Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures

The preferential solvation parameters for indomethacin (IMC) in ethanol (EtOH) + water and propylene glycol (PG) + water binary mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood–Buff integrals (IKBI) and the quasi-lattice quasi-chemical (QLQC) methods. According to IKBI method, the preferential solvation parameter by co-solvents, (dx1,3), is negative in the water-rich mixtures of both binary systems but positive in the other compositions at temperatures of 293.15, 303.15, and 313.15 K. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic rings and methyl groups of the drug plays a relevant role in the solvation. The higher drug solvation by co-solvent in mixtures of similar solvent proportion and in co-solvent-rich mixtures could be due mainly to polarity effects. Here IMC would be acting as a Lewis acid with the EtOH or PG molecules because these co-solvents are more basic than water. © 2016, Copyright © Taylor & Francis Group, LLC.

• Autores: Peña M.Á.; Delgado, Daniel Ricardo; Martínez F.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2016
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41701
• Acceso en línea: https://doi.org/10.15332/s1794-9998.2017.0002.10; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047079018&doi=10.3303%2fCET1864096&partnerID=40&md5=ead173e1b39701df1aa8c7f1df3b5cb3; https://hdl.handle.net/20.500.12494/41701
• Palabra clave: Bins; Ethanol; Glycols; Inverse problems; Mixtures; Polyols; Propylene; Solvation; Solvents; Binary systems; Cosolvent mixtures; Hydrophobic hydration; Indomethacin; Polarity effect; Preferential solvation; Propylene glycols; Quasi-chemical; Binary mixtures
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb