Sobonya R, Minnich L, Taussig LM. Role of canine parainfluenza virus and Bordetella bronchiseptica in kennel cough. Am J Vet Res. 1984;45(9):1862–6.Appel M. Canine Adenovirus type 2 (Infectious laryngotracheitis virus). In: Appel M. Virus infections of carnivores. Elsevier. 1987;45–51.Ford RB. Infectious tracheobronchitis. In: Bonagura JD. Kirk’s current veterinary therapy XII – small animal practice. Saunders. 1995;905–8.Edwards JA, Groathouse NA, Boitano S. Bordetella bronchiseptica Adherence to Cilia Is Mediated by Multiple Adhesin Factors and Blocked by Surfactant Protein A. Infect Immun. 2005 Jun;73(6):3618–26.Lugo S, Peña J. Bordetella bronchiséptica en animales de laboratorio. CENPALAB; 2007.JERICÓ MM. Tratado de Medicina Interna de Cães e Gatos. GUANABARA KOOGAN. Rio de Janeiro; 2014. 748–750 p.M.R L, J B, D B, E.B. Breitschwerdt, L. Guardabassi, D.H. Lloyd, et al. Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases. journal of veterinary internal medicine . 2017;1–16.Brito C, Cortezi A, Gomes D. TRAQUEOBRONQUITE INFECCIOSA CANINA – REVISÃO DE LITERATURA. Revista Cientifica Unilagos. 2019 Sep 14;1(1).Milanov, D., Đilas, M., Velhner, M., & Aleksić, N. (2018). Laboratory diagnosis of Bordetella bronchiseptica tracheobronchitis in dog.. Robbins SN, Goggs R, Lhermie G, et al. Prácticas de prescripción de antimicrobianos en emergencias y cuidados críticos de pequeños animales. Ciencia veterinaria frontal . 2020;7:110.Feyes EE, Díaz-Campos D, Mollenkopf DF, et al. Implementación de un programa de administración de antimicrobianos en una institución de enseñanza médica veterinaria. JAVMA . 2021;258(2):170-178.Wolfson W. Tracheobronchitis, infectious (dog). In: Cohn LA, Côté E, eds. Côté’s Clinical Veterinary Advisor: Dogs and Cats. 4th ed. Philadelphia: Mosby; 2019:987-989.Fletcher J. Upper respiratory infection (cat). In: Cohn LA, Côté E. Côté’s Clinical Veterinary Advisor: Dogs and Cats. 4th ed. Philadelphia: Mosby; 2019:1006-1007.Canonne AM, Roels E, Menard M, et al. Clinical response to 2 protocols of aerosolized gentamicin in 46 dogs with Bordetella bronchiseptica infection (2012-2018). J Vet Intern Med. 2020;34(5):2078Grobman M, Reinero C. Investigation of neurokinin-1 receptor antagonism as a novel treatment for chronic bronchitis in dogs. J Vet Intern Med. 2016;30(3):847-852.Kadlec K, Schwarz S. Antimicrobial Resistance in Bordetella bronchiseptica. Microbiol Spectr. 2018 Jul;6(4).Laura A. Nafe, Diagnostic and Therapeutic Approach: Dogs Infected with Bordetella bronchiseptica and Canine Influenza Virus (H3N8), 2014Mitchell, J. A., & Brownlie, J. (2015). The challenges in developing effective canine infectious respiratory disease vaccines. The Journal of pharmacy and pharmacology, 67(3), 372–381. https://doi.org/10.1111/jphp.12380PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-84334https://repository.ucc.edu.co/bitstreams/2a2c9b05-605c-4588-a1db-b022793cc84b/download3bce4f7ab09dfc588f126e1e36e98a45MD51ORIGINAL2023_actualizacion_alternativas_tratamiento.pdf2023_actualizacion_alternativas_tratamiento.pdfTrabajo de gradosapplication/pdf283913https://repository.ucc.edu.co/bitstreams/e61b3d40-80bd-4cb4-97aa-0d6696506096/download689baccfb6c2bd14eb6492549e9dd842MD522023_actualizacion_alternativas_tratamiento-FormatoLicenciaUso.pdf2023_actualizacion_alternativas_tratamiento-FormatoLicenciaUso.pdfLicencia de usoapplication/pdf192195https://repository.ucc.edu.co/bitstreams/5de9dc4f-aa93-4d51-959f-65694361d9de/download885d272bb6f2c2e9f7da283e11c2e00dMD532023_actualizacion_alternativas_tratamiento-ActaSustentacion1.pdf2023_actualizacion_alternativas_tratamiento-ActaSustentacion1.pdfActa de sustentación 1application/pdf121517https://repository.ucc.edu.co/bitstreams/f8867ed7-e172-42b6-8424-558d1ce595c0/download68ec99aeb575efff7bb9171d7cf8e3f7MD542023_actualizacion_alternativas_tratamiento-ActaSustentacion2.pdf2023_actualizacion_alternativas_tratamiento-ActaSustentacion2.pdfActa de sustentación 2application/pdf121923https://repository.ucc.edu.co/bitstreams/cf2ed38a-9e3a-462a-9388-298bcb701c9a/download3aa1b5dd9c4e48634419b52e0cad7f55MD55TEXT2023_actualizacion_alternativas_tratamiento.pdf.txt2023_actualizacion_alternativas_tratamiento.pdf.txtExtracted texttext/plain46041https://repository.ucc.edu.co/bitstreams/9b6ec770-34bc-4a45-b94e-c30a131763c9/downloadd791c4ac6cf6302d1c6c1bbddc11570aMD562023_actualizacion_alternativas_tratamiento-FormatoLicenciaUso.pdf.txt2023_actualizacion_alternativas_tratamiento-FormatoLicenciaUso.pdf.txtExtracted texttext/plain5952https://repository.ucc.edu.co/bitstreams/1ec632d1-e52c-4b6b-9603-eb3a504d5f20/download0638fe47d6f29fdb70fb5a86ac70e089MD582023_actualizacion_alternativas_tratamiento-ActaSustentacion1.pdf.txt2023_actualizacion_alternativas_tratamiento-ActaSustentacion1.pdf.txtExtracted texttext/plain1243https://repository.ucc.edu.co/bitstreams/801649bf-786b-4b93-a2e2-ae16d565a5bb/download453ee0220da3161b96fc007ee3dec9c9MD5102023_actualizacion_alternativas_tratamiento-ActaSustentacion2.pdf.txt2023_actualizacion_alternativas_tratamiento-ActaSustentacion2.pdf.txtExtracted texttext/plain1244https://repository.ucc.edu.co/bitstreams/7fd33bce-cf0f-4c03-b6cf-be14675a1f38/downloadb4f4b1a97671d3442c2e9fcb185f0e07MD512THUMBNAIL2023_actualizacion_alternativas_tratamiento.pdf.jpg2023_actualizacion_alternativas_tratamiento.pdf.jpgGenerated Thumbnailimage/jpeg10730https://repository.ucc.edu.co/bitstreams/fa520fd3-4e77-49e6-871a-677d138cab92/downloaddef09e4c869b737da3effa7901dfd04fMD572023_actualizacion_alternativas_tratamiento-FormatoLicenciaUso.pdf.jpg2023_actualizacion_alternativas_tratamiento-FormatoLicenciaUso.pdf.jpgGenerated Thumbnailimage/jpeg11927https://repository.ucc.edu.co/bitstreams/63c61312-3cdb-41fa-bab8-155aa184a232/download280bfa48710b6599d32483fbc4c68f8cMD592023_actualizacion_alternativas_tratamiento-ActaSustentacion1.pdf.jpg2023_actualizacion_alternativas_tratamiento-ActaSustentacion1.pdf.jpgGenerated Thumbnailimage/jpeg10493https://repository.ucc.edu.co/bitstreams/d698986f-fceb-4717-ba9b-9c28c0895711/downloadedffbd955d472a5427fca3fca68dc68aMD5112023_actualizacion_alternativas_tratamiento-ActaSustentacion2.pdf.jpg2023_actualizacion_alternativas_tratamiento-ActaSustentacion2.pdf.jpgGenerated Thumbnailimage/jpeg10506https://repository.ucc.edu.co/bitstreams/78342745-58bd-4173-82aa-9e281879f947/downloada9ea350867bbc07e83b167d903a86b5aMD51320.500.12494/52071oai:repository.ucc.edu.co:20.500.12494/520712024-08-09 12:38:06.667open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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 |