Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)

Introduction: Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite, considered as a serious public health problem worldwide. The extracts of the medicinal plant, Renealmia alpina, have been used traditionally by indigenous people...

Full description

Autores:
Patiño A.C.
López J.
Aristizábal M.
Quintana Castillo, Juan Carlos
Benjumea D.
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/41338
Acceso en línea:
https://doi.org/10.7705/biomedica.v32i3.591
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072150393&doi=10.3390%2fijms20184476&partnerID=40&md5=6b30345a684c5d474f3c2271bcde9352
https://hdl.handle.net/20.500.12494/41338
Palabra clave:
acetic acid derivative
acetic acid ethyl ester
alcohol
analgesic agent
dichloromethane
hexane
methanol
plant extract
snake venom
solvent
animal
article
Bagg albino mouse
blood clotting
Bothrops
chemistry
comparative study
drug antagonism
drug effect
drug screening
female
hemolysis
isolation and purification
male
phytotherapy
plant leaf
protein degradation
snakebite
Zingiberaceae
Acetates
Analgesics
Animals
Blood Coagulation
Bothrops
Crotalid Venoms
Drug Evaluation
Preclinical
Ethanol
Female
Hemolysis
Hexanes
Male
Methanol
Methylene Chloride
Mice
Inbred BALB C
Phytotherapy
Plant Extracts
Plant Leaves
Proteolysis
Snake Bites
Solvents
Zingiberaceae
Alpinia
Animalia
Bothrops
Bothrops asper
Renealmia
Renealmia alpinia
Zingiberaceae
Rights
closedAccess
License
http://purl.org/coar/access_right/c_14cb
Description
Summary:Introduction: Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite, considered as a serious public health problem worldwide. The extracts of the medicinal plant, Renealmia alpina, have been used traditionally by indigenous people of Chocó (Colombia) against Bothrops asper snakebite, a snake responsible for the majority of snakebite accidents in Colombia. Objective: The ability of extracts of R. alpinia leaves was tested for its ability to neutralize the hemorrhagic, coagulant and proteolytic effects of the snakebite venom of B. asper. Materials and methods: The acute toxicity tests and analgesic activity of R. alpina were evaluated in vivo. In addition, tests were undertaken in in vitro conditions to demonstrate inhibition of coagulant, haemolytic and proteolytic activity of the B. asper venom. Results: Renealmia alpinia extracts had no toxic effects in experimental animals and also provided analgesic and antiophidian effects and protection against the lethal effects of the venom of B. asper. Conclusion: Renealmia. alpinia was an effective therapeutic alternative in association with antivenom treatment in the event of a B. asper snakebite accident. It was demonstrated to protect against the lethal effects and provided analgesic properties as well.