Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration
The increase in critical bone diseases and defects in the world’s population increases the need for bone substitutes to restore form and function. Organic and inorganic scaffolds with antibacterial properties could provide advantages for bone regeneration. In this study, we obtained scaffolds of pol...
- Autores:
-
García, Claudia
Orozco, Yeison
Betancur, Alejandra
Moreno, Ana Isabel
Fuentes, Katherine
Lopera, Alex
Suarez, Oscar
Lobo, Tatiana
Ossa, Edgar Alexander
Peláez Vargas, Alejandro
Paucar, Carlos
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- eng
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/55129
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/55129
https://doi.org/10.1016/j.heliyon.2023.e13176
- Palabra clave:
- 610 - Medicina y salud
Scaffold
3D- printing
Natural extracts
Polycaprolactone
Calcium phosphate
- Rights
- openAccess
- License
- http://creativecommons.org/publicdomain/zero/1.0/
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| dc.title.eng.fl_str_mv |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration |
| title |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration |
| spellingShingle |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration 610 - Medicina y salud Scaffold 3D- printing Natural extracts Polycaprolactone Calcium phosphate |
| title_short |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration |
| title_full |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration |
| title_fullStr |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration |
| title_full_unstemmed |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration |
| title_sort |
Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration |
| dc.creator.fl_str_mv |
García, Claudia Orozco, Yeison Betancur, Alejandra Moreno, Ana Isabel Fuentes, Katherine Lopera, Alex Suarez, Oscar Lobo, Tatiana Ossa, Edgar Alexander Peláez Vargas, Alejandro Paucar, Carlos |
| dc.contributor.author.none.fl_str_mv |
García, Claudia Orozco, Yeison Betancur, Alejandra Moreno, Ana Isabel Fuentes, Katherine Lopera, Alex Suarez, Oscar Lobo, Tatiana Ossa, Edgar Alexander Peláez Vargas, Alejandro Paucar, Carlos |
| dc.subject.ddc.none.fl_str_mv |
610 - Medicina y salud |
| topic |
610 - Medicina y salud Scaffold 3D- printing Natural extracts Polycaprolactone Calcium phosphate |
| dc.subject.proposal.none.fl_str_mv |
Scaffold 3D- printing Natural extracts Polycaprolactone Calcium phosphate |
| description |
The increase in critical bone diseases and defects in the world’s population increases the need for bone substitutes to restore form and function. Organic and inorganic scaffolds with antibacterial properties could provide advantages for bone regeneration. In this study, we obtained scaffolds of polycaprolactone (PCL) charged with calcium phosphates nanoparticles and impregnated with extracts of Colombian plants as an alternative for potential bone regeneration. Calcium phosphate nanoparticles were obtained via auto-combustion synthesis. The nanoparticles were incorporated into the PCL with a chemical dissolution-disperse process. The composite obtained was used to produce a filament to print Triply Periodic Minimal Surface (TPMS) based scaffolds. Such geometry facilitates cellular growth thanks to its interconnected porosity. The scaffolds were impregnated with extracts of Justicia cf colorifera (Acanthaceae), and Billia rosea (Sapindaceae) due to their ancestral medical applications. A physical and biological characterization was conducted. The process to print scaffolds with an enhanced geometry to facilitate the flux of biological fluids was successful. The scaffolds loaded with B. rosea showed strong antibacterial behavior, suggesting the presence of reported terpenoids with antibacterial properties. The approach used in this study evidenced promising prospects for bone defect repair. |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023-01-25 |
| dc.date.accessioned.none.fl_str_mv |
2024-03-04T23:59:53Z |
| dc.date.available.none.fl_str_mv |
2024-03-04T23:59:53Z |
| dc.type.none.fl_str_mv |
Artículo |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_6501 |
| status_str |
publishedVersion |
| dc.identifier.citation.none.fl_str_mv |
Garcia C, Orozco Y, Betancur A, Moreno AI, Fuentes K, Lopera A, Suarez O, Lobo T, Ossa A, Peláez-Vargas A, Paucar C. Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration. Heliyon. 2023 Jan 25;9(2):e13176. doi: 10.1016/j.heliyon.2023.e13176. |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/55129 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.heliyon.2023.e13176 |
| identifier_str_mv |
Garcia C, Orozco Y, Betancur A, Moreno AI, Fuentes K, Lopera A, Suarez O, Lobo T, Ossa A, Peláez-Vargas A, Paucar C. Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration. Heliyon. 2023 Jan 25;9(2):e13176. doi: 10.1016/j.heliyon.2023.e13176. |
| url |
https://hdl.handle.net/20.500.12494/55129 https://doi.org/10.1016/j.heliyon.2023.e13176 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.references.none.fl_str_mv |
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García, ClaudiaOrozco, YeisonBetancur, AlejandraMoreno, Ana IsabelFuentes, KatherineLopera, AlexSuarez, OscarLobo, TatianaOssa, Edgar Alexander Peláez Vargas, AlejandroPaucar, Carlos2024-03-04T23:59:53Z2024-03-04T23:59:53Z2023-01-25Garcia C, Orozco Y, Betancur A, Moreno AI, Fuentes K, Lopera A, Suarez O, Lobo T, Ossa A, Peláez-Vargas A, Paucar C. Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration. Heliyon. 2023 Jan 25;9(2):e13176. doi: 10.1016/j.heliyon.2023.e13176.https://hdl.handle.net/20.500.12494/55129https://doi.org/10.1016/j.heliyon.2023.e13176The increase in critical bone diseases and defects in the world’s population increases the need for bone substitutes to restore form and function. Organic and inorganic scaffolds with antibacterial properties could provide advantages for bone regeneration. In this study, we obtained scaffolds of polycaprolactone (PCL) charged with calcium phosphates nanoparticles and impregnated with extracts of Colombian plants as an alternative for potential bone regeneration. Calcium phosphate nanoparticles were obtained via auto-combustion synthesis. The nanoparticles were incorporated into the PCL with a chemical dissolution-disperse process. The composite obtained was used to produce a filament to print Triply Periodic Minimal Surface (TPMS) based scaffolds. Such geometry facilitates cellular growth thanks to its interconnected porosity. The scaffolds were impregnated with extracts of Justicia cf colorifera (Acanthaceae), and Billia rosea (Sapindaceae) due to their ancestral medical applications. A physical and biological characterization was conducted. The process to print scaffolds with an enhanced geometry to facilitate the flux of biological fluids was successful. The scaffolds loaded with B. rosea showed strong antibacterial behavior, suggesting the presence of reported terpenoids with antibacterial properties. The approach used in this study evidenced promising prospects for bone defect repair.14 p.application/pdfengUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Odontología, Medellín y EnvigadoMedellínhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessCC0 1.0 Universalhttp://purl.org/coar/access_right/c_abf2https://www-sciencedirect-com.bbibliograficas.ucc.edu.co/science/article/pii/S2405844023003833610 - Medicina y saludScaffold3D- printingNatural extractsPolycaprolactoneCalcium phosphateFabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regenerationArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionD.S. Larionov, M.A. Kuzina, P.V. Evdokimov, A.V. Garshev, N.K. Orlov, V.I. 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