Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis

Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance,...

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Autores:
Velasquez-Agudelo V.
Cardona Arias, Jaiberth Antonio
Tipo de recurso:
Article of journal
Fecha de publicación:
2017
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
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OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/41824
Acceso en línea:
https://doi.org/10.16925/od.v11i20.751
https://hdl.handle.net/20.500.12494/41824
Palabra clave:
Diagnosis
Meta-analysis as topic
Onychomycosis
Test validity
Validation studies
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closedAccess
License
http://purl.org/coar/access_right/c_14cb
id COOPER2_d431582b17701b1619717b92290fe0cb
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/41824
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Velasquez-Agudelo V.Cardona Arias, Jaiberth Antonio2021-12-16T22:15:49Z2021-12-16T22:15:49Z2017https://doi.org/10.16925/od.v11i20.75114712334https://hdl.handle.net/20.500.12494/41824Velasquez V,Cardona JA. Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 2017. 17. (1):p. 1-11. .Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests. © 2017 The Author(s).0000-0002-7101-929Xjaiberth.cardona@campusucc.edu.co11-1BioMed Central Ltd.DiagnosisMeta-analysis as topicOnychomycosisTest validityValidation studiesMeta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionBMC Infectious Diseasesinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41824oai:repository.ucc.edu.co:20.500.12494/418242024-08-20 16:16:22.693metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
spellingShingle Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
Diagnosis
Meta-analysis as topic
Onychomycosis
Test validity
Validation studies
title_short Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_full Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_fullStr Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_full_unstemmed Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_sort Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
dc.creator.fl_str_mv Velasquez-Agudelo V.
Cardona Arias, Jaiberth Antonio
dc.contributor.author.none.fl_str_mv Velasquez-Agudelo V.
Cardona Arias, Jaiberth Antonio
dc.subject.spa.fl_str_mv Diagnosis
Meta-analysis as topic
Onychomycosis
Test validity
Validation studies
topic Diagnosis
Meta-analysis as topic
Onychomycosis
Test validity
Validation studies
description Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests. © 2017 The Author(s).
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:15:49Z
dc.date.available.none.fl_str_mv 2021-12-16T22:15:49Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.16925/od.v11i20.751
dc.identifier.issn.spa.fl_str_mv 14712334
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/41824
dc.identifier.bibliographicCitation.spa.fl_str_mv Velasquez V,Cardona JA. Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 2017. 17. (1):p. 1-11. .
url https://doi.org/10.16925/od.v11i20.751
https://hdl.handle.net/20.500.12494/41824
identifier_str_mv 14712334
Velasquez V,Cardona JA. Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 2017. 17. (1):p. 1-11. .
dc.relation.ispartofjournal.spa.fl_str_mv BMC Infectious Diseases
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv 11-1
dc.publisher.spa.fl_str_mv BioMed Central Ltd.
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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