HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
Although neutrophils are the first-line of host defense against infection and express a wide number of pattern recognition receptors (PRRs), the function of these PRRs, including Toll-like receptors (TLRs), in HIV-1 infection remains unclear. TLRs play an important role in innate immunity, and while...
- Autores:
-
Giraldo, D. M.
Hernández López, Juan Carlos
Velilla, P.
Urcuqui Inchima, S.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/49576
- Acceso en línea:
- https://doi.org/10.1007/s12026-015-8691-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955715365&doi=10.1007%2fs12026-015-8691-8&partnerID=40&md5=5a628bcc0748bf79ea96bc538962e831
https://hdl.handle.net/20.500.12494/49576
- Palabra clave:
- ARTICLE
AUTACOID
CELL CULTURE
CELL ISOLATION
CELL STIMULATION
CELLS, CULTURED
CONTROLLED STUDY
CYTOKINE
CYTOKINE RELEASE
CYTOKINES
GENE EXPRESSION REGULATION
GENETICS
HIV INFECTIONS
HIV-1
HUMAN
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
HUMANS
IMMUNE RESPONSE
IMMUNITY, INNATE
IMMUNOLOGY
INFLAMMATION MEDIATORS
INNATE IMMUNITY
LEUKOCYTE ACTIVATION
METABOLISM
MOLECULAR INTERACTION
NEUTROPHIL
NEUTROPHIL ACTIVATION
NEUTROPHILS
PRIORITY JOURNAL
PROTEIN EXPRESSION
PROTEIN FUNCTION
REACTIVE OXYGEN METABOLITE
REACTIVE OXYGEN SPECIES
TOLL LIKE RECEPTOR
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TOLL LIKE RECEPTOR 7
TOLL LIKE RECEPTOR 8
TOLL LIKE RECEPTOR AGONIST
TOLL-LIKE RECEPTORS
VIROLOGY
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
| Summary: | Although neutrophils are the first-line of host defense against infection and express a wide number of pattern recognition receptors (PRRs), the function of these PRRs, including Toll-like receptors (TLRs), in HIV-1 infection remains unclear. TLRs play an important role in innate immunity, and while their involvement in viral immune pathogenesis was recently proposed, little is known about their expression and function during the neutrophil response to HIV-1 exposure. Here, we have shown that freshly isolated human neutrophils from healthy donors exhibited altered TLR expression, which may affect their function, after being challenged with HIV-1, alone or in the presence of TLR agonists. TLRs may promote neutrophil activation, pro-inflammatory cytokine secretion, and the production of reactive oxygen species. To our knowledge, this study is the first demonstration of functional TLR expression on neutrophils in response to HIV-1 treatment, suggesting a possible neutrophil/HIV-1 interaction through TLRs. Although additional studies are required to confirm the function of TLRs in neutrophils, our data clearly suggest that they play a role in the regulation of innate immunity by neutrophils, which could be engaged in HIV-1 pathogenesis or host defense. © 2015, Springer Science+Business Media New York. |
|---|