Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal

The presence of levonorgestrel (LNG) in water bodies via direct discharge and human excretion has been reported worldwide, but its effects on the reproduction of aquatic species and humans are still unknown. Owing to its recalcitrant properties, LNG is not completely removed during wastewater treatm...

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Autores:: Narvaez, Jhon Fredy
Grant, Hannah
Correa, Vanesa
Porras López, Jazmín
Bueno Sánchez, Julio César
Ocampo Duque, Luz Fanny
Rios Sossa, Ramiro
Quintana Castillo, Juan Carlos

Tipo de recurso:: Article of journal

Fecha de publicación:: 2019

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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repository_id_str
dc.title.spa.fl_str_mv	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal
title	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal
spellingShingle	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal Endocrine disruptor Photocatalytic degradation BeWo cell line β-hCG hormone Photocatalytic removal Levonorgestrel
title_short	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal
title_full	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal
title_fullStr	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal
title_full_unstemmed	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal
title_sort	Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal
dc.creator.fl_str_mv	Narvaez, Jhon Fredy Grant, Hannah Correa, Vanesa Porras López, Jazmín Bueno Sánchez, Julio César Ocampo Duque, Luz Fanny Rios Sossa, Ramiro Quintana Castillo, Juan Carlos
dc.contributor.author.none.fl_str_mv	Narvaez, Jhon Fredy Grant, Hannah Correa, Vanesa Porras López, Jazmín Bueno Sánchez, Julio César Ocampo Duque, Luz Fanny Rios Sossa, Ramiro Quintana Castillo, Juan Carlos
dc.subject.spa.fl_str_mv	Endocrine disruptor Photocatalytic degradation BeWo cell line β-hCG hormone Photocatalytic removal Levonorgestrel
topic	Endocrine disruptor Photocatalytic degradation BeWo cell line β-hCG hormone Photocatalytic removal Levonorgestrel
description	The presence of levonorgestrel (LNG) in water bodies via direct discharge and human excretion has been reported worldwide, but its effects on the reproduction of aquatic species and humans are still unknown. Owing to its recalcitrant properties, LNG is not completely removed during wastewater treatment plants, and many species may be exposed to low traces of this compound from discharged effluents. Thus, in this study, a photocatalytic process for removing LNG along with screening of endocrine disruptor effects for risk assessment was applied. Although the removal rate of LNG by ultraviolet C (UV-C) radiation was>90%, reproductive toxicity testing using the BeWo cell line exposed to LNG and its degraded fraction showed the reduced production of basal human chorionic gonadotropin hormone (β-hCG) by more than 73%, from 8.90 mIU mL−1 to<2.39 mIU mL−1, with both LNG and the degraded fraction. β-hCG hormone has been implicated in the viability of trophoblastic cells during the first trimester of pregnancy; therefore, degraded fractions and waterborne LNG may affect reproduction in some aquatic species and humans with low level of exposure.
publishDate	2019
dc.date.issued.none.fl_str_mv	2019-02-27
dc.date.accessioned.none.fl_str_mv	2020-01-29T16:45:44Z
dc.date.available.none.fl_str_mv	2020-01-29T16:45:44Z
dc.type.none.fl_str_mv	Artículo
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dc.identifier.issn.spa.fl_str_mv	0304-3894
dc.identifier.uri.spa.fl_str_mv	10.1016/j.jhazmat.2019.02.095
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/16453
dc.identifier.bibliographicCitation.spa.fl_str_mv	Narváez, J.F., Grant, H., Correa Gil, V., Porras, J., Bueno Sanchez, J.C., Fanny Ocampo Duque, L.F., Ríos Sossa, R. y Quintana-Castillo, J.C. (2019) Assessment of endocrine disruptor effects of levonorgestrel and its photoproducts: Environmental implications of released fractions after their photocatalytic removal, Journal of Hazardous Materials,Volume 371, 2019, Pages 273-279. Recuperado de: https://www.sciencedirect.com/science/article/pii/S0304389419302389
