Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
HPV variants Genetic ancestry Cervical cancer Admixture
- Autores:
-
Duque Vélez, Constanza Elena
Lopera, Esteban A.
Baena Zapata, Armando
Flórez García, Víctor Alfonso
Montiel, Jehidys
Ramírez Pineda, Arianis Tatiana
Borrero, Mauricio
Cordoba, Carlos M.
Rojas, Fredy
Pareja, Rene
Bedoya, Astrid Milena
Bedoya, Gabriel
Sánchez, Gloria I.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2014
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1236
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1236
- Palabra clave:
- Cervical cancer
Genetic ancestry
Human papillomavirus 16 HPV
Colombia
variants Genetic ancestry
Admixture
- Rights
- embargoedAccess
- License
- Licencia CC
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dc.title.spa.fl_str_mv |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
title |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
spellingShingle |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases Cervical cancer Genetic ancestry Human papillomavirus 16 HPV Colombia variants Genetic ancestry Admixture |
title_short |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
title_full |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
title_fullStr |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
title_full_unstemmed |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
title_sort |
Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
dc.creator.fl_str_mv |
Duque Vélez, Constanza Elena Lopera, Esteban A. Baena Zapata, Armando Flórez García, Víctor Alfonso Montiel, Jehidys Ramírez Pineda, Arianis Tatiana Borrero, Mauricio Cordoba, Carlos M. Rojas, Fredy Pareja, Rene Bedoya, Astrid Milena Bedoya, Gabriel Sánchez, Gloria I. |
dc.contributor.author.none.fl_str_mv |
Duque Vélez, Constanza Elena Lopera, Esteban A. Baena Zapata, Armando Flórez García, Víctor Alfonso Montiel, Jehidys Ramírez Pineda, Arianis Tatiana Borrero, Mauricio Cordoba, Carlos M. Rojas, Fredy Pareja, Rene Bedoya, Astrid Milena Bedoya, Gabriel Sánchez, Gloria I. |
dc.subject.spa.fl_str_mv |
Cervical cancer Genetic ancestry Human papillomavirus 16 HPV Colombia variants Genetic ancestry Admixture |
topic |
Cervical cancer Genetic ancestry Human papillomavirus 16 HPV Colombia variants Genetic ancestry Admixture |
description |
HPV variants Genetic ancestry Cervical cancer Admixture |
publishDate |
2014 |
dc.date.issued.none.fl_str_mv |
2014-10-24 |
dc.date.available.none.fl_str_mv |
2015-10-25 2017-08-22T16:38:37Z |
dc.date.accessioned.none.fl_str_mv |
2017-08-22T16:38:37Z |
dc.type.none.fl_str_mv |
Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/1236 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Duque Vélez, C. E., Lopera, E. A., Baena, A., Florez, V., Montiel, J., Duque, C., Ramirez, T., Borrero, M., Cordoba, M., Rojas, F., Pareja, R., Bedoya, A., Bedoya, G. & Sanchez, G. (2014). Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases. Infection, Genetics and Evolution, 28, 339–348. doi: org/10.1016/j.meegid.2014.10.014 |
url |
https://hdl.handle.net/20.500.12494/1236 |
identifier_str_mv |
Duque Vélez, C. E., Lopera, E. A., Baena, A., Florez, V., Montiel, J., Duque, C., Ramirez, T., Borrero, M., Cordoba, M., Rojas, F., Pareja, R., Bedoya, A., Bedoya, G. & Sanchez, G. (2014). Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases. Infection, Genetics and Evolution, 28, 339–348. doi: org/10.1016/j.meegid.2014.10.014 |
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Licencia CC |
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http://purl.org/coar/access_right/c_f1cf |
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Licencia CC http://purl.org/coar/access_right/c_f1cf |
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embargoedAccess |
dc.publisher.spa.fl_str_mv |
Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Odontología, Medellín y Envigado, Colombia, 00000 |
dc.publisher.program.spa.fl_str_mv |
Odontología |
dc.publisher.place.spa.fl_str_mv |
Medellín |
institution |
Universidad Cooperativa de Colombia |
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spelling |
Duque Vélez, Constanza ElenaLopera, Esteban A.Baena Zapata, ArmandoFlórez García, Víctor AlfonsoMontiel, JehidysRamírez Pineda, Arianis TatianaBorrero, MauricioCordoba, Carlos M.Rojas, FredyPareja, ReneBedoya, Astrid MilenaBedoya, GabrielSánchez, Gloria I.2017-08-22T16:38:37Z2015-10-252017-08-22T16:38:37Z2014-10-24https://hdl.handle.net/20.500.12494/1236Duque Vélez, C. E., Lopera, E. A., Baena, A., Florez, V., Montiel, J., Duque, C., Ramirez, T., Borrero, M., Cordoba, M., Rojas, F., Pareja, R., Bedoya, A., Bedoya, G. & Sanchez, G. (2014). Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases. Infection, Genetics and Evolution, 28, 339–348. doi: org/10.1016/j.meegid.2014.10.014HPV variants Genetic ancestry Cervical cancer AdmixtureBackground: European (E) variants of HPV 16 are evenly distributed among world regions, meanwhile Non-European variants such as European-Asian (Eu), Asian American (AA) and African (Af) are mostly confined to Eastern Asia, The Americas and African regions respectively. Several studies have shown that genetic variation of HPV 16 is associated with the risk of cervical cancer, which also seems to be dependent on the population. This relationship between ethnicity and variants have led to the suggestion that there is co-evolution of variants with humankind. Our aim was to evaluate the relationship between the individual ancestry proportion and infection with HPV 16 variants in cervical cancer. Methods: We examined the association between ancestry and HPV 16 variants in samples of 82 cervical cancer cases from different regions of Colombia. Individual ancestry proportions (European, African and Native American) were estimated by genotyping 106 ancestry informative markers. Variants were identified by PCR amplification of the E6 gene, followed by reverse line blot hybridization (RLB) with variants specific probes. Results: Overall European (E) and Asian American (AA) variants frequency was 66.5% and 33.5% respectively. Similar distribution was observed in cases with higher proportions of European or African ancestry. A higher Native American ancestry was significantly associated with higher frequency of E variants (median ancestry > 23.6%, Age and place of birth adjusted OR: 3.55, 95% CI: 1.26–10.03, p = 0.01). Even further, an inverse geographic correlation between Native American ancestry and frequency of infections with AA variants was observed (q = 0.825, p = 0.008). Regions with higher proportion of Native American ancestry had a lower frequency of AA variants of HPV 16. Conclusions: This study suggests replacement of AA variants by E variants of human papillomavirus 16 in cervical cancer cases with high Native American ancestry.constanza.duquev@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Odontología, Medellín y Envigado, Colombia, 00000OdontologíaMedellínhttp://ac.els-cdn.com/S1567134814003852/1-s2.0-S1567134814003852-main.pdf?_tid=720f1df6-7e03-11e7-a215-00000aab0f01&acdnat=1502394072_532909e564b60e72741d39c98b11f151Cervical cancerGenetic ancestryHuman papillomavirus 16 HPVColombiavariants Genetic ancestryAdmixtureUnexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer casesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia 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