Participación de la vitamina D en la patogénesis de la infección por el virus de la inmunodeficiencia humana tipo 1

Beyond its role in mineral metabolism, vitamin D (VitD) has immunomodulatory functions and can actively participate in the physiopathogenesis of HIV-1 infection; however, scientific evidence in this field is limited and controversial. VitD has anti-inflammatory properties that can reduce immune hyperactivation, decreasing the damage associated with this phenomenon. It also promotes the expression of antimicrobial peptides with anti-HIV-1 activity, supporting its protective role. In contrast, VitD activates the HIV-1 promoter and can increase viral replication. Furthermore, a number of allelic variants in the vitamin D receptor gene,which increase its function, have been associated with susceptibility to HIV-1 infection. Given the implications of this topic for the identification of new therapeutic targets in HIV infection, this review presents scientific evidence on the effect of the VitD pathway in HIV-1 pathogenesis. © 2013 ACIN.

• Autores: Aguilar-Jiménez W.; Zapata Builes, Wildeman; Rugeles L. M.T.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2013
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41639
• Acceso en línea: https://doi.org/10.1186/s13071-016-1500-y; https://www.medwelljournals.com/abstract/?doi=ibm.2018.196.204; https://hdl.handle.net/20.500.12494/41639
• Palabra clave: vitamin D; vitamin D receptor; allele; article; genetic variability; Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; immunomodulation; infection sensitivity; protein expression; virus pathogenesis; virus replication
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb