Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis

Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance,...

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Autores:
Cardona Arias, Jaiberth Antonio
Velásquez Agudelo, Verónica
Tipo de recurso:
Article of journal
Fecha de publicación:
2017
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
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OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/4576
Acceso en línea:
https://hdl.handle.net/20.500.12494/4576
Palabra clave:
Meta-análisis
Onychomycosis
Meta-analysis as topic
Test validity
Validation studies
Diagnosis
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closedAccess
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repository_id_str
spelling Cardona Arias, Jaiberth AntonioVelásquez Agudelo, Verónica2018-06-28T18:27:19Z2018-06-28T18:27:19Z2017-06-15https://hdl.handle.net/20.500.12494/4576Cardona Arias, J. A., & Velásquez Agudelo, V. (2017). Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 1-11. doi: 10.1186/s12879-017-2258-3Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic. Acid-Schiff –PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic. Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic, odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were, evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and. Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y EnvigadoMedicinaMedellínMeta-análisisOnychomycosisMeta-analysis as topicTest validityValidation studiesDiagnosisMeta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-84514https://repository.ucc.edu.co/bitstreams/30d8b2ed-8873-46d3-9e90-38098254469b/downloadf3f5e184cacb7496a3e3345ca148d0f7MD52ORIGINALQ1. Meta-analysis of the utility of culture, biosy and KOH.pdfQ1. Meta-analysis of the utility of culture, biosy and KOH.pdfapplication/pdf3034862https://repository.ucc.edu.co/bitstreams/b4a1bffb-e481-4aa8-8a73-c2a065195a69/download959e13abdff9cbbda2a4fdbd242039fcMD51TEXTQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.txtQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.txtExtracted texttext/plain40800https://repository.ucc.edu.co/bitstreams/a137ffa9-ab5e-4d1d-8ed8-c708417b0319/download66be52ce37dad27b363097d04e959b8fMD53THUMBNAILQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.jpgQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.jpgIM Thumbnailimage/jpeg6094https://repository.ucc.edu.co/bitstreams/4d9229cf-3f8c-47db-98a4-808ee3729828/downloadbdd2dbf34e1ac85d6350780a43743c5dMD5420.500.12494/4576oai:repository.ucc.edu.co:20.500.12494/45762024-08-10 22:40:08.712restrictedhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
spellingShingle Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
Meta-análisis
Onychomycosis
Meta-analysis as topic
Test validity
Validation studies
Diagnosis
title_short Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_full Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_fullStr Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_full_unstemmed Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
title_sort Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
dc.creator.fl_str_mv Cardona Arias, Jaiberth Antonio
Velásquez Agudelo, Verónica
dc.contributor.author.none.fl_str_mv Cardona Arias, Jaiberth Antonio
Velásquez Agudelo, Verónica
dc.subject.spa.fl_str_mv Meta-análisis
Onychomycosis
Meta-analysis as topic
Test validity
Validation studies
Diagnosis
topic Meta-análisis
Onychomycosis
Meta-analysis as topic
Test validity
Validation studies
Diagnosis
description Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic. Acid-Schiff –PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic. Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic, odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were, evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and. Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017-06-15
dc.date.accessioned.none.fl_str_mv 2018-06-28T18:27:19Z
dc.date.available.none.fl_str_mv 2018-06-28T18:27:19Z
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dc.identifier.bibliographicCitation.spa.fl_str_mv Cardona Arias, J. A., & Velásquez Agudelo, V. (2017). Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 1-11. doi: 10.1186/s12879-017-2258-3
url https://hdl.handle.net/20.500.12494/4576
identifier_str_mv Cardona Arias, J. A., & Velásquez Agudelo, V. (2017). Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 1-11. doi: 10.1186/s12879-017-2258-3
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dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y Envigado
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.place.spa.fl_str_mv Medellín
institution Universidad Cooperativa de Colombia
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