Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS

The spontaneous control of HIV replication in HIV-controllers underlines the importance of these subjects for exploring factors related to delayed progression. Several studies have revealed fewer immune alterations and effector mechanisms related to viral control, mainly in peripheral blood, in thes...

Full description

Autores:
Gonzalez, S. M.
Taborda, N. A.
Correa, L. A.
Castro, G. A.
Hernández López, Juan Carlos
Montoya, C. J.
Rugeles, M. T.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49559
Acceso en línea:
https://doi.org/10.1007/s12026-015-8775-5
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa0
https://hdl.handle.net/20.500.12494/49559
Palabra clave:
ACQUIRED IMMUNE DEFICIENCY SYNDROME
ANTIGEN EXPRESSION
APOPTOSIS
ARTICLE
CASPASE 3
CD38 ANTIGEN
CD4 LYMPHOCYTE COUNT
CLINICAL ARTICLE
CONTROLLED STUDY
DISEASE COURSE
HLA DR ANTIGEN
HUMAN
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIRUS
HUMAN TISSUE
IMMUNE RESPONSE
IMMUNOREGULATION
INFECTION CONTROL
INTESTINE LYMPHATIC TISSUE
INTESTINE MUCOSA
NONHUMAN
PHENOTYPE
PRIORITY JOURNAL
PROTEIN CLEAVAGE
PROTEIN EXPRESSION
REGULATORY T LYMPHOCYTE
RETINOID RELATED ORPHAN RECEPTOR GAMMA
T LYMPHOCYTE ACTIVATION
TH17 CELL
TRANSCRIPTION FACTOR
TRANSCRIPTION FACTOR FOXP3
VIRUS LOAD
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_d9bb843a635c8d54b2abd3192a86bea7
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49559
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Gonzalez, S. M.Taborda, N. A.Correa, L. A.Castro, G. A.Hernández López, Juan Carlos Montoya, C. J.Rugeles, M. T.2023-05-24T16:21:31Z2023-05-24T16:21:31Z01/01/2016https://doi.org/10.1007/s12026-015-8775-5https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa00257277Xhttps://hdl.handle.net/20.500.12494/49559Gonzalez S.M.,Taborda N.A.,Correa L.A.,Castro G.A.,Hernandez Lopez Juan carlos,Montoya C.J.,Rugeles M.T..Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS.IMMUNOL RES. 2016. 64. (3):p. 765-774The spontaneous control of HIV replication in HIV-controllers underlines the importance of these subjects for exploring factors related to delayed progression. Several studies have revealed fewer immune alterations and effector mechanisms related to viral control, mainly in peripheral blood, in these individuals compared to normal progressors. However, immune characterization of gut-associated lymphoid tissue (GALT), the major target of infection, has not been thoroughly explored in these subjects. We evaluated the following parameters in GALT samples from 11 HIV-controllers and 15 HIV-progressors: (i) frequency and activation phenotype of T cells; (ii) expression of transcription factors associated with immune response profiles; and (iii) frequency of apoptotic cells. Interestingly, HIV-controllers exhibited a particular activation phenotype, with predominance of T cells expressing HLA-DR but not CD38 in GALT. This phenotype, previously associated with better control of infection, was correlated with low viral load and higher CD4+ T cell count. Furthermore, a positive correlation of this activation phenotype with higher expression of Foxp3 and ROR?T transcription factors suggested a key role for Treg and Th17 cells in the control of the immune activation and in the maintenance of gut mucosal integrity. Although we evaluated apoptosis by measuring expression of cleaved caspase-3 in GALT, we did not find differences between HIV-controllers and HIV-progressors. Taken together, our findings suggest that predominance of HLA-DR+ T cells, along with lower immune activation and higher expression of transcription factors required for the development of Treg and Th17 cells, is associated with better viral control and delayed progression to AIDS. © 2015, Springer Science+Business Media New York.0000-0002-9200-5698juanc.hernandezl@campusucc.edu.co765-774Humana Press Inc.ACQUIRED IMMUNE DEFICIENCY SYNDROMEANTIGEN EXPRESSIONAPOPTOSISARTICLECASPASE 3CD38 ANTIGENCD4 LYMPHOCYTE COUNTCLINICAL ARTICLECONTROLLED STUDYDISEASE COURSEHLA DR ANTIGENHUMANHUMAN CELLHUMAN IMMUNODEFICIENCY VIRUSHUMAN TISSUEIMMUNE RESPONSEIMMUNOREGULATIONINFECTION CONTROLINTESTINE LYMPHATIC TISSUEINTESTINE MUCOSANONHUMANPHENOTYPEPRIORITY JOURNALPROTEIN CLEAVAGEPROTEIN EXPRESSIONREGULATORY T LYMPHOCYTERETINOID RELATED ORPHAN RECEPTOR GAMMAT LYMPHOCYTE ACTIVATIONTH17 CELLTRANSCRIPTION FACTORTRANSCRIPTION FACTOR FOXP3VIRUS LOADParticular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDSArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionIMMUNOL RESinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49559oai:repository.ucc.edu.co:20.500.12494/495592024-08-20 16:18:48.651metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
title Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
spellingShingle Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
ACQUIRED IMMUNE DEFICIENCY SYNDROME
ANTIGEN EXPRESSION
APOPTOSIS
ARTICLE
CASPASE 3
CD38 ANTIGEN
CD4 LYMPHOCYTE COUNT
CLINICAL ARTICLE
CONTROLLED STUDY
DISEASE COURSE
HLA DR ANTIGEN
HUMAN
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIRUS
HUMAN TISSUE
IMMUNE RESPONSE
IMMUNOREGULATION
INFECTION CONTROL
INTESTINE LYMPHATIC TISSUE
INTESTINE MUCOSA
NONHUMAN
PHENOTYPE
PRIORITY JOURNAL
PROTEIN CLEAVAGE
PROTEIN EXPRESSION
REGULATORY T LYMPHOCYTE
RETINOID RELATED ORPHAN RECEPTOR GAMMA
T LYMPHOCYTE ACTIVATION
TH17 CELL
TRANSCRIPTION FACTOR
TRANSCRIPTION FACTOR FOXP3
VIRUS LOAD
title_short Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
title_full Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
title_fullStr Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
title_full_unstemmed Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
title_sort Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS
dc.creator.fl_str_mv Gonzalez, S. M.
Taborda, N. A.
Correa, L. A.
Castro, G. A.
Hernández López, Juan Carlos
Montoya, C. J.
Rugeles, M. T.
dc.contributor.author.none.fl_str_mv Gonzalez, S. M.
Taborda, N. A.
Correa, L. A.
Castro, G. A.
Hernández López, Juan Carlos
Montoya, C. J.
Rugeles, M. T.
dc.subject.spa.fl_str_mv ACQUIRED IMMUNE DEFICIENCY SYNDROME
ANTIGEN EXPRESSION
APOPTOSIS
ARTICLE
CASPASE 3
CD38 ANTIGEN
CD4 LYMPHOCYTE COUNT
CLINICAL ARTICLE
CONTROLLED STUDY
DISEASE COURSE
HLA DR ANTIGEN
HUMAN
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIRUS
HUMAN TISSUE
IMMUNE RESPONSE
IMMUNOREGULATION
INFECTION CONTROL
INTESTINE LYMPHATIC TISSUE
INTESTINE MUCOSA
NONHUMAN
PHENOTYPE
PRIORITY JOURNAL
PROTEIN CLEAVAGE
PROTEIN EXPRESSION
REGULATORY T LYMPHOCYTE
RETINOID RELATED ORPHAN RECEPTOR GAMMA
T LYMPHOCYTE ACTIVATION
TH17 CELL
TRANSCRIPTION FACTOR
TRANSCRIPTION FACTOR FOXP3
VIRUS LOAD
topic ACQUIRED IMMUNE DEFICIENCY SYNDROME
ANTIGEN EXPRESSION
APOPTOSIS
ARTICLE
CASPASE 3
CD38 ANTIGEN
CD4 LYMPHOCYTE COUNT
CLINICAL ARTICLE
CONTROLLED STUDY
DISEASE COURSE
HLA DR ANTIGEN
HUMAN
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIRUS
HUMAN TISSUE
IMMUNE RESPONSE
IMMUNOREGULATION
INFECTION CONTROL
INTESTINE LYMPHATIC TISSUE
INTESTINE MUCOSA
NONHUMAN
PHENOTYPE
PRIORITY JOURNAL
PROTEIN CLEAVAGE
PROTEIN EXPRESSION
REGULATORY T LYMPHOCYTE
RETINOID RELATED ORPHAN RECEPTOR GAMMA
T LYMPHOCYTE ACTIVATION
TH17 CELL
TRANSCRIPTION FACTOR
TRANSCRIPTION FACTOR FOXP3
VIRUS LOAD
description The spontaneous control of HIV replication in HIV-controllers underlines the importance of these subjects for exploring factors related to delayed progression. Several studies have revealed fewer immune alterations and effector mechanisms related to viral control, mainly in peripheral blood, in these individuals compared to normal progressors. However, immune characterization of gut-associated lymphoid tissue (GALT), the major target of infection, has not been thoroughly explored in these subjects. We evaluated the following parameters in GALT samples from 11 HIV-controllers and 15 HIV-progressors: (i) frequency and activation phenotype of T cells; (ii) expression of transcription factors associated with immune response profiles; and (iii) frequency of apoptotic cells. Interestingly, HIV-controllers exhibited a particular activation phenotype, with predominance of T cells expressing HLA-DR but not CD38 in GALT. This phenotype, previously associated with better control of infection, was correlated with low viral load and higher CD4+ T cell count. Furthermore, a positive correlation of this activation phenotype with higher expression of Foxp3 and ROR?T transcription factors suggested a key role for Treg and Th17 cells in the control of the immune activation and in the maintenance of gut mucosal integrity. Although we evaluated apoptosis by measuring expression of cleaved caspase-3 in GALT, we did not find differences between HIV-controllers and HIV-progressors. Taken together, our findings suggest that predominance of HLA-DR+ T cells, along with lower immune activation and higher expression of transcription factors required for the development of Treg and Th17 cells, is associated with better viral control and delayed progression to AIDS. © 2015, Springer Science+Business Media New York.
publishDate 2023
dc.date.issued.none.fl_str_mv 01/01/2016
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:21:31Z
dc.date.available.none.fl_str_mv 2023-05-24T16:21:31Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1007/s12026-015-8775-5
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa0
dc.identifier.issn.spa.fl_str_mv 0257277X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49559
dc.identifier.bibliographicCitation.spa.fl_str_mv Gonzalez S.M.,Taborda N.A.,Correa L.A.,Castro G.A.,Hernandez Lopez Juan carlos,Montoya C.J.,Rugeles M.T..Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS.IMMUNOL RES. 2016. 64. (3):p. 765-774
url https://doi.org/10.1007/s12026-015-8775-5
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952658886&doi=10.1007%2fs12026-015-8775-5&partnerID=40&md5=482e231d6fb337e67890b2d58285aaa0
https://hdl.handle.net/20.500.12494/49559
identifier_str_mv 0257277X
Gonzalez S.M.,Taborda N.A.,Correa L.A.,Castro G.A.,Hernandez Lopez Juan carlos,Montoya C.J.,Rugeles M.T..Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS.IMMUNOL RES. 2016. 64. (3):p. 765-774
dc.relation.ispartofjournal.spa.fl_str_mv IMMUNOL RES
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 765-774
dc.publisher.spa.fl_str_mv Humana Press Inc.
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814246893243334656