Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina

La dermatitis atópica canina es una enfermedad cutánea crónica y pruriginosa que afecta a los perros y tiene un impacto significativo en su calidad de vida. Esta revisión sistemática de literatura examinó 50 estudios para analizar los avances en el tratamiento de la dermatitis atópica, se identifica...

Full description

Autores:: Retes Meza, Santiago

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2023

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

id	COOPER2_d301ab9974304fe40e2209c4c0e2ee2a
oai_identifier_str	oai:repository.ucc.edu.co:20.500.12494/51366
network_acronym_str	COOPER2
network_name_str	Repositorio UCC
repository_id_str
dc.title.none.fl_str_mv	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina
title	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina
spellingShingle	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina Oclacitinib Inmunoterapia Sindrome Prurito Terapia CADESI Multifactorial TG 2023 MVZ Oclacitinib Immunotherapy Syndrome Pruritus Therapy CADESI Multifactorial
title_short	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina
title_full	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina
title_fullStr	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina
title_full_unstemmed	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina
title_sort	Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina
dc.creator.fl_str_mv	Retes Meza, Santiago
dc.contributor.advisor.none.fl_str_mv	Albarracín Navas, Javier Hernando
dc.contributor.author.none.fl_str_mv	Retes Meza, Santiago
dc.subject.none.fl_str_mv	Oclacitinib Inmunoterapia Sindrome Prurito Terapia CADESI Multifactorial
topic	Oclacitinib Inmunoterapia Sindrome Prurito Terapia CADESI Multifactorial TG 2023 MVZ Oclacitinib Immunotherapy Syndrome Pruritus Therapy CADESI Multifactorial
dc.subject.classification.none.fl_str_mv	TG 2023 MVZ
dc.subject.other.none.fl_str_mv	Oclacitinib Immunotherapy Syndrome Pruritus Therapy CADESI Multifactorial
description	La dermatitis atópica canina es una enfermedad cutánea crónica y pruriginosa que afecta a los perros y tiene un impacto significativo en su calidad de vida. Esta revisión sistemática de literatura examinó 50 estudios para analizar los avances en el tratamiento de la dermatitis atópica, se identificaron varias opciones terapéuticas, incluyendo corticosteroides, anticuerpos monoclonales, inmunomoduladores, baños terapéuticos y terapia de eliminación de alérgenos. Sin embargo, se destacó la importancia de un enfoque multimodal y personalizado para el tratamiento de la dermatitis atópica canina, adaptado a las necesidades y características de cada perro. Además, se discutieron estrategias de manejo, como el control ambiental de alérgenos, cambios en la alimentación y cuidados de la piel, para reducir la frecuencia y gravedad de los brotes de dermatitis atópica canina. Sin embargo, se identificaron algunas limitaciones en la literatura, incluyendo la falta de estudios comparativos y la variabilidad en los protocolos de diagnóstico y tratamiento utilizados en los diferentes estudios. Esta revisión sistemática destaca la importancia de un enfoque integral y personalizado para el diagnóstico, tratamiento y manejo de la dermatitis atópica canina, y destaca la necesidad de más investigaciones para mejorar la comprensión de esta enfermedad y optimizar su manejo clínico en perros.
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-06-14T14:34:41Z
dc.date.available.none.fl_str_mv	2023-06-14T14:34:41Z
dc.date.issued.none.fl_str_mv	2023-06-13
dc.type.none.fl_str_mv	Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/acceptedVersion
format	http://purl.org/coar/resource_type/c_7a1f
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/51366
dc.identifier.bibliographicCitation.none.fl_str_mv	Retes Meza, S. (2023). Revisión sistemática de literatura: Tratamiento de la dermatitis atópica canina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC.
url	https://hdl.handle.net/20.500.12494/51366
identifier_str_mv	Retes Meza, S. (2023). Revisión sistemática de literatura: Tratamiento de la dermatitis atópica canina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC.
dc.relation.references.none.fl_str_mv	Patiño G, Consuelo A, María Viviana R, Páez A, Ángel M, Róbles L, et al. REVISIÓN DE LA DERMATITIS ATÓPICA CANINA: UNA MIRADA DESDE LA CONFORMACIÓN DE PIEL Y SU RESPUESTA INMUNOLÓGICA. Update on pathogenesis, diagnosis, and treatment of atopic dermatitis in dogs Almela RM, Rubio CP, Cerón JJ, Ansón A, Tichy A, Mayer U. Selected serum oxidative stress biomarkers in dogs with non-food-induced and food-induced atopic dermatitis. Vet Dermatol. 2018 Jun 1;29(3):229-e82. Olivry T. New diagnostic criteria for canine atopic dermatitis. Vol. 21, Veterinary Dermatology. Blackwell Publishing Ltd; 2010. p. 124–7. Marsella R, De Benedetto A. Atopic dermatitis in animals and people: An update and comparative review. Vol. 4, Veterinary Sciences. MDPI Multidisciplinary Digital Publishing Institute; 2017. Olivry T. Pathogenesis of the Deviated Immune Response What Can Dogs Bring to Atopic Dermatitis Research? Vol. 96, Chem Immunol Allergy. Basel, Karger. 2012. Elias PM, Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Vol. 9, Current Opinion in Allergy and Clinical Immunology. 2009. p. 437–46. Marsella R. Advances in our understanding of canine atopic dermatitis. Vol. 32, Veterinary Dermatology. John Wiley and Sons Inc; 2021. p. 547-e151. Santoro D, Marsella R, Pucheu-Haston CM, Eisenschenk MNC, Nuttall T, Bizikova P. Review: Pathogenesis of canine atopic dermatitis: Skin barrier and host-micro organism interaction. Vol. 26, Veterinary Dermatology. 2015. p. 84-e25. Botoni LS, Torres SMF, Koch SN, Heinemann MB, Costa-Val AP. Comparison of demographic data, disease severity and response to treatment, between dogs with atopic dermatitis and atopic-like dermatitis: a retrospective study. Vet Dermatol. 2019 Feb 1;30(1):10-e4. Suici T, DărăbuȘ G, Mederle N, Sîrbu C, Imre M, Morariu S. The effect of atopic dermatitis on quality of life of affected dogs and their owners in Romania. Journal of Veterinary Behavior. 2021 Nov 1;46:24–30. Spitznagel MB, Hillier A, Gober M, Carlson MD. Treatment complexity and caregiver burden are linked in owners of dogs with allergic/atopic dermatitis. Vet Dermatol. 2021 Apr 1;32(2):192-e50. Santoro D. Therapies in Canine Atopic Dermatitis: An Update. Vol. 49, Veterinary Clinics of North America - Small Animal Practice. W.B. Saunders; 2019. p. 9–26. Thierry Olivry DPDJSMRDFPPPDEGDJFDDNCD the EVDC. Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs. Gonzales AJ, Bowman JW, Fici GJ, Zhang M, Mann DW, Mitton-Fry M. Oclacitinib (APOQUEL®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014;37(4):317–24. DeBoer DJ. The future of immunotherapy for canine atopic dermatitis: a review. Vol. 28, Veterinary Dermatology. Blackwell Publishing Ltd; 2017. p. 25-e6. Fischer NM, Rostaher A, Favrot C. A comparative study of subcutaneous, intralymphatic and sublingual immunotherapy for the long-term control of dogs with nonseasonal atopic dermatitis. Vet Dermatol. 2020 Oct 1;31(5):365-e96. Marsella R, Santoro D, Ahrens K. Early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects. Vet Immunol Immunopathol. 2012 Apr 15;146(2):185–9. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? Vol. 30, Veterinary Dermatology. Blackwell Publishing Ltd; 2019. p. 87– 90. Favrot C, Bizikova P, Fischer N, Rostaher A, Olivry T. The usefulness of short course prednisolone during the initial phase of an elimination diet trial in dogs with food-induced atopic dermatitis. Vet Dermatol. 2019 Dec 1;30(6):498-e149. Olivry T, Lokianskiene V, Blanco A, Mestre PD, Bergvall K, Beco L. A randomised controlled trial testing the rebound-preventing benefit of four days of prednisolone during the induction of oclacitinib therapy in dogs with atopic dermatitis. Vet Dermatol. 2023 Apr 1;34(2):99–106. Takahashi J, Kanda S, Imanishi I, Hisano T, Fukamachi T, Taguchi N, et al. Efficacy and safety of 0.0584% hydrocortisone aceponate topical spray and systemic oclacitinib combination therapy in dogs with atopic dermatitis: a randomized, double-blinded, placebo-controlled trial. Vet Dermatol. 2021 Apr 1;32(2):119-e25. Souza CP, Rosychuk RAW, Contreras ET, Schissler JR, Simpson AC. A retrospective analysis of the use of lokivetmab in the management of allergic pruritus in a referral population of 135 dogs in the western USA. Vet Dermatol. 2018 Dec 1;29(6):489-e164. Tamamoto-Mochizuki C, Paps JS, Olivry T. Proactive maintenance therapy of canine atopic dermatitis with the anti-IL-31 lokivetmab. Can a monoclonal antibody blocking a single cytokine prevent allergy flares? Vet Dermatol. 2019 Apr 1;30(2):98-e26. Van Brussel L, Moyaert H, Escalada M, Mahabir SP, Stegemann MR. A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client-owned dogs with allergic dermatitis. Vet Dermatol. 2021 Oct 1;32(5):477-e131. Bensignor E, Videmont E. Weekly topical therapy based on plant extracts combined with lokivetmab in canine atopic dermatitis. Vet Dermatol. 2022 Feb 1;33(1):68-e22. Szczepanik M, Wilkołek P, Gołyński M, Sitkowski W, Taszkun I, Toczek W. The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis. Vet Dermatol. 2019 Aug 1;30(4):330-e93. Moyaert H, Van Brussel L, Borowski S, Escalada M, Mahabir SP, Walters RR, et al. A blinded, randomized clinical trial evaluating the efficacy and safety of lokivetmab compared to ciclosporin in client-owned dogs with atopic dermatitis. Vet Dermatol. 2017 Dec 1;28(6):593-e145. Puigdemont A, Brazís P, Ordeix L, Dalmau A, Fuertes E, Olivar A, et al. Efficacy of a new topical cyclosporine A formulation in the treatment of atopic dermatitis in dogs. Veterinary Journal. 2013 Aug;197(2):280–5. Efficacy and safety of oclacitinib and cyclosporine for control of atopic dermatitis. Adv Small Anim Med Surg. 2015 Aug;28(8):4–5. Müller MR, Linek M, Löwenstein C, Röthig A, Doucette K, Thorstensen K, et al. Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis. Veterinary Journal. 2016 Apr 1;210:77–81. Fennis EEM, van Damme CMM, Schlotter YM, Sinke JD, Leistra MHG, Bartels RT, et al. Efficacy of subcutaneous allergen immunotherapy in atopic dogs: A retrospective study of 664 cases. Vet Dermatol. 2022 Aug 1;33(4):321-e75. Timm K, Mueller RS, Nett-Mettler CS. Long-term effects of intralymphatic immunotherapy (ILIT) on canine atopic dermatitis. Vet Dermatol. 2018 Apr 1;29(2):123-e49. González JL, Zalve V, Fernández-Caldas E, Cases B, Subiza JL, Casanovas M. A pilot study of immunotherapy in dogs with atopic dermatitis using a mannan Dermatophagoides farinae allergoid targeting dendritic cells. Vet Dermatol. 2018 Oct 1;29(5):449-e152. Cosgrove SB, Wren JA, Cleaver DM, Martin DD, Walsh KF, Harfst JA, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013 Oct;24(5). Cosgrove SB, Wren JA, Cleaver DM, Walsh KF, Follis SI, King VI, et al. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel®) in client-owned dogs with atopic dermatitis. Vet Dermatol. 2013 Dec;24(6). Gadeyne C, Little P, King VL, Edwards N, Davis K, Stegemann MR. Efficacy of oclacitinib (Apoquel®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014 Dec 1;25(6):512-e86. Little PR, King VL, Davis KR, Cosgrove SB, Stegemann MR. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Vet Dermatol. 2015 Feb 1;26(1):23-e8. Caro Martins G, Costa‐Val AP, Coura FM, Diamantino GML, Nogueira MM, Oliveira Melo‐Junior OA, et al. Immunomodulatory effect of long‐term oclacitinib maleate therapy in dogs with atopic dermatitis. Vet Dermatol. 2022 Apr 7;33(2):142. Denti D, Caldin M, Ventura L, De Lucia M. Prolonged twice‐daily administration of oclacitinib for the control of canine atopic dermatitis: a retrospective study of 53 client‐owned atopic dogs. Vet Dermatol. 2022 Apr 11;33(2):149. Lancellotti BA, Angus JC, Edginton HD, Rosenkrantz WS. Age- And breed matched retrospective cohort study of malignancies and benign skin masses in 660 dogs with allergic dermatitis treated long-term with versus without oclacitinib. J Am Vet Med Assoc. 2020 Sep 1;257(5):507–16. Lee S, Yun T, Koo Y, Chae Y, Lee D, Choi D, et al. Clinical efficacy of oclacitinib and lokivetmab in dogs with canine atopic dermatitis. Journal of Veterinary Clinics. 2021;38(3):127–34. Cosgrove SB, Cleaver DM, King VL, Gilmer AR, Daniels AE, Wren JA, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: Safety, efficacy and quality of life. Vet Dermatol. 2015 Jun 1;26(3):171- e35. Yamazaki C, Rosenkrantz W, Griffin C. Pilot evaluation of Enterococcus faecium SF68 as adjunctive therapy for oclacitinib-responsive adult atopic dermatitis in dogs. Journal of Small Animal Practice. 2019;60(8):499–506. Herrmann I, Mamo LB, Holmes J, Mohammed JP, Murphy KM, Bizikova P. Long‐ term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T‐ cells, <scp>IL</scp> ‐10 and <scp>TGF</scp> ‐β, in dogs with atopic dermatitis. Vet Dermatol. 2023 Apr 8;34(2):107–14. Olivry T, DeBoer DJ, Favrot C, Jackson HA, Mueller RS, Nuttall T, et al. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). Vol. 11, BMC Veterinary Research. BioMed Central Ltd; 2015. Panteri A, Strehlau G, Helbig R, Prost C, Doucette K. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Vet Dermatol. 2016 Feb 1;27(1):22-e7. Forsythe P, Jackson H. New therapies for canine atopic dermatitis. Vol. 42, In Practice. BMJ Publishing Group; 2020. p. 82–90. Blaskovic M, Rosenkrantz W, Neuber A, Sauter-Louis C, Mueller RS. The effect of a spot-on formulation containing polyunsaturated fatty acids and essential oils on dogs with atopic dermatitis. Veterinary Journal. 2014 Jan;199(1):39–43. Bensignor EJ, Fabriès LJ. Use of antipruritic and rehydrating foams on localized lesions of atopic dermatitis in dogs: a small-scale pilot and comparative double blinded study. Vet Dermatol. 2018 Oct 1;29(5):446-e150. Hobi S, Klinger C, Classen J, Mueller RS. The effects of a topical lipid complex therapy on dogs with atopic dermatitis: a double blind, randomized, placebo controlled study. Vet Dermatol. 2017 Aug 1;28(4):369-e84. Santoro D, Fagman L, Zhang Y, Fahong Y. Clinical efficacy of spray-based heat treated lactobacilli in canine atopic dermatitis: a preliminary, open-label, uncontrolled study. Vet Dermatol. 2021 Apr 1;32(2):114-e23. Osumi T, Shimada T, Sakaguchi M, Tsujimoto H. A double-blind, placebo controlled evaluation of orally administered heat-killed Enterococcus faecalis FK-23 preparation in atopic dogs. Vet Dermatol. 2019 Apr 1;30(2):127-e36. Santoro D, Bohannon M, Ahrens K, Navarro C, Gatto H, Marsella R. Evaluation on the effects of 0.1% Peumus boldus leaf and Spiraea ulmaria plant extract combination on bacterial colonization in canine atopic dermatitis: A preliminary randomized, placebo controlled, double-blinded study. Res Vet Sci. 2018 Jun 1;118:164–70. Gugliandolo E, Palma E, Cordaro M, D’Amico R, Peritore AF, Licata P, et al. Canine atopic dermatitis: Role of luteolin as new natural treatment. Vet Med Sci. 2020 Nov 1;6(4):926–32. Watson A, Rostaher A, Fischer NM, Favrot C. A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine-month controlled study. Vet Dermatol. 2022 Feb 1;33(1):55-e18. Loewinger M, Wakshlag JJ, Bowden D, Peters-Kennedy J, Rosenberg A. The effect of a mixed cannabidiol and cannabidiolic acid based oil on client-owned dogs with atopic dermatitis. Vet Dermatol. 2022 Aug 1;33(4):329-e77. Santoro D. Therapies in Canine Atopic Dermatitis: An Update. Vol. 49, Veterinary Clinics of North America - Small Animal Practice. W.B. Saunders; 2019. p. 9–26. Sofou EI, Aleksandrova S, Badulescu E, Chatzis M, Saridomichelakis M. Efficacy of Antimicrobial Treatment in Dogs with Atopic Dermatitis: An Observational Study. Vet Sci. 2022 Jul 27;9(8):385. Mueller RS. Update on Allergen Immunotherapy. Vol. 49, Veterinary Clinics of North America - Small Animal Practice. W.B. Saunders; 2019. p. 1–7. Bachmann MF, Zeltins A, Kalnins G, Balke I, Fischer N, Rostaher A, et al. Vaccination against IL-31 for the treatment of atopic dermatitis in dogs. Journal of Allergy and Clinical Immunology. 2018 Jul;142(1):279-281.e1. Archer TM, Boothe DM, Langston VC, Fellman CL, Lunsford KV, Mackin AJ. Oral Cyclosporine Treatment in Dogs: A Review of the Literature. J Vet Intern Med. 2014 Jan;28(1):1–20. Marsella R, Segarra S, Ahrens K, Alonso C, Ferrer L. Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis. BMC Vet Res. 2020 Mar 20;16(1). Fujimura M, Nakatsuji Y, Ishimaru H. Cyclosporin A Treatment in Intrinsic Canine Atopic Dermatitis (Atopic-like Dermatitis): Open Trial Study. Pol J Vet Sci. 2016 Sep 1;19(3):567–72. Gober M, Hillier A, Vasquez-Hidalgo MA, Amodie D, Mellencamp MA. Use of Cytopoint in the Allergic Dog. Front Vet Sci. 2022 Jul 19;9. Ramió-Lluch L, Brazís P, Ferrer L, Puigdemont A. Allergen-specific immunotherapy in dogs with atopic dermatitis: is owner compliance the main success-limiting factor? Veterinary Record. 2020 Dec;187(12):493–493. Palmeiro BS. Cyclosporine in Veterinary Dermatology. Veterinary Clinics of North America: Small Animal Practice. 2013 Jan 1;43(1):153–71. Carr MN, Torres SMF, Koch SN, Reiter L V. Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs. Vet Dermatol. 2009 Apr;20(2):105–10.
dc.rights.license.none.fl_str_mv	Atribución – Sin Derivar
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv	http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv	Atribución – Sin Derivar http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.extent.none.fl_str_mv	51 p.
dc.publisher.none.fl_str_mv	Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Bucaramanga
dc.publisher.program.none.fl_str_mv	Medicina veterinaria y zootecnia
dc.publisher.place.none.fl_str_mv	Bucaramanga
publisher.none.fl_str_mv	Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Bucaramanga
institution	Universidad Cooperativa de Colombia
bitstream.url.fl_str_mv	https://repository.ucc.edu.co/bitstreams/691c0c73-d1bf-4f54-b170-f4740a3fb8f5/download https://repository.ucc.edu.co/bitstreams/6fb49d25-c957-4b80-8157-5d46426b1572/download https://repository.ucc.edu.co/bitstreams/cba42670-bee0-41b1-829f-fb96b9c9a455/download https://repository.ucc.edu.co/bitstreams/a5e60555-ca71-4151-958b-0a220545a943/download https://repository.ucc.edu.co/bitstreams/e88cc137-8cb8-4b6a-a9c8-898965fcc8fd/download https://repository.ucc.edu.co/bitstreams/abe3466f-468e-4163-a093-f81b859811c2/download https://repository.ucc.edu.co/bitstreams/6c9302b2-b41c-4724-ad6a-a93fba197040/download https://repository.ucc.edu.co/bitstreams/423e0195-69f6-4656-ad8d-15b1e9631b8b/download https://repository.ucc.edu.co/bitstreams/4ada75f3-6065-46d7-b2a3-8b18a83d8bf8/download https://repository.ucc.edu.co/bitstreams/79391a29-95b4-4b22-94d1-1e8fe2e8c42d/download
bitstream.checksum.fl_str_mv	3bce4f7ab09dfc588f126e1e36e98a45 62ee13ab1acb6651ee6d1754d10bf3e6 5852024797aca0d78dcb9f67bc872e8e 291b3d22b8140e28dd6c52bb79810e70 e15896ee592aa6ccd4c0afccd7bf68d6 e18f438fe6484d7caf096fe2d1a5408a cb8ef9aa11f77207bd535af6e668886f 45a8ae0f7a86e8ac35591d373bfe3de5 775e958e01c091e113ffd00b0153a7c1 c4ac2b4ff20c34943fd33a47c32a6038
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
_version_	1814247117211828224
spelling	Albarracín Navas, Javier HernandoRetes Meza, Santiago2023-06-14T14:34:41Z2023-06-14T14:34:41Z2023-06-13https://hdl.handle.net/20.500.12494/51366Retes Meza, S. (2023). Revisión sistemática de literatura: Tratamiento de la dermatitis atópica canina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC.La dermatitis atópica canina es una enfermedad cutánea crónica y pruriginosa que afecta a los perros y tiene un impacto significativo en su calidad de vida. Esta revisión sistemática de literatura examinó 50 estudios para analizar los avances en el tratamiento de la dermatitis atópica, se identificaron varias opciones terapéuticas, incluyendo corticosteroides, anticuerpos monoclonales, inmunomoduladores, baños terapéuticos y terapia de eliminación de alérgenos. Sin embargo, se destacó la importancia de un enfoque multimodal y personalizado para el tratamiento de la dermatitis atópica canina, adaptado a las necesidades y características de cada perro. Además, se discutieron estrategias de manejo, como el control ambiental de alérgenos, cambios en la alimentación y cuidados de la piel, para reducir la frecuencia y gravedad de los brotes de dermatitis atópica canina. Sin embargo, se identificaron algunas limitaciones en la literatura, incluyendo la falta de estudios comparativos y la variabilidad en los protocolos de diagnóstico y tratamiento utilizados en los diferentes estudios. Esta revisión sistemática destaca la importancia de un enfoque integral y personalizado para el diagnóstico, tratamiento y manejo de la dermatitis atópica canina, y destaca la necesidad de más investigaciones para mejorar la comprensión de esta enfermedad y optimizar su manejo clínico en perros.Canine atopic dermatitis is a chronic and pruritic skin disease that affects dogs and has a significant impact on their quality of life. This systematic literature review examined 50 studies to analyze advances in the treatment of canine atopic dermatitis, identifying several therapeutic options, including corticosteroids, monoclonal antibodies, immunomodulators, therapeutic baths, and allergen elimination therapy. However, the importance of a multimodal and personalized approach to the treatment of canine atopic dermatitis, tailored to the needs and characteristics of each dog, was emphasized. Additionally, management strategies such as environmental allergen control, dietary changes, and skin care were discussed to reduce the frequency and severity of canine atopic dermatitis flares. However, some limitations in the literature were identified, including the lack of comparative studies and variability in diagnostic and treatment protocols used in different studies. In summary, this systematic review highlights the importance of a comprehensive and personalized approach to the diagnosis, treatment, and management of canine atopic dermatitis, and emphasizes the need for further research to improve understanding of this disease and optimize its clinical management in dogs.Tabla de abreviaturas. -- Resumen. -- Abstract. -- Introducción. -- Objetivos. -- Estado del arte. -- Metodología. -- Resultados. -- Discusión. -- Conclusiones. -- Bibliografia.santiago.reyes@campusucc.edu.co51 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, BucaramangaMedicina veterinaria y zootecniaBucaramangaOclacitinibInmunoterapiaSindromePruritoTerapiaCADESIMultifactorialTG 2023 MVZOclacitinibImmunotherapySyndromePruritusTherapyCADESIMultifactorialRevisión sistematica de literatura: Tratamiento de la dermatitis atópica caninaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Patiño G, Consuelo A, María Viviana R, Páez A, Ángel M, Róbles L, et al. REVISIÓN DE LA DERMATITIS ATÓPICA CANINA: UNA MIRADA DESDE LA CONFORMACIÓN DE PIEL Y SU RESPUESTA INMUNOLÓGICA.Update on pathogenesis, diagnosis, and treatment of atopic dermatitis in dogsAlmela RM, Rubio CP, Cerón JJ, Ansón A, Tichy A, Mayer U. Selected serum oxidative stress biomarkers in dogs with non-food-induced and food-induced atopic dermatitis. Vet Dermatol. 2018 Jun 1;29(3):229-e82.Olivry T. New diagnostic criteria for canine atopic dermatitis. Vol. 21, Veterinary Dermatology. Blackwell Publishing Ltd; 2010. p. 124–7.Marsella R, De Benedetto A. Atopic dermatitis in animals and people: An update and comparative review. Vol. 4, Veterinary Sciences. MDPI Multidisciplinary Digital Publishing Institute; 2017.Olivry T. Pathogenesis of the Deviated Immune Response What Can Dogs Bring to Atopic Dermatitis Research? Vol. 96, Chem Immunol Allergy. Basel, Karger. 2012.Elias PM, Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Vol. 9, Current Opinion in Allergy and Clinical Immunology. 2009. p. 437–46.Marsella R. Advances in our understanding of canine atopic dermatitis. Vol. 32, Veterinary Dermatology. John Wiley and Sons Inc; 2021. p. 547-e151.Santoro D, Marsella R, Pucheu-Haston CM, Eisenschenk MNC, Nuttall T, Bizikova P. Review: Pathogenesis of canine atopic dermatitis: Skin barrier and host-micro organism interaction. Vol. 26, Veterinary Dermatology. 2015. p. 84-e25.Botoni LS, Torres SMF, Koch SN, Heinemann MB, Costa-Val AP. Comparison of demographic data, disease severity and response to treatment, between dogs with atopic dermatitis and atopic-like dermatitis: a retrospective study. Vet Dermatol. 2019 Feb 1;30(1):10-e4.Suici T, DărăbuȘ G, Mederle N, Sîrbu C, Imre M, Morariu S. The effect of atopic dermatitis on quality of life of affected dogs and their owners in Romania. Journal of Veterinary Behavior. 2021 Nov 1;46:24–30.Spitznagel MB, Hillier A, Gober M, Carlson MD. Treatment complexity and caregiver burden are linked in owners of dogs with allergic/atopic dermatitis. Vet Dermatol. 2021 Apr 1;32(2):192-e50.Santoro D. Therapies in Canine Atopic Dermatitis: An Update. Vol. 49, Veterinary Clinics of North America - Small Animal Practice. W.B. Saunders; 2019. p. 9–26.Thierry Olivry DPDJSMRDFPPPDEGDJFDDNCD the EVDC. Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs.Gonzales AJ, Bowman JW, Fici GJ, Zhang M, Mann DW, Mitton-Fry M. Oclacitinib (APOQUEL®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014;37(4):317–24.DeBoer DJ. The future of immunotherapy for canine atopic dermatitis: a review. Vol. 28, Veterinary Dermatology. Blackwell Publishing Ltd; 2017. p. 25-e6.Fischer NM, Rostaher A, Favrot C. A comparative study of subcutaneous, intralymphatic and sublingual immunotherapy for the long-term control of dogs with nonseasonal atopic dermatitis. Vet Dermatol. 2020 Oct 1;31(5):365-e96.Marsella R, Santoro D, Ahrens K. Early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects. Vet Immunol Immunopathol. 2012 Apr 15;146(2):185–9.Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? Vol. 30, Veterinary Dermatology. Blackwell Publishing Ltd; 2019. p. 87– 90.Favrot C, Bizikova P, Fischer N, Rostaher A, Olivry T. The usefulness of short course prednisolone during the initial phase of an elimination diet trial in dogs with food-induced atopic dermatitis. Vet Dermatol. 2019 Dec 1;30(6):498-e149.Olivry T, Lokianskiene V, Blanco A, Mestre PD, Bergvall K, Beco L. A randomised controlled trial testing the rebound-preventing benefit of four days of prednisolone during the induction of oclacitinib therapy in dogs with atopic dermatitis. Vet Dermatol. 2023 Apr 1;34(2):99–106.Takahashi J, Kanda S, Imanishi I, Hisano T, Fukamachi T, Taguchi N, et al. Efficacy and safety of 0.0584% hydrocortisone aceponate topical spray and systemic oclacitinib combination therapy in dogs with atopic dermatitis: a randomized, double-blinded, placebo-controlled trial. Vet Dermatol. 2021 Apr 1;32(2):119-e25.Souza CP, Rosychuk RAW, Contreras ET, Schissler JR, Simpson AC. A retrospective analysis of the use of lokivetmab in the management of allergic pruritus in a referral population of 135 dogs in the western USA. Vet Dermatol. 2018 Dec 1;29(6):489-e164.Tamamoto-Mochizuki C, Paps JS, Olivry T. Proactive maintenance therapy of canine atopic dermatitis with the anti-IL-31 lokivetmab. Can a monoclonal antibody blocking a single cytokine prevent allergy flares? Vet Dermatol. 2019 Apr 1;30(2):98-e26.Van Brussel L, Moyaert H, Escalada M, Mahabir SP, Stegemann MR. A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client-owned dogs with allergic dermatitis. Vet Dermatol. 2021 Oct 1;32(5):477-e131.Bensignor E, Videmont E. Weekly topical therapy based on plant extracts combined with lokivetmab in canine atopic dermatitis. Vet Dermatol. 2022 Feb 1;33(1):68-e22.Szczepanik M, Wilkołek P, Gołyński M, Sitkowski W, Taszkun I, Toczek W. The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis. Vet Dermatol. 2019 Aug 1;30(4):330-e93.Moyaert H, Van Brussel L, Borowski S, Escalada M, Mahabir SP, Walters RR, et al. A blinded, randomized clinical trial evaluating the efficacy and safety of lokivetmab compared to ciclosporin in client-owned dogs with atopic dermatitis. Vet Dermatol. 2017 Dec 1;28(6):593-e145.Puigdemont A, Brazís P, Ordeix L, Dalmau A, Fuertes E, Olivar A, et al. Efficacy of a new topical cyclosporine A formulation in the treatment of atopic dermatitis in dogs. Veterinary Journal. 2013 Aug;197(2):280–5.Efficacy and safety of oclacitinib and cyclosporine for control of atopic dermatitis. Adv Small Anim Med Surg. 2015 Aug;28(8):4–5.Müller MR, Linek M, Löwenstein C, Röthig A, Doucette K, Thorstensen K, et al. Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis. Veterinary Journal. 2016 Apr 1;210:77–81.Fennis EEM, van Damme CMM, Schlotter YM, Sinke JD, Leistra MHG, Bartels RT, et al. Efficacy of subcutaneous allergen immunotherapy in atopic dogs: A retrospective study of 664 cases. Vet Dermatol. 2022 Aug 1;33(4):321-e75.Timm K, Mueller RS, Nett-Mettler CS. Long-term effects of intralymphatic immunotherapy (ILIT) on canine atopic dermatitis. Vet Dermatol. 2018 Apr 1;29(2):123-e49.González JL, Zalve V, Fernández-Caldas E, Cases B, Subiza JL, Casanovas M. A pilot study of immunotherapy in dogs with atopic dermatitis using a mannan Dermatophagoides farinae allergoid targeting dendritic cells. Vet Dermatol. 2018 Oct 1;29(5):449-e152.Cosgrove SB, Wren JA, Cleaver DM, Martin DD, Walsh KF, Harfst JA, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013 Oct;24(5).Cosgrove SB, Wren JA, Cleaver DM, Walsh KF, Follis SI, King VI, et al. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel®) in client-owned dogs with atopic dermatitis. Vet Dermatol. 2013 Dec;24(6).Gadeyne C, Little P, King VL, Edwards N, Davis K, Stegemann MR. Efficacy of oclacitinib (Apoquel®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014 Dec 1;25(6):512-e86.Little PR, King VL, Davis KR, Cosgrove SB, Stegemann MR. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Vet Dermatol. 2015 Feb 1;26(1):23-e8.Caro Martins G, Costa‐Val AP, Coura FM, Diamantino GML, Nogueira MM, Oliveira Melo‐Junior OA, et al. Immunomodulatory effect of long‐term oclacitinib maleate therapy in dogs with atopic dermatitis. Vet Dermatol. 2022 Apr 7;33(2):142.Denti D, Caldin M, Ventura L, De Lucia M. Prolonged twice‐daily administration of oclacitinib for the control of canine atopic dermatitis: a retrospective study of 53 client‐owned atopic dogs. Vet Dermatol. 2022 Apr 11;33(2):149.Lancellotti BA, Angus JC, Edginton HD, Rosenkrantz WS. Age- And breed matched retrospective cohort study of malignancies and benign skin masses in 660 dogs with allergic dermatitis treated long-term with versus without oclacitinib. J Am Vet Med Assoc. 2020 Sep 1;257(5):507–16.Lee S, Yun T, Koo Y, Chae Y, Lee D, Choi D, et al. Clinical efficacy of oclacitinib and lokivetmab in dogs with canine atopic dermatitis. Journal of Veterinary Clinics. 2021;38(3):127–34.Cosgrove SB, Cleaver DM, King VL, Gilmer AR, Daniels AE, Wren JA, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: Safety, efficacy and quality of life. Vet Dermatol. 2015 Jun 1;26(3):171- e35.Yamazaki C, Rosenkrantz W, Griffin C. Pilot evaluation of Enterococcus faecium SF68 as adjunctive therapy for oclacitinib-responsive adult atopic dermatitis in dogs. Journal of Small Animal Practice. 2019;60(8):499–506.Herrmann I, Mamo LB, Holmes J, Mohammed JP, Murphy KM, Bizikova P. Long‐ term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T‐ cells, <scp>IL</scp> ‐10 and <scp>TGF</scp> ‐β, in dogs with atopic dermatitis. Vet Dermatol. 2023 Apr 8;34(2):107–14.Olivry T, DeBoer DJ, Favrot C, Jackson HA, Mueller RS, Nuttall T, et al. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). Vol. 11, BMC Veterinary Research. BioMed Central Ltd; 2015.Panteri A, Strehlau G, Helbig R, Prost C, Doucette K. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Vet Dermatol. 2016 Feb 1;27(1):22-e7.Forsythe P, Jackson H. New therapies for canine atopic dermatitis. Vol. 42, In Practice. BMJ Publishing Group; 2020. p. 82–90.Blaskovic M, Rosenkrantz W, Neuber A, Sauter-Louis C, Mueller RS. The effect of a spot-on formulation containing polyunsaturated fatty acids and essential oils on dogs with atopic dermatitis. Veterinary Journal. 2014 Jan;199(1):39–43.Bensignor EJ, Fabriès LJ. Use of antipruritic and rehydrating foams on localized lesions of atopic dermatitis in dogs: a small-scale pilot and comparative double blinded study. Vet Dermatol. 2018 Oct 1;29(5):446-e150.Hobi S, Klinger C, Classen J, Mueller RS. The effects of a topical lipid complex therapy on dogs with atopic dermatitis: a double blind, randomized, placebo controlled study. Vet Dermatol. 2017 Aug 1;28(4):369-e84.Santoro D, Fagman L, Zhang Y, Fahong Y. Clinical efficacy of spray-based heat treated lactobacilli in canine atopic dermatitis: a preliminary, open-label, uncontrolled study. Vet Dermatol. 2021 Apr 1;32(2):114-e23.Osumi T, Shimada T, Sakaguchi M, Tsujimoto H. A double-blind, placebo controlled evaluation of orally administered heat-killed Enterococcus faecalis FK-23 preparation in atopic dogs. Vet Dermatol. 2019 Apr 1;30(2):127-e36.Santoro D, Bohannon M, Ahrens K, Navarro C, Gatto H, Marsella R. Evaluation on the effects of 0.1% Peumus boldus leaf and Spiraea ulmaria plant extract combination on bacterial colonization in canine atopic dermatitis: A preliminary randomized, placebo controlled, double-blinded study. Res Vet Sci. 2018 Jun 1;118:164–70.Gugliandolo E, Palma E, Cordaro M, D’Amico R, Peritore AF, Licata P, et al. Canine atopic dermatitis: Role of luteolin as new natural treatment. Vet Med Sci. 2020 Nov 1;6(4):926–32.Watson A, Rostaher A, Fischer NM, Favrot C. A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine-month controlled study. Vet Dermatol. 2022 Feb 1;33(1):55-e18.Loewinger M, Wakshlag JJ, Bowden D, Peters-Kennedy J, Rosenberg A. The effect of a mixed cannabidiol and cannabidiolic acid based oil on client-owned dogs with atopic dermatitis. Vet Dermatol. 2022 Aug 1;33(4):329-e77.Santoro D. Therapies in Canine Atopic Dermatitis: An Update. Vol. 49, Veterinary Clinics of North America - Small Animal Practice. W.B. Saunders; 2019. p. 9–26.Sofou EI, Aleksandrova S, Badulescu E, Chatzis M, Saridomichelakis M. Efficacy of Antimicrobial Treatment in Dogs with Atopic Dermatitis: An Observational Study. Vet Sci. 2022 Jul 27;9(8):385.Mueller RS. Update on Allergen Immunotherapy. Vol. 49, Veterinary Clinics of North America - Small Animal Practice. W.B. Saunders; 2019. p. 1–7.Bachmann MF, Zeltins A, Kalnins G, Balke I, Fischer N, Rostaher A, et al. Vaccination against IL-31 for the treatment of atopic dermatitis in dogs. Journal of Allergy and Clinical Immunology. 2018 Jul;142(1):279-281.e1.Archer TM, Boothe DM, Langston VC, Fellman CL, Lunsford KV, Mackin AJ. Oral Cyclosporine Treatment in Dogs: A Review of the Literature. J Vet Intern Med. 2014 Jan;28(1):1–20.Marsella R, Segarra S, Ahrens K, Alonso C, Ferrer L. Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis. BMC Vet Res. 2020 Mar 20;16(1).Fujimura M, Nakatsuji Y, Ishimaru H. Cyclosporin A Treatment in Intrinsic Canine Atopic Dermatitis (Atopic-like Dermatitis): Open Trial Study. Pol J Vet Sci. 2016 Sep 1;19(3):567–72.Gober M, Hillier A, Vasquez-Hidalgo MA, Amodie D, Mellencamp MA. Use of Cytopoint in the Allergic Dog. Front Vet Sci. 2022 Jul 19;9.Ramió-Lluch L, Brazís P, Ferrer L, Puigdemont A. Allergen-specific immunotherapy in dogs with atopic dermatitis: is owner compliance the main success-limiting factor? Veterinary Record. 2020 Dec;187(12):493–493.Palmeiro BS. Cyclosporine in Veterinary Dermatology. Veterinary Clinics of North America: Small Animal Practice. 2013 Jan 1;43(1):153–71.Carr MN, Torres SMF, Koch SN, Reiter L V. Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs. Vet Dermatol. 2009 Apr;20(2):105–10.PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-84334https://repository.ucc.edu.co/bitstreams/691c0c73-d1bf-4f54-b170-f4740a3fb8f5/download3bce4f7ab09dfc588f126e1e36e98a45MD51ORIGINAL2023_revision_sistematica_literatura-FormatoLicenciaUso.pdf2023_revision_sistematica_literatura-FormatoLicenciaUso.pdfLicencia de usoapplication/pdf196561https://repository.ucc.edu.co/bitstreams/6fb49d25-c957-4b80-8157-5d46426b1572/download62ee13ab1acb6651ee6d1754d10bf3e6MD522023_revision_sistematica_literatura-ActaSustentacion.pdf2023_revision_sistematica_literatura-ActaSustentacion.pdfActa de sustentacionapplication/pdf139086https://repository.ucc.edu.co/bitstreams/cba42670-bee0-41b1-829f-fb96b9c9a455/download5852024797aca0d78dcb9f67bc872e8eMD532023_revision_sistematica_literatura.pdf2023_revision_sistematica_literatura.pdfTrabajo de gradoapplication/pdf454788https://repository.ucc.edu.co/bitstreams/a5e60555-ca71-4151-958b-0a220545a943/download291b3d22b8140e28dd6c52bb79810e70MD54TEXT2023_revision_sistematica_literatura-FormatoLicenciaUso.pdf.txt2023_revision_sistematica_literatura-FormatoLicenciaUso.pdf.txtExtracted texttext/plain5786https://repository.ucc.edu.co/bitstreams/e88cc137-8cb8-4b6a-a9c8-898965fcc8fd/downloade15896ee592aa6ccd4c0afccd7bf68d6MD552023_revision_sistematica_literatura-ActaSustentacion.pdf.txt2023_revision_sistematica_literatura-ActaSustentacion.pdf.txtExtracted texttext/plain949https://repository.ucc.edu.co/bitstreams/abe3466f-468e-4163-a093-f81b859811c2/downloade18f438fe6484d7caf096fe2d1a5408aMD572023_revision_sistematica_literatura.pdf.txt2023_revision_sistematica_literatura.pdf.txtExtracted texttext/plain85914https://repository.ucc.edu.co/bitstreams/6c9302b2-b41c-4724-ad6a-a93fba197040/downloadcb8ef9aa11f77207bd535af6e668886fMD59THUMBNAIL2023_revision_sistematica_literatura-FormatoLicenciaUso.pdf.jpg2023_revision_sistematica_literatura-FormatoLicenciaUso.pdf.jpgGenerated Thumbnailimage/jpeg12740https://repository.ucc.edu.co/bitstreams/423e0195-69f6-4656-ad8d-15b1e9631b8b/download45a8ae0f7a86e8ac35591d373bfe3de5MD562023_revision_sistematica_literatura-ActaSustentacion.pdf.jpg2023_revision_sistematica_literatura-ActaSustentacion.pdf.jpgGenerated Thumbnailimage/jpeg11119https://repository.ucc.edu.co/bitstreams/4ada75f3-6065-46d7-b2a3-8b18a83d8bf8/download775e958e01c091e113ffd00b0153a7c1MD582023_revision_sistematica_literatura.pdf.jpg2023_revision_sistematica_literatura.pdf.jpgGenerated Thumbnailimage/jpeg7805https://repository.ucc.edu.co/bitstreams/79391a29-95b4-4b22-94d1-1e8fe2e8c42d/downloadc4ac2b4ff20c34943fd33a47c32a6038MD51020.500.12494/51366oai:repository.ucc.edu.co:20.500.12494/513662024-08-09 12:58:12.862restrictedhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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

Revisión sistematica de literatura: Tratamiento de la dermatitis atópica canina

Publicaciones similares