Extended Hildebrand solubility approach applied to sulphadiazine, sulphamerazine and sulphamethazine in some {1-propanol (1) + water (2)} mixtures at 298.15 K

Extended Hildebrand solubility approach (EHSA) was applied in this research to analyse the equilibrium solubility of sulphadiazine, sulphamerazine and sulphamethazine in some {1-propanol (1) + water (2)} mixtures at 298.15 K. Reported experimental solubilities and some fusion properties of these drugs were used for EHSA calculations. A good predictive character of EHSA (with mean deviations lower than 4.0%) was found by using regular polynomials in order five when correlating the interaction parameter (W) and the Hildebrand solubility parameter of solvent mixtures free of drug (d1+2). Nevertheless, the predictive character of EHSA was almost the same as obtained when logarithmic drug solubilities (log x3) were correlated with d1+2 by using a fifth-degree regular polynomial. © 2018 Informa UK Limited, trading as Taylor & Francis Group

• Autores: Delgado, Daniel ricardo; Peña M.; Martínez F.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/50362
• Acceso en línea: https://doi.org/10.1080/00319104.2018.1476976; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049127418&doi=10.1080%2f00319104.2018.1476976&partnerID=40&md5=9831f371c105b9d809c9cf81b0a2b604; https://hdl.handle.net/20.500.12494/50362
• Palabra clave: 1-PROPANOL; AMIDES; BINARY MIXTURES; DRUG DELIVERY; EHSA; EQUILIBRIUM SOLUBILITIES; FUSION PROPERTY; HILDEBRAND SOLUBILITY; INTERACTION PARAMETERS; SOLUBILITY; SOLVENT MIXTURES; SULPHONAMIDES
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2