Overcoming research barriers in Chagas disease—designing effective implementation science
Chagas disease remains a substantial source of morbidity and mortality in Latin America. The Pan American Health Organization estimates that 8 million people are infected in this part of the world ( Uruguay (2006). In the United States, which has high rates of Hispanic immigration, about 300,000 peo...
- Autores:
-
Henao Martínez, Andrés
Colborn, Kathryn
Parra Henao, Gabriel
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/945
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/945
- Palabra clave:
- Chagas
Implementation science
Health policies
- Rights
- openAccess
- License
- Licencia CC
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dc.title.spa.fl_str_mv |
Overcoming research barriers in Chagas disease—designing effective implementation science |
title |
Overcoming research barriers in Chagas disease—designing effective implementation science |
spellingShingle |
Overcoming research barriers in Chagas disease—designing effective implementation science Chagas Implementation science Health policies |
title_short |
Overcoming research barriers in Chagas disease—designing effective implementation science |
title_full |
Overcoming research barriers in Chagas disease—designing effective implementation science |
title_fullStr |
Overcoming research barriers in Chagas disease—designing effective implementation science |
title_full_unstemmed |
Overcoming research barriers in Chagas disease—designing effective implementation science |
title_sort |
Overcoming research barriers in Chagas disease—designing effective implementation science |
dc.creator.fl_str_mv |
Henao Martínez, Andrés Colborn, Kathryn Parra Henao, Gabriel |
dc.contributor.author.none.fl_str_mv |
Henao Martínez, Andrés Colborn, Kathryn Parra Henao, Gabriel |
dc.subject.spa.fl_str_mv |
Chagas Implementation science Health policies |
topic |
Chagas Implementation science Health policies |
description |
Chagas disease remains a substantial source of morbidity and mortality in Latin America. The Pan American Health Organization estimates that 8 million people are infected in this part of the world ( Uruguay (2006). In the United States, which has high rates of Hispanic immigration, about 300,000 people are infected (Bern and Montgomery 2009; Kuehn 2015). Chagas transmission occurs mainly through contact with a triatomine or the Bkissing bug^ which carries the parasite, Trypanosoma cruzi. Transmission also occurs orally through food contamination with vector’s feces, vertically (perinatal), from organ donation and blood transfusion. Acute infections may be associated with fever or swelling around the site of the inoculation. Parasites can be detected in the blood for a few weeks following initial infection. If patients are not treated, they can develop severe medical complications, and this happens in about 20–30 % of those infected. These complications typically present as cardiac abnormalities and can lead to death (Morillo et al. 2015). |
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2016 |
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2016-10-23 |
dc.date.accessioned.none.fl_str_mv |
2017-08-09T00:44:45Z |
dc.date.available.none.fl_str_mv |
2017-08-09T00:44:45Z |
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Artículo |
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https://hdl.handle.net/20.500.12494/945 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Henao Martínez, A., Colborn, K., Parra Henao, G. . (2016). Overcoming research barriers in Chagas disease—designing . Santa Marta: Universidad Cooperativa de Colombia |
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https://hdl.handle.net/20.500.12494/945 |
identifier_str_mv |
Henao Martínez, A., Colborn, K., Parra Henao, G. . (2016). Overcoming research barriers in Chagas disease—designing . Santa Marta: Universidad Cooperativa de Colombia |
dc.relation.isversionof.spa.fl_str_mv |
https://www.researchgate.net/publication/309381920 |
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Licencia CC |
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Licencia CC http://purl.org/coar/access_right/c_abf2 |
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openAccess |
dc.publisher.spa.fl_str_mv |
Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Santa Marta, Colombia, 00000 |
dc.publisher.program.spa.fl_str_mv |
Medicina |
dc.publisher.place.spa.fl_str_mv |
Santa Marta |
institution |
Universidad Cooperativa de Colombia |
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Henao Martínez, AndrésColborn, KathrynParra Henao, Gabriel2017-08-09T00:44:45Z2017-08-09T00:44:45Z2016-10-23https://hdl.handle.net/20.500.12494/945Henao Martínez, A., Colborn, K., Parra Henao, G. . (2016). Overcoming research barriers in Chagas disease—designing . Santa Marta: Universidad Cooperativa de ColombiaChagas disease remains a substantial source of morbidity and mortality in Latin America. The Pan American Health Organization estimates that 8 million people are infected in this part of the world ( Uruguay (2006). In the United States, which has high rates of Hispanic immigration, about 300,000 people are infected (Bern and Montgomery 2009; Kuehn 2015). Chagas transmission occurs mainly through contact with a triatomine or the Bkissing bug^ which carries the parasite, Trypanosoma cruzi. Transmission also occurs orally through food contamination with vector’s feces, vertically (perinatal), from organ donation and blood transfusion. Acute infections may be associated with fever or swelling around the site of the inoculation. Parasites can be detected in the blood for a few weeks following initial infection. If patients are not treated, they can develop severe medical complications, and this happens in about 20–30 % of those infected. These complications typically present as cardiac abnormalities and can lead to death (Morillo et al. 2015).Chagas disease is a complex tropical parasitic infection. It affects a significant portion of the population in Latin America, especially in areas of poverty and poor access to health care. It also affects immigrants in high-income countries who lack access to health care due to their legal status. Millions of people are at risk of contracting the disease, and approximately 30 % of chronically infected patients will develop cardiomyopathy. The cost of caring for patients that have been infected is substantial. Basic science research has introduced new concepts and knowledge for the parasite and vector biology as well as better understanding of the pathophysiology of the disease. These research findings nevertheless require effective and timely translation into clinical practice. Likewise, the design of new research projects should account for the multiple system–based barriers. Implementation science facilitates the applicability of research findings and identifies barriers to its execution. Creation of implementation science measures to reach and sustain research programs with greater potential to impact Chagas disease are lacking. This point of view proposes opportunities for implementation science in Chagas disease and strategies for researching effective interventions for preventing and treating the disease.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Santa Marta, Colombia, 00000MedicinaSanta Martahttps://www.researchgate.net/publication/309381920ChagasImplementation scienceHealth policiesOvercoming research barriers in Chagas disease—designing effective implementation scienceArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationTHUMBNAILOvercoming research barriers in Chagas disease.pdf.jpgOvercoming research barriers in Chagas disease.pdf.jpgIM Thumbnailimage/jpeg3962https://repository.ucc.edu.co/bitstreams/bf706433-20a5-4b14-b3b3-7911cef4c8da/download8152c387e9615f7e37e43ef6ef1d689dMD54ORIGINALOvercoming research barriers in Chagas disease.pdfOvercoming research barriers in Chagas disease.pdfapplication/pdf961432https://repository.ucc.edu.co/bitstreams/f4547052-90b5-473d-b702-53b67f8ad0a2/downloadb543f509e115d2d1dc27fbe52bc130d4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/150e9b01-8e04-4174-888d-3b2a33a15cb5/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTOvercoming research barriers in Chagas disease.pdf.txtOvercoming research barriers in Chagas disease.pdf.txtExtracted texttext/plain50607https://repository.ucc.edu.co/bitstreams/cf8d1033-5dc0-41ce-b4bf-b5fbd32562c0/download51a03b29eb2c0109a856d7535d5cff8bMD5320.500.12494/945oai:repository.ucc.edu.co:20.500.12494/9452024-08-10 22:44:52.988open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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 |