Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
The spontaneous control of HIV replication in HIV-controllers underlines the importance of these subjects for exploring factors related to delayed progression. Several studies have revealed fewer immune alterations and effector mechanisms related to viral control, mainly in peripheral blood, in thes...
- Autores:
-
Gonzalez, S. M.
Taborda, N. A.
Correa, L. A.
Castro, G. A.
Hernández López, Juan Carlos
Montoya, C. J.
Rugeles, M. T.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/49559
- Acceso en línea:
- https://doi.org/10.1007/s12026-015-8775-5
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa0
https://hdl.handle.net/20.500.12494/49559
- Palabra clave:
- ACQUIRED IMMUNE DEFICIENCY SYNDROME
ANTIGEN EXPRESSION
APOPTOSIS
ARTICLE
CASPASE 3
CD38 ANTIGEN
CD4 LYMPHOCYTE COUNT
CLINICAL ARTICLE
CONTROLLED STUDY
DISEASE COURSE
HLA DR ANTIGEN
HUMAN
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIRUS
HUMAN TISSUE
IMMUNE RESPONSE
IMMUNOREGULATION
INFECTION CONTROL
INTESTINE LYMPHATIC TISSUE
INTESTINE MUCOSA
NONHUMAN
PHENOTYPE
PRIORITY JOURNAL
PROTEIN CLEAVAGE
PROTEIN EXPRESSION
REGULATORY T LYMPHOCYTE
RETINOID RELATED ORPHAN RECEPTOR GAMMA
T LYMPHOCYTE ACTIVATION
TH17 CELL
TRANSCRIPTION FACTOR
TRANSCRIPTION FACTOR FOXP3
VIRUS LOAD
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
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Gonzalez, S. M.Taborda, N. A.Correa, L. A.Castro, G. A.Hernández López, Juan Carlos Montoya, C. J.Rugeles, M. T.2023-05-24T16:21:31Z2023-05-24T16:21:31Z01/01/2016https://doi.org/10.1007/s12026-015-8775-5https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa00257277Xhttps://hdl.handle.net/20.500.12494/49559Gonzalez S.M.,Taborda N.A.,Correa L.A.,Castro G.A.,Hernandez Lopez Juan carlos,Montoya C.J.,Rugeles M.T..Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS.IMMUNOL RES. 2016. 64. (3):p. 765-774The spontaneous control of HIV replication in HIV-controllers underlines the importance of these subjects for exploring factors related to delayed progression. Several studies have revealed fewer immune alterations and effector mechanisms related to viral control, mainly in peripheral blood, in these individuals compared to normal progressors. However, immune characterization of gut-associated lymphoid tissue (GALT), the major target of infection, has not been thoroughly explored in these subjects. We evaluated the following parameters in GALT samples from 11 HIV-controllers and 15 HIV-progressors: (i) frequency and activation phenotype of T cells; (ii) expression of transcription factors associated with immune response profiles; and (iii) frequency of apoptotic cells. Interestingly, HIV-controllers exhibited a particular activation phenotype, with predominance of T cells expressing HLA-DR but not CD38 in GALT. This phenotype, previously associated with better control of infection, was correlated with low viral load and higher CD4+ T cell count. Furthermore, a positive correlation of this activation phenotype with higher expression of Foxp3 and ROR?T transcription factors suggested a key role for Treg and Th17 cells in the control of the immune activation and in the maintenance of gut mucosal integrity. Although we evaluated apoptosis by measuring expression of cleaved caspase-3 in GALT, we did not find differences between HIV-controllers and HIV-progressors. Taken together, our findings suggest that predominance of HLA-DR+ T cells, along with