HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression

Although neutrophils are the first-line of host defense against infection and express a wide number of pattern recognition receptors (PRRs), the function of these PRRs, including Toll-like receptors (TLRs), in HIV-1 infection remains unclear. TLRs play an important role in innate immunity, and while...

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Autores:: Giraldo D.M.
Hernández López, Juan Carlos
Velilla P.
Urcuqui-Inchima S.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2016

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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repository_id_str
spelling	Giraldo D.M.Hernández López, Juan Carlos Velilla P.Urcuqui-Inchima S.2021-12-16T22:15:29Z2021-12-16T22:15:29Z2016https://doi.org/10.1007/s13320-014-0210-3https://revistas.ucc.edu.co/index.php/od/article/view/25960257277Xhttps://hdl.handle.net/20.500.12494/41394Giraldo DM,Hernandez JC,Velilla P,Urcuqui S. HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression. IMMUNOL RES. 2016. 64. (1):p. 93-103. .Although neutrophils are the first-line of host defense against infection and express a wide number of pattern recognition receptors (PRRs), the function of these PRRs, including Toll-like receptors (TLRs), in HIV-1 infection remains unclear. TLRs play an important role in innate immunity, and while their involvement in viral immune pathogenesis was recently proposed, little is known about their expression and function during the neutrophil response to HIV-1 exposure. Here, we have shown that freshly isolated human neutrophils from healthy donors exhibited altered TLR expression, which may affect their function, after being challenged with HIV-1, alone or in the presence of TLR agonists. TLRs may promote neutrophil activation, pro-inflammatory cytokine secretion, and the production of reactive oxygen species. To our knowledge, this study is the first demonstration of functional TLR expression on neutrophils in response to HIV-1 treatment, suggesting a possible neutrophil/HIV-1 interaction through TLRs. Although additional studies are required to confirm the function of TLRs in neutrophils, our data clearly suggest that they play a role in the regulation of innate immunity by neutrophils, which could be engaged in HIV-1 pathogenesis or host defense. © 2015, Springer Science+Business Media New York.0000-0002-9200-5698juanc.hernandezl@campusucc.edu.co103-93Humana Press Inc.cytokinereactive oxygen metabolitetoll like receptortoll like receptor 2toll like receptor 4toll like receptor 7toll like receptor 8toll like receptor agonistautacoidcytokinereactive oxygen metabolitetoll like receptorArticlecell isolationcell stimulationcontrolled studycytokine releasehumanhuman cellHuman immunodeficiency virus 1 infectionimmune responseleukocyte activationmolecular interactionpriority journalprotein expressionprotein functioncell culturegene expression regulationgeneticsHuman immunodeficiency virus 1Human immunodeficiency virus infectionimmunologyinnate immunityleukocyte activationmetabolismneutrophilvirologyCellsCulturedCytokinesGene Expression RegulationHIV InfectionsHIV-1HumansImmunityInnateInflammation MediatorsNeutrophil ActivationNeutrophilsReactive Oxygen SpeciesToll-Like ReceptorsHIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expressionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionIMMUNOL RESinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41394oai:repository.ucc.edu.co:20.500.12494/413942024-08-20 16:20:13.959metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
title	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
spellingShingle	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression cytokine reactive oxygen metabolite toll like receptor toll like receptor 2 toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor agonist autacoid cytokine reactive oxygen metabolite toll like receptor Article cell isolation cell stimulation controlled study cytokine release human human cell Human immunodeficiency virus 1 infection immune response leukocyte activation molecular interaction priority journal protein expression protein function cell culture gene expression regulation genetics Human immunodeficiency virus 1 Human immunodeficiency virus infection immunology innate immunity leukocyte activation metabolism neutrophil virology Cells Cultured Cytokines Gene Expression Regulation HIV Infections HIV-1 Humans Immunity Innate Inflammation Mediators Neutrophil Activation Neutrophils Reactive Oxygen Species Toll-Like Receptors
title_short	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
title_full	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
title_fullStr	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
