Relationship between ocular abnormalities and hematologic alterations

To determine the association between ocular abnormalities and hematologic findings in Ehrlichia canis-infected dogs, 120 dogs suspected of canine ehrlichiosis were studied. All patients were subjected to rapid serologic diagnostic test for Ehrlichia canis, and the diagnosis was confirmed by quantita...

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Autores:
Trujillo Piso, Dunia Yisela
Padilla Barreto, Mónica Yamile
Sánchez Bonilla, María del Pilar
Lima de Andrade, Alexandre
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
eng
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/54114
Acceso en línea:
https://hdl.handle.net/20.500.12494/54114
https://doi.org/10.1590/0103-8478cr20200651
Palabra clave:
Uveítis
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
Uveíte; ; ; ; ;
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
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closedAccess
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Atribución 4.0 Internacional (CC BY 4.0)
id COOPER2_ca3880eb362e09ccde523c67613cff78
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/54114
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.eng.fl_str_mv Relationship between ocular abnormalities and hematologic alterations
dc.title.translated.none.fl_str_mv Alteraciones hematológicas y su relación con anormalidades oculares y pacientes infectados naturalmente con Ehrlichia canis
title Relationship between ocular abnormalities and hematologic alterations
spellingShingle Relationship between ocular abnormalities and hematologic alterations
Uveítis
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
Uveíte; ; ; ; ;
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
title_short Relationship between ocular abnormalities and hematologic alterations
title_full Relationship between ocular abnormalities and hematologic alterations
title_fullStr Relationship between ocular abnormalities and hematologic alterations
title_full_unstemmed Relationship between ocular abnormalities and hematologic alterations
title_sort Relationship between ocular abnormalities and hematologic alterations
dc.creator.fl_str_mv Trujillo Piso, Dunia Yisela
Padilla Barreto, Mónica Yamile
Sánchez Bonilla, María del Pilar
Lima de Andrade, Alexandre
dc.contributor.author.none.fl_str_mv Trujillo Piso, Dunia Yisela
Padilla Barreto, Mónica Yamile
Sánchez Bonilla, María del Pilar
Lima de Andrade, Alexandre
dc.subject.proposal.eng.fl_str_mv Uveítis
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
topic Uveítis
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
Uveíte; ; ; ; ;
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
dc.subject.proposal.spa.fl_str_mv Uveíte; ; ; ; ;
Trombocitopenia
Ehrlichia
PIO
Hematología
Gen TRAG
description To determine the association between ocular abnormalities and hematologic findings in Ehrlichia canis-infected dogs, 120 dogs suspected of canine ehrlichiosis were studied. All patients were subjected to rapid serologic diagnostic test for Ehrlichia canis, and the diagnosis was confirmed by quantitative PCR. PCR-positive patients underwent ophthalmologic examination and a hemogram and were grouped into patients with thrombocytopenia and anemia (G1), patients with thrombocytopenia (G2), and patients without hematologic disorders (G3). For ophthalmic evaluation, the patients were grouped into those having mild, severe, both mild and severe, and no ocular alterations. All patients presented with uveitis (100%). Severe ocular disorders predominated in G1 and G2 patients. Dogs with anemia and leukopenia showed severe ocular disorders. In dogs with a greater number of leukocytes and copies/µl of the TRAG gene, the intraocular pressure (IOP) tends to decrease and vice versa (r = −0.23, r = −0.26). In conclusion, uveitis is the earliest ocular alteration of canine ehrlichiosis. The severity of ocular abnormalities in patients with ehrlichiosis is associated with thrombocytopenia and may be aggravated by anemia and leukopenia. The hemogram and IOP are useful tools for predicting eye involvement in Ehrlichia canis-infected patients. In regions where Ehrlichia canis is endemic, the use of the tonometer should be routinely in dog general consultation
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2024-01-31T14:47:57Z
dc.date.available.none.fl_str_mv 2024-01-31T14:47:57Z
dc.type.none.fl_str_mv Artículo
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dc.identifier.citation.none.fl_str_mv Piso DYT, Barreto MYP, Bonilla M del PS, Andrade AL de. Relationship between ocular abnormalities and hematologic alterations in patients infected naturally by Ehrlichia canis. Cienc Rural [Internet]. 2021;51(8):e20200651. Available from: https://doi.org/10.1590/0103-8478cr20200651
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/54114
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1590/0103-8478cr20200651
identifier_str_mv Piso DYT, Barreto MYP, Bonilla M del PS, Andrade AL de. Relationship between ocular abnormalities and hematologic alterations in patients infected naturally by Ehrlichia canis. Cienc Rural [Internet]. 2021;51(8):e20200651. Available from: https://doi.org/10.1590/0103-8478cr20200651
url https://hdl.handle.net/20.500.12494/54114
https://doi.org/10.1590/0103-8478cr20200651
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofjournal.none.fl_str_mv SciELO - Brasil
dc.relation.references.none.fl_str_mv BADILLO, M. et al. Infection by Ehrlichia canis and Anaplasma sp . in dogs attended in veterinary clinics , Barranquilla, Colombia. Revista MVZ Córdoba, v.22, p.6023–6033, 2017.
BÉLANGER, M. et al. Comparison of serological detection methods for diagnosis of Ehrlichia canisiinfections in Dogs Comparison of Serological Detection Methods for Diagnosis of Ehrlichia canis Infections in Dogs. Journal of Clinical Microbiology, v.40, n.9, p.3506–3508, 2002. Available from: <https://doi.org/10.1128/JCM.40.9.3506>. Accessed: Jul. 09, 2020. doi: 10.1128/JCM.40.9.3506.
CAMPOS, L. et al. Molecular detection and identification of Rickettsiales pathogens in dog ticks from Costa Rica. Ticks and Tick-borne Diseases, v.7, n.6, p.1198–1202, 2016. Available from: <https://doi.org/10.1016/j.ttbdis.2016.07.015>. Accessed: Jul 09, 2020. doi: 10.1016/j.ttbdis.2016.07.015.
CARRILLO, L. M. et al. Implementation of a PCR-based method for the diagnosis of Ehrlichia spp , in canine in Medellin ( Colombia )*. Revista CES, v.7, n.2, p.38–46, 2012.
COOK, C. S. et al. Clinical basic science. In: PETERSENJONES, R. P. S. (Ed.). . Small Animal Ophthalmology. 4th. ed. Philadelphia: Saunders Ltd., 2008. p. 1–13.
DAVOUST, B. et al. Usefulness of a rapid immuno-migration test for the detection of canine monocytic ehrlichiosis in Africa. Comparative Immunology, Microbiology and Infectious Diseases, v.37, n.1, p.31–37, 2014. Available from: <https://doi. org/10.1016/j.cimid.2013.10.005>. Accessed: Jul 09, 2020. doi: 10.1016/j.cimid.2013.10.005.
DINIZ, P. P. V. P. et al. Serum c para manter uniformidade todas as primeiras letras minúsculaardiac Troponin I Concentration in Dogs with Ehrlichiosis. Journal of Veterinary Internal Medicine, v.22, n.5, p.1136–1143, 2008. Available from: <https://doi.org/1 0.1111/j.1939-1676.2008.0145.x>. Accessed: Jul. 09, 2020. doi: 10.1111/j.1939-1676.2008.0145.x.
ENGLER, R. L. et al. Leukocyte capillary Plugging in Myocardial Ischemia and Reperfusion in the Dog. American Journal of Pathology, v.111, n.1, p.98–111, 1982.
FELEK, S. et al. Sequence and expression Analysis of virB9 of the Type IV Secretion System of Ehrlichia canis Strains in Ticks , Dogs , and Cultured Cells. Infection and Immunity, v71, n.10, p.6063–6067, 2003. doi: 10.1128/IAI.71.10.6063-6067.2003.
HARRUS, S. et al. Acute blindness associated with monoclonal gammopathy induced by Ehrlichia canis infection. Veterinary parasitology, v.78, n.2, p.155–60, 1998. Available from: <https:// doi.org/10.1016/s0304-4017(98)00132-0>. Accessed: Jul 09, 2020. doi: 10.1016/s0304-4017(98)00132-0.
HARRUS, S. et al. Presence of immune-complexes, and absence of antinuclear antibodies, in sera of dogs naturally and experimentally infected with Ehrlichia canis. Veterinary microbiology, v.83, n.4, p.343–9, 2001. Available from: <https://doi.org/10.1016/S0378- 1135(01)00431-X>. Accessed: Jul. 09, 2020. doi: 10.1016/S0378- 1135(01)00431-X.
HARRUS, S.; WANER, T. Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): An overview. The Veterinary Journal, p.292–296, 2011. Available from: <https://doi. org/10.1016/j.tvjl.2010.02.001>. Accessed: Jul. 09, 2020. doi: 10.1016/j.tvjl.2010.02.001.
KITTLESON, M. Primary myocardial disease leading to chronic myocardial failure (dilated cardiomyopathy and related diseases). In: Small Animal Cardiovascular Medicine. 1. ed. Philadelphia: Mosby, 1998. p. 319–346.
KOMNENOU, A. et al. Ocular manifestations of natural canine monocytic ehrlichiosis (Ehrlichia canis): A retrospective study of 90 cases. Veterinary Ophthalmology, v.10, n.3, p.137–142, 2007. Available from: <https://doi.org/10.1111 /j.1463-5224.2007.00508.x>. Accessed: Jul. 09, 2020. doi: 10.1111/j.1463-5224.2007.00508.x.
LEIVA, M. et al. Ocular signs of canine monocytic ehrlichiosis: A retrospective study in dogs from Barcelona, Spain. Veterinary Ophthalmology, v.8, n.6, p.387–393, 2005. Available from: <https://doi.org/10.1111/j.1463-5224.2005.00409.x>. Accessed: Jul. 09, 2020. doi: 10.1111/j.1463-5224.2005.00409.x.
LIN, A. V. Indirect ELISA. In: HNASKO, R. (Ed.). . ELISA Methods and Protocols. [s.l.] Springer, 2015. p. 51–61.
MANNA, L. et al. First molecular characterization of a granulocytic Ehrlichia strain isolated from a dog in South Italy. Veterinary journal (London, England: 1997), v.167, n.3, p.224–7, 2004. Available from: <https://doi.org/10.1016/j.tvjl.2004.02.008>. Accessed: Jul. 09, 2020. doi: 10.1016/j.tvjl.2004.02.008.
MARTIN, C. Ocular manifestations of systemic disease. Veterinary Ophthalmology, p. 1401–1447, 1999.
ORIÁ, A. et al. Ophthalmic, hematologic and serologic findings in dogs with suspected Ehrlichia canis infections. R. Bras. Ci. Vet, p.94–97, 2008. Available from: <http://dx.doi.org/10.4322/ rbcv.2014.202>. Accessed: Jul 09, 2020. doi: 10.4322/rbcv.2014.202.
ORIÁ, A. P. et al. Uveitis in dogs infected with Ehrlichia canis. Ciência Rural, v.34, n.4, p.1289–1295, 2004. Available from: <https://doi.org/10.1590/S0103-84782004000400055>. Accessed: Jul. 09, 2020. doi: 10.1590/S0103-84782004000400055.
OSBORNE, N. N. et al. Retinal ischemia : mechanisms of damage and potential therapeutic strategies. Progress in Retinal and Eye Research, v.23, n.1, p.91–147, 2004. Available from: <https://doi. org/10.1016/j.preteyeres.2003.12.001>. Accessed: Jul. 09, 2020. doi: 10.1016/j.preteyeres.2003.12.001.
