Vitamin C supplementation does not improve hypoxia-induced erythropoiesis

Martinez-Bello,Vladimir E., Fabian Sanchis-Gomar, Daniel Martinez-Bello, Gloria Olaso-Gonzalez, Mari Carmen Gomez-Cabrera, and Jose Viña. Vitamin C Supplementation Does Not Improve Hypoxia-Induced Erythropoiesis. High Alt Med Biol 13:269-274, 2012. - Hypoxia induces reactive oxygen species productio...

Full description

Autores:
Martínez Bello, Daniel Adyro
Sanchis-Gomar F.
Martinez-Bello D.
Olaso-Gonzalez G.
Gomez-Cabrera M.C.
Viña J.
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/41729
Acceso en línea:
https://doi.org/10.15446/dyna.v81n186.39446
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f732
https://hdl.handle.net/20.500.12494/41729
Palabra clave:
ascorbic acid
erythropoietin
hemoglobin
malonaldehyde
article
controlled study
erythrocyte
erythrocyte count
erythropoiesis
hematocrit
hematological parameters
intermittent hypoxia
male
nonhuman
oxidative stress
priority journal
randomized controlled trial
rat
reticulocyte
vitamin supplementation
Animals
Anoxia
Antioxidants
Ascorbic Acid
Biological Markers
Blood Proteins
Dietary Supplements
Drug Administration Schedule
Erythropoiesis
Hematologic Tests
Male
Malondialdehyde
Oxidation-Reduction
Oxidative Stress
Random Allocation
Rats
Rats
Wistar
Rights
closedAccess
License
http://purl.org/coar/access_right/c_14cb
id COOPER2_d59482258ea72888ebdee6f7acf90c21
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/41729
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Martínez Bello, Daniel AdyroSanchis-Gomar F.Martinez-Bello D.Olaso-Gonzalez G.Gomez-Cabrera M.C.Viña J.2021-12-16T22:15:44Z2021-12-16T22:15:44Z2012https://doi.org/10.15446/dyna.v81n186.39446https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f73215270297https://hdl.handle.net/20.500.12494/41729Martinez VE,Sanchis F,Martinez D,Olaso G,Gomez MC,Viña J. Vitamin C supplementation does not improve hypoxia-induced erythropoiesis. HIGH ALT MED BIOL. 2012. 13. (4):p. 269-274. .Martinez-Bello,Vladimir E., Fabian Sanchis-Gomar, Daniel Martinez-Bello, Gloria Olaso-Gonzalez, Mari Carmen Gomez-Cabrera, and Jose Viña. Vitamin C Supplementation Does Not Improve Hypoxia-Induced Erythropoiesis. High Alt Med Biol 13:269-274, 2012. - Hypoxia induces reactive oxygen species production. Supplements with antioxidant mixtures can compensate for the decline in red cell membrane stability following intermittent hypobaric hypoxia by decreasing protein and lipid oxidation. We aimed to determine whether supplementation with vitamin C is implicated in the regulation of erythropoiesis and in the oxygen-carrying capacity of the blood, and also whether antioxidant supplementation prevents the oxidative stress associated to intermittent hypoxia. Twenty-four male Wistar rats were randomly divided into four experimental groups: normoxia control (n=6), normoxia + vitamin C (n=6), hypoxia control (12 h pO2 12%/12 h pO2 21%) (n=6), and hypoxia + vitamin C (n=6). Animals were supplemented with vitamin C at a dose of 250 mg kg-1 day-1 for 21 days. Red blood cell count, hemoglobin, hematocrit, reticulocytes, erythropoietin, and oxidative stress parameters such as malondialdehyde and protein oxidation in plasma were analyzed at two different time points: basal sample (day zero) and final sample (day 21). Similar RBC, Hb, Hct, and Epo increments were observed in both hypoxic groups regardless of the vitamin C supplementation. There was no change on MDA levels after intermittent hypoxic exposure in any experimental group. However, we found an increase in plasma protein oxidation in both hypoxic groups. Vitamin C does not affect erythropoiesis and protein oxidation in rats submitted to intermittent hypoxic exposure. © Copyright 2012, Mary Ann Liebert, Inc. 2012.274-269Mary Ann Liebert Inc.ascorbic aciderythropoietinhemoglobinmalonaldehydearticlecontrolled studyerythrocyteerythrocyte counterythropoiesishematocrithematological parametersintermittent hypoxiamalenonhumanoxidative stresspriority journalrandomized controlled trialratreticulocytevitamin supplementationAnimalsAnoxiaAntioxidantsAscorbic AcidBiological MarkersBlood ProteinsDietary SupplementsDrug Administration ScheduleErythropoiesisHematologic TestsMaleMalondialdehydeOxidation-ReductionOxidative StressRandom AllocationRatsRatsWistarVitamin C supplementation does not improve hypoxia-induced erythropoiesisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionHIGH ALT MED BIOLinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41729oai:repository.ucc.edu.co:20.500.12494/417292024-08-20 16:09:37.422metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
title Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
spellingShingle Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
ascorbic acid
erythropoietin
hemoglobin
malonaldehyde
article
controlled study
erythrocyte
erythrocyte count
erythropoiesis
hematocrit
hematological parameters
intermittent hypoxia
male
nonhuman
oxidative stress
priority journal
randomized controlled trial
rat
reticulocyte
