Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues

Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reas...

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Autores:
Díaz Torres, Jairo Alberto
Murillo, Mauricio F.
Mendoza Prieto, Jhonan Alexon
Barreto Torres, Ana María
Poveda Sanchez, Lina Sofía
Sanchez Gonzalez, Lina Katherin
Poveda Urrego, Laura Camila
Mora Mora, Katherine Tatiana
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/1410
Acceso en línea:
https://hdl.handle.net/20.500.12494/1410
Palabra clave:
Hypoxia
Cancer
Intercellular collisions
Actin-myosin filaments
Embryoid-like metamorphosis
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
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dc.title.spa.fl_str_mv Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
spellingShingle Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
Hypoxia
Cancer
Intercellular collisions
Actin-myosin filaments
Embryoid-like metamorphosis
title_short Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_full Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_fullStr Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_full_unstemmed Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_sort Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
dc.creator.fl_str_mv Díaz Torres, Jairo Alberto
Murillo, Mauricio F.
Mendoza Prieto, Jhonan Alexon
Barreto Torres, Ana María
Poveda Sanchez, Lina Sofía
Sanchez Gonzalez, Lina Katherin
Poveda Urrego, Laura Camila
Mora Mora, Katherine Tatiana
dc.contributor.author.none.fl_str_mv Díaz Torres, Jairo Alberto
Murillo, Mauricio F.
Mendoza Prieto, Jhonan Alexon
Barreto Torres, Ana María
Poveda Sanchez, Lina Sofía
Sanchez Gonzalez, Lina Katherin
Poveda Urrego, Laura Camila
Mora Mora, Katherine Tatiana
dc.subject.spa.fl_str_mv Hypoxia
Cancer
Intercellular collisions
Actin-myosin filaments
topic Hypoxia
Cancer
Intercellular collisions
Actin-myosin filaments
Embryoid-like metamorphosis
dc.subject.none.fl_str_mv Embryoid-like metamorphosis
description Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reassembled into the original mold, using one common connection, i.e., a fractal self-similarity that guides the system from the beginning in reverse metamorphosis, with spontaneous self-assembly of past forms that mimics an embryoid phenotype. We captured this hidden collective filamentous assemblage in progress: Hypoxic deformed cells enter into intercellular collisions, generate migratory ejected filaments, and produce self-assembly of triangular chiral hexagon complexes; this dynamic geometry guides the microenvironment scaffold in which this biological process is incubated, recapitulating embryonic morphogenesis. In all injured tissues, especially in damaged skeletal (striated) muscle cells, visibly hypertrophic intercalated actin-myosin filaments are organized in zebra stripe pattern along the anterior-posterior axis in the interior of the cell, generating cephalic-caudal polarity segmentation, with a high selective level of immunopositivity for Actin, Alpha Skeletal Muscle antibody and for Neuron-Specific Enolase expression of ectodermal differentiation. The function of actin filaments in emergent responses to tissue injury is to reconstitute, reactivate and orchestrate cellular metamorphosis, involving the re-expression of fetal genes, providing evidence of the reverse flow of genetic information within a biological system. The resultant embryoid phenotype emerges as a microscopic fractal template copy of the organization of the whole body, likely allowing the modification and reprogramming of the phenotype of the tumor in which these structures develop, as well as establishing a reverse primordial microscopic mold to collectively re-form cellular building blocks to regenerate injured tissues. Tumorigenesis mimics a self-organizing process of early embryo development. All malignant tumors produce fetal proteins, we now know from which these proteins proceed. Embryoid-like metamorphosis phenomena would represent the anatomical and functional entity of the injury stem cell niche. The sufficiently fast identification, isolation, culture, and expansion of these self-organized structures or genetically derived products could, in our opinion, be used to develop new therapeutic strategies against cancer and in regenerative medicine.