identifier_str_mv	0304-3894 10.1016/j.jhazmat.2019.02.095 Narváez, J.F., Grant, H., Correa Gil, V., Porras, J., Bueno Sanchez, J.C., Fanny Ocampo Duque, L.F., Ríos Sossa, R. y Quintana-Castillo, J.C. (2019) Assessment of endocrine disruptor effects of levonorgestrel and its photoproducts: Environmental implications of released fractions after their photocatalytic removal, Journal of Hazardous Materials,Volume 371, 2019, Pages 273-279. Recuperado de: https://www.sciencedirect.com/science/article/pii/S0304389419302389
url	https://hdl.handle.net/20.500.12494/16453
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dc.relation.ispartofjournal.spa.fl_str_mv	Journal of Hazardous Materials
dc.relation.references.spa.fl_str_mv	J.P. Besse, J. Garric, Progestagens for human use, exposure and hazard assessment for the aquatic environment, Environ. Pollut. 157 (2009) 3485–3494. J. Narvaez, C. Jimenez, Pharmaceutical products in the environment: sources, effects and risks, Vitae, Rev. La Fac. Química Farm. 19 (2012) 93–108 R.E. Alcock, a. Sweetman, K.C. Jones, Assessment of organic contanhnant fate in waste water treatment plants I: selected compounds and physicochemical properties, Chemosphere 38 (1999) 2247–2262 H.J. Geyer, et al., Bioaccumulation and occurrence of endocrine-disrupting chemicals (EDCs), persistent organic pollutants (POPs), and other organic compounds in fish and other organisms including humans, Handb. Environ. Chem. 2 (2000) 1–166. T. Manickum, W. John, Occurrence, fate and environmental risk assessment of endocrine disrupting compounds at the wastewater treatment works in Pietermaritzburg (South Africa), Sci. Total Environ. 468–469 (2014) 584–597. A. Ramirez, et al., Occurence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States, Environ. Toxicol. Chem. 28 (2009) 2587–2597 M. Durand, et al., On the mechanisms of action of short-term levonorgestrel administration in emergency contraception, Contraception 64 (2001) 227–234 L. Viglino, K. Aboulfadl, M. Prévost, S. Sauvé, Analysis of natural and synthetic estrogenic endocrine disruptors in environmental waters using online preconcentration coupled with LC-APPI-MS/MS, Talanta 76 (2008) 1088–1096. J. Zeilinger, et al., Effects of synthetic gestagens on fish reproduction, Environ. Toxicol. Chem. 28 (2009) 2663–2670 M. Contraceptive, C. Alvin, A. Bebb, D. Anawalt, W. Mellon, Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach, J. Clin. Endocrinol. Metab. 81 (1996) 4–9 O.C. King, J.P. van de Merwe, J.A. McDonald, F.D.L. Leusch, Concentrations of levonorgestrel and ethinylestradiol in wastewater effluents: is the progestin also cause for concern? Environ. Toxicol. Chem. 35 (2016) 1378–1385 D. Nasuhoglu, D. Berk, V. Yargeau, Photocatalytic removal of 17α-ethinylestradiol (EE2) and levonorgestrel (LNG) from contraceptive pill manufacturing plant wastewater under UVC radiation, Chem. Eng. J. 185–186 (2012) 52–60. G. Li, et al., Phytoremediation of levonorgestrel in aquatic environment by hydrophytes, J. Environ. Sci. (China) 26 (2014) 1869–1873 M. Guedes Maniero, D. Maia Bila, M. Dezotti, Degradation and estrogenic activity removal of 17β-estradiol and 17α-ethinylestradiol by ozonation and O3/H2O2, Sci. Total Environ. 407 (2008) 105–115. B. Lomonte, et al., An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies, J. Immunol. Methods 161 (1993) 231–237. B.A. Logue, E. Manandhar, Percent residual accuracy for quantifying goodness-of-fit of linear calibration curves, Talanta 189 (2018) 527–533 J.J. Berzas, J. Rodríguez, G. Castañeda, Simultaneous determination of ethinylestradiol and levonorgestrel in oral contraceptives by derivative spectrophotometry, Analyst 122 (1997) 41–44 T. Tang, et al., Adsorption properties and degradation dynamics of endocrine disrupting chemical levonorgestrel in soils, J. Agric. Food Chem. 60 (2012) 3999–4004. R.A. Pattillo, et al., Control mechanisms for gonadotrophic hormone production in vitro, In Vitro 6 (1970) 205–214. D.J. Caldwell, et al., An assessment of potential exposure and risk from estrogens in drinking water, Environ. Health Perspect. 