vitamin supplementation
Animals
Anoxia
Antioxidants
Ascorbic Acid
Biological Markers
Blood Proteins
Dietary Supplements
Drug Administration Schedule
Erythropoiesis
Hematologic Tests
Male
Malondialdehyde
Oxidation-Reduction
Oxidative Stress
Random Allocation
Rats
Rats
Wistar
title_short Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
title_full Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
title_fullStr Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
title_full_unstemmed Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
title_sort Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
dc.creator.fl_str_mv Martínez Bello, Daniel Adyro
Sanchis-Gomar F.
Martinez-Bello D.
Olaso-Gonzalez G.
Gomez-Cabrera M.C.
Viña J.
dc.contributor.author.none.fl_str_mv Martínez Bello, Daniel Adyro
Sanchis-Gomar F.
Martinez-Bello D.
Olaso-Gonzalez G.
Gomez-Cabrera M.C.
Viña J.
dc.subject.spa.fl_str_mv ascorbic acid
erythropoietin
hemoglobin
malonaldehyde
article
controlled study
erythrocyte
erythrocyte count
erythropoiesis
hematocrit
hematological parameters
intermittent hypoxia
male
nonhuman
oxidative stress
priority journal
randomized controlled trial
rat
reticulocyte
vitamin supplementation
Animals
Anoxia
Antioxidants
Ascorbic Acid
Biological Markers
Blood Proteins
Dietary Supplements
Drug Administration Schedule
Erythropoiesis
Hematologic Tests
Male
Malondialdehyde
Oxidation-Reduction
Oxidative Stress
Random Allocation
Rats
Rats
Wistar
topic ascorbic acid
erythropoietin
hemoglobin
malonaldehyde
article
controlled study
erythrocyte
erythrocyte count
erythropoiesis
hematocrit
hematological parameters
intermittent hypoxia
male
nonhuman
oxidative stress
priority journal
randomized controlled trial
rat
reticulocyte
vitamin supplementation
Animals
Anoxia
Antioxidants
Ascorbic Acid
Biological Markers
Blood Proteins
Dietary Supplements
Drug Administration Schedule
Erythropoiesis
Hematologic Tests
Male
Malondialdehyde
Oxidation-Reduction
Oxidative Stress
Random Allocation
Rats
Rats
Wistar
description Martinez-Bello,Vladimir E., Fabian Sanchis-Gomar, Daniel Martinez-Bello, Gloria Olaso-Gonzalez, Mari Carmen Gomez-Cabrera, and Jose Viña. Vitamin C Supplementation Does Not Improve Hypoxia-Induced Erythropoiesis. High Alt Med Biol 13:269-274, 2012. - Hypoxia induces reactive oxygen species production. Supplements with antioxidant mixtures can compensate for the decline in red cell membrane stability following intermittent hypobaric hypoxia by decreasing protein and lipid oxidation. We aimed to determine whether supplementation with vitamin C is implicated in the regulation of erythropoiesis and in the oxygen-carrying capacity of the blood, and also whether antioxidant supplementation prevents the oxidative stress associated to intermittent hypoxia. Twenty-four male Wistar rats were randomly divided into four experimental groups: normoxia control (n=6), normoxia + vitamin C (n=6), hypoxia control (12 h pO2 12%/12 h pO2 21%) (n=6), and hypoxia + vitamin C (n=6). Animals were supplemented with vitamin C at a dose of 250 mg kg-1 day-1 for 21 days. Red blood cell count, hemoglobin, hematocrit, reticulocytes, erythropoietin, and oxidative stress parameters such as malondialdehyde and protein oxidation in plasma were analyzed at two different time points: basal sample (day zero) and final sample (day 21). Similar RBC, Hb, Hct, and Epo increments were observed in both hypoxic groups regardless of the vitamin C supplementation. There was no change on MDA levels after intermittent hypoxic exposure in any experimental group. However, we found an increase in plasma protein oxidation in both hypoxic groups. Vitamin C does not affect erythropoiesis and protein oxidation in rats submitted to intermittent hypoxic exposure. © Copyright 2012, Mary Ann Liebert, Inc. 2012.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:15:44Z
dc.date.available.none.fl_str_mv 2021-12-16T22:15:44Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.15446/dyna.v81n186.39446
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f732
dc.identifier.issn.spa.fl_str_mv 15270297
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/41729
dc.identifier.bibliographicCitation.spa.fl_str_mv Martinez VE,Sanchis F,Martinez D,Olaso G,Gomez MC,Viña J. Vitamin C supplementation does not improve hypoxia-induced erythropoiesis. HIGH ALT MED BIOL. 2012. 13. (4):p. 269-274. .
url https://doi.org/10.15446/dyna.v81n186.39446
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053604160&doi=10.15448%2f1984-7289.2018.2.29593&partnerID=40&md5=7b84729ef8736afb88c761c384f8f732
https://hdl.handle.net/20.500.12494/41729
identifier_str_mv 15270297
Martinez VE,Sanchis F,Martinez D,Olaso G,Gomez MC,Viña J. Vitamin C supplementation does not improve hypoxia-induced erythropoiesis. HIGH ALT MED BIOL. 2012. 13. (4):p. 269-274. .
dc.relation.ispartofjournal.spa.fl_str_mv HIGH ALT MED BIOL
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv 274-269
dc.publisher.spa.fl_str_mv Mary Ann Liebert Inc.
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814246514043650048