publishDate 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2017-08-25T14:18:13Z
dc.date.available.none.fl_str_mv 2017-08-25T14:18:13Z
dc.type.none.fl_str_mv Artículo
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dc.identifier.bibliographicCitation.spa.fl_str_mv Díaz, J. A., Murillo, M. F., Mendoza, J. A., Barreto, A. M., Poveda, L. S., Sanchez, L. K., … Mora, K. T. (2016). Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues. American Journal of Stem Cells, 5(2), 53–73.
url https://hdl.handle.net/20.500.12494/1410
identifier_str_mv Díaz, J. A., Murillo, M. F., Mendoza, J. A., Barreto, A. M., Poveda, L. S., Sanchez, L. K., … Mora, K. T. (2016). Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues. American Journal of Stem Cells, 5(2), 53–73.
dc.relation.isversionof.spa.fl_str_mv https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043097/#
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dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Villavicencio, Colombia
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.place.spa.fl_str_mv Villavicencio
institution Universidad Cooperativa de Colombia
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spelling Díaz Torres, Jairo AlbertoMurillo, Mauricio F.Mendoza Prieto, Jhonan AlexonBarreto Torres, Ana MaríaPoveda Sanchez, Lina SofíaSanchez Gonzalez, Lina KatherinPoveda Urrego, Laura CamilaMora Mora, Katherine Tatiana2017-08-25T14:18:13Z2017-08-25T14:18:13Z2016https://hdl.handle.net/20.500.12494/1410Díaz, J. A., Murillo, M. F., Mendoza, J. A., Barreto, A. M., Poveda, L. S., Sanchez, L. K., … Mora, K. T. (2016). Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues. American Journal of Stem Cells, 5(2), 53–73.Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reassembled into the original mold, using one common connection, i.e., a fractal self-similarity that guides the system from the beginning in reverse metamorphosis, with spontaneous self-assembly of past forms that mimics an embryoid phenotype. We captured this hidden collective filamentous assemblage in progress: Hypoxic deformed cells enter into intercellular collisions, generate migratory ejected filaments, and produce self-assembly of triangular chiral hexagon complexes; this dynamic geometry guides the microenvironment scaffold in which this biological process is incubated, recapitulating embryonic morphogenesis. In all injured tissues, especially in damaged skeletal (striated) muscle cells, visibly hypertrophic intercalated actin-myosin filaments are organized in zebra stripe pattern along the anterior-posterior axis in the interior of the cell, generating cephalic-caudal polarity segmentation, with a high selective level of immunopositivity for Actin, Alpha Skeletal Muscle antibody and for Neuron-Specific Enolase expression of ectodermal differentiation. The function of actin filaments in emergent responses to tissue injury is to reconstitute, reactivate and orchestrate cellular metamorphosis, involving the re-expression of fetal genes, providing evidence of the reverse flow of genetic information within a biological system. The resultant embryoid phenotype emerges as a microscopic fractal template copy of the organization of the whole body, likely allowing the modification and reprogramming of the phenotype of the tumor in which these structures develop, as well as establishing a reverse primordial microscopic mold to collectively re-form cellular building blocks to regenerate injured tissues. Tumorigenesis mimics a self-organizing process of early embryo development. All malignant tumors produce fetal proteins, we now know from which these proteins proceed. Embryoid-like metamorphosis phenomena would represent the anatomical and functional entity of the injury stem cell niche. The sufficiently fast identification, isolation, culture, and expansion of these self-organized structures or genetically derived products could, in our opinion, be used to develop new therapeutic strategies against cancer and in regenerative medicine.jairo.díaz@campusucc.edu.cojhonan.mendozap@campusucc.edu.coana.barretot@campusucc.edu.colina.povedas@campusucc.edu.colina.sanchezgo@campusucc.edu.colaura.povedau@campusucc.edu.cokatherinet.mora@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Villavicencio, ColombiaMedicinaVillavicenciohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043097/#HypoxiaCancerIntercellular collisionsActin-myosin filamentsEmbryoid-like metamorphosisHuman somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured 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