Tropism and molecular pathogenesis of Canine Distemper Virus
BACKGROUND: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member of Mononegavirales, CDV has a negative, single...
- Autores:
-
Ruiz Sáenz, Julián
Rendón Marín, Santiago
Da Fontoura Budaszewski, Renata
Wageck Canal, Cláudio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/15171
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/15171
- Palabra clave:
- Canine distemper virus
Canine morbillivirus
Molecular pathogenesis
Neuropathogenesis
Tropism
Zoonosis
- Rights
- openAccess
- License
- Atribución
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Tropism and molecular pathogenesis of Canine Distemper Virus |
| title |
Tropism and molecular pathogenesis of Canine Distemper Virus |
| spellingShingle |
Tropism and molecular pathogenesis of Canine Distemper Virus Canine distemper virus Canine morbillivirus Molecular pathogenesis Neuropathogenesis Tropism Zoonosis |
| title_short |
Tropism and molecular pathogenesis of Canine Distemper Virus |
| title_full |
Tropism and molecular pathogenesis of Canine Distemper Virus |
| title_fullStr |
Tropism and molecular pathogenesis of Canine Distemper Virus |
| title_full_unstemmed |
Tropism and molecular pathogenesis of Canine Distemper Virus |
| title_sort |
Tropism and molecular pathogenesis of Canine Distemper Virus |
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Ruiz Sáenz, Julián Rendón Marín, Santiago Da Fontoura Budaszewski, Renata Wageck Canal, Cláudio |
| dc.contributor.author.none.fl_str_mv |
Ruiz Sáenz, Julián Rendón Marín, Santiago Da Fontoura Budaszewski, Renata Wageck Canal, Cláudio |
| dc.subject.spa.fl_str_mv |
Canine distemper virus Canine morbillivirus Molecular pathogenesis Neuropathogenesis Tropism Zoonosis |
| topic |
Canine distemper virus Canine morbillivirus Molecular pathogenesis Neuropathogenesis Tropism Zoonosis |
| description |
BACKGROUND: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member of Mononegavirales, CDV has a negative, single-stranded RNA genome, which encodes eight proteins. MAIN BODY: Regarding the molecular pathogenesis, the hemagglutinin protein (H) plays a crucial role both in the antigenic recognition and the viral interaction with SLAM and nectin-4, the host cells' receptors. These cellular receptors have been studied widely as CDV receptors in vitro in different cellular models. The SLAM receptor is located in lymphoid cells; therefore, the infection of these cells by CDV leads to immunosuppression, the severity of which can lead to variability in the clinical disease with the potential of secondary bacterial infection, up to and including the development of neurological signs in its later stage. CONCLUSION: Improving the understanding of the CDV molecules implicated in the determination of infection, especially the H protein, can help to enhance the biochemical comprehension of the difference between a wide range of CDV variants, their tropism, and different steps in viral infection. The regions of interaction between the viral proteins and the identified host cell receptors have been elucidated to facilitate this understanding. Hence, this review describes the significant molecular and cellular characteristics of CDV that contribute to viral pathogenesis. |
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2019 |
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2019-11-20T20:55:40Z |
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2019-03-07 |
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Rendon Marin, S., Fontoura Budaszewski, R. D., Canal C. W., Ruiz Saenz, J. (2019) Tropism and molecular pathogenesis of Canine Distemper Virus. Virol J. 2019 Mar 7;16(1):30. DOI: 10.1186/s12985-019-1136-6 |
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1743-422X doi: 10.1186/s12985-019-1136-6. Rendon Marin, S., Fontoura Budaszewski, R. D., Canal C. W., Ruiz Saenz, J. (2019) Tropism and molecular pathogenesis of Canine Distemper Virus. Virol J. 2019 Mar 7;16(1):30. DOI: 10.1186/s12985-019-1136-6 |
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Virol J. |
