A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals

Intestinal microbiota facilitates food breakdown for energy metabolism and influences the im-mune response and maintaining mucosal homeostasis. Overall, HIV infection is associated with intestinal dysbiosis and immune activation, which has been related to seroconversion in HIV-exposed individuals. H...

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Autores:
Zapata Builes, Wildeman
Lopera, Tulio J.
Lujan, Jorge A.
Zurek, Eduardo
Hernández López, Juan Carlos
Toro, Miguel A.
Alzate, Juan F.
Taborda, Natalia Andrea
Rugeles López, María Teresa
Aguilar Jiménez, Wbeimar
Tipo de recurso:
Article of investigation
Fecha de publicación:
2021
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/43603
Acceso en línea:
https://hdl.handle.net/20.500.12494/43603
Palabra clave:
Intestinal microbiota, richness, HIV-1, HESN, Treg cells
Intestinal microbiota, richness, HIV-1, HESN, Treg cells
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openAccess
License
Atribución
id COOPER2_c72593e96eaf4caedf718911ef8f386c
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/43603
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
title A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
spellingShingle A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
Intestinal microbiota, richness, HIV-1, HESN, Treg cells
Intestinal microbiota, richness, HIV-1, HESN, Treg cells
title_short A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
title_full A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
title_fullStr A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
title_full_unstemmed A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
title_sort A specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individuals
dc.creator.fl_str_mv Zapata Builes, Wildeman
Lopera, Tulio J.
Lujan, Jorge A.
Zurek, Eduardo
Hernández López, Juan Carlos
Toro, Miguel A.
Alzate, Juan F.
Taborda, Natalia Andrea
Rugeles López, María Teresa
Aguilar Jiménez, Wbeimar
dc.contributor.author.none.fl_str_mv Zapata Builes, Wildeman
Lopera, Tulio J.
Lujan, Jorge A.
Zurek, Eduardo
Hernández López, Juan Carlos
Toro, Miguel A.
Alzate, Juan F.
Taborda, Natalia Andrea
Rugeles López, María Teresa
Aguilar Jiménez, Wbeimar
dc.subject.spa.fl_str_mv Intestinal microbiota, richness, HIV-1, HESN, Treg cells
topic Intestinal microbiota, richness, HIV-1, HESN, Treg cells
Intestinal microbiota, richness, HIV-1, HESN, Treg cells
dc.subject.other.spa.fl_str_mv Intestinal microbiota, richness, HIV-1, HESN, Treg cells
description Intestinal microbiota facilitates food breakdown for energy metabolism and influences the im-mune response and maintaining mucosal homeostasis. Overall, HIV infection is associated with intestinal dysbiosis and immune activation, which has been related to seroconversion in HIV-exposed individuals. However, to date, it is unclear whether microbiota dysbiosis is the cause or the effect of immune alterations and disease progression. We characterize the intestinal microbiota and determine its association with immune regulation in HIV-exposed seronegative individuals (HESN), HIV-infected progressors (HIV+), and healthy control (HC) subjects. For this, feces and blood were collected. The microbiota composition of HESN showed a significantly higher alpha and beta diversity compared to HC, but similar to HIV+. A lower Treg percentage was observed in HESN than HC and HIV+, with enrichment of the genus Butyrivibrio being characteristic of this profile. Interestingly, an increase in Succinivibrio and Prevotella and a re-duction in Bacteroides genus were observed in HESN compared to HC, which is typical of HIV-infected individuals. Thus, HESNs have a microbiota profile, similar to that observed in HIV+, most likely because HESN are cohabiting with their HIV+ partners.
publishDate 2021
dc.date.issued.none.fl_str_mv 2021-12-02
dc.date.accessioned.none.fl_str_mv 2022-02-02T20:53:49Z
dc.date.available.none.fl_str_mv 2022-02-02T20:53:49Z
dc.type.none.fl_str_mv Artículos Científicos
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_2df8fbb1
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dc.identifier.issn.spa.fl_str_mv 1932-6203
dc.identifier.uri.spa.fl_str_mv 10.1371/journal.pone.0260729
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/43603
dc.identifier.bibliographicCitation.spa.fl_str_mv Lopera TJ, Lujan JA, Zurek E, Zapata W, Hernandez JC, Toro MA, et al. (2021) A specific structure and high richness characterize intestinal microbiota of HIV-exposed seronegative individuals. PLoS ONE 16(12): e0260729. https://doi.org/10.1371/journal.pone.0260729.
identifier_str_mv 1932-6203
10.1371/journal.pone.0260729
Lopera TJ, Lujan JA, Zurek E, Zapata W, Hernandez JC, Toro MA, et al. (2021) A specific structure and high richness characterize intestinal microbiota of HIV-exposed seronegative individuals. PLoS ONE 16(12): e0260729. https://doi.org/10.1371/journal.pone.0260729.
