Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance,...
- Autores:
-
Cardona Arias, Jaiberth Antonio
Velásquez Agudelo, Verónica
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2017
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/4576
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/4576
- Palabra clave:
- Meta-análisis
Onychomycosis
Meta-analysis as topic
Test validity
Validation studies
Diagnosis
- Rights
- closedAccess
- License
- Licencia CC
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Cardona Arias, Jaiberth AntonioVelásquez Agudelo, Verónica2018-06-28T18:27:19Z2018-06-28T18:27:19Z2017-06-15https://hdl.handle.net/20.500.12494/4576Cardona Arias, J. A., & Velásquez Agudelo, V. (2017). Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 1-11. doi: 10.1186/s12879-017-2258-3Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic. Acid-Schiff –PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic. Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic, odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were, evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and. Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y EnvigadoMedicinaMedellínMeta-análisisOnychomycosisMeta-analysis as topicTest validityValidation studiesDiagnosisMeta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-84514https://repository.ucc.edu.co/bitstreams/30d8b2ed-8873-46d3-9e90-38098254469b/downloadf3f5e184cacb7496a3e3345ca148d0f7MD52ORIGINALQ1. Meta-analysis of the utility of culture, biosy and KOH.pdfQ1. Meta-analysis of the utility of culture, biosy and KOH.pdfapplication/pdf3034862https://repository.ucc.edu.co/bitstreams/b4a1bffb-e481-4aa8-8a73-c2a065195a69/download959e13abdff9cbbda2a4fdbd242039fcMD51TEXTQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.txtQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.txtExtracted texttext/plain40800https://repository.ucc.edu.co/bitstreams/a137ffa9-ab5e-4d1d-8ed8-c708417b0319/download66be52ce37dad27b363097d04e959b8fMD53THUMBNAILQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.jpgQ1. Meta-analysis of the utility of culture, biosy and KOH.pdf.jpgIM Thumbnailimage/jpeg6094https://repository.ucc.edu.co/bitstreams/4d9229cf-3f8c-47db-98a4-808ee3729828/downloadbdd2dbf34e1ac85d6350780a43743c5dMD5420.500.12494/4576oai:repository.ucc.edu.co:20.500.12494/45762024-08-10 22:40:08.712restrictedhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
spellingShingle |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis Meta-análisis Onychomycosis Meta-analysis as topic Test validity Validation studies Diagnosis |
title_short |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_full |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_fullStr |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_full_unstemmed |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_sort |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
dc.creator.fl_str_mv |
Cardona Arias, Jaiberth Antonio Velásquez Agudelo, Verónica |
dc.contributor.author.none.fl_str_mv |
Cardona Arias, Jaiberth Antonio Velásquez Agudelo, Verónica |
dc.subject.spa.fl_str_mv |
Meta-análisis Onychomycosis Meta-analysis as topic Test validity Validation studies Diagnosis |
topic |
Meta-análisis Onychomycosis Meta-analysis as topic Test validity Validation studies Diagnosis |
description |
Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic. Acid-Schiff –PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic. Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic, odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were, evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and. Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests. |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017-06-15 |
dc.date.accessioned.none.fl_str_mv |
2018-06-28T18:27:19Z |
dc.date.available.none.fl_str_mv |
2018-06-28T18:27:19Z |
dc.type.none.fl_str_mv |
Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/4576 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Cardona Arias, J. A., & Velásquez Agudelo, V. (2017). Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 1-11. doi: 10.1186/s12879-017-2258-3 |
url |
https://hdl.handle.net/20.500.12494/4576 |
identifier_str_mv |
Cardona Arias, J. A., & Velásquez Agudelo, V. (2017). Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis. BMC Infectious Diseases. 1-11. doi: 10.1186/s12879-017-2258-3 |
dc.rights.cc.none.fl_str_mv |
Licencia CC |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/closedAccess |
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http://purl.org/coar/access_right/c_14cb |
rights_invalid_str_mv |
Licencia CC http://purl.org/coar/access_right/c_14cb |
eu_rights_str_mv |
closedAccess |
dc.publisher.spa.fl_str_mv |
Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y Envigado |
dc.publisher.program.spa.fl_str_mv |
Medicina |
dc.publisher.place.spa.fl_str_mv |
Medellín |
institution |
Universidad Cooperativa de Colombia |
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