118 (2010) 338–344. J.R. Latendresse, et al., Genistein and ethinyl estradiol dietary exposure in multigenerational and chronic studies induce similar proliferative lesions in mammary gland of male Sprague-Dawley rats, Reprod. Toxicol. 28 (2009) 342–353. M.D. Jurgens, et al., The potential for estradiol and ethyinylestradiol degradation in English rivers, Environ. Toxicol. Chem. 21 (2002) 480–488. levonorgestrel in wastewater samples by a newly developed indirect competitive enzyme- linked immunosorbent assay (ELISA) coupled with solid phase extraction, Anal. Chim. Acta 628 (2008) 73–79. D.M. Leech, M.T. Snyder, R.G. Wetzel, Natural organic matter and sunlight accelerate the degradation of 17ß-estradiol in water, Sci. Total Environ. 407 (2009) 2087–2092. M. Shalev, et al., Monitoring of progestins: development of immunochemical methods for purification and detection of levonorgestrel, Anal. Chim. Acta 665 (2010) 176–184. T.A. Ternes, et al., Behavior and occurrence of estrogens in municipal sewage treatment plants – I. Investigations in Germany, Canada and Brazil, Sci. Total Environ. 225 (1999) 81–90. J. Shi, S. Fujisawa, S. Nakai, M. Hosomi, Biodegradation of natural and synthetic estrogens by nitrifying activated sludge and ammonia-oxidizing bacterium Nitrosomonas europaea, Water Res. 38 (2004) 2322–2329. Hashem AlAani, Shahir Hashem, François Karabet, Photocatalytic (UV-A/TiO2) and photolytic (UV-A) degradation of steroid hormones: ethinyl estradiol, levonorgestrel, and progesterone, Int. J. ChemTech Res. 10 (2017) 1061–1070. V. Contardo-Jara, et al., Molecular effects and bioaccumulation of levonorgestrel in the non-target organism Dreissena polymorpha, Environ. Pollut. 159 (2011) 38–44. Jhon Narváez, J. Berrio, Sara Correa, J. Palacio, F. Molina, Degradación hidrlítica de clorpirifós y evaluación de la toxicidad del extracto, Rev. Politécnica ISSN 10 (2014) 15. F. Maranghi, et al., Reproductive toxicity and thyroid effects in Sprague Dawley rats exposed to low doses of ethylenethiourea, Food Chem. Toxicol. 59 (2013) 261–271. C. Ticconi, et al., Pregnancy-promoting actions of HCG in human myometrium and fetal membranes, Placenta 28 (2007) 137–143. N. Kane, R. Kelly, P.T.K. Saunders, H.O.D. Critchley, Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor, Endocrinology 150 (2009) 2882–2888. A.U. Oz, J.M. Kingston, S. Shahabi, C.D. Hsu, L. Cole, The role of hyperglycosylated hCG in trophoblast invasion and the prediction of subsequent pre-eclampsia, Prenat. Diagn. 22 (2002) 478–481. L.A. Cole, hCG, five independent molecules, Clin. Chim. Acta 413 (2012) 48–65. E. Honkisz, D. Zieba-Przybylska, A.K. Wojtowicz, The effect of triclosan on hormone secretion and viability of human choriocarcinoma JEG-3 cells, Reprod. Toxicol. 34 (2012) 385–392. E.R. Barnea, Modification of pulsatile human chorionic gonadotrophin secretion in first trimester placental explants induced by polycyclic aromatic hydrocarbons, Hum. Reprod. 7 (1992) 305–310
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spelling	Narvaez, Jhon FredyGrant, HannahCorrea, VanesaPorras López, JazmínBueno Sánchez, Julio CésarOcampo Duque, Luz FannyRios Sossa, RamiroQuintana Castillo, Juan Carlos3712020-01-29T16:45:44Z2020-01-29T16:45:44Z2019-02-270304-389410.1016/j.jhazmat.2019.02.095https://hdl.handle.net/20.500.12494/16453Narváez, J.F., Grant, H., Correa Gil, V., Porras, J., Bueno Sanchez, J.C., Fanny Ocampo Duque, L.F., Ríos Sossa, R. y Quintana-Castillo, J.C. (2019) Assessment of endocrine disruptor effects of levonorgestrel and its photoproducts: Environmental implications of released fractions after their photocatalytic removal, Journal of Hazardous Materials,Volume 371, 2019, Pages 273-279. Recuperado de: https://www.sciencedirect.com/science/article/pii/S0304389419302389The presence of levonorgestrel (LNG) in water bodies via direct discharge and human excretion has been reported worldwide, but its effects on the reproduction of aquatic species and humans are still unknown. Owing to its recalcitrant properties, LNG is not completely removed during wastewater treatment plants, and many species