title_full_unstemmed	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
title_sort	HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
dc.creator.fl_str_mv	Giraldo D.M. Hernández López, Juan Carlos Velilla P. Urcuqui-Inchima S.
dc.contributor.author.none.fl_str_mv	Giraldo D.M. Hernández López, Juan Carlos Velilla P. Urcuqui-Inchima S.
dc.subject.spa.fl_str_mv	cytokine reactive oxygen metabolite toll like receptor toll like receptor 2 toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor agonist autacoid cytokine reactive oxygen metabolite toll like receptor Article cell isolation cell stimulation controlled study cytokine release human human cell Human immunodeficiency virus 1 infection immune response leukocyte activation molecular interaction priority journal protein expression protein function cell culture gene expression regulation genetics Human immunodeficiency virus 1 Human immunodeficiency virus infection immunology innate immunity leukocyte activation metabolism neutrophil virology Cells Cultured Cytokines Gene Expression Regulation HIV Infections HIV-1 Humans Immunity Innate Inflammation Mediators Neutrophil Activation Neutrophils Reactive Oxygen Species Toll-Like Receptors
topic	cytokine reactive oxygen metabolite toll like receptor toll like receptor 2 toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor agonist autacoid cytokine reactive oxygen metabolite toll like receptor Article cell isolation cell stimulation controlled study cytokine release human human cell Human immunodeficiency virus 1 infection immune response leukocyte activation molecular interaction priority journal protein expression protein function cell culture gene expression regulation genetics Human immunodeficiency virus 1 Human immunodeficiency virus infection immunology innate immunity leukocyte activation metabolism neutrophil virology Cells Cultured Cytokines Gene Expression Regulation HIV Infections HIV-1 Humans Immunity Innate Inflammation Mediators Neutrophil Activation Neutrophils Reactive Oxygen Species Toll-Like Receptors
description	Although neutrophils are the first-line of host defense against infection and express a wide number of pattern recognition receptors (PRRs), the function of these PRRs, including Toll-like receptors (TLRs), in HIV-1 infection remains unclear. TLRs play an important role in innate immunity, and while their involvement in viral immune pathogenesis was recently proposed, little is known about their expression and function during the neutrophil response to HIV-1 exposure. Here, we have shown that freshly isolated human neutrophils from healthy donors exhibited altered TLR expression, which may affect their function, after being challenged with HIV-1, alone or in the presence of TLR agonists. TLRs may promote neutrophil activation, pro-inflammatory cytokine secretion, and the production of reactive oxygen species. To our knowledge, this study is the first demonstration of functional TLR expression on neutrophils in response to HIV-1 treatment, suggesting a possible neutrophil/HIV-1 interaction through TLRs. Although additional studies are required to confirm the function of TLRs in neutrophils, our data clearly suggest that they play a role in the regulation of innate immunity by neutrophils, which could be engaged in HIV-1 pathogenesis or host defense. © 2015, Springer Science+Business Media New York.
publishDate	2016
dc.date.issued.none.fl_str_mv	2016
dc.date.accessioned.none.fl_str_mv	2021-12-16T22:15:29Z
dc.date.available.none.fl_str_mv	2021-12-16T22:15:29Z
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.1007/s13320-014-0210-3 https://revistas.ucc.edu.co/index.php/od/article/view/2596
dc.identifier.issn.spa.fl_str_mv	0257277X
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/41394
dc.identifier.bibliographicCitation.spa.fl_str_mv	Giraldo DM,Hernandez JC,Velilla P,Urcuqui S. HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression. IMMUNOL RES. 2016. 64. (1):p. 93-103. .
url	https://doi.org/10.1007/s13320-014-0210-3 https://revistas.ucc.edu.co/index.php/od/article/view/2596 https://hdl.handle.net/20.500.12494/41394
identifier_str_mv	0257277X Giraldo DM,Hernandez JC,Velilla P,Urcuqui S. HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression. IMMUNOL RES. 2016. 64. (1):p. 93-103. .
dc.relation.ispartofjournal.spa.fl_str_mv	IMMUNOL RES
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/closedAccess
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dc.format.extent.spa.fl_str_mv	103-93
dc.publisher.spa.fl_str_mv	Humana Press Inc.
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
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HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression

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