ÖZATA, F.; URAL, K. Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum. MVZ Córdoba, v.19, n.3, p.4277–4288, 2014.
PEDA, A. et al. Dermatophytosis in a Dog Seropositive for Ehrlichia Spp. Journal of Veterinary Science & Animal Husbandry, v.2, n.2, p.21–23, 2014. Available from: <https://doi. org/10.15744/2348-9790.1.501>. Accessed: Jul. 09, 2020. doi: 10.15744/2348-9790.1.501.
REINE, N. J. Infection and blood transfusion: A guide to donor screening. Clinical Techniques in Small Animal Practice, v.19, n.2, p.68–74, 2004. Available from: <https://doi.org/10.1053/j.ctsap.2004.01.002>. Accessed: Jul. 09, 2020. doi: 10.1053/j.ctsap.2004.01.002.
VARGAS-HERNÁNDEZ, G. et al. Molecular and serological detection of Ehrlichia canis and Babesia vogeli in dogs in Colombia. Veterinary Parasitology, v.186, n.3–4, p.254–260, 2012. Available from: <https://doi.org/10.1016/j.vetpar.2011.11.011>. Accessed: Jul. 09, 2020. doi: 10.1016/j.vetpar.2011.11.011.
VELOSO, J. F. et al. Molecular diagnosis of Ehrlichia canis infection in dogs with uveitis Diagnóstico molecular da infecção por Ehrlichia canis em cães com uveíte. Ciências Agrárias, v.39, n.3, p.1049–1056, 2018. Available from: <https://doi. org/10.5433/1679-0359.2018v39n3p1049>. Accessed: Jul. 09, 2020. doi: 10.5433/1679-0359.2018v39n3p1049.
WONG, S. S. Y. et al. Comparative Evaluation of a Point-ofCare Immunochromatographic Test SNAP 4Dx with Molecular Detection Tests for Vector-Borne Canine Pathogens in Hong Kong. Vector-Borne and Zoonotic Diseases, v.11, n.9, p.1269–1277, 2011. Available from: <https://doi.org/10.1089/vbz.2010.0265>. Accessed: Jul. 09, 2020. doi: 10.1089/vbz.2010.0265.
YOKOTA, H. et al. Neuroprotection from retinal ischemia / Reperfusion Injury by NOX2 NADPH Oxidase Deletion. Investigative Ophthalmology & Visual Science, v.52, n.11, p.8123–8131, 2011. Available from: <https://doi.org/10.1167/ iovs.11-8318>. Accessed: Jul. 09, 2020. doi: 10.1167/iovs.11-8318.
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spelling Trujillo Piso, Dunia YiselaPadilla Barreto, Mónica YamileSánchez Bonilla, María del PilarLima de Andrade, Alexandre2024-01-31T14:47:57Z2024-01-31T14:47:57Z2021Piso DYT, Barreto MYP, Bonilla M del PS, Andrade AL de. Relationship between ocular abnormalities and hematologic alterations in patients infected naturally by Ehrlichia canis. Cienc Rural [Internet]. 2021;51(8):e20200651. Available from: https://doi.org/10.1590/0103-8478cr20200651https://hdl.handle.net/20.500.12494/54114https://doi.org/10.1590/0103-8478cr20200651To determine the association between ocular abnormalities and hematologic findings in Ehrlichia canis-infected dogs, 120 dogs suspected of canine ehrlichiosis were studied. All patients were subjected to rapid serologic diagnostic test for Ehrlichia canis, and the diagnosis was confirmed by quantitative PCR. PCR-positive patients underwent ophthalmologic examination and a hemogram and were grouped into patients with thrombocytopenia and anemia (G1), patients with thrombocytopenia (G2), and patients without hematologic disorders (G3). For ophthalmic evaluation, the patients were grouped into those having mild, severe, both mild and severe, and no ocular alterations. All patients presented with uveitis (100%). Severe ocular disorders predominated in G1 and G2 patients. Dogs with anemia and leukopenia showed severe ocular disorders. In dogs with a greater number of leukocytes and copies/µl of the TRAG gene, the intraocular pressure (IOP) tends to decrease and vice versa (r = −0.23, r = −0.26). In conclusion, uveitis is the earliest ocular alteration of canine ehrlichiosis. The severity of ocular abnormalities in patients with ehrlichiosis is associated with thrombocytopenia and may be aggravated by anemia and leukopenia. The hemogram and IOP are useful tools for predicting eye involvement in Ehrlichia canis-infected patients. In regions where Ehrlichia canis is endemic, the use of the tonometer should be routinely in dog general consultationPara determinar una asociación entre anormalidades oculares y dolores hematológicos en células infectadas con Ehrlichia canis, foram estudados 120 células con sospecha de erliquiose canina. Todos los pacientes sometidos a una prueba de diagnóstico sorológico rápido para Ehrlichia canis, eo diagnóstico confirmado por PCR cuantitativa. Os pacientes com PCR positivo foram submetidos a exame oftalmológico e hemograma completo e foram agrupados em pacientes com trombocitopenia e anemia (G1), pacientes com trombocitopenia (G2) e pacientes sem distúrbios hematológicos (G3). Para la evaluación oftalmológica, los pacientes están agrupados en pacientes con alteraciones leves o graves, leves y graves y sin anormalidades oculares. Todos los pacientes presentarán uveíte (100%). Los trastornos oculares graves predominan en los pacientes de G1 y G2. Cães com anemia y leucopenia presentan trastornos oculares graves. En cantidades con mayor número de leucócitos y copias/μl del gen TRAG, la presión intraocular tiende a disminuir y viceversa (r = -0,23, r = -0,26). En conclusión, a uveíte é o primeiro distúrbio ocular da erliquiose canina. La gestación de anormalidades oculares en pacientes con erliquiosis está asociada a trombocitopenia y puede agravarse por anemia y leucopenia. Hemograma y PIO son herramientas útiles para prevenir el envolvimiento ocular en pacientes infectados con Ehrlichia canis. En las regiones en que la Ehrlichia canis es endémica, el uso del tonómetro debe ser rotineiro en las consultas generales de cañas.CONADIClínica y cirugía veterinaria9 p.application/pdfengBrasilUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Ibaguéhttps://www.scielo.br/j/cr/a/LYsQYVmqH4z3bBCpzwCNLvH/?lang=enRelationship between ocular abnormalities and hematologic alterationsAlteraciones hematológicas y su relación con anormalidades oculares y pacientes infectados naturalmente con Ehrlichia canisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionSciELO - BrasilBADILLO, M. et al. Infection by Ehrlichia canis and Anaplasma sp . in dogs attended in veterinary clinics , Barranquilla, Colombia. Revista MVZ Córdoba, v.22, p.6023–6033, 2017.BÉLANGER, M. et al. Comparison of serological detection methods for diagnosis of Ehrlichia canisiinfections in Dogs Comparison of Serological Detection Methods for Diagnosis of Ehrlichia canis Infections in Dogs. Journal of Clinical Microbiology, v.40, n.9, p.3506–3508, 2002. Available from: <https://doi.org/10.1128/JCM.40.9.3506>. Accessed: Jul. 09, 2020. doi: 10.1128/JCM.40.9.3506.CAMPOS, L. et al. Molecular detection and identification of Rickettsiales pathogens in dog ticks from Costa Rica. Ticks and Tick-borne Diseases, v.7, n.6, p.1198–1202, 2016. Available from: <https://doi.org/10.1016/j.ttbdis.2016.07.015>. Accessed: Jul 09, 2020. doi: 10.1016/j.ttbdis.2016.07.015.CARRILLO, L. M. et al. Implementation of a PCR-based method for the diagnosis of Ehrlichia spp , in canine in Medellin ( Colombia )*. Revista CES, v.7, n.2, p.38–46, 2012.COOK, C. S. et al. Clinical basic science. In: PETERSENJONES, R. P. S. (Ed.). . Small Animal Ophthalmology. 