may be exposed to low traces of this compound from discharged effluents. Thus, in this study, a photocatalytic process for removing LNG along with screening of endocrine disruptor effects for risk assessment was applied. Although the removal rate of LNG by ultraviolet C (UV-C) radiation was>90%, reproductive toxicity testing using the BeWo cell line exposed to LNG and its degraded fraction showed the reduced production of basal human chorionic gonadotropin hormone (β-hCG) by more than 73%, from 8.90 mIU mL−1 to<2.39 mIU mL−1, with both LNG and the degraded fraction. β-hCG hormone has been implicated in the viability of trophoblastic cells during the first trimester of pregnancy; therefore, degraded fractions and waterborne LNG may affect reproduction in some aquatic species and humans with low level of exposure.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000029823https://orcid.org/0000-0002-7923-9158https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000011355juan.quintanac@campusucc.edu.co7Diana AgaGrupo de Investigación INFETTARE, Universidad Cooperativa de Colombia, Cra. 42 #49-137, Medellín, ColombiaMedicinaMedellínhttps://www.sciencedirect.com/science/article/pii/S0304389419302389Journal of Hazardous MaterialsJ.P. Besse, J. Garric, Progestagens for human use, exposure and hazard assessment for the aquatic environment, Environ. Pollut. 157 (2009) 3485–3494.J. Narvaez, C. Jimenez, Pharmaceutical products in the environment: sources, effects and risks, Vitae, Rev. La Fac. Química Farm. 19 (2012) 93–108R.E. Alcock, a. Sweetman, K.C. Jones, Assessment of organic contanhnant fate in waste water treatment plants I: selected compounds and physicochemical properties, Chemosphere 38 (1999) 2247–2262H.J. Geyer, et al., Bioaccumulation and occurrence of endocrine-disrupting chemicals (EDCs), persistent organic pollutants (POPs), and other organic compounds in fish and other organisms including humans, Handb. Environ. Chem. 2 (2000) 1–166.T. Manickum, W. John, Occurrence, fate and environmental risk assessment of endocrine disrupting compounds at the wastewater treatment works in Pietermaritzburg (South Africa), Sci. Total Environ. 468–469 (2014) 584–597.A. Ramirez, et al., Occurence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States, Environ. Toxicol. Chem. 28 (2009) 2587–2597M. Durand, et al., On the mechanisms of action of short-term levonorgestrel administration in emergency contraception, Contraception 64 (2001) 227–234L. Viglino, K. Aboulfadl, M. Prévost, S. Sauvé, Analysis of natural and synthetic estrogenic endocrine disruptors in environmental waters using online preconcentration coupled with LC-APPI-MS/MS, Talanta 76 (2008) 1088–1096.J. Zeilinger, et al., Effects of synthetic gestagens on fish reproduction, Environ. Toxicol. Chem. 28 (2009) 2663–2670M. Contraceptive, C. Alvin, A. Bebb, D. Anawalt, W. Mellon, Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach, J. Clin. Endocrinol. Metab. 81 (1996) 4–9O.C. King, J.P. van de Merwe, J.A. McDonald, F.D.L. Leusch, Concentrations of levonorgestrel and ethinylestradiol in wastewater effluents: is the progestin also cause for concern? Environ. Toxicol. Chem. 35 (2016) 1378–1385D. Nasuhoglu, D. Berk, V. Yargeau, Photocatalytic removal of 17α-ethinylestradiol (EE2) and levonorgestrel (LNG) from contraceptive pill manufacturing plant wastewater under UVC radiation, Chem. Eng. J. 185–186 (2012) 52–60.G. Li, et al., Phytoremediation of levonorgestrel in aquatic environment by hydrophytes, J. Environ. Sci. (China) 26 (2014) 1869–1873M. Guedes Maniero, D. Maia Bila, M. Dezotti, Degradation and estrogenic activity removal of 17β-estradiol and 17α-ethinylestradiol by ozonation and O3/H2O2, Sci. Total Environ. 