Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as V...

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Autores:: Gonzalez, Sandra M
Aguilar-Jimenez, Wbeimar
Trujillo-Gil, Edison
Zapata Builes, Wildeman
Su, Ruey-Chyi
Ball, T Blake
Rugeles, Maria T

Tipo de recurso:: Article of journal

Fecha de publicación:: 2019

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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network_acronym_str	COOPER2
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repository_id_str
spelling	Gonzalez, Sandra MAguilar-Jimenez, WbeimarTrujillo-Gil, EdisonZapata Builes, WildemanSu, Ruey-ChyiBall, T BlakeRugeles, Maria T2021-12-16T22:15:54Z2021-12-16T22:15:54Z2019https://doi.org/10.18041/1794-4953/avances.2.256https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029379594&doi=10.1155%2f2017%2f1090534&partnerID=40&md5=cdaf6480d676a3c1077735c6ae9286b019326203https://hdl.handle.net/20.500.12494/41929Gonzalez SM,Aguilar W,Trujillo E,Zapata W,Su RC,Ball TB,Rugeles MT. Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes. PLoS One. 2019. 14. (9):e0222878. .Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as Vitamin D (VitD) may reduce HIV-1 transmission and might be used as a safe and cost-effective strategy for prevention. Considering this, we examined the in vitro effect of the treatment of peripheral blood mononuclear cells (PBMCs) with the active form of VitD, calcitriol, on cellular activation, function and susceptibility of CD4+ T cells to HIV-1 infection.0000-0002-7351-8738wildeman.zapatab@campusucc.edu.co-Public Library of ScienceADP ribosyl cyclase/cyclic ADP ribose hydrolase 1apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3GcalcitriolcathelicidingranzymeHLA DR antigenimmunoglobulin enhancer binding proteininterleukin 2macrophage inflammatory protein 1betavirus receptorantimicrobial cationic peptideAPOBEC3G proteinhumanapolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3GcalcitriolCAP18 lipopolysaccharide-binding proteinHLA DR antigenvitaminAPOBEC3G geneArticleCAMP geneCanadaCD4+ T lymphocytecell cloningcohort analysisColombiacontrolled studydrug effectfemalehumanhuman cellHuman immunodeficiency virus infectionimmunomodulationin vitro studyinfection sensitivitylymphocyte activationlymphocyte functionmaleperipheral blood mononuclear cellprotein expressionserodiagnosisT lymphocyte subpopulationviral tropismvirus genevirus strainbloodCD4+ T lymphocytecell cultureHuman immunodeficieVitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.Artículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionPlos Oneinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41929oai:repository.ucc.edu.co:20.500.12494/419292024-08-20 16:18:27.041metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
spellingShingle	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes. ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1 apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G calcitriol cathelicidin granzyme HLA DR antigen immunoglobulin enhancer binding protein interleukin 2 macrophage inflammatory protein 1beta virus receptor antimicrobial cationic peptide APOBEC3G protein human apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G calcitriol CAP18 lipopolysaccharide-binding protein HLA DR antigen vitamin APOBEC3G gene Article CAMP gene Canada CD4+ T lymphocyte cell cloning cohort analysis Colombia controlled study drug effect female human human cell Human immunodeficiency virus infection immunomodulation in vitro study infection sensitivity lymphocyte activation lymphocyte function male peripheral blood mononuclear cell protein expression serodiagnosis T lymphocyte subpopulation viral tropism virus gene virus strain blood CD4+ T lymphocyte cell culture Human immunodeficie
title_short	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_full	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_fullStr	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_full_unstemmed	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_sort	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
dc.creator.fl_str_mv	Gonzalez, Sandra M Aguilar-Jimenez, Wbeimar Trujillo-Gil, Edison Zapata Builes, Wildeman Su, Ruey-Chyi Ball, T Blake Rugeles, Maria T
dc.contributor.author.none.fl_str_mv	Gonzalez, Sandra M Aguilar-Jimenez, Wbeimar Trujillo-Gil, Edison Zapata Builes, Wildeman Su, Ruey-Chyi Ball, T Blake Rugeles, Maria T
dc.subject.spa.fl_str_mv	ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1 apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G calcitriol cathelicidin granzyme HLA DR antigen immunoglobulin enhancer binding protein interleukin 2 macrophage inflammatory protein 1beta virus receptor antimicrobial cationic peptide APOBEC3G protein human apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G calcitriol CAP18 lipopolysaccharide-binding protein HLA DR antigen vitamin APOBEC3G gene Article CAMP gene Canada CD4+ T lymphocyte cell cloning cohort analysis Colombia controlled study drug effect female human human cell Human immunodeficiency virus infection immunomodulation in vitro study infection sensitivity lymphocyte activation lymphocyte function male peripheral blood mononuclear cell protein expression serodiagnosis T lymphocyte subpopulation viral tropism virus gene virus strain blood CD4+ T lymphocyte cell culture Human immunodeficie
topic	ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1 apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G calcitriol cathelicidin granzyme HLA DR antigen immunoglobulin enhancer binding protein interleukin 2 macrophage inflammatory protein 1beta virus receptor antimicrobial cationic peptide APOBEC3G protein human apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G calcitriol CAP18 lipopolysaccharide-binding protein HLA DR antigen vitamin APOBEC3G gene Article CAMP gene Canada CD4+ T lymphocyte cell cloning cohort analysis Colombia controlled study drug effect female human human cell Human immunodeficiency virus infection immunomodulation in vitro study infection sensitivity lymphocyte activation lymphocyte function male peripheral blood mononuclear cell protein expression serodiagnosis T lymphocyte subpopulation viral tropism virus gene virus strain blood CD4+ T lymphocyte cell culture Human immunodeficie
description	Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as Vitamin D (VitD) may reduce HIV-1 transmission and might be used as a safe and cost-effective strategy for prevention. Considering this, we examined the in vitro effect of the treatment of peripheral blood mononuclear cells (PBMCs) with the active form of VitD, calcitriol, on cellular activation, function and susceptibility of CD4+ T cells to HIV-1 infection.
publishDate	2019
dc.date.issued.none.fl_str_mv	2019
dc.date.accessioned.none.fl_str_mv	2021-12-16T22:15:54Z
dc.date.available.none.fl_str_mv	2021-12-16T22:15:54Z
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.18041/1794-4953/avances.2.256 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029379594&doi=10.1155%2f2017%2f1090534&partnerID=40&md5=cdaf6480d676a3c1077735c6ae9286b0
dc.identifier.issn.spa.fl_str_mv	19326203
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/41929
dc.identifier.bibliographicCitation.spa.fl_str_mv	Gonzalez SM,Aguilar W,Trujillo E,Zapata W,Su RC,Ball TB,Rugeles MT. Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes. PLoS One. 2019. 14. (9):e0222878. .
url	https://doi.org/10.18041/1794-4953/avances.2.256 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029379594&doi=10.1155%2f2017%2f1090534&partnerID=40&md5=cdaf6480d676a3c1077735c6ae9286b0 https://hdl.handle.net/20.500.12494/41929
identifier_str_mv	19326203 Gonzalez SM,Aguilar W,Trujillo E,Zapata W,Su RC,Ball TB,Rugeles MT. Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes. PLoS One. 2019. 14. (9):e0222878. .
dc.relation.ispartofjournal.spa.fl_str_mv	Plos One
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/closedAccess
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dc.format.extent.spa.fl_str_mv	-
dc.publisher.spa.fl_str_mv	Public Library of Science
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
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Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

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