4th. ed. Philadelphia: Saunders Ltd., 2008. p. 1–13.DAVOUST, B. et al. Usefulness of a rapid immuno-migration test for the detection of canine monocytic ehrlichiosis in Africa. Comparative Immunology, Microbiology and Infectious Diseases, v.37, n.1, p.31–37, 2014. Available from: <https://doi. org/10.1016/j.cimid.2013.10.005>. Accessed: Jul 09, 2020. doi: 10.1016/j.cimid.2013.10.005.DINIZ, P. P. V. P. et al. Serum c para manter uniformidade todas as primeiras letras minúsculaardiac Troponin I Concentration in Dogs with Ehrlichiosis. Journal of Veterinary Internal Medicine, v.22, n.5, p.1136–1143, 2008. Available from: <https://doi.org/1 0.1111/j.1939-1676.2008.0145.x>. Accessed: Jul. 09, 2020. doi: 10.1111/j.1939-1676.2008.0145.x.ENGLER, R. L. et al. Leukocyte capillary Plugging in Myocardial Ischemia and Reperfusion in the Dog. American Journal of Pathology, v.111, n.1, p.98–111, 1982.FELEK, S. et al. Sequence and expression Analysis of virB9 of the Type IV Secretion System of Ehrlichia canis Strains in Ticks , Dogs , and Cultured Cells. Infection and Immunity, v71, n.10, p.6063–6067, 2003. doi: 10.1128/IAI.71.10.6063-6067.2003.HARRUS, S. et al. Acute blindness associated with monoclonal gammopathy induced by Ehrlichia canis infection. Veterinary parasitology, v.78, n.2, p.155–60, 1998. Available from: <https:// doi.org/10.1016/s0304-4017(98)00132-0>. Accessed: Jul 09, 2020. doi: 10.1016/s0304-4017(98)00132-0.HARRUS, S. et al. Presence of immune-complexes, and absence of antinuclear antibodies, in sera of dogs naturally and experimentally infected with Ehrlichia canis. Veterinary microbiology, v.83, n.4, p.343–9, 2001. Available from: <https://doi.org/10.1016/S0378- 1135(01)00431-X>. Accessed: Jul. 09, 2020. doi: 10.1016/S0378- 1135(01)00431-X.HARRUS, S.; WANER, T. Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): An overview. The Veterinary Journal, p.292–296, 2011. Available from: <https://doi. org/10.1016/j.tvjl.2010.02.001>. Accessed: Jul. 09, 2020. doi: 10.1016/j.tvjl.2010.02.001.KITTLESON, M. Primary myocardial disease leading to chronic myocardial failure (dilated cardiomyopathy and related diseases). In: Small Animal Cardiovascular Medicine. 1. ed. Philadelphia: Mosby, 1998. p. 319–346.KOMNENOU, A. et al. Ocular manifestations of natural canine monocytic ehrlichiosis (Ehrlichia canis): A retrospective study of 90 cases. Veterinary Ophthalmology, v.10, n.3, p.137–142, 2007. Available from: <https://doi.org/10.1111 /j.1463-5224.2007.00508.x>. Accessed: Jul. 09, 2020. doi: 10.1111/j.1463-5224.2007.00508.x.LEIVA, M. et al. Ocular signs of canine monocytic ehrlichiosis: A retrospective study in dogs from Barcelona, Spain. Veterinary Ophthalmology, v.8, n.6, p.387–393, 2005. Available from: <https://doi.org/10.1111/j.1463-5224.2005.00409.x>. 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