Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population

Background: CHEK2 (Checkpoint Kinase 2) encodes CHK2, a serine/threonine kinase involved in maintaining the G1/S and G2/M checkpoints and repair of double-strand DNA breaks via homologous recombination. Functions of CHK2 include the prevention of damaged

Autores:
Guauque Olarte, Sandra milena
Cifuentes Cardona, Laura Fernanda
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/50238
Acceso en línea:
https://doi.org/10.12688/f1000research.9932.1
https://hdl.handle.net/20.500.12494/50238
Palabra clave:
CANCER
CHEK2
CHEK2*1100DELC
CHK2
DATABASES
GENOMICS.
LATIN AMERICA
MUTATIONS
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
Description
Summary:Background: CHEK2 (Checkpoint Kinase 2) encodes CHK2, a serine/threonine kinase involved in maintaining the G1/S and G2/M checkpoints and repair of double-strand DNA breaks via homologous recombination. Functions of CHK2 include the prevention of damaged