Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study

The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic f...

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Autores:: Quintana Castillo, Juan Carlos
Vargas Muñoz, Leidy Johana
Segura C.
Estrada-Gómez S.
Bueno-Sánchez J.C.
Alarcón J.C.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2018

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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spelling	Quintana Castillo, Juan CarlosVargas Muñoz, Leidy JohanaSegura C.Estrada-Gómez S.Bueno-Sánchez J.C.Alarcón J.C.2021-12-16T22:16:35Z2021-12-16T22:16:35Z2018https://doi.org/10.6018/eglobal.16.2.255821https://www.tandfonline.com/doi/abs/10.1080/00319104.2011.58431120726651https://hdl.handle.net/20.500.12494/42877Quintana JC,Johanavargas L,Segura C,Estrada S,Bueno JC,Alarcón JC. Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study. Toxins (Basel). 2018. 10. (2):p. 1-12. .The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity. © 2018 by the authors.leidy.vargasmu@campusucc.edu.co12-1MDPI AGcrotaminecrotoxindisintegrinlectinserine proteinasesnake venomreptilian proteinsnake venomvenom antiserumamino acid sequenceArticleCrotalusCrotalus durissus cumanensiselectrophoresiselectrospray mass spectrometrynonhumanoxidationprotein analysisprotein isolationproteomicsreversed phase high performance liquid chromatographyWestern blottinganimalchemistryColombiaCrotalusimmunologyproteomicsAnimalsAntiveninsColombiaCrotalid VenomsCrotalusProteomicsReptilian ProteinsCharacterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic studyArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionToxinsinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/42877oai:repository.ucc.edu.co:20.500.12494/428772024-08-20 16:18:13.363metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
title	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
spellingShingle	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study crotamine crotoxin disintegrin lectin serine proteinase snake venom reptilian protein snake venom venom antiserum amino acid sequence Article Crotalus Crotalus durissus cumanensis electrophoresis electrospray mass spectrometry nonhuman oxidation protein analysis protein isolation proteomics reversed phase high performance liquid chromatography Western blotting animal chemistry Colombia Crotalus immunology proteomics Animals Antivenins Colombia Crotalid Venoms Crotalus Proteomics Reptilian Proteins
title_short	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
title_full	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
title_fullStr	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
title_full_unstemmed	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
title_sort	Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
dc.creator.fl_str_mv	Quintana Castillo, Juan Carlos Vargas Muñoz, Leidy Johana Segura C. Estrada-Gómez S. Bueno-Sánchez J.C. Alarcón J.C.
dc.contributor.author.none.fl_str_mv	Quintana Castillo, Juan Carlos Vargas Muñoz, Leidy Johana Segura C. Estrada-Gómez S. Bueno-Sánchez J.C. Alarcón J.C.
dc.subject.spa.fl_str_mv	crotamine crotoxin disintegrin lectin serine proteinase snake venom reptilian protein snake venom venom antiserum amino acid sequence Article Crotalus Crotalus durissus cumanensis electrophoresis electrospray mass spectrometry nonhuman oxidation protein analysis protein isolation proteomics reversed phase high performance liquid chromatography Western blotting animal chemistry Colombia Crotalus immunology proteomics Animals Antivenins Colombia Crotalid Venoms Crotalus Proteomics Reptilian Proteins
topic	crotamine crotoxin disintegrin lectin serine proteinase snake venom reptilian protein snake venom venom antiserum amino acid sequence Article Crotalus Crotalus durissus cumanensis electrophoresis electrospray mass spectrometry nonhuman oxidation protein analysis protein isolation proteomics reversed phase high performance liquid chromatography Western blotting animal chemistry Colombia Crotalus immunology proteomics Animals Antivenins Colombia Crotalid Venoms Crotalus Proteomics Reptilian Proteins
description	The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity. © 2018 by the authors.
publishDate	2018
dc.date.issued.none.fl_str_mv	2018
dc.date.accessioned.none.fl_str_mv	2021-12-16T22:16:35Z
dc.date.available.none.fl_str_mv	2021-12-16T22:16:35Z
dc.type.none.fl_str_mv	Artículo
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dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv	https://doi.org/10.6018/eglobal.16.2.255821 https://www.tandfonline.com/doi/abs/10.1080/00319104.2011.584311
dc.identifier.issn.spa.fl_str_mv	20726651
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/42877
dc.identifier.bibliographicCitation.spa.fl_str_mv	Quintana JC,Johanavargas L,Segura C,Estrada S,Bueno JC,Alarcón JC. Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study. Toxins (Basel). 2018. 10. (2):p. 1-12. .
url	https://doi.org/10.6018/eglobal.16.2.255821 https://www.tandfonline.com/doi/abs/10.1080/00319104.2011.584311 https://hdl.handle.net/20.500.12494/42877
identifier_str_mv	20726651 Quintana JC,Johanavargas L,Segura C,Estrada S,Bueno JC,Alarcón JC. Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study. Toxins (Basel). 2018. 10. (2):p. 1-12. .
dc.relation.ispartofjournal.spa.fl_str_mv	Toxins
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/closedAccess
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dc.format.extent.spa.fl_str_mv	12-1
dc.publisher.spa.fl_str_mv	MDPI AG
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
_version_	1814246838802317312

Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study

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