url https://hdl.handle.net/20.500.12494/43603
dc.relation.isversionof.spa.fl_str_mv https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260729
dc.relation.ispartofjournal.spa.fl_str_mv PLOS ONE
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dc.publisher.spa.fl_str_mv Aftab A. Ansari, Emory University School of Medicine, UNITED STATES
Grupo Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellin, Colombia
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spelling Zapata Builes, WildemanLopera, Tulio J.Lujan, Jorge A.Zurek, EduardoHernández López, Juan CarlosToro, Miguel A.Alzate, Juan F.Taborda, Natalia AndreaRugeles López, María TeresaAguilar Jiménez, Wbeimar16(12): e0260729.2022-02-02T20:53:49Z2022-02-02T20:53:49Z2021-12-021932-620310.1371/journal.pone.0260729https://hdl.handle.net/20.500.12494/43603Lopera TJ, Lujan JA, Zurek E, Zapata W, Hernandez JC, Toro MA, et al. (2021) A specific structure and high richness characterize intestinal microbiota of HIV-exposed seronegative individuals. PLoS ONE 16(12): e0260729. https://doi.org/10.1371/journal.pone.0260729.Intestinal microbiota facilitates food breakdown for energy metabolism and influences the im-mune response and maintaining mucosal homeostasis. Overall, HIV infection is associated with intestinal dysbiosis and immune activation, which has been related to seroconversion in HIV-exposed individuals. However, to date, it is unclear whether microbiota dysbiosis is the cause or the effect of immune alterations and disease progression. We characterize the intestinal microbiota and determine its association with immune regulation in HIV-exposed seronegative individuals (HESN), HIV-infected progressors (HIV+), and healthy control (HC) subjects. For this, feces and blood were collected. The microbiota composition of HESN showed a significantly higher alpha and beta diversity compared to HC, but similar to HIV+. A lower Treg percentage was observed in HESN than HC and HIV+, with enrichment of the genus Butyrivibrio being characteristic of this profile. Interestingly, an increase in Succinivibrio and Prevotella and a re-duction in Bacteroides genus were observed in HESN compared to HC, which is typical of HIV-infected individuals. Thus, HESNs have a microbiota profile, similar to that observed in HIV+, most likely because HESN are cohabiting with their HIV+ partners.Intestinal microbiota facilitates food breakdown for energy metabolism and influences the im-mune response and maintaining mucosal homeostasis. Overall, HIV infection is associated with intestinal dysbiosis and immune activation, which has been related to seroconversion in HIV-exposed individuals. However, to date, it is unclear whether microbiota dysbiosis is the cause or the effect of immune alterations and disease progression. We characterize the intestinal microbiota and determine its association with immune regulation in HIV-exposed seronegative individuals (HESN), HIV-infected progressors (HIV+), and healthy control (HC) subjects. For this, feces and blood were collected. The microbiota composition of HESN showed a significantly higher alpha and beta diversity compared to HC, but similar to HIV+. A lower Treg percentage was observed in HESN than HC and HIV+, with enrichment of the genus Butyrivibrio being characteristic of this profile. Interestingly, an increase in Succinivibrio and Prevotella and a re-duction in Bacteroides genus were observed in HESN compared to HC, which is typical of HIV-infected individuals. Thus, HESNs have a microbiota profile, similar to that observed in HIV+, most likely because HESN are cohabiting with their HIV+ partners.https://scienti.minciencias.gov.co/cvlac/EnProdArticulo/query.do?cod_producto=73&cod_rh=0000157775https://orcid.org/0000-0002-7351-8738COL0112548wildeman.zapatab@campusucc.edu.cohttps://scholar.google.com.co/citations?hl=en&user=VLZxl1UAAAAJ14Aftab A. Ansari, Emory University School of Medicine, UNITED STATESGrupo Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellin, ColombiaMedicinaMedellínhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260729PLOS ONE1. 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Clin Infect Dis. 2020; 71: e359–e367. https://doi.org/10.1093/cid/ciz1235 PMID: 31894240Intestinal microbiota, richness, HIV-1, HESN, Treg cellsIntestinal microbiota, richness, HIV-1, HESN, Treg cellsA specific structure and high richness characterize intestinal microbiota of HIVexposed seronegative individualsArtículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-84334https://repository.ucc.edu.co/bitstreams/21fd1873-058d-44d8-b9c4-201ea4241bdd/download3bce4f7ab09dfc588f126e1e36e98a45MD52ORIGINALMicrobiota HESN UCC_UdeA 2021.pdfMicrobiota HESN UCC_UdeA 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