Study of Colombia North Wiwa El Encanto Amerindians HLA- genes: Pacific Islanders relatedness

We have studied Wiwa/Sanja Amerindians HLA-A, -B, -C, -DRB1 and DQB1 allele frequencies and extended haplotypes in 52 unrelated individuals from “El Encanto” town at Guanachaca riverside. High frequency alleles were in general present in other Amerindian populations. Also, three extended haplotypes and eight ones were respectively both “new found” and already described in Amerindians from North, Central and South America, including Lakota-Sioux, Mayas, Teeneks, Quechua and Aymaras. Analyses of HLA-A*24:02 and -C*01:02 Wiwa high frequency alleles suggested a specific relatedness with another Amerindian and Pacific Islander ethnic groups (these two particular alleles bearing in high frequencies); they include New Zealand Maoris, Taiwanese, Japanese, Papua New Guinea, and Samoans among others. This may indicate that selective forces are maintaining these two alleles high frequency within this wide American/Pacific area. © 2018

• Autores: Arnaiz-Villena A.; Palacio-Grüber J.; Juarez I.; Muñiz E.; Hernandez Aguirre, Enio; Bayona B.; Campos C.; Nuñez J.; Lopez-Nares A.; Martin-Villa M.; Silvera C.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/50335
• Acceso en línea: https://doi.org/10.1016/j.humimm.2018.04.016; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047297160&doi=10.1016%2fj.humimm.2018.04.016&partnerID=40&md5=1ed3aed9c6e50c72063a22a9cb45550f; https://hdl.handle.net/20.500.12494/50335
• Palabra clave: AMERICAN INDIAN; ARTICLE; AYMARA (PEOPLE); CENTRAL AMERICA; COLOMBIA; ETHNIC GROUP; ETHNIC GROUPS; GENE FREQUENCY; GENETIC RELATEDNESS; GENETICS; GENOTYPE; HAPLOTYPE; HAPLOTYPES; HISTOCOMPATIBILITY GENE; HISTOCOMPATIBILITY TEST; HISTOCOMPATIBILITY TESTING; HLA A ANTIGEN; HLA ANTIGEN; HLA ANTIGENS; HLA B ANTIGEN; HLA C ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; HUMAN; HUMANS; INDIANS, SOUTH AMERICAN; JAPANESE (PEOPLE); LAKOTA (PEOPLE); LINGUISTICS; MAORI (PEOPLE); MAYA (PEOPLE); NEW ZEALANDER; NORTH AMERICA; OCEANIC ANCESTRY GROUP; PACIFIC ISLANDER; PACIFIC ISLANDS; PAPUA NEW GUINEAN; PHYLOGENY; POPULATION; POPULATION GENETIC PARAMETERS; PRIORITY JOURNAL; QUECHUA (PEOPLE); SAMOAN (PEOPLE); SIOUX (PEOPLE); SOUTH AMERICA; TAIWANESE; TEENEK (PEOPLE)
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2