A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect. © 2016 Institut Pasteur

• Autores: Biasin M.; Sironi M.; Saulle I.; Pontremoli C.; Garziano M.; Cagliani R.; Trabattoni D.; Lo Caputo S.; Vichi F.; Mazzotta F.; Forni D.; Riva S.; Aguilar-Jimenez W.; Cedeño S.; Sanchez J.; Brander C.; Zapata Builes, Wildeman; Rugeles M.T.; Clerici M.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2017
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41509
• Acceso en línea: https://doi.org/10.1016/j.wem.2012.11.005; http://revistaeixo.ifb.edu.br/index.php/RevistaEixo/article/view/632; https://hdl.handle.net/20.500.12494/41509
• Palabra clave: HESN; HIV; Polymorphism; Resistance to infection,TIM-1
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb