Nanoparticulas de plata como tratamiento del Distemper canino

El Distemper es una enfermedad infecciosa de tipo viral con altos índices de morbilidad y mortalidad a nivel mundial, es causada por un virus de ARN monocatenario negativo de la familia Paramyxoviridae y genero Morbillivirus, el cual presenta una amplia variedad de hospederos entre estos las familia...

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Autores:
Ariza Arboleda, Maria Alejandra
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49134
Acceso en línea:
https://hdl.handle.net/20.500.12494/49134
Palabra clave:
Nanopartículas
Distemper canino
Morbillivirus
Tratamiento
Virus del distemper
TG 2023 MVZ 49134
Nanoparticles
Canine distemper
Morbillivirus
Treatment
Distemper virus
Rights
openAccess
License
Atribución – No comercial – Sin Derivar
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oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49134
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.none.fl_str_mv Nanoparticulas de plata como tratamiento del Distemper canino
title Nanoparticulas de plata como tratamiento del Distemper canino
spellingShingle Nanoparticulas de plata como tratamiento del Distemper canino
Nanopartículas
Distemper canino
Morbillivirus
Tratamiento
Virus del distemper
TG 2023 MVZ 49134
Nanoparticles
Canine distemper
Morbillivirus
Treatment
Distemper virus
title_short Nanoparticulas de plata como tratamiento del Distemper canino
title_full Nanoparticulas de plata como tratamiento del Distemper canino
title_fullStr Nanoparticulas de plata como tratamiento del Distemper canino
title_full_unstemmed Nanoparticulas de plata como tratamiento del Distemper canino
title_sort Nanoparticulas de plata como tratamiento del Distemper canino
dc.creator.fl_str_mv Ariza Arboleda, Maria Alejandra
dc.contributor.advisor.none.fl_str_mv Plazas Hernández, Fernely Augusto
Trujillo Piso, Dunia Yisela
dc.contributor.author.none.fl_str_mv Ariza Arboleda, Maria Alejandra
dc.subject.none.fl_str_mv Nanopartículas
Distemper canino
Morbillivirus
Tratamiento
Virus del distemper
topic Nanopartículas
Distemper canino
Morbillivirus
Tratamiento
Virus del distemper
TG 2023 MVZ 49134
Nanoparticles
Canine distemper
Morbillivirus
Treatment
Distemper virus
dc.subject.classification.none.fl_str_mv TG 2023 MVZ 49134
dc.subject.other.none.fl_str_mv Nanoparticles
Canine distemper
Morbillivirus
Treatment
Distemper virus
description El Distemper es una enfermedad infecciosa de tipo viral con altos índices de morbilidad y mortalidad a nivel mundial, es causada por un virus de ARN monocatenario negativo de la familia Paramyxoviridae y genero Morbillivirus, el cual presenta una amplia variedad de hospederos entre estos las familias Canidae, Felidae, Procyonidae, Mustelidae, Viverridae, Hyaenidae, Phocidae y Ursidae, quienes adquieren el patógeno por vía aerógena gracias a aerosoles o fómites. Este virus codifica proteínas capaces de integrarse a la membrana celular, haciendo que células infectadas (tejido linfoide, epitelial y nervioso) sean susceptibles a daños por citólisis inmunomediada, lo que ocasiona afectaciones graves a nivel gastroentérico, respiratorio, cutáneo, ocular y nervioso. Actualmente no existe un tratamiento específico para combatirla, sin embargo, nuevas investigaciones arrojan el uso de nanopartículas de plata como un agente bloqueador en la adhesión y replicación viral del Distemper canino; Motivo por el cual la presente revisión, busca establecer el mecanismo de acción, uso y eficacia de dichas partículas como tratamiento del distemper canino para futuras generaciones, a través una recopilación de información en bases de datos como: PROQUEST, ELSIEVER, DIALNET, PUBMED, SCIENCE DIRECT, entre otros.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-04-13T16:18:22Z
dc.date.available.none.fl_str_mv 2023-04-13T16:18:22Z
dc.date.issued.none.fl_str_mv 2023-04-13
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49134
dc.identifier.bibliographicCitation.none.fl_str_mv Ariza Arboleda, M. A. (2023). Nanoparticulas de plata como tratamiento del Distemper canino. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/49134
url https://hdl.handle.net/20.500.12494/49134
identifier_str_mv Ariza Arboleda, M. A. (2023). Nanoparticulas de plata como tratamiento del Distemper canino. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/49134
dc.relation.references.none.fl_str_mv Hurtado Contreras J. Prevalencia de Distemper canino (Canis lupus familiaris) en la ciudad de Abancay. Repos Inst UNAMBA. 2018;87.
Rikula UK. Canine distemper in Finland: vaccination and epidemiology. Evira Research Reports. 2008. 71 pp.
Rodas, Noemí B., Gisselle Barra AEV. El Virus del Distemper Canino, ¿Podría ser una zoonosis? 2021;5(2):28–32
Martinez Gutierrez M, Ruiz Saenz J. Diversity of susceptible hosts in canine distemper virus infection: A systematic review and data synthesis. BMC Vet Res [Internet]. 2016;12(1):1–11. Available from: http://dx.doi.org/10.1186/s12917-016-0702-z
Nikolin VM, Wibbelt G, Michler FUF, Wolf P, East ML. Susceptibility of carnivore hosts to strains of canine distemper virus from distinct genetic lineages. Vet Microbiol [Internet]. 2012;156(1–2):45–53. Available from: http://dx.doi.org/10.1016/j.vetmic.2011.10.009
Beineke A, Baumgärtner W, Wohlsein P. Cross-species transmission of canine distemper virus-an update. One Heal [Internet]. 2015;1:49–59. Available from: http://dx.doi.org/10.1016/j.onehlt.2015.09.002
Panzera Y, Sarute N, Carrau L, Aldaz J, Pérez R. Review Genetic Diversity of Canine Distemper Virus in South America. 2014;(March 2015).
Torres González-Chávez M, Peraza-González B, Díaz-Rodríguez S, Camacho-Socarrás C, Vega-Rodríguez N, Vega-Cañizares E. Caracterización clínica del moquillo canino en dos municipios de La Habana. Rev Salud Anim. 2017;39(1):2224–4697.
Maleny R, L MA, N GE, Adán Á, Benjamín V, Valente V, et al. Análisis epidemiológico retrospectivo de Distemper Canino en la ciudad de Pachuca de Soto, Estado de Hidalgo. 2020
Soto AR, Luna LRE, Rosadio RA, Maturrano LH. Molecular detection of canine distemper virus in clinical cases from unvaccinated domestic dogs and assessment of risk factors. Rev Investig Vet del Peru. 2018;29(3):964–71.
Liseth ÁIM, Vélez Cusme Kerly Roxana. Análisis Retrospectivo del Distemper Canino - Morbillivirus en los siete cantones de la provincia Bolívar en el periodo 2017 - 2020. 2021;
Martella V, Elia G, Buonavoglia C. Canine Distemper Virus. Vet Clin North Am - Small Anim Pract. 2008;38(4):787–97.
Headley SA, Oliveira TES, Pereira AHT, Moreira JR, Michelazzo MMZ, Pires BG, et al. Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study. Sci Rep. 2018;8(1):1–17.
Linares Villalba SE, Correa Salgado AM, Velásquez Garzón LH. Diagnóstico de moquillo canino. VetZootec. 2010;4(2):77–84.
Loots AK, Mitchell E, Dalton DL, Kotzé A, Venter EH. Advances in canine distemper virus pathogenesis research: A wildlife perspective. J Gen Virol. 2017;98(3):311–21.
Rojas CAF. Efecto de plata coloidal en el tratamiento de Distemper canino en fase aguda en cachorros de 3 a 12 meses de edad. 2019
Rendon Marin S, Da Fontoura Budaszewski R, Canal CW, Ruiz Saenz J. Tropism and molecular pathogenesis of canine distemper virus. Virol J. 2019;16(1):1–15.
Forero Muñoz NR, Barato P. Caracterización molecular de genotipos vacunales y de campo del virus del distemper canino en Bogotá D.C. – Colombia. 2016;1–40. Available from: http://repository.lasalle.edu.co/bitstream/handle/10185/18857/14111105_2016.pdf?sequence=1
Sarute N, Pérez R, Francia L, Hernández M, Bedó G, Bonilla B, et al. Primer diagnóstico molecular y caracterización parcial del gen de la nucleoproteína del virus Distemper Canino en Uruguay. Veterinaria. 2011;47(182):7–13.
Gámiz-mejía, C E; Simon Martinez J, Fajardo-muñoz RC. Identification of new genovariants of canine distemper virus in dogs from the State of Mexico by analyzing the nucleocapsid gene Identificación de nuevas genovariantes del virus del distemper canino mediante el análisis del gen de la nucleocápside en perro. Arch Med V (2012), v44, pg 53-58. 2012;44:53–8
Sarute N. Análisis de la dinámica poblacional del virus distemper canino mediante secuenciación masiva. 2014;1–141. Available from: https://www.colibri.udelar.edu.uy/jspui/bitstream/20.500.12008/5157/1/uy24-17283.pdf
Audsley MD. Paramyxovirus evasion of innate immunity: Diverse strategies for common targets. World J Virol. 2013;2(2):57.
Gallegos MJZ. Detección Molecular Del Gen M Del Virus Distemper Canino Molecular Detection of Canine Distemper Virus M Gene Del Virus Distemper Canino Molecular Detection of Canine. Dep Med [Internet]. 2018; Available from: http://repositorio.uchile.cl/bitstream/handle/2250/159254/Deteccion-molecular-del-gen-M-del-virus-distemper-canino.pdf?sequence=1&isAllowed=y
Svitek N, Gerhauser I, Goncalves C, Grabski E, Döring M, Kalinke U, et al. Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but Not STAT1 for Canine Distemper Virus Virulence in Ferrets. J Virol. 2014;88(5):2941–50
Ram L, Co-orientador YP, Secci S. Caracterizacion genetica de aislamientos brasileros del virus distemper canino en base al analisis del gen de la proteina de fusion. 2014
Sarute N, Calderón MG, Pérez R, La Torre J, Hernández M, Francia L, et al. The Fusion Protein Signal-Peptide-Coding Region of Canine Distemper Virus: A Useful Tool for Phylogenetic Reconstruction and Lineage Identification. PLoS One. 2013;8(5):1–6.
Portela VA de, Guarines K, Farias CK da, Carvalho O, Oliveira-Filho E, Silva A da, et al. Hemagglutinin Gene Diversity of Canine Distemper Virus from Clinical Samples in Brazil. J Appl Vet Sci. 2022;0(0):0–0
Fuques E. Análisis filodinámico del virus Distemper Canino. 2017;0–61. Available from: https://www.colibri.udelar.edu.uy/jspui/bitstream/20.500.12008/21375/1/uy24-18704.pdf
Santos-Lopez G, Hernandez J, Borraz-Argüello, Ramirez-Mendoza H, Vallejo V, Reyes-Leyva J. Proteins of Porcine rubulavirus: Structure, function and pathological implications | Estructura, función e implicaciones patológicas de las proteínas del Rubulavirus porcino. Arch Med Vet. 2004;36(2):119–36.
Shrestha N, Gall FM, Vesin J, Chambon M, Turcatti G, Fotiadis D, et al. Antiviral screen against canine distemper virus-induced membrane fusion activity. Viruses. 2021;13(1).
Delpeut S, Noyce RS, Richardson CD. The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread. Virology [Internet]. 2014;454–455(1):109–17. Available from: http://dx.doi.org/10.1016/j.virol.2014.02.014
Alves L, Khosravi M, Avila M, Ader-Ebert N, Bringolf F, Zurbriggen A, et al. SLAM- and Nectin-4-Independent Noncytolytic Spread of Canine Distemper Virus in Astrocytes. J Virol. 2015;89(10):5724–33.
Greene CE. Infectious Diseases of the dog and cat. Fourth edi. Atena, Georgia: ELSIVIER; 2012
Pinotti MA. Distemper Canino: Evaluación De Dos Alternativas Terapéuticas Y Caracterización De Aspectos Clínico-Epidemiológico En La Ciudad De Santa Fe. Univ Nac del Litorial. 2017;1–114
Canales K´ana DH. Virus del distemper canino: Revisión actualizada del agente y la patogenia de la enfermedad. Univ Nac Mayor San Marcos [Internet]. 2020;60. Available from:https://cybertesis.unmsm.edu.pe/bitstream/handle/20.500.12672/12267/Canales_kd.pdf?sequence=1&isAllowed=y
Céspedes PF, Cruz P, Navarro CO. Modulación de la respuesta inmune durante la infección por virus distemper canino : implicancias terapéuticas y en el desarrollo de vacunas Modulation of immune response during canine distemper virus infection : therapeutic and vaccine development implica. Arch Med Vet [Internet]. 2010;42:15–28. Available from: https://scielo.conicyt.cl/pdf/amv/v42n2/art03.pdf
Carvalho OV, Botelho CV, Ferreira CGT, Scherer PO, Soares-Martins JAP, Almeida MR, et al. Immunopathogenic and neurological mechanisms of canine distemper virus. Adv Virol. 2012;2012.
Beineke A, Puff C, Seehusen F, Baumgärtner W. Pathogenesis and immunopathology of systemic and nervous canine distemper. Vet Immunol Immunopathol. 2009;127(1–2):1–18.
Navaratnarajah CK, Generous AR, Yousaf I, Cattaneo R. Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis. J Biol Chem [Internet]. 2020;295(9):2771–86. Available from: http://dx.doi.org/10.1074/jbc.REV119.009961
Zhao J, Shi N, Sun Y, Martella V, Nikolin V, Zhu C, et al. Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks. Antiviral Res. 2015;122:1–11.
Christian Griot, Marc Vandevelde MS and AZ. Canine distemper, a re-emerging morbillivirus with complex neuropathogenic mechanisms. 2003;
Rudd PA, Cattaneo R, von Messling V. Canine Distemper Virus Uses both the Anterograde and the Hematogenous Pathway for Neuroinvasion. J Virol. 2006;80(19):9361–70.
De Nardo TFS, Bertolo PHL, Bernardes PA, Munari DP, Machado GF, Jardim LS, et al. Contribution of astrocytes and macrophage migration inhibitory factor to immune-mediated canine encephalitis caused by the distemper virus. Vet Immunol Immunopathol [Internet]. 2020;221(March 2019):110010. Available from: https://doi.org/10.1016/j.vetimm.2020.110010
Zurbriggen A, Vandevelde M. Canine distemper virus-induced glial cell changes in vitro. Acta Neuropathol. 1983;62(1–2):51–8.
Zhao J, Ren Y. Multiple Receptors Involved in Invasion and Neuropathogenicity of Canine Distemper Virus: A Review. Viruses. 2022;14(7).
Vandevelde M, Zurbriggen A. The neurobiology of canine distemper virus infection. Vet Microbiol. 1995;44(2–4):271–80.
Zurbriggen A, Schmid I, Graber HU, Vandevelde M. Oligodendroglial pathology in canine distemper. Acta Neuropathol. 1997;95(1):71–7.
Vandevelde M, Zurbriggen A. Demyelination in canine distemper virus infection: A review. Acta Neuropathol. 2005;109(1):56–68.
Akhtar T, Sciences A, Naeem MI, Sciences A, Aziz S, Sciences A. Use of Nanotechnology in Treating Some Important Viral Animal Diseases. Int J Vet Sci. 2022;(Volume 2):254–60.
Hartemann P, Hoet P, Proykova A, Fernandes T, Baun A, De Jong W, et al. Nanosilver: Safety, health and environmental effects and role in antimicrobial resistance. Mater Today [Internet]. 2015;18(3):122–3. Available from: http://dx.doi.org/10.1016/j.mattod.2015.02.014
Ortiz Arana G, Talavera Rojas M, Velazquez Ordonez V, Acosta-Dibarrat J. Applications of metallic nanoparticles in veterinary science. Rev Mvz Cordoba. 2021;26(3).
Davenport LL, Hsieh H, Eppert BL, Carreira VS, Krishan M, Ingle T, et al. Systemic and behavioral effects of intranasal administration of silver nanoparticles. Neurotoxicol Teratol [Internet]. 2015;51:68–76. Available from: http://dx.doi.org/10.1016/j.ntt.2015.08.006
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M. Broad-spectrum bioactivities of silver nanoparticles: The emerging trends and future prospects. Appl Microbiol Biotechnol. 2014;98(5):1951–61.
Gurunathan S, Qasim M, Choi Y, Do JT, Park C, Hong K, et al. Antiviral potential of nanoparticles—can nanoparticles fight against coronaviruses? Nanomaterials. 2020;10(9):1–29.
Imamishi J, Tanaka A. Heparanase from basic research to clinical applications. Vol. 11, Japanese Journal of Cancer and Chemotherapy. 1984. 53–59 p
Sharmin S, Rahaman MM, Sarkar C, Atolani O, Islam MT, Adeyemi OS. Nanoparticles as antimicrobial and antiviral agents: A literature-based perspective study. Heliyon [Internet]. 2021;7(3):e06456. Available from: https://doi.org/10.1016/j.heliyon.2021.e06456
Cagno V, Andreozzi P, D’Alicarnasso M, Silva PJ, Mueller M, Galloux M, et al. Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism. Nat Mater. 2018;17(2):195–203
Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, et al. Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses. Antiviral Res [Internet]. 2015;116:34–44. Available from: http://dx.doi.org/10.1016/j.antiviral.2015.01.008
Zhou J, Krishnan N, Jiang Y, Fang RH, Zhang L. Nanotechnology for virus treatment. 2020;(January).
Gaikwad S, Ingle A, Gade A, Rai M, Falanga A, Incoronato N, et al. Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3. Int J Nanomedicine. 2013;8:4303–14.
Karla Oyuky Juárez Moreno D, Huerta Saquero Dra Elizabeth Ponce Rivas Dra María Evarista Arellano García Sergio Fuentes Moyado Coordinador del Posgrado en Nanociencias Dra Rufina Hernández Martínez A. Genotipificacion del virus del moquillo canino aislado de perros enfermos y su relacion con la eficacia del tratamiento antiviral con nanoparticulas de plata. 2018
Moreno-Figueroa LD, Hernández-Adame L, Monroy-Gamboa AG. Use of nanoparticle biosensors to evaluate carnivore health: A new approach. Therya. 2022;13(3):345–53.
Vazquez Muñoz R, Borrego B, Juárez Moreno K, García García M, Mota Morales JD, Bogdanchikova N, et al. Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter? Toxicol Lett [Internet]. 2017;276(April):11–20. Available from: http://dx.doi.org/10.1016/j.toxlet.2017.05.007
Bogdanchikova N, Vázquez-Muñoz R, Huerta-Saquero A,Pena-Jasso A, Aguilar-Uzcanga G, Picos-Díaz PL, et al. Silver nanoparticles composition for treatment of distemper in dogs. Int J Nanotechnol. 2016;13(1–3):227–37.
Gastelum-leyva F, Pena-jasso A, Alvarado-vera M, Plascencia-lópez I. Evaluation of the Efficacy and Safety of Silver Nanoparticles in the Treatment of Non-Neurological and Neurological Distemper in Dogs : A Randomized Clinical Trial. 2022;1–25.
Ghosh U, Sayef Ahammed K, Mishra S, Bhaumik A. The Emerging Roles of Silver Nanoparticles to Target Viral Life Cycle and Detect Viral Pathogens. Chem - An Asian J. 2022;17(5).
Galdiero S, Falanga A, Vitiello M, Cantisani M, Marra V, Galdiero M. Silver nanoparticles as potential antiviral agents. Molecules. 2011;16(10):8894–918.
Ortiz-Arana G, Talavera-Rojas M, Velázquez-Ordoñez V, Acosta-Dibarrat J. Aplicaciones de las nanopartículas metálicas en las ciencias veterinarias. Rev MVZ Cordoba. 2021;26(3):1–12
Lara HH, Garza-Treviño EN, Ixtepan-Turrent L, Singh DK. Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds. J Nanobiotechnology [Internet]. 2011;9(1):30. Available from: http://www.jnanobiotechnology.com/content/9/1/30
Ávalos, A, Haza, AI, Mateo, D y Morales P. NANOPARTÍCULAS DE PLATA: APLICACIONES Y RIESGOS TÓXICOS PARA LA SALUD HUMANA Y EL MEDIO AMBIENTE. Soc Stud Stud. 2014;11(1):81–108.
Lara HH, Garza-Treviño EN, Ixtepan-Turrent L, Singh DK. Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds. J Nanobiotechnology. 2011;9(1):30.
González-Jiménez A, García A. Nanopartículas de plata como agente antibacteriano en infecciones óseas. FarmaJournal. 2020;5(1):27–36.
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spelling Plazas Hernández, Fernely AugustoTrujillo Piso, Dunia YiselaAriza Arboleda, Maria Alejandra2023-04-13T16:18:22Z2023-04-13T16:18:22Z2023-04-13https://hdl.handle.net/20.500.12494/49134Ariza Arboleda, M. A. (2023). Nanoparticulas de plata como tratamiento del Distemper canino. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/49134El Distemper es una enfermedad infecciosa de tipo viral con altos índices de morbilidad y mortalidad a nivel mundial, es causada por un virus de ARN monocatenario negativo de la familia Paramyxoviridae y genero Morbillivirus, el cual presenta una amplia variedad de hospederos entre estos las familias Canidae, Felidae, Procyonidae, Mustelidae, Viverridae, Hyaenidae, Phocidae y Ursidae, quienes adquieren el patógeno por vía aerógena gracias a aerosoles o fómites. Este virus codifica proteínas capaces de integrarse a la membrana celular, haciendo que células infectadas (tejido linfoide, epitelial y nervioso) sean susceptibles a daños por citólisis inmunomediada, lo que ocasiona afectaciones graves a nivel gastroentérico, respiratorio, cutáneo, ocular y nervioso. Actualmente no existe un tratamiento específico para combatirla, sin embargo, nuevas investigaciones arrojan el uso de nanopartículas de plata como un agente bloqueador en la adhesión y replicación viral del Distemper canino; Motivo por el cual la presente revisión, busca establecer el mecanismo de acción, uso y eficacia de dichas partículas como tratamiento del distemper canino para futuras generaciones, a través una recopilación de información en bases de datos como: PROQUEST, ELSIEVER, DIALNET, PUBMED, SCIENCE DIRECT, entre otros.Distemper is a viral-type infectious disease with high morbidity and mortality rates worldwide, it is caused by a negative single-stranded RNA virus of the Paramyxoviridae family and the Morbillivirus genus, which has a wide variety of hosts among these the families Canidae, Felidae, Procyonidae, Mustelidae, Viverridae, Hyaenidae, Phocidae and Ursidae, who acquire the pathogen through the air thanks to aerosols or fomites. This virus encodes proteins capable of integrating into the cell membrane, making infected cells (lymphoid, epithelial, and nervous tissue) susceptible to damage by immune-mediated cytolysis, which causes serious damage at the gastroenteric, respiratory, skin, eye, and nervous levels. Currently there is no specific treatment to combat it, however, new research shows the use of silver nanoparticles as a blocking agent for the adhesion and viral replication of canine Distemper; Reason for which the present review seeks to establish the mechanism of action, use and efficacy of said particles as a treatment for canine distemper for future generations, through a compilation of information in databases such as: PROQUEST, ELSIEVER, DIALNET, PUBMED, SCIENCE DIRECT, among others.maria.arizaar@campusucc.edu.co28 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéNanopartículasDistemper caninoMorbillivirusTratamientoVirus del distemperTG 2023 MVZ 49134NanoparticlesCanine distemperMorbillivirusTreatmentDistemper virusNanoparticulas de plata como tratamiento del Distemper caninoTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Hurtado Contreras J. Prevalencia de Distemper canino (Canis lupus familiaris) en la ciudad de Abancay. Repos Inst UNAMBA. 2018;87.Rikula UK. Canine distemper in Finland: vaccination and epidemiology. Evira Research Reports. 2008. 71 pp.Rodas, Noemí B., Gisselle Barra AEV. El Virus del Distemper Canino, ¿Podría ser una zoonosis? 2021;5(2):28–32Martinez Gutierrez M, Ruiz Saenz J. Diversity of susceptible hosts in canine distemper virus infection: A systematic review and data synthesis. BMC Vet Res [Internet]. 2016;12(1):1–11. Available from: http://dx.doi.org/10.1186/s12917-016-0702-zNikolin VM, Wibbelt G, Michler FUF, Wolf P, East ML. Susceptibility of carnivore hosts to strains of canine distemper virus from distinct genetic lineages. Vet Microbiol [Internet]. 2012;156(1–2):45–53. Available from: http://dx.doi.org/10.1016/j.vetmic.2011.10.009Beineke A, Baumgärtner W, Wohlsein P. Cross-species transmission of canine distemper virus-an update. One Heal [Internet]. 2015;1:49–59. Available from: http://dx.doi.org/10.1016/j.onehlt.2015.09.002Panzera Y, Sarute N, Carrau L, Aldaz J, Pérez R. Review Genetic Diversity of Canine Distemper Virus in South America. 2014;(March 2015).Torres González-Chávez M, Peraza-González B, Díaz-Rodríguez S, Camacho-Socarrás C, Vega-Rodríguez N, Vega-Cañizares E. Caracterización clínica del moquillo canino en dos municipios de La Habana. Rev Salud Anim. 2017;39(1):2224–4697.Maleny R, L MA, N GE, Adán Á, Benjamín V, Valente V, et al. Análisis epidemiológico retrospectivo de Distemper Canino en la ciudad de Pachuca de Soto, Estado de Hidalgo. 2020Soto AR, Luna LRE, Rosadio RA, Maturrano LH. Molecular detection of canine distemper virus in clinical cases from unvaccinated domestic dogs and assessment of risk factors. Rev Investig Vet del Peru. 2018;29(3):964–71.Liseth ÁIM, Vélez Cusme Kerly Roxana. Análisis Retrospectivo del Distemper Canino - Morbillivirus en los siete cantones de la provincia Bolívar en el periodo 2017 - 2020. 2021;Martella V, Elia G, Buonavoglia C. Canine Distemper Virus. Vet Clin North Am - Small Anim Pract. 2008;38(4):787–97.Headley SA, Oliveira TES, Pereira AHT, Moreira JR, Michelazzo MMZ, Pires BG, et al. Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study. Sci Rep. 2018;8(1):1–17.Linares Villalba SE, Correa Salgado AM, Velásquez Garzón LH. Diagnóstico de moquillo canino. VetZootec. 2010;4(2):77–84.Loots AK, Mitchell E, Dalton DL, Kotzé A, Venter EH. Advances in canine distemper virus pathogenesis research: A wildlife perspective. J Gen Virol. 2017;98(3):311–21.Rojas CAF. Efecto de plata coloidal en el tratamiento de Distemper canino en fase aguda en cachorros de 3 a 12 meses de edad. 2019Rendon Marin S, Da Fontoura Budaszewski R, Canal CW, Ruiz Saenz J. Tropism and molecular pathogenesis of canine distemper virus. Virol J. 2019;16(1):1–15.Forero Muñoz NR, Barato P. Caracterización molecular de genotipos vacunales y de campo del virus del distemper canino en Bogotá D.C. – Colombia. 2016;1–40. Available from: http://repository.lasalle.edu.co/bitstream/handle/10185/18857/14111105_2016.pdf?sequence=1Sarute N, Pérez R, Francia L, Hernández M, Bedó G, Bonilla B, et al. Primer diagnóstico molecular y caracterización parcial del gen de la nucleoproteína del virus Distemper Canino en Uruguay. Veterinaria. 2011;47(182):7–13.Gámiz-mejía, C E; Simon Martinez J, Fajardo-muñoz RC. Identification of new genovariants of canine distemper virus in dogs from the State of Mexico by analyzing the nucleocapsid gene Identificación de nuevas genovariantes del virus del distemper canino mediante el análisis del gen de la nucleocápside en perro. Arch Med V (2012), v44, pg 53-58. 2012;44:53–8Sarute N. Análisis de la dinámica poblacional del virus distemper canino mediante secuenciación masiva. 2014;1–141. Available from: https://www.colibri.udelar.edu.uy/jspui/bitstream/20.500.12008/5157/1/uy24-17283.pdfAudsley MD. Paramyxovirus evasion of innate immunity: Diverse strategies for common targets. World J Virol. 2013;2(2):57.Gallegos MJZ. Detección Molecular Del Gen M Del Virus Distemper Canino Molecular Detection of Canine Distemper Virus M Gene Del Virus Distemper Canino Molecular Detection of Canine. Dep Med [Internet]. 2018; Available from: http://repositorio.uchile.cl/bitstream/handle/2250/159254/Deteccion-molecular-del-gen-M-del-virus-distemper-canino.pdf?sequence=1&isAllowed=ySvitek N, Gerhauser I, Goncalves C, Grabski E, Döring M, Kalinke U, et al. Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but Not STAT1 for Canine Distemper Virus Virulence in Ferrets. J Virol. 2014;88(5):2941–50Ram L, Co-orientador YP, Secci S. Caracterizacion genetica de aislamientos brasileros del virus distemper canino en base al analisis del gen de la proteina de fusion. 2014Sarute N, Calderón MG, Pérez R, La Torre J, Hernández M, Francia L, et al. The Fusion Protein Signal-Peptide-Coding Region of Canine Distemper Virus: A Useful Tool for Phylogenetic Reconstruction and Lineage Identification. PLoS One. 2013;8(5):1–6.Portela VA de, Guarines K, Farias CK da, Carvalho O, Oliveira-Filho E, Silva A da, et al. Hemagglutinin Gene Diversity of Canine Distemper Virus from Clinical Samples in Brazil. J Appl Vet Sci. 2022;0(0):0–0Fuques E. Análisis filodinámico del virus Distemper Canino. 2017;0–61. Available from: https://www.colibri.udelar.edu.uy/jspui/bitstream/20.500.12008/21375/1/uy24-18704.pdfSantos-Lopez G, Hernandez J, Borraz-Argüello, Ramirez-Mendoza H, Vallejo V, Reyes-Leyva J. Proteins of Porcine rubulavirus: Structure, function and pathological implications | Estructura, función e implicaciones patológicas de las proteínas del Rubulavirus porcino. Arch Med Vet. 2004;36(2):119–36.Shrestha N, Gall FM, Vesin J, Chambon M, Turcatti G, Fotiadis D, et al. Antiviral screen against canine distemper virus-induced membrane fusion activity. Viruses. 2021;13(1).Delpeut S, Noyce RS, Richardson CD. The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread. Virology [Internet]. 2014;454–455(1):109–17. Available from: http://dx.doi.org/10.1016/j.virol.2014.02.014Alves L, Khosravi M, Avila M, Ader-Ebert N, Bringolf F, Zurbriggen A, et al. SLAM- and Nectin-4-Independent Noncytolytic Spread of Canine Distemper Virus in Astrocytes. J Virol. 2015;89(10):5724–33.Greene CE. Infectious Diseases of the dog and cat. Fourth edi. Atena, Georgia: ELSIVIER; 2012Pinotti MA. Distemper Canino: Evaluación De Dos Alternativas Terapéuticas Y Caracterización De Aspectos Clínico-Epidemiológico En La Ciudad De Santa Fe. Univ Nac del Litorial. 2017;1–114Canales K´ana DH. Virus del distemper canino: Revisión actualizada del agente y la patogenia de la enfermedad. Univ Nac Mayor San Marcos [Internet]. 2020;60. Available from:https://cybertesis.unmsm.edu.pe/bitstream/handle/20.500.12672/12267/Canales_kd.pdf?sequence=1&isAllowed=yCéspedes PF, Cruz P, Navarro CO. Modulación de la respuesta inmune durante la infección por virus distemper canino : implicancias terapéuticas y en el desarrollo de vacunas Modulation of immune response during canine distemper virus infection : therapeutic and vaccine development implica. Arch Med Vet [Internet]. 2010;42:15–28. Available from: https://scielo.conicyt.cl/pdf/amv/v42n2/art03.pdfCarvalho OV, Botelho CV, Ferreira CGT, Scherer PO, Soares-Martins JAP, Almeida MR, et al. Immunopathogenic and neurological mechanisms of canine distemper virus. Adv Virol. 2012;2012.Beineke A, Puff C, Seehusen F, Baumgärtner W. Pathogenesis and immunopathology of systemic and nervous canine distemper. Vet Immunol Immunopathol. 2009;127(1–2):1–18.Navaratnarajah CK, Generous AR, Yousaf I, Cattaneo R. Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis. J Biol Chem [Internet]. 2020;295(9):2771–86. Available from: http://dx.doi.org/10.1074/jbc.REV119.009961Zhao J, Shi N, Sun Y, Martella V, Nikolin V, Zhu C, et al. Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks. Antiviral Res. 2015;122:1–11.Christian Griot, Marc Vandevelde MS and AZ. Canine distemper, a re-emerging morbillivirus with complex neuropathogenic mechanisms. 2003;Rudd PA, Cattaneo R, von Messling V. Canine Distemper Virus Uses both the Anterograde and the Hematogenous Pathway for Neuroinvasion. J Virol. 2006;80(19):9361–70.De Nardo TFS, Bertolo PHL, Bernardes PA, Munari DP, Machado GF, Jardim LS, et al. Contribution of astrocytes and macrophage migration inhibitory factor to immune-mediated canine encephalitis caused by the distemper virus. Vet Immunol Immunopathol [Internet]. 2020;221(March 2019):110010. Available from: https://doi.org/10.1016/j.vetimm.2020.110010Zurbriggen A, Vandevelde M. Canine distemper virus-induced glial cell changes in vitro. Acta Neuropathol. 1983;62(1–2):51–8.Zhao J, Ren Y. Multiple Receptors Involved in Invasion and Neuropathogenicity of Canine Distemper Virus: A Review. Viruses. 2022;14(7).Vandevelde M, Zurbriggen A. The neurobiology of canine distemper virus infection. Vet Microbiol. 1995;44(2–4):271–80.Zurbriggen A, Schmid I, Graber HU, Vandevelde M. Oligodendroglial pathology in canine distemper. Acta Neuropathol. 1997;95(1):71–7.Vandevelde M, Zurbriggen A. Demyelination in canine distemper virus infection: A review. Acta Neuropathol. 2005;109(1):56–68.Akhtar T, Sciences A, Naeem MI, Sciences A, Aziz S, Sciences A. Use of Nanotechnology in Treating Some Important Viral Animal Diseases. Int J Vet Sci. 2022;(Volume 2):254–60.Hartemann P, Hoet P, Proykova A, Fernandes T, Baun A, De Jong W, et al. Nanosilver: Safety, health and environmental effects and role in antimicrobial resistance. Mater Today [Internet]. 2015;18(3):122–3. Available from: http://dx.doi.org/10.1016/j.mattod.2015.02.014Ortiz Arana G, Talavera Rojas M, Velazquez Ordonez V, Acosta-Dibarrat J. Applications of metallic nanoparticles in veterinary science. Rev Mvz Cordoba. 2021;26(3).Davenport LL, Hsieh H, Eppert BL, Carreira VS, Krishan M, Ingle T, et al. Systemic and behavioral effects of intranasal administration of silver nanoparticles. Neurotoxicol Teratol [Internet]. 2015;51:68–76. Available from: http://dx.doi.org/10.1016/j.ntt.2015.08.006Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M. Broad-spectrum bioactivities of silver nanoparticles: The emerging trends and future prospects. Appl Microbiol Biotechnol. 2014;98(5):1951–61.Gurunathan S, Qasim M, Choi Y, Do JT, Park C, Hong K, et al. Antiviral potential of nanoparticles—can nanoparticles fight against coronaviruses? Nanomaterials. 2020;10(9):1–29.Imamishi J, Tanaka A. Heparanase from basic research to clinical applications. Vol. 11, Japanese Journal of Cancer and Chemotherapy. 1984. 53–59 pSharmin S, Rahaman MM, Sarkar C, Atolani O, Islam MT, Adeyemi OS. Nanoparticles as antimicrobial and antiviral agents: A literature-based perspective study. Heliyon [Internet]. 2021;7(3):e06456. Available from: https://doi.org/10.1016/j.heliyon.2021.e06456Cagno V, Andreozzi P, D’Alicarnasso M, Silva PJ, Mueller M, Galloux M, et al. Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism. Nat Mater. 2018;17(2):195–203Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, et al. Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses. Antiviral Res [Internet]. 2015;116:34–44. Available from: http://dx.doi.org/10.1016/j.antiviral.2015.01.008Zhou J, Krishnan N, Jiang Y, Fang RH, Zhang L. Nanotechnology for virus treatment. 2020;(January).Gaikwad S, Ingle A, Gade A, Rai M, Falanga A, Incoronato N, et al. Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3. Int J Nanomedicine. 2013;8:4303–14.Karla Oyuky Juárez Moreno D, Huerta Saquero Dra Elizabeth Ponce Rivas Dra María Evarista Arellano García Sergio Fuentes Moyado Coordinador del Posgrado en Nanociencias Dra Rufina Hernández Martínez A. Genotipificacion del virus del moquillo canino aislado de perros enfermos y su relacion con la eficacia del tratamiento antiviral con nanoparticulas de plata. 2018Moreno-Figueroa LD, Hernández-Adame L, Monroy-Gamboa AG. Use of nanoparticle biosensors to evaluate carnivore health: A new approach. Therya. 2022;13(3):345–53.Vazquez Muñoz R, Borrego B, Juárez Moreno K, García García M, Mota Morales JD, Bogdanchikova N, et al. Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter? Toxicol Lett [Internet]. 2017;276(April):11–20. Available from: http://dx.doi.org/10.1016/j.toxlet.2017.05.007Bogdanchikova N, Vázquez-Muñoz R, Huerta-Saquero A,Pena-Jasso A, Aguilar-Uzcanga G, Picos-Díaz PL, et al. Silver nanoparticles composition for treatment of distemper in dogs. Int J Nanotechnol. 2016;13(1–3):227–37.Gastelum-leyva F, Pena-jasso A, Alvarado-vera M, Plascencia-lópez I. Evaluation of the Efficacy and Safety of Silver Nanoparticles in the Treatment of Non-Neurological and Neurological Distemper in Dogs : A Randomized Clinical Trial. 2022;1–25.Ghosh U, Sayef Ahammed K, Mishra S, Bhaumik A. The Emerging Roles of Silver Nanoparticles to Target Viral Life Cycle and Detect Viral Pathogens. Chem - An Asian J. 2022;17(5).Galdiero S, Falanga A, Vitiello M, Cantisani M, Marra V, Galdiero M. Silver nanoparticles as potential antiviral agents. Molecules. 2011;16(10):8894–918.Ortiz-Arana G, Talavera-Rojas M, Velázquez-Ordoñez V, Acosta-Dibarrat J. Aplicaciones de las nanopartículas metálicas en las ciencias veterinarias. Rev MVZ Cordoba. 2021;26(3):1–12Lara HH, Garza-Treviño EN, Ixtepan-Turrent L, Singh DK. Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds. J Nanobiotechnology [Internet]. 2011;9(1):30. Available from: http://www.jnanobiotechnology.com/content/9/1/30Ávalos, A, Haza, AI, Mateo, D y Morales P. NANOPARTÍCULAS DE PLATA: APLICACIONES Y RIESGOS TÓXICOS PARA LA SALUD HUMANA Y EL MEDIO AMBIENTE. Soc Stud Stud. 2014;11(1):81–108.Lara HH, Garza-Treviño EN, Ixtepan-Turrent L, Singh DK. Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds. J Nanobiotechnology. 2011;9(1):30.González-Jiménez A, García A. Nanopartículas de plata como agente antibacteriano en infecciones óseas. 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