Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
Martinez-Bello,Vladimir E., Fabian Sanchis-Gomar, Daniel Martinez-Bello, Gloria Olaso-Gonzalez, Mari Carmen Gomez-Cabrera, and Jose Viña. Vitamin C Supplementation Does Not Improve Hypoxia-Induced Erythropoiesis. High Alt Med Biol 13:269-274, 2012. - Hypoxia induces reactive oxygen species productio...
- Autores:
-
Martínez Bello, Daniel Adyro
Sanchis-Gomar F.
Martinez-Bello D.
Olaso-Gonzalez G.
Gomez-Cabrera M.C.
Viña J.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2012
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/41729
- Acceso en línea:
- https://doi.org/10.15446/dyna.v81n186.39446
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f732
https://hdl.handle.net/20.500.12494/41729
- Palabra clave:
- ascorbic acid
erythropoietin
hemoglobin
malonaldehyde
article
controlled study
erythrocyte
erythrocyte count
erythropoiesis
hematocrit
hematological parameters
intermittent hypoxia
male
nonhuman
oxidative stress
priority journal
randomized controlled trial
rat
reticulocyte
vitamin supplementation
Animals
Anoxia
Antioxidants
Ascorbic Acid
Biological Markers
Blood Proteins
Dietary Supplements
Drug Administration Schedule
Erythropoiesis
Hematologic Tests
Male
Malondialdehyde
Oxidation-Reduction
Oxidative Stress
Random Allocation
Rats
Rats
Wistar
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb
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Martínez Bello, Daniel AdyroSanchis-Gomar F.Martinez-Bello D.Olaso-Gonzalez G.Gomez-Cabrera M.C.Viña J.2021-12-16T22:15:44Z2021-12-16T22:15:44Z2012https://doi.org/10.15446/dyna.v81n186.39446https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f73215270297https://hdl.handle.net/20.500.12494/41729Martinez VE,Sanchis F,Martinez D,Olaso G,Gomez MC,Viña J. Vitamin C supplementation does not improve hypoxia-induced erythropoiesis. HIGH ALT MED BIOL. 2012. 13. (4):p. 269-274. .Martinez-Bello,Vladimir E., Fabian Sanchis-Gomar, Daniel Martinez-Bello, Gloria Olaso-Gonzalez, Mari Carmen Gomez-Cabrera, and Jose Viña. Vitamin C Supplementation Does Not Improve Hypoxia-Induced Erythropoiesis. High Alt Med Biol 13:269-274, 2012. - Hypoxia induces reactive oxygen species production. Supplements with antioxidant mixtures can compensate for the decline in red cell membrane stability following intermittent hypobaric hypoxia by decreasing protein and lipid oxidation. We aimed to determine whether supplementation with vitamin C is implicated in the regulation of erythropoiesis and in the oxygen-carrying capacity of the blood, and also whether antioxidant supplementation prevents the oxidative stress associated to intermittent hypoxia. Twenty-four male Wistar rats were randomly divided into four experimental groups: normoxia control (n=6), normoxia + vitamin C (n=6), hypoxia control (12 h pO2 12%/12 h pO2 21%) (n=6), and hypoxia + vitamin C (n=6). Animals were supplemented with vitamin C at a dose of 250 mg kg-1 day-1 for 21 days. Red blood cell count, hemoglobin, hematocrit, reticulocytes, erythropoietin, and oxidative stress parameters such as malondialdehyde and protein oxidation in plasma were analyzed at two different time points: basal sample (day zero) and final sample (day 21). Similar RBC, Hb, Hct, and Epo increments were observed in both hypoxic groups regardless of the vitamin C supplementation. There was no change on MDA levels after intermittent hypoxic exposure in any experimental group. However, we found an increase in plasma protein oxidation in both hypoxic groups. Vitamin C does not affect erythropoiesis and protein oxidation in rats submitted to intermittent hypoxic exposure. © Copyright 2012, Mary Ann Liebert, Inc. 2012.274-269Mary Ann Liebert Inc.ascorbic aciderythropoietinhemoglobinmalonaldehydearticlecontrolled studyerythrocyteerythrocyte counterythropoiesishematocrithematological parametersintermittent hypoxiamalenonhumanoxidative stresspriority journalrandomized controlled trialratreticulocytevitamin supplementationAnimalsAnoxiaAntioxidantsAscorbic AcidBiological MarkersBlood ProteinsDietary SupplementsDrug Administration ScheduleErythropoiesisHematologic TestsMaleMalondialdehydeOxidation-ReductionOxidative StressRandom AllocationRatsRatsWistarVitamin C supplementation does not improve hypoxia-induced erythropoiesisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionHIGH ALT MED BIOLinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41729oai:repository.ucc.edu.co:20.500.12494/417292024-08-20 16:09:37.422metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis |
title |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis |
spellingShingle |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis ascorbic acid erythropoietin hemoglobin malonaldehyde article controlled study erythrocyte erythrocyte count erythropoiesis hematocrit hematological parameters intermittent hypoxia male nonhuman oxidative stress priority journal randomized controlled trial rat reticulocyte vitamin supplementation Animals Anoxia Antioxidants Ascorbic Acid Biological Markers Blood Proteins Dietary Supplements Drug Administration Schedule Erythropoiesis Hematologic Tests Male Malondialdehyde Oxidation-Reduction Oxidative Stress Random Allocation Rats Rats Wistar |
