Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1

Infections caused by human immunodeficiency virus (HIV) are considered one of the main public health problems worldwide. Antiretroviral therapy (ART) is the current modality of treatment for HIV-1 infection. It comprises the combined use of several drugs and can decrease the viral load and increase...

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Autores:: Zapata Builes, Wildeman
Serna Arbeláez, Maria S.
Flórez Sampedro, Laura
Orozco, Lina P.
Ramírez, Katherin
Galeano, Elkin

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2021

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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network_acronym_str	COOPER2
network_name_str	Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1
title	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1
spellingShingle	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1 HIV-1 ART Alternative therapy Natural products Anti-HIV activity HIV-1 ART Alternative therapy Natural products Anti-HIV activity
title_short	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1
title_full	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1
title_fullStr	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1
title_full_unstemmed	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1
title_sort	Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1
dc.creator.fl_str_mv	Zapata Builes, Wildeman Serna Arbeláez, Maria S. Flórez Sampedro, Laura Orozco, Lina P. Ramírez, Katherin Galeano, Elkin
dc.contributor.author.none.fl_str_mv	Zapata Builes, Wildeman Serna Arbeláez, Maria S. Flórez Sampedro, Laura Orozco, Lina P. Ramírez, Katherin Galeano, Elkin
dc.subject.spa.fl_str_mv	HIV-1 ART Alternative therapy Natural products Anti-HIV activity
topic	HIV-1 ART Alternative therapy Natural products Anti-HIV activity HIV-1 ART Alternative therapy Natural products Anti-HIV activity
dc.subject.other.spa.fl_str_mv	HIV-1 ART Alternative therapy Natural products Anti-HIV activity
description	Infections caused by human immunodeficiency virus (HIV) are considered one of the main public health problems worldwide. Antiretroviral therapy (ART) is the current modality of treatment for HIV-1 infection. It comprises the combined use of several drugs and can decrease the viral load and increase the CD4+ Tcell count in patients with HIV-1 infection, thereby proving to be an effective modality. This therapy significantly decreases the rate of morbidity and mortality owing to acquired immunodeficiency syndrome (AIDS) and prolongs and improves the quality of life of infected patients. However, nonadherence to ARTmay increase viral resistance to antiretroviral drugs and transmission of drug-resistant strains of HIV. +erefore, it is necessary to continue research for compounds with anti-HIV-1 activity, exhibiting a potential for the development of an alternative or complementary therapy to ARTwith low cost and fewer side effects. Natural products and their derivatives represent an excellent option owing to their therapeutic potential against HIV. Currently, the derivatives of natural products available as anti-HIV-1 agents include zidovudine, an arabinonucleoside derivative of the Caribbean marine sponge (Tectitethya crypta), which inhibits the reverse transcriptase of the virus. +is was the first antiviral agent approved for treatment of HIV infection. Additionally, bevirimat (isolated from Syzygium claviflorum) and calanolide A (isolated from Calophyllum sp.) are inhibitors of viral maturation and reverse transcription process, respectively. In the present review, we aimed to describe the wide repertoire of natural compounds exhibiting anti-HIV-1 activity that can be considered for designing new therapeutic strategies to curb the HIV pandemic.
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-08-02T22:38:24Z
dc.date.available.none.fl_str_mv	2021-08-02T22:38:24Z
dc.date.issued.none.fl_str_mv	2021-05-30
dc.type.none.fl_str_mv	Artículos Científicos
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_2df8fbb1
status_str	publishedVersion
dc.identifier.issn.spa.fl_str_mv	1687-8647
dc.identifier.uri.spa.fl_str_mv	10.1155/2021/5552088
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/35509
dc.identifier.bibliographicCitation.spa.fl_str_mv	Serna-Arbeláez, M. S., Florez-Sampedro, Orozco, L. P., Ramírez, K., Galeano, E. y Zapata, W. (2021) Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1. Advances in Virology, vol. 2021, Article ID 5552088, 22 pages, 2021. https://doi.org/10.1155/2021/5552088
identifier_str_mv	1687-8647 10.1155/2021/5552088 Serna-Arbeláez, M. S., Florez-Sampedro, Orozco, L. P., Ramírez, K., Galeano, E. y Zapata, W. (2021) Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1. Advances in Virology, vol. 2021, Article ID 5552088, 22 pages, 2021. https://doi.org/10.1155/2021/5552088
url	https://hdl.handle.net/20.500.12494/35509
dc.relation.isversionof.spa.fl_str_mv	https://www.hindawi.com/journals/av/2021/5552088/