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1. Murphy FA, Fauquet CM, Bishop DH, Ghabrial SA, Jarvis AW, Martelli GP, Mayo MA, Summers MD: Virus taxonomy: classification and nomenclature of viruses. Springer Science & Business Media; 2012. 2. MacLachlan N, Dubovi E, Fenner F: Paramyxoviridae. 2011. 3. Lempp C, Spitzbarth I, Puff C, Cana A, Kegler K, Techangamsuwan S, Baumgartner W, Seehusen F. New aspects of the pathogenesis of canine distemper leukoencephalitis. Viruses. 2014;6:2571–601. 4. Martinez-Gutierrez M, Ruiz-Saenz J. Diversity of susceptible hosts in canine distemper virus infection: a systematic review and data synthesis. BMC Vet Res. 2016;12:78. 5. Beineke A, Baumgartner W, Wohlsein P. Cross-species transmission of canine distemper virus-an update. One Health. 2015;1:49–59. 6. da Fontoura BR, Streck AF, Nunes Weber M, Maboni Siqueira F, Muniz Guedes RL, Wageck Canal C. Influence of vaccine strains on the evolution of canine distemper virus. Infect Genet Evol. 2016;41:262–9. 7. Kolakofsky D. Paramyxovirus RNA synthesis, mRNA editing, and genome hexamer phase: a review. Virology. 2016;498:94–8. 8. da Fontoura BR, von Messling V. Morbillivirus experimental animal models: measles virus pathogenesis insights from canine distemper virus. Viruses. 2016;8. 9. Cattaneo R, Kaelin K, Baczko K, Billeter MA. Measles virus editing provides an additional cysteine-rich protein. Cell. 1989;56:759–64. 10. Mahy BW, Van Regenmortel MH. Desk encyclopedia animal and bacterial virology. Cambridge: Elsevier; 2010. 11. von Messling V, Svitek N, Cattaneo R. Receptor (SLAM [CD150]) recognition and the V protein sustain swift lymphocyte-based invasion of mucosal tissue and lymphatic organs by a morbillivirus. J Virol. 2006;80:6084–92. 12. von Messling V, Zimmer G, Herrler G, Haas L, Cattaneo R. The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity. J Virol. 2001;75:6418–27. 13. Tumpey TM, Basler CF, Aguilar PV, Zeng H, Solorzano A, Swayne DE, Cox NJ, Katz JM, Taubenberger JK, Palese P, Garcia-Sastre A. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science. 2005;310:77–80 14. von Messling V, Oezguen N, Zheng Q, Vongpunsawad S, Braun W, Cattaneo R. Nearby clusters of hemagglutinin residues sustain SLAM-dependent canine distemper virus entry in peripheral blood mononuclear cells. J Virol. 2005;79:5857–62. 15. Pratakpiriya W, Seki F, Otsuki N, Sakai K, Fukuhara H, Katamoto H, Hirai T, Maenaka K, Techangamsuwan S, Lan NT: Nectin4 is an epithelial cell receptor for canine distemper virus and involved in the neurovirulence. J Virol 2012:JVI. 00824–00812. 16. Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature. 2011;480:530. 17. Chen J, Liang X, Chen PF. Canine distemper virus utilizes different receptors to infect chicken embryo fibroblasts and vero cells. Virol Sin. 2011;26:139–45. 18. Ke GM, Ho CH, Chiang MJ, Sanno-Duanda B, Chung CS, Lin MY, Shi YY, Yang MH, Tyan YC, Liao PC, Chu PY. Phylodynamic analysis of the canine distemper virus hemagglutinin gene. BMC Vet Res. 2015;11:164. 19. Mochizuki M, Hashimoto M, Hagiwara S, Yoshida Y, Ishiguro S. Genotypes of canine distemper virus determined by analysis of the hemagglutinin genes of recent isolates from dogs in Japan. J Clin Microbiol. 1999;37:2936–42. 20. Anis E, Newell TK, Dyer N, Wilkes RP. Phylogenetic analysis of the wild-type strains of canine distemper virus circulating in the United States. Virol J. 2018;15:118. 21. Blixenkrone-Møller M, Svansson V, Appel M, Krogsrud J, Have P, Örvell C. Antigenic relationships between field isolates of morbilliviruses from different carnivores. Arch Virol. 1992;123:279–94. 22. Espinal MA, Diaz FJ, Ruiz-Saenz J. Phylogenetic evidence of a new canine distemper virus lineage among domestic dogs in Colombia, South America. Vet Microbiol. 2014;172:168–76. 23. Haas L, Martens W, Greiser-Wilke I, Mamaev L, Butina T, Maack D, Barrett T. Analysis of the haemagglutinin gene of current wild-type canine distemper virus isolates from Germany. Virus Res. 1997;48:165–71. |
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Ruiz Sáenz, JuliánRendón Marín, SantiagoDa Fontoura Budaszewski, RenataWageck Canal, Cláudio16(1)2019-11-20T20:55:40Z2019-11-20T20:55:40Z2019-03-071743-422Xdoi: 10.1186/s12985-019-1136-6.https://hdl.handle.net/20.500.12494/15171Rendon Marin, S., Fontoura Budaszewski, R. D., Canal C. W., Ruiz Saenz, J. (2019) Tropism and molecular pathogenesis of Canine Distemper Virus. Virol J. 2019 Mar 7;16(1):30. DOI: 10.1186/s12985-019-1136-6BACKGROUND: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member of Mononegavirales, CDV has a negative, single-stranded RNA genome, which encodes eight proteins. MAIN BODY: Regarding the molecular pathogenesis, the hemagglutinin protein (H) plays a crucial role both in the antigenic recognition and the viral interaction with SLAM and nectin-4, the host cells' receptors. These cellular receptors have been studied widely as CDV receptors in vitro in different cellular models. The SLAM receptor is located in lymphoid cells; therefore, the infection of these cells by CDV leads to immunosuppression, the severity of which can lead to variability in the clinical disease with the potential of secondary bacterial infection, up to and including the development of neurological signs in its later stage. CONCLUSION: Improving the understanding of the CDV molecules implicated in the determination of infection, especially the H protein, can help