Overcoming research barriers in Chagas disease—designing effective implementation science

Chagas disease remains a substantial source of morbidity and mortality in Latin America. The Pan American Health Organization estimates that 8 million people are infected in this part of the world ( Uruguay (2006). In the United States, which has high rates of Hispanic immigration, about 300,000 peo...

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Autores:
Henao Martínez, Andrés
Colborn, Kathryn
Parra Henao, Gabriel
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/945
Acceso en línea:
https://hdl.handle.net/20.500.12494/945
Palabra clave:
Chagas
Implementation science
Health policies
Rights
openAccess
License
Licencia CC
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dc.title.spa.fl_str_mv Overcoming research barriers in Chagas disease—designing effective implementation science
title Overcoming research barriers in Chagas disease—designing effective implementation science
spellingShingle Overcoming research barriers in Chagas disease—designing effective implementation science
Chagas
Implementation science
Health policies
title_short Overcoming research barriers in Chagas disease—designing effective implementation science
title_full Overcoming research barriers in Chagas disease—designing effective implementation science
title_fullStr Overcoming research barriers in Chagas disease—designing effective implementation science
title_full_unstemmed Overcoming research barriers in Chagas disease—designing effective implementation science
title_sort Overcoming research barriers in Chagas disease—designing effective implementation science
dc.creator.fl_str_mv Henao Martínez, Andrés
Colborn, Kathryn
Parra Henao, Gabriel
dc.contributor.author.none.fl_str_mv Henao Martínez, Andrés
Colborn, Kathryn
Parra Henao, Gabriel
dc.subject.spa.fl_str_mv Chagas
Implementation science
Health policies
topic Chagas
Implementation science
Health policies
description Chagas disease remains a substantial source of morbidity and mortality in Latin America. The Pan American Health Organization estimates that 8 million people are infected in this part of the world ( Uruguay (2006). In the United States, which has high rates of Hispanic immigration, about 300,000 people are infected (Bern and Montgomery 2009; Kuehn 2015). Chagas transmission occurs mainly through contact with a triatomine or the Bkissing bug^ which carries the parasite, Trypanosoma cruzi. Transmission also occurs orally through food contamination with vector’s feces, vertically (perinatal), from organ donation and blood transfusion. Acute infections may be associated with fever or swelling around the site of the inoculation. Parasites can be detected in the blood for a few weeks following initial infection. If patients are not treated, they can develop severe medical complications, and this happens in about 20–30 % of those infected. These complications typically present as cardiac abnormalities and can lead to death (Morillo et al. 2015).
publishDate 2016
dc.date.issued.none.fl_str_mv 2016-10-23
dc.date.accessioned.none.fl_str_mv 2017-08-09T00:44:45Z
dc.date.available.none.fl_str_mv 2017-08-09T00:44:45Z
dc.type.none.fl_str_mv Artículo
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/945
dc.identifier.bibliographicCitation.spa.fl_str_mv Henao Martínez, A., Colborn, K., Parra Henao, G. . (2016). Overcoming research barriers in Chagas disease—designing . Santa Marta: Universidad Cooperativa de Colombia
url https://hdl.handle.net/20.500.12494/945
identifier_str_mv Henao Martínez, A., Colborn, K., Parra Henao, G. . (2016). Overcoming research barriers in Chagas disease—designing . Santa Marta: Universidad Cooperativa de Colombia
dc.relation.isversionof.spa.fl_str_mv https://www.researchgate.net/publication/309381920
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eu_rights_str_mv openAccess
dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Santa Marta, Colombia, 00000
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.place.spa.fl_str_mv Santa Marta
institution Universidad Cooperativa de Colombia
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spelling Henao Martínez, AndrésColborn, KathrynParra Henao, Gabriel2017-08-09T00:44:45Z2017-08-09T00:44:45Z2016-10-23https://hdl.handle.net/20.500.12494/945Henao Martínez, A., Colborn, K., Parra Henao, G. . (2016). Overcoming research barriers in Chagas disease—designing . Santa Marta: Universidad Cooperativa de ColombiaChagas disease remains a substantial source of morbidity and mortality in Latin America. The Pan American Health Organization estimates that 8 million people are infected in this part of the world ( Uruguay (2006). In the United States, which has high rates of Hispanic immigration, about 300,000 people are infected (Bern and Montgomery 2009; Kuehn 2015). Chagas transmission occurs mainly through contact with a triatomine or the Bkissing bug^ which carries the parasite, Trypanosoma cruzi. Transmission also occurs orally through food contamination with vector’s feces, vertically (perinatal), from organ donation and blood transfusion. Acute infections may be associated with fever or swelling around the site of the inoculation. Parasites can be detected in the blood for a few weeks following initial infection. If patients are not treated, they can develop severe medical complications, and this happens in about 20–30 % of those infected. These complications typically present as cardiac abnormalities and can lead to death (Morillo et al. 2015).Chagas disease is a complex tropical parasitic infection. It affects a significant portion of the population in Latin America, especially in areas of poverty and poor access to health care. It also affects immigrants in high-income countries who lack access to health care due to their legal status. Millions of people are at risk of contracting the disease, and approximately 30 % of chronically infected patients will develop cardiomyopathy. The cost of caring for patients that have been infected is substantial. Basic science research has introduced new concepts and knowledge for the parasite and vector biology as well as better understanding of the pathophysiology of the disease. These research findings nevertheless require effective and timely translation into clinical practice. Likewise, the design of new research projects should account for the multiple system–based barriers. Implementation science facilitates the applicability of research findings and identifies barriers to its execution. Creation of implementation science measures to reach and sustain research programs with greater potential to impact Chagas disease are lacking. This point of view proposes opportunities for implementation science in Chagas disease and strategies for researching effective interventions for preventing and treating the disease.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Santa Marta, Colombia, 00000MedicinaSanta Martahttps://www.researchgate.net/publication/309381920ChagasImplementation scienceHealth policiesOvercoming research barriers in Chagas disease—designing effective implementation scienceArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationTHUMBNAILOvercoming research barriers in Chagas disease.pdf.jpgOvercoming research barriers in Chagas disease.pdf.jpgIM Thumbnailimage/jpeg3962https://repository.ucc.edu.co/bitstreams/bf706433-20a5-4b14-b3b3-7911cef4c8da/download8152c387e9615f7e37e43ef6ef1d689dMD54ORIGINALOvercoming research barriers in Chagas disease.pdfOvercoming research barriers in Chagas disease.pdfapplication/pdf961432https://repository.ucc.edu.co/bitstreams/f4547052-90b5-473d-b702-53b67f8ad0a2/downloadb543f509e115d2d1dc27fbe52bc130d4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/150e9b01-8e04-4174-888d-3b2a33a15cb5/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTOvercoming research barriers in Chagas disease.pdf.txtOvercoming research barriers in Chagas disease.pdf.txtExtracted texttext/plain50607https://repository.ucc.edu.co/bitstreams/cf8d1033-5dc0-41ce-b4bf-b5fbd32562c0/download51a03b29eb2c0109a856d7535d5cff8bMD5320.500.12494/945oai:repository.ucc.edu.co:20.500.12494/9452024-08-10 22:44:52.988open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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