dc.relation.ispartofjournal.spa.fl_str_mv	Advances in Virology
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spelling	Zapata Builes, WildemanSerna Arbeláez, Maria S.Flórez Sampedro, LauraOrozco, Lina P.Ramírez, KatherinGaleano, ElkinVolume 2021, Article ID 55520882021-08-02T22:38:24Z2021-08-02T22:38:24Z2021-05-301687-864710.1155/2021/5552088https://hdl.handle.net/20.500.12494/35509Serna-Arbeláez, M. S., Florez-Sampedro, Orozco, L. P., Ramírez, K., Galeano, E. y Zapata, W. (2021) Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1. Advances in Virology, vol. 2021, Article ID 5552088, 22 pages, 2021. https://doi.org/10.1155/2021/5552088Infections caused by human immunodeficiency virus (HIV) are considered one of the main public health problems worldwide. Antiretroviral therapy (ART) is the current modality of treatment for HIV-1 infection. It comprises the combined use of several drugs and can decrease the viral load and increase the CD4+ Tcell count in patients with HIV-1 infection, thereby proving to be an effective modality. This therapy significantly decreases the rate of morbidity and mortality owing to acquired immunodeficiency syndrome (AIDS) and prolongs and improves the quality of life of infected patients. However, nonadherence to ARTmay increase viral resistance to antiretroviral drugs and transmission of drug-resistant strains of HIV. +erefore, it is necessary to continue research for compounds with anti-HIV-1 activity, exhibiting a potential for the development of an alternative or complementary therapy to ARTwith low cost and fewer side effects. Natural products and their derivatives represent an excellent option owing to their therapeutic potential against HIV. Currently, the derivatives of natural products available as anti-HIV-1 agents include zidovudine, an arabinonucleoside derivative of the Caribbean marine sponge (Tectitethya crypta), which inhibits the reverse transcriptase of the virus. +is was the first antiviral agent approved for treatment of HIV infection. Additionally, bevirimat (isolated from Syzygium claviflorum) and calanolide A (isolated from Calophyllum sp.) are inhibitors of viral maturation and reverse transcription process, respectively. In the present review, we aimed to describe the wide repertoire of natural compounds exhibiting anti-HIV-1 activity that can be considered for designing new therapeutic strategies to curb the HIV pandemic.Infections caused by human immunodeficiency virus (HIV) are considered one of the main public health problems worldwide. Antiretroviral therapy (ART) is the current modality of treatment for HIV-1 infection. It comprises the combined use of several drugs and can decrease the viral load and increase the CD4+ Tcell count in patients with HIV-1 infection, thereby proving to be an effective modality. This therapy significantly decreases the rate of morbidity and mortality owing to acquired immunodeficiency syndrome (AIDS) and prolongs and improves the quality of life of infected patients. However, nonadherence to ARTmay increase viral resistance to antiretroviral drugs and transmission of drug-resistant strains of HIV. +erefore, it is necessary to continue research for compounds with anti-HIV-1 activity, exhibiting a potential for the development of an alternative or complementary therapy to ARTwith low cost and fewer side effects. Natural products and their derivatives represent an excellent option owing to their therapeutic potential against HIV. Currently, the derivatives of natural products available as anti-HIV-1 agents include zidovudine, an arabinonucleoside derivative of the Caribbean marine sponge (Tectitethya crypta), which inhibits the reverse transcriptase of the virus. +is was the first antiviral agent approved for treatment of HIV infection. Additionally, bevirimat (isolated from Syzygium claviflorum) and calanolide A (isolated from Calophyllum sp.) are inhibitors of viral maturation and reverse transcription process, respectively. 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VII bromocompounds from the caribbean sponge Aplysina archeri,” Tetrahedron, vol. 52, no. 29, pp. 9863–9868, 1996.HIV-1ARTAlternative therapyNatural productsAnti-HIV activityHIV-1ARTAlternative therapyNatural productsAnti-HIV activityNatural products with inhibitory activity against Human Immunodeficiency Virus Type 1Artículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINALNatural Products with Inhibitory Activity against Human UCC_UdeA 2021.pdfNatural Products with Inhibitory Activity against Human UCC_UdeA 2021.pdfArtículoapplication/pdf2525288https://repository.ucc.edu.co/bitstreams/bba8f300-b351-4118-bd8f-60afe8fe0b8a/download8ff075d273cc5447f801ad9c947ef0deMD51LICENSElicense.txtlicense.txttext/plain; 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Natural products with inhibitory activity against Human Immunodeficiency Virus Type 1

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