407 (2008) 105–115.B. Lomonte, et al., An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies, J. Immunol. Methods 161 (1993) 231–237.B.A. Logue, E. Manandhar, Percent residual accuracy for quantifying goodness-of-fit of linear calibration curves, Talanta 189 (2018) 527–533J.J. Berzas, J. Rodríguez, G. Castañeda, Simultaneous determination of ethinylestradiol and levonorgestrel in oral contraceptives by derivative spectrophotometry, Analyst 122 (1997) 41–44T. Tang, et al., Adsorption properties and degradation dynamics of endocrine disrupting chemical levonorgestrel in soils, J. Agric. Food Chem. 60 (2012) 3999–4004.R.A. Pattillo, et al., Control mechanisms for gonadotrophic hormone production in vitro, In Vitro 6 (1970) 205–214.D.J. Caldwell, et al., An assessment of potential exposure and risk from estrogens in drinking water, Environ. Health Perspect. 118 (2010) 338–344.J.R. Latendresse, et al., Genistein and ethinyl estradiol dietary exposure in multigenerational and chronic studies induce similar proliferative lesions in mammary gland of male Sprague-Dawley rats, Reprod. Toxicol. 28 (2009) 342–353.M.D. Jurgens, et al., The potential for estradiol and ethyinylestradiol degradation in English rivers, Environ. Toxicol. Chem. 21 (2002) 480–488.levonorgestrel in wastewater samples by a newly developed indirect competitive enzyme- linked immunosorbent assay (ELISA) coupled with solid phase extraction, Anal. Chim. Acta 628 (2008) 73–79.D.M. Leech, M.T. Snyder, R.G. Wetzel, Natural organic matter and sunlight accelerate the degradation of 17ß-estradiol in water, Sci. Total Environ. 407 (2009) 2087–2092.M. Shalev, et al., Monitoring of progestins: development of immunochemical methods for purification and detection of levonorgestrel, Anal. Chim. Acta 665 (2010) 176–184.T.A. Ternes, et al., Behavior and occurrence of estrogens in municipal sewage treatment plants – I. Investigations in Germany, Canada and Brazil, Sci. Total Environ. 225 (1999) 81–90.J. Shi, S. Fujisawa, S. Nakai, M. Hosomi, Biodegradation of natural and synthetic estrogens by nitrifying activated sludge and ammonia-oxidizing bacterium Nitrosomonas europaea, Water Res. 38 (2004) 2322–2329.Hashem AlAani, Shahir Hashem, François Karabet, Photocatalytic (UV-A/TiO2) and photolytic (UV-A) degradation of steroid hormones: ethinyl estradiol, levonorgestrel, and progesterone, Int. J. ChemTech Res. 10 (2017) 1061–1070.V. Contardo-Jara, et al., Molecular effects and bioaccumulation of levonorgestrel in the non-target organism Dreissena polymorpha, Environ. Pollut. 159 (2011) 38–44.Jhon Narváez, J. Berrio, Sara Correa, J. Palacio, F. Molina, Degradación hidrlítica de clorpirifós y evaluación de la toxicidad del extracto, Rev. Politécnica ISSN 10 (2014) 15.F. Maranghi, et al., Reproductive toxicity and thyroid effects in Sprague Dawley rats exposed to low doses of ethylenethiourea, Food Chem. Toxicol. 59 (2013) 261–271.C. Ticconi, et al., Pregnancy-promoting actions of HCG in human myometrium and fetal membranes, Placenta 28 (2007) 137–143.N. Kane, R. Kelly, P.T.K. Saunders, H.O.D. Critchley, Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor, Endocrinology 150 (2009) 2882–2888.A.U. Oz, J.M. Kingston, S. Shahabi, C.D. Hsu, L. Cole, The role of hyperglycosylated hCG in trophoblast invasion and the prediction of subsequent pre-eclampsia, Prenat. Diagn. 22 (2002) 478–481.L.A. Cole, hCG, five independent molecules, Clin. Chim. Acta 413 (2012) 48–65.E. Honkisz, D. Zieba-Przybylska, A.K. Wojtowicz, The effect of triclosan on hormone secretion and viability of human choriocarcinoma JEG-3 cells, Reprod. Toxicol. 34 (2012) 385–392.E.R. Barnea, Modification of pulsatile human chorionic gonadotrophin secretion in first trimester placental explants induced by polycyclic aromatic hydrocarbons, Hum. Reprod. 7 (1992) 305–310Endocrine disruptorPhotocatalytic degradationBeWo cell lineβ-hCG hormonePhotocatalytic removalLevonorgestrelAssessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removalArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINALHAZMAT-D-18-05031.pdfHAZMAT-D-18-05031.pdfapplication/pdf1050059https://repository.ucc.edu.co/bitstreams/291f3fec-cd88-4d2a-8eec-3e89f704cebb/downloadc125cbbbf0514845a4eb93f2bac9248aMD53LICENSElicense.txtlicense.txttext/plain; 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Assessment of endocrine disruptor effects of levonorgestrel and itsphotoproducts: Environmental implications of released fractions after theirphotocatalytic removal

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