title_short |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis |
title_full |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis |
title_fullStr |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis |
title_full_unstemmed |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis |
title_sort |
Vitamin C supplementation does not improve hypoxia-induced erythropoiesis |
dc.creator.fl_str_mv |
Martínez Bello, Daniel Adyro Sanchis-Gomar F. Martinez-Bello D. Olaso-Gonzalez G. Gomez-Cabrera M.C. Viña J. |
dc.contributor.author.none.fl_str_mv |
Martínez Bello, Daniel Adyro Sanchis-Gomar F. Martinez-Bello D. Olaso-Gonzalez G. Gomez-Cabrera M.C. Viña J. |
dc.subject.spa.fl_str_mv |
ascorbic acid erythropoietin hemoglobin malonaldehyde article controlled study erythrocyte erythrocyte count erythropoiesis hematocrit hematological parameters intermittent hypoxia male nonhuman oxidative stress priority journal randomized controlled trial rat reticulocyte vitamin supplementation Animals Anoxia Antioxidants Ascorbic Acid Biological Markers Blood Proteins Dietary Supplements Drug Administration Schedule Erythropoiesis Hematologic Tests Male Malondialdehyde Oxidation-Reduction Oxidative Stress Random Allocation Rats Rats Wistar |
topic |
ascorbic acid erythropoietin hemoglobin malonaldehyde article controlled study erythrocyte erythrocyte count erythropoiesis hematocrit hematological parameters intermittent hypoxia male nonhuman oxidative stress priority journal randomized controlled trial rat reticulocyte vitamin supplementation Animals Anoxia Antioxidants Ascorbic Acid Biological Markers Blood Proteins Dietary Supplements Drug Administration Schedule Erythropoiesis Hematologic Tests Male Malondialdehyde Oxidation-Reduction Oxidative Stress Random Allocation Rats Rats Wistar |
description |
Martinez-Bello,Vladimir E., Fabian Sanchis-Gomar, Daniel Martinez-Bello, Gloria Olaso-Gonzalez, Mari Carmen Gomez-Cabrera, and Jose Viña. Vitamin C Supplementation Does Not Improve Hypoxia-Induced Erythropoiesis. High Alt Med Biol 13:269-274, 2012. - Hypoxia induces reactive oxygen species production. Supplements with antioxidant mixtures can compensate for the decline in red cell membrane stability following intermittent hypobaric hypoxia by decreasing protein and lipid oxidation. We aimed to determine whether supplementation with vitamin C is implicated in the regulation of erythropoiesis and in the oxygen-carrying capacity of the blood, and also whether antioxidant supplementation prevents the oxidative stress associated to intermittent hypoxia. Twenty-four male Wistar rats were randomly divided into four experimental groups: normoxia control (n=6), normoxia + vitamin C (n=6), hypoxia control (12 h pO2 12%/12 h pO2 21%) (n=6), and hypoxia + vitamin C (n=6). Animals were supplemented with vitamin C at a dose of 250 mg kg-1 day-1 for 21 days. Red blood cell count, hemoglobin, hematocrit, reticulocytes, erythropoietin, and oxidative stress parameters such as malondialdehyde and protein oxidation in plasma were analyzed at two different time points: basal sample (day zero) and final sample (day 21). Similar RBC, Hb, Hct, and Epo increments were observed in both hypoxic groups regardless of the vitamin C supplementation. There was no change on MDA levels after intermittent hypoxic exposure in any experimental group. However, we found an increase in plasma protein oxidation in both hypoxic groups. Vitamin C does not affect erythropoiesis and protein oxidation in rats submitted to intermittent hypoxic exposure. © Copyright 2012, Mary Ann Liebert, Inc. 2012. |
publishDate |
2012 |
dc.date.issued.none.fl_str_mv |
2012 |
dc.date.accessioned.none.fl_str_mv |
2021-12-16T22:15:44Z |
dc.date.available.none.fl_str_mv |
2021-12-16T22:15:44Z |
dc.type.none.fl_str_mv |
Artículo |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://doi.org/10.15446/dyna.v81n186.39446 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f732 |
dc.identifier.issn.spa.fl_str_mv |
15270297 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/41729 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Martinez VE,Sanchis F,Martinez D,Olaso G,Gomez MC,Viña J. Vitamin C supplementation does not improve hypoxia-induced erythropoiesis. HIGH ALT MED BIOL. 2012. 13. (4):p. 269-274. . |
url |
https://doi.org/10.15446/dyna.v81n186.39446 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f732 https://hdl.handle.net/20.500.12494/41729 |
identifier_str_mv |
15270297 Martinez VE,Sanchis F,Martinez D,Olaso G,Gomez MC,Viña J. Vitamin C supplementation does not improve hypoxia-induced erythropoiesis. HIGH ALT MED BIOL. 2012. 13. (4):p. 269-274. . |
dc.relation.ispartofjournal.spa.fl_str_mv |
HIGH ALT MED BIOL |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/closedAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_14cb |
eu_rights_str_mv |
closedAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_14cb |
dc.format.extent.spa.fl_str_mv |
274-269 |
dc.publisher.spa.fl_str_mv |
Mary Ann Liebert Inc. |
institution |
Universidad Cooperativa de Colombia |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1814246514043650048 |