to enhance the biochemical comprehension of the difference between a wide range of CDV variants, their tropism, and different steps in viral infection. The regions of interaction between the viral proteins and the identified host cell receptors have been elucidated to facilitate this understanding. Hence, this review describes the significant molecular and cellular characteristics of CDV that contribute to viral pathogenesis.http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000153095https://orcid.org/0000-0002-1447-1458julian.ruizs@campusucc.edu.cohttps://scholar.google.com/citations?user=o3Y7mZwAAAAJ&hl=esUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, BucaramangaSpringerMedicina veterinaria y zootecniaBucaramangahttps://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1136-6Virol J.1. Murphy FA, Fauquet CM, Bishop DH, Ghabrial SA, Jarvis AW, Martelli GP, Mayo MA, Summers MD: Virus taxonomy: classification and nomenclature of viruses. Springer Science & Business Media; 2012.2. MacLachlan N, Dubovi E, Fenner F: Paramyxoviridae. 2011.3. Lempp C, Spitzbarth I, Puff C, Cana A, Kegler K, Techangamsuwan S, Baumgartner W, Seehusen F. New aspects of the pathogenesis of canine distemper leukoencephalitis. Viruses. 2014;6:2571–601.4. Martinez-Gutierrez M, Ruiz-Saenz J. Diversity of susceptible hosts in canine distemper virus infection: a systematic review and data synthesis. BMC Vet Res. 2016;12:78.5. Beineke A, Baumgartner W, Wohlsein P. Cross-species transmission of canine distemper virus-an update. One Health. 2015;1:49–59.6. da Fontoura BR, Streck AF, Nunes Weber M, Maboni Siqueira F, Muniz Guedes RL, Wageck Canal C. Influence of vaccine strains on the evolution of canine distemper virus. Infect Genet Evol. 2016;41:262–9.7. Kolakofsky D. Paramyxovirus RNA synthesis, mRNA editing, and genome hexamer phase: a review. Virology. 2016;498:94–8.8. da Fontoura BR, von Messling V. Morbillivirus experimental animal models: measles virus pathogenesis insights from canine distemper virus. Viruses. 2016;8.9. Cattaneo R, Kaelin K, Baczko K, Billeter MA. Measles virus editing provides an additional cysteine-rich protein. Cell. 1989;56:759–64.10. Mahy BW, Van Regenmortel MH. Desk encyclopedia animal and bacterial virology. Cambridge: Elsevier; 2010.11. von Messling V, Svitek N, Cattaneo R. Receptor (SLAM [CD150]) recognition and the V protein sustain swift lymphocyte-based invasion of mucosal tissue and lymphatic organs by a morbillivirus. J Virol. 2006;80:6084–92.12. von Messling V, Zimmer G, Herrler G, Haas L, Cattaneo R. The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity. J Virol. 2001;75:6418–27.13. Tumpey TM, Basler CF, Aguilar PV, Zeng H, Solorzano A, Swayne DE, Cox NJ, Katz JM, Taubenberger JK, Palese P, Garcia-Sastre A. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science. 2005;310:77–8014. von Messling V, Oezguen N, Zheng Q, Vongpunsawad S, Braun W, Cattaneo R. Nearby clusters of hemagglutinin residues sustain SLAM-dependent canine distemper virus entry in peripheral blood mononuclear cells. J Virol. 2005;79:5857–62.15. Pratakpiriya W, Seki F, Otsuki N, Sakai K, Fukuhara H, Katamoto H, Hirai T, Maenaka K, Techangamsuwan S, Lan NT: Nectin4 is an epithelial cell receptor for canine distemper virus and involved in the neurovirulence. J Virol 2012:JVI. 00824–00812.16. Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature. 2011;480:530.17. Chen J, Liang X, Chen PF. Canine distemper virus utilizes different receptors to infect chicken embryo fibroblasts and vero cells. Virol Sin. 2011;26:139–45.18. Ke GM, Ho CH, Chiang MJ, Sanno-Duanda B, Chung CS, Lin MY, Shi YY, Yang MH, Tyan YC, Liao PC, Chu PY. Phylodynamic analysis of the canine distemper virus hemagglutinin gene. BMC Vet Res. 2015;11:164.19. Mochizuki M, Hashimoto M, Hagiwara S, Yoshida Y, Ishiguro S. Genotypes of canine distemper virus determined by analysis of the hemagglutinin genes of recent isolates from dogs in Japan. J Clin Microbiol. 1999;37:2936–42.20. Anis E, Newell TK, Dyer N, Wilkes RP. Phylogenetic analysis of the wild-type strains of canine distemper virus circulating in the United States. Virol J. 2018;15:118.21. Blixenkrone-Møller M, Svansson V, Appel M, Krogsrud J, Have P, Örvell C. Antigenic relationships between field isolates of morbilliviruses from different carnivores. Arch Virol. 1992;123:279–94.22. Espinal MA, Diaz FJ, Ruiz-Saenz J. Phylogenetic evidence of a new canine distemper virus lineage among domestic dogs in Colombia, South America. Vet Microbiol. 2014;172:168–76.23. Haas L, Martens W, Greiser-Wilke I, Mamaev L, Butina T, Maack D, Barrett T. Analysis of the haemagglutinin gene of current wild-type canine distemper virus isolates from Germany. 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