HLA in North Colombia Chimila Amerindians.

HLA-A,-B,-C,-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing. A frequent extended haplotype was found:HLA-A*24:02-B*51:10-C*15:02-BRB1*04:07-DQB1*03:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico, California Gulf, Pacific Ocean). Other haplotypes had already been found in Amerindians from Mexico (Pacific and Atlantic Coast), Peru (highlands and Amazon Basin), Bolivia and North USA. A geographic pattern according to HLA allele or haplotype frequencies is lacking in Amerindians, as already known. Also, five new extended haplotypes were found in Chimila Amerindians. Their HLA-A*24:02 high frequencies characteristic is shared with aboriginal populations of Taiwan; also, HLA-C*01:02 high frequencies are found in New Zealand Maoris, New Caledonians and Kimberly Aborigines from Australia. Finally, this study may show a model of evolutionary factors acting and rising one HLA allele frequency (-A*24:02), but not in others that belong to the same or different HLA loci. © 2018

• Autores: Arnaiz Villena, Antonio; Palacio Grüber, Jose; Juarez, Ignacio; Hernandez Aguirre, Enio Armando; Muñiz, Ester; Bayona, Brayan; Camposa, Cristina; Nietoa, Jorge; Martin Villa, Manuel; Silvera, Carlos
• Tipo de recurso: Article of journal
• Fecha de publicación: 2018
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41467
• Acceso en línea: https://doi.org/10.1016/j.molliq.2015.01.047; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064138388&doi=10.1016%2fj.tourman.2019.04.001&partnerID=40&md5=3391676420bf4c4512ede38990556004; https://hdl.handle.net/20.500.12494/41467
• Palabra clave: HLA A24 antigen; HLA antigen; HLA B51 antigen; HLA DQB1 antigen; HLA antigen; American Indian; Article; Australia; Bolivia; Colombia; evolution; gene frequency; geographic distribution; haplotype; human; indigenous people; Maori (people); Mexico; molecular typing; New Caledonian; New Zealand; Peru; priority journal; Taiwan; United States; gene frequency; genetics; Colombia; Gene Frequency; Haplotypes; HLA Antigens; Humans; Indians; South American
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb