Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures
Artículo de investigación
- Autores:
-
Peña, María A.
Delgado, Daniel Ricardo
Martínez, Fleming
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1014
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1014
- Palabra clave:
- Ethanol; Indomethacin; Inverse Kirkwood–Buff integrals (IKBI); Preferential Solvation; Propylene glycol; Quasi-lattice quasi-chemical (QLQC)
- Rights
- closedAccess
- License
- Licencia CC
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Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures |
| title |
Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures |
| spellingShingle |
Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures Ethanol; Indomethacin; Inverse Kirkwood–Buff integrals (IKBI); Preferential Solvation; Propylene glycol; Quasi-lattice quasi-chemical (QLQC) |
| title_short |
Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures |
| title_full |
Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures |
| title_fullStr |
Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures |
| title_full_unstemmed |
Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures |
| title_sort |
Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures |
| dc.creator.fl_str_mv |
Peña, María A. Delgado, Daniel Ricardo Martínez, Fleming |
| dc.contributor.advisor.none.fl_str_mv |
Delgado, Daniel Ricardo |
| dc.contributor.author.none.fl_str_mv |
Peña, María A. Delgado, Daniel Ricardo Martínez, Fleming |
| dc.subject.spa.fl_str_mv |
Ethanol; Indomethacin; Inverse Kirkwood–Buff integrals (IKBI); Preferential Solvation; Propylene glycol; Quasi-lattice quasi-chemical (QLQC) |
| topic |
Ethanol; Indomethacin; Inverse Kirkwood–Buff integrals (IKBI); Preferential Solvation; Propylene glycol; Quasi-lattice quasi-chemical (QLQC) |
| description |
Artículo de investigación |
| publishDate |
2015 |
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2015-08-04 |
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2017-08-10T20:30:31Z |
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2017-08-10T20:30:31Z |
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Artículo |
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https://hdl.handle.net/20.500.12494/1014 |
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María Á Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures, Chemical Engineering Communications, 203:5, 619-627, DOI: 10.1080/00986445.2015.1074898 |
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https://hdl.handle.net/20.500.12494/1014 |
| identifier_str_mv |
María Á Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures, Chemical Engineering Communications, 203:5, 619-627, DOI: 10.1080/00986445.2015.1074898 |
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http://www.tandfonline.com/doi/abs/10.1080/00986445.2015.1074898 |
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Licencia CC |
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Universidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000 |
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Ingeniería Industrial |
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Neiva |
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Universidad Cooperativa de Colombia |
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Delgado, Daniel RicardoPeña, María A.Delgado, Daniel RicardoMartínez, Fleming2017-08-10T20:30:31Z2017-08-10T20:30:31Z2015-08-04https://hdl.handle.net/20.500.12494/1014María Á Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures, Chemical Engineering Communications, 203:5, 619-627, DOI: 10.1080/00986445.2015.1074898Artículo de investigaciónThe preferential solvation parameters for indomethacin (IMC) in ethanol (EtOH) þ water and propylene glycol (PG) þ water binary mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood–Buff integrals (IKBI) and the quasi-lattice quasi-chemical (QLQC) methods. According to IKBI method, the preferential solvation parameter by co-solvents, (dx1,3), is negative in the water-rich mixtures of both binary systems but positive in the other compositions at temperatures of 293.15, 303.15, and 313.15 K. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic rings and methyl groups of the drug plays a relevant role in the solvation. The higher drug solvation by co-solvent in mixtures of similar solvent proportion and in co-solvent-rich mixtures could be due mainly to polarity effects. Here IMC would be acting as a Lewis acid with the EtOH or PG molecules because these co-solvents are more basic than water.Introduction, Theoretical Background, Results and Discussion, Conclusions, Nomenclature, Referencesdanielr.delgado@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000Ingeniería IndustrialNeivahttp://www.tandfonline.com/doi/abs/10.1080/00986445.2015.1074898Ethanol; Indomethacin; Inverse Kirkwood–Buff integrals (IKBI); Preferential Solvation; Propylene glycol; Quasi-lattice quasi-chemical (QLQC)Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent MixturesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia 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