Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases

HPV variants Genetic ancestry Cervical cancer Admixture

Autores:
Duque Vélez, Constanza Elena
Lopera, Esteban A.
Baena Zapata, Armando
Flórez García, Víctor Alfonso
Montiel, Jehidys
Ramírez Pineda, Arianis Tatiana
Borrero, Mauricio
Cordoba, Carlos M.
Rojas, Fredy
Pareja, Rene
Bedoya, Astrid Milena
Bedoya, Gabriel
Sánchez, Gloria I.
Tipo de recurso:
Article of journal
Fecha de publicación:
2014
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/1236
Acceso en línea:
https://hdl.handle.net/20.500.12494/1236
Palabra clave:
Cervical cancer
Genetic ancestry
Human papillomavirus 16 HPV
Colombia
variants Genetic ancestry
Admixture
Rights
embargoedAccess
License
Licencia CC
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dc.title.spa.fl_str_mv Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
title Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
spellingShingle Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
Cervical cancer
Genetic ancestry
Human papillomavirus 16 HPV
Colombia
variants Genetic ancestry
Admixture
title_short Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
title_full Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
title_fullStr Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
title_full_unstemmed Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
title_sort Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases
dc.creator.fl_str_mv Duque Vélez, Constanza Elena
Lopera, Esteban A.
Baena Zapata, Armando
Flórez García, Víctor Alfonso
Montiel, Jehidys
Ramírez Pineda, Arianis Tatiana
Borrero, Mauricio
Cordoba, Carlos M.
Rojas, Fredy
Pareja, Rene
Bedoya, Astrid Milena
Bedoya, Gabriel
Sánchez, Gloria I.
dc.contributor.author.none.fl_str_mv Duque Vélez, Constanza Elena
Lopera, Esteban A.
Baena Zapata, Armando
Flórez García, Víctor Alfonso
Montiel, Jehidys
Ramírez Pineda, Arianis Tatiana
Borrero, Mauricio
Cordoba, Carlos M.
Rojas, Fredy
Pareja, Rene
Bedoya, Astrid Milena
Bedoya, Gabriel
Sánchez, Gloria I.
dc.subject.spa.fl_str_mv Cervical cancer
Genetic ancestry
Human papillomavirus 16 HPV
Colombia
variants Genetic ancestry
Admixture
topic Cervical cancer
Genetic ancestry
Human papillomavirus 16 HPV
Colombia
variants Genetic ancestry
Admixture
description HPV variants Genetic ancestry Cervical cancer Admixture
publishDate 2014
dc.date.issued.none.fl_str_mv 2014-10-24
dc.date.available.none.fl_str_mv 2015-10-25
2017-08-22T16:38:37Z
dc.date.accessioned.none.fl_str_mv 2017-08-22T16:38:37Z
dc.type.none.fl_str_mv Artículo
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/1236
dc.identifier.bibliographicCitation.spa.fl_str_mv Duque Vélez, C. E., Lopera, E. A., Baena, A., Florez, V., Montiel, J., Duque, C., Ramirez, T., Borrero, M., Cordoba, M., Rojas, F., Pareja, R., Bedoya, A., Bedoya, G. & Sanchez, G. (2014). Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases. Infection, Genetics and Evolution,  28, 339–348. doi: org/10.1016/j.meegid.2014.10.014
url https://hdl.handle.net/20.500.12494/1236
identifier_str_mv Duque Vélez, C. E., Lopera, E. A., Baena, A., Florez, V., Montiel, J., Duque, C., Ramirez, T., Borrero, M., Cordoba, M., Rojas, F., Pareja, R., Bedoya, A., Bedoya, G. & Sanchez, G. (2014). Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases. Infection, Genetics and Evolution,  28, 339–348. doi: org/10.1016/j.meegid.2014.10.014
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dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Odontología, Medellín y Envigado, Colombia, 00000
dc.publisher.program.spa.fl_str_mv Odontología
dc.publisher.place.spa.fl_str_mv Medellín
institution Universidad Cooperativa de Colombia
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spelling Duque Vélez, Constanza ElenaLopera, Esteban A.Baena Zapata, ArmandoFlórez García, Víctor AlfonsoMontiel, JehidysRamírez Pineda, Arianis TatianaBorrero, MauricioCordoba, Carlos M.Rojas, FredyPareja, ReneBedoya, Astrid MilenaBedoya, GabrielSánchez, Gloria I.2017-08-22T16:38:37Z2015-10-252017-08-22T16:38:37Z2014-10-24https://hdl.handle.net/20.500.12494/1236Duque Vélez, C. E., Lopera, E. A., Baena, A., Florez, V., Montiel, J., Duque, C., Ramirez, T., Borrero, M., Cordoba, M., Rojas, F., Pareja, R., Bedoya, A., Bedoya, G. & Sanchez, G. (2014). Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases. Infection, Genetics and Evolution,  28, 339–348. doi: org/10.1016/j.meegid.2014.10.014HPV variants Genetic ancestry Cervical cancer AdmixtureBackground: European (E) variants of HPV 16 are evenly distributed among world regions, meanwhile Non-European variants such as European-Asian (Eu), Asian American (AA) and African (Af) are mostly confined to Eastern Asia, The Americas and African regions respectively. Several studies have shown that genetic variation of HPV 16 is associated with the risk of cervical cancer, which also seems to be dependent on the population. This relationship between ethnicity and variants have led to the suggestion that there is co-evolution of variants with humankind. Our aim was to evaluate the relationship between the individual ancestry proportion and infection with HPV 16 variants in cervical cancer. Methods: We examined the association between ancestry and HPV 16 variants in samples of 82 cervical cancer cases from different regions of Colombia. Individual ancestry proportions (European, African and Native American) were estimated by genotyping 106 ancestry informative markers. Variants were identified by PCR amplification of the E6 gene, followed by reverse line blot hybridization (RLB) with variants specific probes. Results: Overall European (E) and Asian American (AA) variants frequency was 66.5% and 33.5% respectively. Similar distribution was observed in cases with higher proportions of European or African ancestry. A higher Native American ancestry was significantly associated with higher frequency of E variants (median ancestry > 23.6%, Age and place of birth adjusted OR: 3.55, 95% CI: 1.26–10.03, p = 0.01). Even further, an inverse geographic correlation between Native American ancestry and frequency of infections with AA variants was observed (q = 0.825, p = 0.008). Regions with higher proportion of Native American ancestry had a lower frequency of AA variants of HPV 16. Conclusions: This study suggests replacement of AA variants by E variants of human papillomavirus 16 in cervical cancer cases with high Native American ancestry.constanza.duquev@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Odontología, Medellín y Envigado, Colombia, 00000OdontologíaMedellínhttp://ac.els-cdn.com/S1567134814003852/1-s2.0-S1567134814003852-main.pdf?_tid=720f1df6-7e03-11e7-a215-00000aab0f01&acdnat=1502394072_532909e564b60e72741d39c98b11f151Cervical cancerGenetic ancestryHuman papillomavirus 16 HPVColombiavariants Genetic ancestryAdmixtureUnexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer casesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia 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