lower immune activation and higher expression of transcription factors required for the development of Treg and Th17 cells, is associated with better viral control and delayed progression to AIDS. © 2015, Springer Science+Business Media New York.0000-0002-9200-5698juanc.hernandezl@campusucc.edu.co765-774Humana Press Inc.ACQUIRED IMMUNE DEFICIENCY SYNDROMEANTIGEN EXPRESSIONAPOPTOSISARTICLECASPASE 3CD38 ANTIGENCD4 LYMPHOCYTE COUNTCLINICAL ARTICLECONTROLLED STUDYDISEASE COURSEHLA DR ANTIGENHUMANHUMAN CELLHUMAN IMMUNODEFICIENCY VIRUSHUMAN TISSUEIMMUNE RESPONSEIMMUNOREGULATIONINFECTION CONTROLINTESTINE LYMPHATIC TISSUEINTESTINE MUCOSANONHUMANPHENOTYPEPRIORITY JOURNALPROTEIN CLEAVAGEPROTEIN EXPRESSIONREGULATORY T LYMPHOCYTERETINOID RELATED ORPHAN RECEPTOR GAMMAT LYMPHOCYTE ACTIVATIONTH17 CELLTRANSCRIPTION FACTORTRANSCRIPTION FACTOR FOXP3VIRUS LOADParticular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDSArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionIMMUNOL RESinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49559oai:repository.ucc.edu.co:20.500.12494/495592024-08-20 16:18:48.651metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS |
title |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS |
spellingShingle |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS ACQUIRED IMMUNE DEFICIENCY SYNDROME ANTIGEN EXPRESSION APOPTOSIS ARTICLE CASPASE 3 CD38 ANTIGEN CD4 LYMPHOCYTE COUNT CLINICAL ARTICLE CONTROLLED STUDY DISEASE COURSE HLA DR ANTIGEN HUMAN HUMAN CELL HUMAN IMMUNODEFICIENCY VIRUS HUMAN TISSUE IMMUNE RESPONSE IMMUNOREGULATION INFECTION CONTROL INTESTINE LYMPHATIC TISSUE INTESTINE MUCOSA NONHUMAN PHENOTYPE PRIORITY JOURNAL PROTEIN CLEAVAGE PROTEIN EXPRESSION REGULATORY T LYMPHOCYTE RETINOID RELATED ORPHAN RECEPTOR GAMMA T LYMPHOCYTE ACTIVATION TH17 CELL TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR FOXP3 VIRUS LOAD |
title_short |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS |
title_full |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS |
title_fullStr |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS |
title_full_unstemmed |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS |
title_sort |
Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS |
dc.creator.fl_str_mv |
Gonzalez, S. M. Taborda, N. A. Correa, L. A. Castro, G. A. Hernández López, Juan Carlos Montoya, C. J. Rugeles, M. T. |
dc.contributor.author.none.fl_str_mv |
Gonzalez, S. M. Taborda, N. A. Correa, L. A. Castro, G. A. Hernández López, Juan Carlos Montoya, C. J. Rugeles, M. T. |
dc.subject.spa.fl_str_mv |
ACQUIRED IMMUNE DEFICIENCY SYNDROME ANTIGEN EXPRESSION APOPTOSIS ARTICLE CASPASE 3 CD38 ANTIGEN CD4 LYMPHOCYTE COUNT CLINICAL ARTICLE CONTROLLED STUDY DISEASE COURSE HLA DR ANTIGEN HUMAN HUMAN CELL HUMAN IMMUNODEFICIENCY VIRUS HUMAN TISSUE IMMUNE RESPONSE IMMUNOREGULATION INFECTION CONTROL INTESTINE LYMPHATIC TISSUE INTESTINE MUCOSA NONHUMAN PHENOTYPE PRIORITY JOURNAL PROTEIN CLEAVAGE PROTEIN EXPRESSION REGULATORY T LYMPHOCYTE RETINOID RELATED ORPHAN RECEPTOR GAMMA T LYMPHOCYTE ACTIVATION TH17 CELL TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR FOXP3 VIRUS LOAD |
topic |
ACQUIRED IMMUNE DEFICIENCY SYNDROME ANTIGEN EXPRESSION APOPTOSIS ARTICLE CASPASE 3 CD38 ANTIGEN CD4 LYMPHOCYTE COUNT CLINICAL ARTICLE CONTROLLED STUDY DISEASE COURSE HLA DR ANTIGEN HUMAN HUMAN CELL HUMAN IMMUNODEFICIENCY VIRUS HUMAN TISSUE IMMUNE RESPONSE IMMUNOREGULATION INFECTION CONTROL INTESTINE LYMPHATIC TISSUE INTESTINE MUCOSA NONHUMAN PHENOTYPE PRIORITY JOURNAL PROTEIN CLEAVAGE PROTEIN EXPRESSION REGULATORY T LYMPHOCYTE RETINOID RELATED ORPHAN RECEPTOR GAMMA T LYMPHOCYTE ACTIVATION TH17 CELL TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR FOXP3 VIRUS LOAD |
description |
The spontaneous control of HIV replication in HIV-controllers underlines the importance of these subjects for exploring factors related to delayed progression. Several studies have revealed fewer immune alterations and effector mechanisms related to viral control, mainly in peripheral blood, in these individuals compared to normal progressors. However, immune characterization of gut-associated lymphoid tissue (GALT), the major target of infection, has not been thoroughly explored in these subjects. We evaluated the following parameters in GALT samples from 11 HIV-controllers and 15 HIV-progressors: (i) frequency and activation phenotype of T cells; (ii) expression of transcription factors associated with immune response profiles; and (iii) frequency of apoptotic cells. Interestingly, HIV-controllers exhibited a particular activation phenotype, with predominance of T cells expressing HLA-DR but not CD38 in GALT. This phenotype, previously associated with better control of infection, was correlated with low viral load and higher CD4+ T cell count. Furthermore, a positive correlation of this activation phenotype with higher expression of Foxp3 and ROR?T transcription factors suggested a key role for Treg and Th17 cells in the control of the immune activation and in the maintenance of gut mucosal integrity. Although we evaluated apoptosis by measuring expression of cleaved caspase-3 in GALT, we did not find differences between HIV-controllers and HIV-progressors. Taken together, our findings suggest that predominance of HLA-DR+ T cells, along with lower immune activation and higher expression of transcription factors required for the development of Treg and Th17 cells, is associated with better viral control and delayed progression to AIDS. © 2015, Springer Science+Business Media New York. |
publishDate |
2023 |
dc.date.issued.none.fl_str_mv |
01/01/2016 |
dc.date.accessioned.none.fl_str_mv |
2023-05-24T16:21:31Z |
dc.date.available.none.fl_str_mv |
2023-05-24T16:21:31Z |
dc.type.none.fl_str_mv |
Artículo |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://doi.org/10.1007/s12026-015-8775-5 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa0 |
dc.identifier.issn.spa.fl_str_mv |
0257277X |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/49559 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Gonzalez S.M.,Taborda N.A.,Correa L.A.,Castro G.A.,Hernandez Lopez Juan carlos,Montoya C.J.,Rugeles M.T..Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS.IMMUNOL RES. 2016. 64. (3):p. 765-774 |
url |
https://doi.org/10.1007/s12026-015-8775-5 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa0 https://hdl.handle.net/20.500.12494/49559 |
identifier_str_mv |
0257277X Gonzalez S.M.,Taborda N.A.,Correa L.A.,Castro G.A.,Hernandez Lopez Juan carlos,Montoya C.J.,Rugeles M.T..Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS.IMMUNOL RES. 2016. 64. (3):p. 765-774 |
dc.relation.ispartofjournal.spa.fl_str_mv |
IMMUNOL RES |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.spa.fl_str_mv |
765-774 |
dc.publisher.spa.fl_str_mv |
Humana Press Inc. |
institution |
Universidad Cooperativa de Colombia |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1814246893243334656 |